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Novel insights into immune-related genes associated with type 2 diabetes mellitus-related cognitive impairment

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World Journal of Diabetes 2024年第4期15卷 735-757页

作者： Jing Gao Ying Zou Xiao-Yu Lv Li Chen Xin-Guo Hou department of Endocrinology Qilu Hospital of Shandong UniversityCheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina Institute of Endocrine and Metabolic Diseases Shandong UniversityJinan 250012Shandong ProvinceChina Key Laboratory of Endocrine and Metabolic Diseases Shandong Province Medicine&HealthJinan 250012Shandong ProvinceChina department of Endocrinology Jinan Clinical Research Center for Endocrine and Metabolic DiseaseJinan 250012Shandong ProvinceChina

BACKGROUND The cognitive impairment in type 2 diabetes mellitus(T2DM)is a multifaceted and advancing state that requires further exploration to fully ***-roinflammation is considered to be one of the main mechanisms and the immune system has played a vital role in the progression of the *** To identify and validate the immune-related genes in the hippocampus associated with T2DM-related cognitive *** To identify differentially expressed genes(DEGs)between T2DM and controls,we used data from the Gene Expression Omnibus database *** identify T2DM module genes,we used Weighted Gene Co-Expression Network *** the genes were subject to Gene Set Enrichment ***-protein interaction network construction and machine learning were utilized to identify three hub *** cell infiltration analysis was *** three hub genes were validated in GSE152539 via receiver operating characteristic curve *** experiments including reverse transcription quantitative real-time PCR,Western blotting and immunohistochemistry were conducted both in vivo and in *** identify potential drugs associated with hub genes,we used the Comparative Toxicogenomics Database(CTD).RESULTS A total of 576 DEGs were identified using *** taking the intersection of DEGs,T2DM module genes,and immune-related genes,a total of 59 genes associated with the immune system were ***,machine learning was utilized to identify three hub genes(H2-T24,Rac3,and Tfrc).The hub genes were associated with a variety of immune *** three hub genes were validated in *** experiments were conducted at the mRNA and protein levels both in vivo and in vitro,consistent with the bioinformatics ***,11 potential drugs associated with RAC3 and TFRC were identified based on the *** Immune-related genes that differ in expression in the hippocampus are closely linked to microgli

关键词： Bioinformatics analysis Type 2 diabetes mellitus Cognitive impairment Hippocampus Immune Microglia

IoV environment exploring coordination:A federated learning approach

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Digital Communications and Networks 2024年第1期10卷 135-141页

作者： Tong Ding Lei Liu Yi Zhu Lizhen Cui Zhongmin Yan School of Software Shandong UniversityJinan250101China

Exploring open fields with coordinated unmanned vehicles is popular in academia and *** of the most impressive applicable approaches is the Internet of Vehicles(lov).The IoV connects vehicles,road infrastructures and communication facilities to provide solutions for exploration ***,the coordination of acquiring information from multi-vehicles may risk data *** this end,sharing high-quality experiences instead of raw data has become an urgent *** paper employs a Deep Reinforcement Learning(DRL)method to enable IoVs to generate training data with prioritized experience and states,which can support the IoV to explore the environment more ***,a Federated Learning(FL)experience sharing model is established to guarantee the vehicles'*** numerical results show that the proposed method presents a better successful sharing rate and a more stable convergence within the comparison of fundamental *** experiments also suggest that the proposed method could support agents without full information to achieve the tasks.

关键词： Internet of vehicle Deep reinforcement learning Federated learning Data privacy

Progress in the Correlation Between Inflammasome NLRP3 and Liver Fibrosis

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Journal of Clinical and Translational Hepatology 2024年第2期12卷 191-200页

作者： Meihua Sun Yanqing Zhang Anbing Guo Zongting Xia Lijun Peng School of Clinical Medicine Weifang Medical UniversityWeifangShandongChina department of Gastroenterology Linyi People’s HospitalLinyiShandongChina

Liver fibrosis is a reversible condition that occurs in the early stages of chronic liver *** develop effective treatments for liver fibrosis,understanding the underlying mechanism is *** NOD-like receptor protein 3(NLRP3)inflammasome,which is a part of the innate immune system,plays a crucial role in the progression of various inflammatory ***3 activation is also important in the development of various liver diseases,including viral hepatitis,alcoholic or nonalcoholic liver disease,and autoimmune liver *** review discusses the role of NLRP3 and its associated molecules in the development of liver *** also highlights the signal pathways involved in NLRP3 activation,their downstream effects on liver disease progression,and potential therapeutic targets in liver *** research is encouraged to develop effective treatments for liver fibrosis.

关键词： NLRP3 Liver disease Liver fibrosis Hepatic stellate cells Macrophages

Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions

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World Journal of Gastroenterology 2024年第14期30卷 1968-1981页

作者： Hong-Ju Sun Bo Jiao Yan Wang Yue-Hua Zhang Ge Chen Zi-Xuan Wang Hong Zhao Qing Xie Xiao-Hua Song department of general Medicine Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina department of Gastroenterology Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina department of Medical Administration Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Qingdao Medical College Qingdao UniversityQingdao 266042Shandong ProvinceChina department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Nonalcoholic fatty liver disease(NAFLD)is the most prevalent type of chronic liver ***,the disease is underappreciated as a remarkable chronic disorder as there are rare managing *** studies have focused on determining NAFLD-caused hepatocyte death to elucidate the disease pathoe-tiology and suggest functional therapeutic and diagnostic ***,ferroptosis,and necroptosis are the main subtypes of non-apoptotic regulated cell deaths(RCDs),each of which represents particular *** the complexity of the findings,the present study aimed to review these types of RCDs and their contribution to NAFLD progression,and subsequently discuss in detail the role of necroptosis in the pathoetiology,diagnosis,and treatment of the *** study revealed that necroptosis is involved in the occurrence of NAFLD and its progression towards steatohepatitis and cancer,hence it has potential in diagnostic and therapeutic ***,further studies are necessary.

关键词： Nonalcoholic fatty liver disease Apoptosis Necroptosis Cell death Diagnosis Treatment

An Online Algorithm Based on Replication for Using Spot Instances in IaaS Clouds

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Journal of Computer Science & Technology 2024年第1期39卷 103-115页

作者：许志伟潘丽刘士军 School of Software Shandong UniversityJinan 250101China

Infrastructure-as-a-Service(IaaS)cloud platforms offer resources with diverse buying *** can run an instance on the on-demand market which is stable but expensive or on the spot market with a significant ***,users have to carefully weigh the low cost of spot instances against their poor *** instances will be revoked when the revocation event ***,an important problem that an IaaS user faces now is how to use spot in-stances in a cost-effective and low-risk *** on the replication-based fault tolerance mechanism,we propose an on-line termination algorithm that optimizes the cost of using spot instances while ensuring operational *** prove that in most cases,the cost of our proposed online algorithm will not exceed twice the minimum cost of the optimal of-fline algorithm that knows the exact future a *** a large number of experiments,we verify that our algorithm in most cases has a competitive ratio of no more than 2,and in other cases it can also reach the guaranteed competitive ratio.

关键词： Infrastructure-as-a-Service(IaaS)cloud cost management competitive analysis online algorithm spot instance

ZmCER1,a putative ECERIFERUM 1 protein in maize,functions in cuticular wax biosynthesis and bulliform cell development

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The Crop Journal 2024年第3期12卷 743-752页

作者： Yan Zhao Qingzhi Liu Xueran Wang Weixiao Zhang Wei Xu Yongzhong Zhang Baoshen Liu College of Agronomy Shandong Agricultural UniversityTai’an 271018ShandongChina Qingdao Academy of Agricultural Sciences Qingdao 266100ShandongChina

The cuticular wax,acting as the ultimate defense barrier,is essential for the normal morphogenesis of plant *** this importance,the connection between wax composition and leaf development has not been thoroughly *** this study,we characterized a new maize mutant,ragged leaf4(rgd4),which exhibits crinkled and ragged leaves starting from the sixth leaf *** phenotype of rgd4 is conferred by ZmCER1,which encoding an aldehyde decarbonylase involved in wax ***1 function deficient mutant displayed reduced cuticular wax density and disordered bulliform cells(BCs),while ZmCER1 overexpressing plants exhibited the opposite effects,indicating that ZmCER1 regulates cuticular wax biosynthesis and BCs ***,as the density of cuticular wax increased,the water loss rate of detached leaf decreases,suggesting that ZmCER1 is positively correlated with plant drought tolerance.

关键词： Ragged leaf ZmCER1 Cuticular wax Bulliform cells

The fast method and convergence analysis of the fractional magnetohydrodynamic coupled flow and heat transfer model for the generalized second-grade fluid

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Science China Mathematics 2024年第4期67卷 919-950页

作者： Xiaoqing Chi Hui Zhang Xiaoyun Jiang School of Mathematics and Statistics Shandong UniversityWeihai 264209China School of Mathematics Shandong UniversityJinan 250100China

In this paper,we first establish a new fractional magnetohydrodynamic(MHD)coupled flow and heat transfer model for a generalized second-grade *** coupled model consists of a fractional momentum equation and a heat conduction equation with a generalized form of Fourier *** second-order fractional backward difference formula is applied to the temporal discretization and the Legendre spectral method is used for the spatial *** fully discrete scheme is proved to be stable and convergent with an accuracy of O(τ^(2)+N-r),whereτis the time step-size and N is the polynomial *** reduce the memory requirements and computational cost,a fast method is developed,which is based on a globally uniform approximation of the trapezoidal rule for integrals on the real *** strict convergence of the numerical scheme with this fast method is *** present the results of several numerical experiments to verify the effectiveness of the proposed ***,we simulate the unsteady fractional MHD flow and heat transfer of the generalized second-grade fluid through a porous *** effects of the relevant parameters on the velocity and temperature are presented and analyzed in detail.

关键词： fractional MHD coupled flow and heat transfer model generalized second-grade fuid fast method convergence analysis numerical simulation

Entropy of deterministic trajectory via trajectories ensemble

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Chinese Physics B 2024年第6期33卷 347-354页

作者：彭勇刚冉翠平郑雨军 School of Physics Shandong UniversityJinan 250100China

We present a formulation of the single-trajectory entropy using the trajectories ensemble. The single-trajectory entropy is affected by its surrounding trajectories via the distribution function. The single-trajectory entropies are studied in two typical potentials, i.e., harmonic potential and double-well potential, and in viscous environment by interacting trajectory method. The results of the trajectory methods are in agreement well with the numerical methods(Monte Carlo simulation and difference equation). The single-trajectory entropies increasing(decreasing) could be caused by absorption(emission) heat from(to) the thermal environment. Also, some interesting trajectories, which correspond to the rare evens in the processes, are demonstrated.

关键词： trajectory entropy trajectories ensemble

Kinetic scale magnetic holes in the terrestrial magnetosheath:A review

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Science China Earth Sciences 2024年第9期67卷 2739-2771页

作者： Quanqi SHI Shutao YAO Maria HAMRIN Ji LIU shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment Institute of Space SciencesShandong UniversityWeihai 264209China department of Physics UmeåUniversityUmeå90746Sweden department of Physics University of AlbertaEdmonton T6K 2P6Canada

Magnetic holes at the ion-to-electron kinetic scale(KSMHs)are one of the extremely small intermittent structures generated in turbulent magnetized *** recent years,the explorations of KSMHs have made substantial strides,driven by the ultra-high-precision observational data gathered from the Magnetospheric Multiscale(MMS)*** review paper summarizes the up-to-date characteristics of the KSMHs observed in Earth’s turbulent magnetosheath,as well as their potential impacts on space *** review starts by introducing the fundamental properties of the KSMHs,including observational features,particle behaviors,scales,geometries,and distributions in terrestrial *** have discovered that KSMHs display a quasi-circular electron vortex-like structure attributed to electron diamagnetic *** electrons exhibit noticeable non-gyrotropy and undergo *** occurrence rate of KSMH in the Earth’s magnetosheath is significantly greater than in the solar wind and magnetotail,suggesting the turbulent magnetosheath is a primary source ***,KSMHs have also been generated in turbulence simulations and successfully reproduced by the kinetic equilibrium ***,KSMHs have demonstrated their ability to accelerate electrons by a novel non-adiabatic electron acceleration mechanism,serve as an additional avenue for energy dissipation during magnetic reconnection,and generate diverse wave phenomena,including whistler waves,electrostatic solitary waves,and electron cyclotron waves in space *** results highlight the magnetic hole’s impact such as wave-particle interaction,energy cascade/dissipation,and particle acceleration/heating in space *** end this paper by summarizing these discoveries,discussing the generation mechanism,similar structures,and observations in the Earth’s magnetotail and solar wind,and presenting a future extension perspective in this active field.

关键词： Magnetic hole Magnetic dip/cavity Electron vortex Magnetosheath Turbulence Coherent structure Mirror mode Kinetic scale Electron acceleration Whistler