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Surgical approaches to correct corneal astigmatism at time of cataract surgery: a mini-review

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International Journal of ophthalmology(English edition) 2024年第7期17卷 1370-1374页

作者： Xiao-Lei Yin Zhi-Yang Ji Xiu-Xin Li Xue-Mei Liang Shu-Xing Ji department of ophthalmology the 305 Hospital of PLABeijing 100017China department of ophthalmology Daping HospitalArmy Medical UniversityChongqing 400042China department of Medical Administration the 305 Hospital of PLABeijing 100017China

Among refractive errors,astigmatism is the most common optical aberration,where refraction changes in different meridians of the *** causes blurred vision at any distance and includes corneal,lenticular,and retinal *** surgery used to cause a progressive increase in the pre-exisiting corneal astigmatism because of creating a surgically induced astigmatism,for example,a large size surgery *** development of surgical techniques during last decades has made cataract surgery interchange to treat preoperative corneal astigmatism at time of ***,three surgical approaches can be *** placing a sutureless clear corneal incision on the steep meridian of the cornea,a preoperative corneal astigmatism less than 1.0 D can be *** or paired peripheral corneal relaxing incisions(PCRIs)provide 1.0-3.0 D corneal astigmatism *** are typically used for treating 1.0-1.5 D of regular corneal astigmatism,if more than 2.0 D,the risk of overcorrection and irregular astigmatism is *** toric intraocular lenses(IOLs)are unavailable in markets,PCRIs are still a reasonable option for patients with up to 3.0 D of pre-existing corneal *** IOLs implantation can correct 1.0-4.5 D of corneal *** IOLs are approved to correct a high degree of corneal astigmatism with cylinder power up to 12.0 *** approaches can be used alone or in combination.

关键词： cornea astigmatism cataract surgery peripheral corneal relaxing incisions toric intraocular lens

Prognostic factors and clinical features of rhino-orbitalmucormycosis cases:an update for patient and visual survivals

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International Journal of ophthalmology(English edition) 2024年第5期17卷 916-923页

作者： Mustafa Aksoy Altan Atakan Ozcan Burak Ulas department of ophthalmology Cukurova University Faculty of MedicineSaricamAdana 01330Türkiye

AIM:To determine the frequency of patients’vision survival and prognostic factors and evaluate clinical features in rhino-orbital ***:Forty-three eyes of 43 patients followed up with orbital mucormycosis infections were included in the *** characteristics of the patients,symptoms at admission,ophthalmologic and non-ophthalmologic examination findings,clinical findings during follow-up,medical and surgical procedures,and complications were *** survival was determined by assessing the incidence of mortality,and vision survival was defined as achieving a final visual acuity of at least light ***:Twenty-seven(62.8%)patients were male,and 16(37.2%)were *** the underlying disease status of the patients was examined,it was observed that all patients had an underlying disease and diabetes constituted the majority(65.2%).Periorbital swelling(69.8%)and ophthalmoplegia(53.5%)were the most common symptoms and findings at the admission of patients with mucormycosis *** disease resulted in death in 22(51.2%)*** presence of fever and shorter duration of antifungal therapy were associated with lower patient *** surgery was not found to be associated with the survival of the *** eye,loss of pupillary light reflex,and development of central retinal artery occlusion were associated with lower vision ***:This study presents one of the most extensive patient series in the literature on rhino-orbital *** the patients’symptoms at the time of admission and the clinical findings during the infection process will increase awareness about the disease.

关键词： mucormycosis rhino-orbital-mucormycosis orbital apex syndrome retinal arterial occlusion

Heyingwuzi formulation alleviates diabetic retinopathy by promoting mitophagy via the HIF-1α/BNIP3/NIX axis

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World Journal of Diabetes 2024年第6期15卷 1317-1339页

作者： Jia-Jun Wu Shu-Yan Zhang Lin Mu Zhi-Guo Dong Yin-Jian Zhang department of ophthalmology Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China department of ophthalmology Eye and ENT HospitalFudan UniversityShanghai 200031China

BACKGROUND Diabetic retinopathy(DR)is the primary cause of visual problems in patients with *** Heyingwuzi formulation(HYWZF)is effective against *** To determine the HYWZF prevention mechanisms,especially those underlying *** Human retinal capillary endothelial cells(HRCECs)were treated with high glucose(hg),HYWZF serum,PX-478,or Mdivi-1 in ***,cell counting kit-8,transwell,and tube formation assays were used to evaluate HRCEC proliferation,invasion,and tube formation,*** electron microscopy was used to assess mitochondrial morphology,and Western blotting was used to determine the protein *** cytometry was used to assess cell apoptosis,reactive oxygen species(ROS)production,and mitochondrial membrane ***,C57BL/6 mice were established in vivo using streptozotocin and treated with HYWZF for four *** glucose levels and body weight were monitored *** in retinal characteristics were evaluated using hematoxylin and eosin,tar violet,and periodic acid-Schiff *** levels in retinal tissues were determined via Western blotting,immunohistochemistry,and *** HYWZF inhibited excessive ROS production,apoptosis,tube formation,and invasion in hg-induced HRCECs via mitochondrial autophagy in *** increased the mRNA expression levels of BCL2-interacting protein 3(BNIP3),FUN14 domain-containing 1,BNIP3-like(BNIP3L,also known as NIX),PARKIN,PTEN-induced kinase 1,and hypoxia-inducible factor(HIF)-1α.Moreover,it downregulated the protein levels of vascular endothelial cell growth factor and increased the light chain 3-II/I ***,PX-478 and Mdivi-1 reversed these ***,PX-478 and Mdivi-1 rescued the effects of HYWZF by decreasing oxidative stress and apoptosis and increasing *** intervention improved the symptoms of diabetes,tissue damage,number of acellular capillaries,and oxidative stress in ***,in vivo

关键词： Diabetic retinopathy HIF-1α/BNIP3/NIX axis Mitophagy Heyingwuzi formulation Traditional Chinese medicine

Reduced macular thickness and vascular density in abnormal glucose metabolism patients:A meta-analysis of optical coherence tomography(OCT)and OCT angiography studies

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Chinese Medical Journal 2024年第9期137卷 1054-1068页

作者： Xiangyu Fu Xiang Ren Wenyue Chen Danian Chen department of ophthalmology West China HospitalSichuan UniversityChengduSichuan 610041China Research Laboratory of ophthalmology and vision sciences State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China department of ophthalmology The People’s Hospital of Guizhou ProvinceGuiyangGuizhou 550002China

Background:Alterations in macular thickness and vascular density before clinically visible diabetic retinopathy(DR)remain *** study aimed to determine whether retinal manifestations in abnormal glucose metabolism(AGM)patients differ from those in the healthy ***:PubMed,Embase,and Web of science were searched between 2000 and *** eligibility criteria were AGM patients without *** and secondary outcomes measured by optical coherence tomography(OCT)and OCT angiography(OCTA)were analyzed and expressed as standardized mean differences(SMDs)with 95%confidence intervals(CIs).A random-effects model was used in the data *** potential publication bias for the variables was evaluated using Egger’s ***:A total of 86 observational studies involving 13,773 participants and 15,416 eyes were *** revealed that compared to healthy controls,the total macular thickness of AGM patients was thinner,including the thickness of fovea(-0.24,95%CI[-0.39,-0.08];P=0.002,I^(2)=87.7%),all regions of parafovea(-0.32,95%CI[-0.54,-0.11];P=0.003;I^(2)=71.7%)and the four quadrants of perifovea;the thickness of peripapillary retinal nerve fiber layer(pRNFL),macular retinal nerve fiber layer(mRNFL),and ganglion cell layer(GCL)also *** indicated that the superficial and deep vascular density decreased,the foveal avascular zone(FAZ)area enlarged,and the acircularity index(AI)reduced in AGM ***:Retinal thinning and microvascular lesions have occurred before the advent of clinically detectable DR;OCT and OCTA may have the potential to detect these preclinical ***:PROSPERO;http://***/prospero/;***42021269885.

关键词： Abnormal glucose metabolism Optical coherence tomography Optical coherence tomography angiography Diabetic retinopathy Prediabetes Meta-analysis

Botulinum toxin type A in treating early-stage patients with small-angle acute acquired comitant esotropia

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International Journal of ophthalmology(English edition) 2024年第6期17卷 1094-1101页

作者： Run-Ting Ma Die-Wen-Jie Hu Lian-Hong Zhou Wen-Ping Li Yuan-Jin Li Bei-Xi Yi department of ophthalmology Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

AIM:To investigate botulinum toxin A(BTXA)efficacy on small-angle(≤25Δ)acute acquired concomitant esotropia(AACE)in early-stage ***:The electronic medical record data of AACE patients during March 2019 and June 2023 were collected in this retrospective and hospital-based cohort study.A total of 72 small-angle AACE patients received BTXA extraocular muscle *** were grouped by onset-to-treatment time(Group A:≤6mo,Group B:>6mo).Deviation of esotropia,eye alignment and stereopsis were analyzed at the period of pre/post-injection(1wk,1,3,and 6mo).Orthophoria rate at 6mo(horizontal deviationvision)were considered as outcome ***:There were no significant baseline differences(P>0.05)between two groups except onset-to-treatment time(2mo vs 11mo,P0.05);while in 3 and 6mo Group A was significantly smaller than group B(all P6mo)may reduce BTXA *** BTXA intervention benefits long-term eye alignment and stereopsis recovery.

关键词： acute acquired comitant esotropia botulinum toxin type A stereopsis

Generative deep-learning-embedded asynchronous structured light for three-dimensional imaging

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Advanced Photonics 2024年第4期6卷 45-58页

作者： Lei Lu Chenhao Bu Zhilong Su Banglei Guan Qifeng Yu Wei Pan Qinghui Zhang Henan University of Technology College of Information Science and Engineering Shanghai University Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai Key Laboratory of Mechanics in Energy Engineering Shaoxing Research Institute of Shanghai University National University of Defense Technology College of Aerospace Science and Engineering OPT Machine vision Tech Co. Ltd. Department of Research and Development

Three-dimensional(3D) imaging with structured light is crucial in diverse scenarios, ranging from intelligent manufacturing and medicine to entertainment. However, current structured light methods rely on projector–camera synchronization, limiting the use of affordable imaging devices and their consumer applications. In this work, we introduce an asynchronous structured light imaging approach based on generative deep neural networks to relax the synchronization constraint, accomplishing the challenges of fringe pattern aliasing, without relying on any a priori constraint of the projection system. To overcome this need, we propose a generative deep neural network with U-Net-like encoder–decoder architecture to learn the underlying fringe features directly by exploring the intrinsic prior principles in the fringe pattern aliasing. We train within an adversarial learning framework and supervise the network training via a statisticsinformed loss function. We demonstrate that by evaluating the performance on fields of intensity, phase, and 3D reconstruction. It is shown that the trained network can separate aliased fringe patterns for producing comparable results with the synchronous one: the absolute error is no greater than 8 μm, and the standard deviation does not exceed 3 μm. Evaluation results on multiple objects and pattern types show it could be generalized for any asynchronous structured light scene.

关键词： asynchrony deep learning fringe pattern projection generative neural networks structured light three-dimensional imaging

Bidirectional link between periodontitis and systemic inflammation in diabetic retinopathy

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World Journal of Diabetes 2024年第7期15卷 1651-1653页

作者： Prateek Nishant Sony Sinha Ranjeet Kumar Sinha Arvind Kumar Morya department of ophthalmology ESIC Medical CollegePatna 801103BiharIndia department of ophthalmology-Vitreo-Retina Neuro-Ophthalmology and OculoplastyAll India Institute of Medical SciencesPatna 801507BiharIndia department of Community Medicine Patna Medical CollegePatna 800004BiharIndia department of ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia

Periodontitis is independently associated with numerous lifestyle *** patients have approximately threefold increased odds of periodontitis,which in turn increases the risk of systemic *** study by Thazhe Poyil et al is an effort to establish the inflammatory link between diabetic retinopathy(DR)and periodontitis based on the periodontal inflamed surface area in diabetic patients with and without *** further advance the study,we suggest refining the eligibility criteria to explicitly state the clinical correlates of periodontitis and DR,larger sample size and improved sampling methodology,matching of baseline characteristics of the two groups,as well as improved statistical approach and interpretation of the study *** of hemoglobin A1c(HbA1c)in studies comparing type 2 diabetes mellitus patients with DR of matched severity with and without periodontitis could provide a clearer picture of whether HbA1c level is indeed influenced by periodontitis.

关键词： Glucose intolerance Hyperglycemia Inflammation Research methodology vision

Multimodal imaging diagnosis and analysis of prognostic factors in patients with adult-onset Coats disease

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International Journal of ophthalmology(English edition) 2024年第8期17卷 1469-1476页

作者： Wei Zhou Hui Zhou Yuan-Yuan Liu Meng-Xuan Li Xiao-Han Wu Jiao Liang Jing Hao Sheng-Nan Liu Chun-Jie Jin department of ophthalmology Tianjin Medical University General HospitalTianjin 300052China department of ophthalmology Shanxi Yuncheng Tongde HospitalYuncheng 044000Shanxi ProvinceChina department of Information Tianjin Medical University General HospitalTianjin 300052China

AIM:To describe the multimodal imaging features,treatment,and outcomes of patients diagnosed with adultonset Coats ***:This retrospective study included patients first diagnosed with Coats disease at≥18 years of age between September 2017 and September *** patients received anti-vascular endothelial growth factor(VEGF)therapy(conbercept,0.5 mg)as the initial treatment,which was combined with laser photocoagulation as *** the patients underwent best corrected visual acuity(BCVA)and intraocular pressure examinations,fundus color photography,spontaneous fluorescence tests,fundus fluorescein angiography,optical coherence tomography(OCT),OCT angiography,and other *** alterations and multimodal image findings in the affected eyes following treatment were compared and the prognostic factors were ***:The study included 15 patients who were aged 24-72(57.33±12.61)y at *** hypertension was the most common associated systemic condition,occurring in 13(86.7%)*** BCVA ranged from 2.0 to 5.0(4.0±1.1),which showed improvement following treatment(4.2±1.0).Multimodal imaging revealed retinal telangiectasis in 13 patients(86.7%),patchy hemorrhage in 5 patients(33.3%),and stage 2B disease(Shield’s staging criteria)in 11 patients(73.3%).OCT revealed that the baseline central macular thickness(CMT)ranged from 129 to 964μm(473.0±230.1μm),with 13 patients(86.7%)exhibiting a baseline CMT exceeding 250μ***,8 patients(53.3%)presented with an epiretinal membrane at baseline or during ***-reflective scars were observed on OCT in five patients(33.3%)with poor visual *** deteriorated in one patient who did not receive *** vision was stable in three patients who received laser treatment,whereas improvement was observed in one of two patients who received anti-VEGF therapy *** addition,8 of 9 patients(88.9%)who received laser treatment and conbercept exhibited sta

关键词： adult-onset Coats disease multimodal imaging anti-vascular endothelial growth factor conbercept

Psychometric validation of the Chinese version of the dry eye-related quality-of-life score questionnaire

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International Journal of ophthalmology(English edition) 2024年第9期17卷 1614-1620页

作者： Yu-Wen Liu Shu-Jia Guo Jia-Ni Li Yu-Ting Zhang Wei-Jie Ouyang Yu-Qian Wang Cai-Hong Huang Yi Liao Jiaoyue Hu Zuguo Liu Xiamen University Affiliated Xiamen Eye Center Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceFujian Engineering and Research Center of Eye Regenerative MedicineEye Institute of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361005Fujian ProvinceChina department of ophthalmology Xiang’an Hospital of Xiamen UniversityXiamen 361005Fujian ProvinceChina department of ophthalmology the First Affiliated Hospital of University of South ChinaHengyang 421001Hunan ProvinceChina

AIM:To psychometrically validate the Chinese version of the dry eye-related quality-of-life score questionnaire(DEQSCHN)among Chinese patients with dry ***:This study involved 231 participants,including 191 with dry eye disease(DED)comprising the dry eye disease group,and 40 healthy participants forming the control *** were required to complete the DEQS-CHN,and Chinese dry eye questionnaire and undergo clinical tests including the fluorescein breakup time(FBUT),corneal fluorescein staining(CFS),and Schirmer I *** assess the internal consistency and retest reliability,Cronbach’sαand the intraclass correlation coefficient(ICC)were *** validity was assessed by item-level content validity index(ICV)and an average scale-level content validity index(S-CVI/Ave).Construct validity was assessed by confirmatory factor *** concurrent validity was assessed by calculating correlations between DEQS-CHN and Chinese dry eye *** validity was evaluated through nonparametric tests,with receiver operating characteristic(ROC)curve serving as conclusive indicators of the questionnaire’s distinguishing ***:The Cronbach’sαcoefficients for frequency and degree of ocular symptoms,impact on daily life,and summary score were 0.736,0.704,0.811,0.818,0.861,and 0.860,respectively,and the ICC were 0.611,0.677,0.715,0.769,0.711,and 0.779,*** I-CVI scores ranged from 0.833 to 1.000,with an S-CVI/Ave of *** factor analysis results exhibited a wellfitting model consistent with the original questionnaire[χ^(2)/df=2.653,incremental fit index(IFI)=0.924,comparative fit index(CFI)=0.924,Tucker-Lewis index(TLI)=0.909,and root mean square error of approximation(RMSEA)=0.065].There was a moderate positive correlation between the DEQS-CHN and the Chinese dry eye questionnaire(r^(2)=0.588).The dry eye group demonstrated significantly higher scores compared to the control group,and the area under

关键词： dry eye quality-of-life questionnaire