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Surgical approach affecting long-term urinary continence status after robot-assisted laparoscopic prostatectomy prospectively evaluated using self-reported functional status(Expanded Prostate Cancer Index Composite,EPIC-26)

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Effi cacy of partial and complete resuscitative endovascular balloon occlusion of the aorta in the hemorrhagic shock model of liver injury

当代泌尿学（英文） 2024年第1期18卷 61-65页

作者： Mathias Reichert Ame Strauß Joost Wilhelm Voß Hans Christoph von Knobloch Hannah Maria Neuenhofer Annemarie Uhlig Lutz Trojan Mirjam Naomi Mohr department of Urology University Medical CenterGoettingenGermany department of pediatrics University HospitalBonnGermany

Purpose:The aim of the study was to examine the influence of the surgical approach for robot-assisted laparoscopic prostatectomy(RALP)on long-term urinary continence status in the era of self-reported functional status measures using the Expanded Prostate Can-cer Index Composite 26.Materials and methods:This is a prospective evaluation of 232 patients undergoing RALP between September,2019 and September,*** continence status and postoperative incontinence(pad usage)were evaluated 12 months after RALP using Expanded Prostate Cancer Index Composite 26 *** were categorized according to their surgical approach and outcome into the following groups:successful nerve sparing(NS),primarily without nerve sparing(***),and no nerve sparing by secondary resection(NNS by SR).The median levels of their questionnaire outcomes were evaluated and compared using the Wilcoxon rank sum test with continuity correction.Results:Urinary continence status 12 months after RALP differed significantly between the NS and ***(p=0.0071)and the NS and NNS by SR(p=0.0076)*** was no significant difference between the *** and NNS by SR(p=0.53)*** usage 12 months after RALP had no significant difference with regard to SR of the neurovascular bundle(p=0.14).Conclusions:Patient-reported outcomes of long-term urinary continence status seem to show no difference in postoperative conti-nence,regardless of whether a non-nerve-sparing result was planned or reached through ***,preservation of neurovascular bundle seems to lead to better long-term continence rates.

关键词： Expanded Prostate Cancer Index Composite 26 Nerve sparing Prostate cancer Robot-assisted radical prostatectomy Surgical approach Urinary incontinence

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World Journal of Emergency Medicine 2024年第1期15卷 10-15页

作者： Yi Shan Yang Zhao Chengcheng Li Jianxin Gao Guogeng Song Tanshi Li department of Emergency Medicine Chinese PLA Medical SchoolBeijing 100853China department of Emergency Medicine the Sixth Medical Center of PLA General HospitalBeijing 100048China department of Emergency Medicine School of MedicineSouth China University of TechnologyGuangzhou 510006China department of Emergency Medicine the First Medical Center of PLA General HospitalBeijing 100853China

BACKGROUND:Resuscitative endovascular balloon occlusion of the aorta(REBOA)can temporarily control traumatic ***,its prolonged use potentially leads to ischemia-reperfusion injury(IRI).Partial REBOA(pREBOA)can alleviate ischemic burden;however,its security and eff ectiveness prior to operative hemorrhage control remains ***,we aimed to estimate the effi cacy of pREBOA in a swine model of liver injury using an experimental sliding-chamber ballistic ***:Twenty Landrace pigs were randomized into control(no aortic occlusion)(n=5),intervention with complete REBOA(cREBOA)(n=5),continuous pREBOA(C-pREBOA)(n=5),and sequential pREBOA(S-pREBOA)(n=5)*** the cREBOA and C-pREBOA groups,the balloon was inflated for 60 *** hemodynamic and laboratory values were compared at various observation time *** samples immediately after animal euthanasia from the myocardium,liver,kidneys,and duodenum were collected for histological assessment using hematoxylin and eosin ***:Compared with the control group,the survival rate of the REBOA groups was prominently improved(all P<0.05).The total volume of blood loss was markedly lower in the cREBOA group(493.14±127.31 mL)compared with other groups(P<0.01).The pH was significantly lower at 180 min in the cREBOA and S-pREBOA groups(P<0.05).At 120 min,the S-pREBOA group showed higher alanine aminotransferase(P<0.05)but lower blood urea nitrogen compared with the cREBOA group(P<0.05).CONCLUSION:In this trauma model with liver injury,a 60-minute pREBOA resulted in improved survival rate and was effective in maintaining reliable aortic pressure,despite persistent *** tolerance time for aortic occlusion in Zone I for non-compressible torso hemorrhage was feasible with both continuous partial and sequential partial measures,and the significant improvement in the severity of acidosis and distal organ injury was observed in the sequential pREBOA.

关键词： Non-compressible torso hemorrhage Liver injury Ischemia-reperfusion injury Resuscitative endovascular balloon occlusion of the aorta

Association between childhood obesity and gut microbiota:16S rRNA gene sequencing-based cohort study

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World Journal of Gastroenterology 2024年第16期30卷 2249-2257页

作者： Xu-Ming Li Qing Lv Ya-Jun Chen Lu-Biao Yan Xin Xiong Laboratory department Nanjing Medical University Affiliated Obstetrics and Gynecology Hospital(Nanjing Maternal and Child Health Hospital)Nanjing 210004Jiangsu ProvinceChina department of pediatrics Shenzhen University General HospitalShenzhen 518055Guangdong ProvinceChina department of Inspection Division Women’s Hospital of Nanjing Medical University(Nanjing Maternity and Child Health Care Hospital)Nanjing 210004Jiangsu ProvinceChina department of pediatrics Women’s Hospital of Nanjing Medical University(Nanjing Maternity and Child Health Care Hospital)Nanjing 210004Jiangsu ProvinceChina department of Neonatology Chenzhou First People’s HospitalChenzhou 423000Hunan ProvinceChina

BACKGROUND This study aimed to identify characteristic gut genera in obese and normal-weight children(8-12 years old)using 16S rDNA *** research aimed to provide insights for mechanistic studies and prevention strategies for childhood *** normal-weight and thirty age-and sex-matched obese children were *** and body measurements were collected,and fecal samples underwent 16S rDNA *** differences in body mass index(BMI)and body-fat percentage were observed between the *** of gut microbiota diversity revealed lowerα-diversity in obese *** in gut microbiota composition were found between the two *** and Firmicutes were more abundant in the obese group,while Bacteroides and Sanguibacteroides were more prevalent in the control *** To identify the characteristic gut genera in obese and normal-weight children(8-12-year-old)using 16S rDNA sequencing,and provide a basis for subsequent mechanistic studies and prevention strategies for childhood *** Thirty each normal-weight,1:1 matched for age and sex,and obese children,with an obese status from 2020 to 2022,were included in the control and obese groups,*** information was collected through questionnaires and body measurements were obtained from both obese and normal-weight *** samples were collected from both groups and subjected to 16S rDNA sequencing using an Illumina MiSeq sequencing platform for gut microbiota diversity *** Significant differences in BMI and body-fat percentage were observed between the two *** Ace and Chao1 indices were significantly lower in the obese group than those in the control group,whereas differences were not significant in the Shannon and Simpson ***-Wallis tests indicated significant differences in unweighted and weighted UniFrac distances between the gut microbiota of normal-weight and obese children(P<0.01),suggest

关键词： Childhood obesity Gut microbiota 16S rDNA sequencing Diversity analysis Genus identification Body mass index

New direction for surgery:Super minimally invasive surgery

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World Journal of Gastroenterology 2024年第12期30卷 1676-1679页

作者： En-Qiang Linghu department of Gastroenterology First Medical Center of Chinese PLA General HospitalBeijing 100853China

The top goal of modern medicine is treating disease without destroying organ structures and making patients as healthy as they were before their *** invasive surgery(MIS)has dominated the surgical realm because of its lesser ***,changes in anatomical structures of the body and reconstruction of internal organs or different organs are common after traditional surgery or MIS,decreasing the quality of life of patients ***,I propose a new treatment mode,super MIS(SMIS),which is defined as“curing a disease or lesion which used to be treated by MIS while preserving the integrity of the organs”.In this study,I describe the origin,definition,operative channels,advantages,and future perspectives of SMIS.

关键词： Super minimally invasive surgery Minimally invasive surgery Treatment mode Traditional Surgery New direction for surgery

Endoscopic intramural cystogastrostomy for treatment of peripancreatic fluid collection: A viewpoint from a surgeon

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World Journal of Gastroenterology 2024年第6期30卷 610-613页

作者： Chen-Guo Ker department of general Surgery E-Da HospitalI-Shou UniversityKaohsiung 824Taiwan

Percutaneous or endoscopic drainage is the initial choice for the treatment of peripancreatic fluid collection in symptomatic *** transgastric fenestration(ETGF)was first reported for the management of pancreatic pseu-docysts of 20 patients in *** a surgeon’s viewpoint,ETGF is a similar procedure to cystogastrostomy in that they both produce a wide outlet orifice for the drainage of fluid and necrotic *** can be performed at least 4 wk after the initial onset of acute pancreatitis and it has a high priority over the surgical ***,the surgical approach usually has a better success rate because surgical cystogastrostomy has a wider outlet(>6 cm vs 2 cm)than ***,percutaneous or endoscopic drainage,ETGF,and surgical approach offer various treatment options for peripancreatic fluid collection patients based on their conditions.

关键词： Pancreatitis Pancreatic pseudocyst Endoscopic cystogastrostomy Surgical cystogastrostomy Peripancreatic fluid collection Fenestration for pancreatic cyst

Synergistic effect of additional anlotinib and immunotherapy as second‐line or later‐line treatment in pancreatic cancer:A retrospective cohort study

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Cancer Innovation 2024年第4期3卷 57-66页

作者： Boyu Qin Qi Xiong Lingli Xin Ke Li Weiwei Shi Qi Song Qiong Sun Jiakang Shao Jing Zhang Xiao Zhao Jinyu Liu Jinliang Wang Bo Yang department of Oncology The Fifth Medical Center of Chinese PLA General HospitalBeijingChina department of Gynaecology and Obstetrics PLA Rocket Force Characteristic Medical CenterBeijingChina department of Graduate Administration Chinese PLA General HospitalBeijingChina department of Oncology The First Medical Center of Chinese PLA General HospitalBeijingChina department of Pharmacy Medical Supplies Center of Chinese PLA General HospitalBeijingChina

Background:Pancreatic ductal adenocarcinoma(PDAC)is in urgent need of a second‐line or later‐line treatment *** aimed to analyze the efficacy and safety of additional anlotinib,specifically anlotinib in combination with immunotherapy,in patients with PDAC who have failed first‐line ***:Patients with pathological diagnosis of PDAC were additionally treated with anlotinib,and some patients were treated with anti‐PD‐1 agents at the same time,which could be retrospectively *** efficacy and safety of additional anlotinib were ***:A total of 23 patients were *** patients treated with additional anlotinib,the overall median progression‐free survival(PFS)was 1.8 months and the median overall survival(OS)was 6.3 months,regardless of anti‐PD‐1 *** patients receiving additional anlotinib in combination with anti‐PD‐1 agents,median PFS and OS were 1.8 and 6.5 months,*** events(AEs)were observed in 16 patients(69.6%).In patients treated with additional anlotinib,the majority of AEs were grade 1–*** analysis revealed that patients with baseline red blood cell distribution width(RDW)<14%treated with additional anlotinib plus anti‐PD‐1 agents had significantly longer OS than patients with baseline RDW≥14%(p=0.025).Patients with additional anlotinib plus anti‐PD‐1 agents as second‐line therapy had a longer OS than those treated as later‐line therapy(p=0.012).Multivariate analysis showed that baseline RDW was the only independent risk factor for OS(p=0.042).Conclusion:The combination of anlotinib and immunotherapy represents an effective add‐on therapy with tolerable AEs as second‐or later‐line therapy in patients with PDAC,particularly in patients with baseline RDW<14%.

关键词： anlotinib efficacy immunotherapy independent risk factors pancreatic ductal adenocarcinoma

Clinical application of eight-zone laparoscopic dissection strategy for rectal cancer:Experience and discussion

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World Journal of Gastroenterology 2024年第30期30卷 3574-3583页

作者： Chang Chen Xiang Zhang Xin Li Yan-Lei Wang department of general Surgery Rongchang People's HospitalChongqing 250012China department of Colorectal Surgery Qilu HospitalShandong UniversityJinan 250012Shandong ProvinceChina department of general Surgery Huantai Branch of Qilu Hospital of Shandong UniversityZibo 255000Shandong ProvinceChina

BACKGROUND The incidence of rectal cancer is increasing worldwide,and surgery remains the primary treatment *** the advent of total mesorectal excision(TME)technique,the probability of tumor recurrence post-surgery has significantly ***'focus has gradually shifted towards minimizing the impact of surgery on urinary and sexual *** these concerns,the optimal dissection of the rectal lateral ligaments and preservation of the pelvic floor neuro-vascular bundle have become *** explore the optimal surgical technique for TME and establish a standardized surgical protocol to minimize the impact on urinary and sexual functions,we propose the eight-zone dissection strategy for pelvic floor *** To compare the differences in surgical specimen integrity and postoperative quality of life satisfaction between the traditional pelvic floor dissection strategy and the innovative eight-zone dissection *** We analyzed the perioperative data of patients who underwent laparoscopic radical resection of rectal cancer at Qilu Hospital of Shandong University between January 1,2021 and December 1,*** study included a total of 218 patients undergoing laparoscopic radical surgery for rectal cancer,among whom 109 patients underwent traditional pelvic floor dissection strategy,and 109 patients received the eight-zone dissection *** There were no significant differences in general characteristics between the two *** in the eight-zone dissection group had higher postoperative specimen integrity(88.1%vs 78.0%,P=0.047).At the 3-month followup,patients in the eight-zone surgery group had better scores in urinary issues(6.8±3.3 vs 5.3±2.5,P=0.045)and male sexual desire(2.2±0.6 vs 2.5±0.5,P=0.047)compared to the traditional surgery strategy *** This study demonstrates that the eight-zone dissection strategy for laparoscopic lateral ligament dissection of rectal cancer is safe and ***

关键词： Eight-zone dissection strategy Rectal cancer Lateral ligament dissection Nerve injury Total mesorectal excision surgery

miR-557 suppresses hepatocellular carcinoma cell proliferation and migration via downregulating CBX4

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BIOCELL 2024年第7期48卷 1071-1079页

作者： XULONG SUN WENTAO DING CHAO JIANG ZHIAN FANG department of Orthopedics Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China department of general Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China department of Thoracic Surgery Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai200030China department of Radiology Zhongda HospitalSoutheast University School of MedicineNanjing210009China

Introduction:Hepatocellular carcinoma(HCC),a prevalent malignancy,poses signiﬁcant challenges with high tumor heterogeneity and poor ***(miRNAs)play a pivotal role in *** abnormalities in microRNA-557(miR-557)expression have been implicated in various cancer types,its role in HCC remains ***,there is a need to explore the function of microRNA-557 in ***:Candidate miRNAs were identiﬁed through screening in GSE108724 and ***-time PCR was employed to analyze the expression level of miR-557 in hepatoma cell lines and *** viability and migration assays were applied to assess the impact of miR-557 on HCC cell ***,the miR-557 target was predicted through three algorithms(Targetscan,miRWalk,and miRanda),and this was conﬁrmed through luciferase assay and Western ***:In this study,miR-557 was identiﬁed in two datasets and expressed at a low level in both hepatoma cell lines and ***,high expression of miR-557 in HCC cells inhibited ***,low expression of miR-557 enhanced tumor proliferation and *** chromobox 4(CBX4)was identiﬁed as a direct target of *** CBX4 inﬂuenced the functional impact of miR-557 on HCC cell ***:Taken together,our study contributed to elucidating the hepatoma molecular heterogeneity and provided novel insights into miR-557 role and its target CBX4 in HCC,suggesting its potential as a future effectively druggable target for HCC intervention.

关键词： Hepatocellular carcinoma miR-557 Chromobox 4 Hepatocarcinogenesis

High‐fat‐diet‐induced obesity promotes simultaneous progression of lung cancer and atherosclerosis in apolipoprotein E‐knockout mice

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Cancer Innovation 2024年第4期3卷 103-112页

作者： Yihao Wang Kaixin Yan Han Duan Ning Tao Shaoning Zhu Yuning Zhang Yonggang You Zhen Zhang Hua Wang Shunying Hu department of Cardiology Chinese PLA General HospitalBeijingChina Beijing Institute of Radiation Medicine BeijingChina department of Orthopaedics Chinese PLA General HospitalBeijingChina

Background:Clinical studies have shown that atherosclerotic cardiovascular disease and cancer often co‐exist in the same *** present study aimed to investigate the role of high‐fat‐diet(HFD)‐induced obesity in the coexistence of the two diseases and the underlying mechanism in apolipoprotein E‐knockout(ApoE^(−/−))***:Male ApoE^(−/−)mice were fed with a HFD or a normal diet(ND)for 15 *** the first day of Week 13,the mice were inoculated subcutaneously in the right axilla with Lewis lung cancer *** Weeks 12 and 15,serum lectin‐like oxidized low‐density lipoprotein receptor‐1(LOX‐1)and vascular endothelial growth factor levels were measured by enzyme‐linked immunosorbent assay,and blood monocytes and macrophages were measured by fluorescence‐activated cell *** Week 15,the volume and weight of the local subcutaneous lung cancer and metastatic lung cancer and the amount of aortic atherosclerosis were ***:At Week 15,compared with mice in the ND group,those in the HFD group had a larger volume of local subcutaneous cancer(p=0.0004),heavier tumors(p=0.0235),more metastatic cancer in the lungs(p<0.0001),a larger area of lung involved in metastatic cancer(p=0.0031),and larger areas of atherosclerosis in the aorta(p<0.0001).At Week 12,serum LOX‐1,serum vascular endothelial growth factor,and proportions of blood monocytes and macrophages were significantly higher in the HFD group than those in the ND group(p=0.0002,p=0.0029,p=0.0480,and p=0.0106,respectively);this trend persisted until Week 15(p=0.0014,p=0.0012,p=0.0001,and p=0.0204).Conclusions:In this study,HFD‐induced obesity could simultaneously promote progression of lung cancer and atherosclerosis in the same ***‐induced upregulation of LOX‐1 may play an important role in the simultaneous progression of these two conditions via the inflammatory response and VEGF.

关键词： atherosclerosis high‐fat diet LOX‐1 lung cancer obesity