Progress in the Correlation Between Inflammasome NLRP3 and Liver Fibrosis

作     者：Meihua Sun Yanqing Zhang Anbing Guo Zongting Xia Lijun Peng 

作者机构：School of Clinical MedicineWeifang Medical UniversityWeifangShandongChina Department of GastroenterologyLinyi People’s HospitalLinyiShandongChina 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2024年第12卷第2期

页      面：191-200页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported in part by Shandong Provincial Natural Science Foundation(ZR2023MH295,LJP) Linyi People’s Hospital Postgraduate Fund Project(YJS2023002,MHS) 

主　　题：NLRP3 Liver disease Liver fibrosis Hepatic stellate cells Macrophages 

摘      要：Liver fibrosis is a reversible condition that occurs in the early stages of chronic liver *** develop effective treatments for liver fibrosis,understanding the underlying mechanism is *** NOD-like receptor protein 3(NLRP3)inflammasome,which is a part of the innate immune system,plays a crucial role in the progression of various inflammatory ***3 activation is also important in the development of various liver diseases,including viral hepatitis,alcoholic or nonalcoholic liver disease,and autoimmune liver *** review discusses the role of NLRP3 and its associated molecules in the development of liver *** also highlights the signal pathways involved in NLRP3 activation,their downstream effects on liver disease progression,and potential therapeutic targets in liver *** research is encouraged to develop effective treatments for liver fibrosis.