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From text to image:challenges in integrating vision into ChatGPT for medical image interpretation

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Neural Regeneration Research 2025年第2期20卷 487-488页

作者： Shunsuke Koga Wei Du department of pathology and Laboratory Medicine Hospital of the University of PennsylvaniaPhiladelphiaPAUSA

Large language models(LLMs),such as ChatGPT developed by OpenAI,represent a significant advancement in artificial intelligence(AI),designed to understand,generate,and interpret human language by analyzing extensive text *** potential integration into clinical settings offers a promising avenue that could transform clinical diagnosis and decision-making processes in the future(Thirunavukarasu et al.,2023).This article aims to provide an in-depth analysis of LLMs’current and potential impact on clinical *** ability to generate differential diagnosis lists underscores their potential as invaluable tools in medical practice and education(Hirosawa et al.,2023;Koga et al.,2023).

关键词： image diagnosis text

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay Liu Young-Ju Kim Wangyun Won department of Chemical and Biological Engineering Korea University department of Chemical Engineering (Integrated process) Kyung Hee University department of Chemical Engineering and Materials Science Ewha Womans University department of Chemical Engineering Pukyong National University Resources Engineering plant Research department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

Comparative research of effective utilization and efficacy duration of phenamacrilon rice bakanae disease control by different seed treatment methods department of plant pathology,China Agricultural University

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Comparative research of effective utilization and efficacy d...

Transfer RNA-derived small RNA serves as potential non-invasive diagnostic marker and a novel therapeutic target for acute pancreatitis

中国植物病理学会2017年学术年会

作者： Liu Panqing Wang Mingqi Liu Pengfei department of plant pathology China Agricultural University

Phenamacril is a domestically created new fungicide,which showed a good control effecton rice bakanae *** clarify the effective utilization and efficacy duration of phenamacril on rice bakanae disease control,the flowable concentrate for seed coating(FSC) and flowable concentrate for seed treatment(FS) of phenamacril were prepared and used by seed *** residue of phenamacril on seeds after soaking was studied by means of QuEChERS——High performance liquid chromatography(HPLC).The sample(3 g) was extracted with 1%acetic acid acetonitrile(3 mL),purified by graphite carbon black(GCB)(7.5 mg/mL).The solution was detected by HPLC with UV detection at290 *** linear regression formulations of phenamacril in seed and plant were y= 41.106 0 x-2.722 4(R=0.999 5) and y = 45.739 x-26.764(R=0.999 4) *** recoveries were ranged from 88%to 115%.The results showed that the method of quantitative determination was of a high accuracy and *** showed that there was no significant difference in pesticide utilization between seed soaking with water after coated with FSC and seed soaking with *** degradation dynamics study of phenamacril in rice plants used by seed coating was in conformity with the first-order dynamic *** decline coefficient was K = 0.085 5,T1/2 = *** and a residue of 2.78 mg/kg could be detected after 25 days of *** residue is quite more than the EC of phenamacril on Fusarium fujikuroi in vitrowhich shows the efficacy duration on rice bakanae disease can be more than 25 d in *** study may offer an effective reference for the research and development of phenamacril by seed coating.

关键词： Phenamacril Seed treatment QuEChERS HPLC

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World Journal of Gastroenterology 2025年第1期31卷 152-156页

作者： Jing Zhang Chun-Lin Ou department of Immunology School of Basic MedicineCentral South UniversityChangsha 410000Hunan ProvinceChina department of pathology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

Transfer RNA(tRNA)-derived fragments,a new type of tRNA-derived small RNA(tsRNA),can be cleaved from tRNA by enzymes to regulate target gene expression at the transcriptional and translational *** are not only degradation fragments but also have biological functions,including those in immune inflammation,metabolic disorders,and cell *** dysregulation is closely associated with multiple diseases,including various cancers and acute pancreatitis(AP).AP is a common gastrointestinal disease,and its incidence increases *** development is associated with tsRNAs,which regulate cell injury and induce inflammation,especially pyroptosis and ***,serum tRF36 has the potential to serve as a non-invasive diagnostic biomarker and leads to pancreatic acinar cell ferroptosis causing inflammation to promote *** show the characteristics of tsRNAs and their diagnostic value and function in AP,and discuss the potential opportunities and challenges of using tsRNAs in clinical applications and research.

关键词： Transfer RNA derived small RNAs Acute pancreatitis Liquid biopsy Biomarker Cell pyroptosis Ferroptosis

Rice plant growth and yield: foliar application of plasma activated water

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Plasma Science and Technology 2021年第7期23卷 134-143页

作者： M M RASHID Mamunur RASHID M M HASAN M R TALUKDER Plasma Science and Technology Lab Department of Electrical and Electronic EngineeringUniversity of RajshahiRajshahi 6205Bangladesh plant pathology and mycology Lab Department of BotanyUniversity of RajshahiRajshahi 6205Bangladesh plant pathology Lab Department of Agronomy and Agricultural ExtensionUniversity of RajshahiRajshahi 6205Bangladesh

Plasma activated water(PAW)was prepared for 10 min to be applied one toﬁve times as a foliar spray to rice plants,to investigate plant growth,yield and the concentrations of total soluble protein and sugar in the rice grains *** results reveal that(1)the plant height,stem diameter,dry weight,chlorophyll and total carotene concentrations were improved by∼15%,∼25%,∼24%,∼47%and∼45%,respectively,with respect to control,(2)defense mechanisms of the plants treated with PAW were improved,(3)concentrations of total soluble protein and sugar were enhanced in the rice grains of PAW treated plants and(4)yield was increased by∼14%.

关键词： plasma agriculture plasma activated water rice plant growth rice yield total soluble protein

Ecophysiological aspects of in vitro biotechnological studies using somatic embryogenesis of callus tissue toward protecting forest ecosystems

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Journal of forestry Research 2019年第4期30卷 1159-1166页

作者： Katarzyna Nawrot-Chorabik Marcin Pietrzykowski department of forest pathology Mycology and Tree PhysiologyInstitute of Forest Ecosystem Protection31-425 KrakowPoland department of forest Ecology and Reclamation University of Agriculture in Krakow29-Listopada Ave 4631-425 KrakowPoland

This review on current biotechnological methods in forestry for in vitro tissue cultures to define the effect of stress conditions on trees,concentrates on somatic *** tissue,the key product of somatic embryogenesis,grows over a tree wound under ex vitro *** tissue can be used in research in areas such as pathogenic susceptibility at the embryonic level,effect of heavy metals,influence of low temperatures(cryopreservation),production of secondary metabolites and transformation of *** of arborescent plants can be induced in vitro by fungal elicitors to produce secondary metabolites for pharmaceutical and cosmetic industries and are strongly repellant to herbivores and can thus act to protect *** of dual cultures demonstrated that callus tissue exposed to a pathogenic fungus responds by synthesizing low-molecular-mass proteins belonging to an immune protein *** of embryonic callus tissue also has broad applications,e.g.,for valuable plant genotypes in gene *** strategies to protect forests against stressfactors,forest ecosystems will degrade to the detriment of all life,including *** vitro biotechnological research using callus tissue contributes to progress in forestry and the disciplines of ecology,physiology,phytopathology,culture and selection of plants.

关键词： Callus Environmental stress Micropropagation Tissue cultures Trees

Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi Zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li Zhang Zheng Gang Zhang department of Neurology Henry Ford HospitalDetroitMIUSA department of Physics Oakland UniversityRochesterMIUSA department of pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

Evaluation of the virulence of entomopathogenic fungus, Isaria fumosorosea isolates against subterranean termites Coptotermes spp.(Isoptera:Rhinotermitidae)

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Journal of forestry Research 2019年第1期30卷 213-218页

作者： J.J.Jessica T.L.Peng A.S.Sajap S.H.Lee S.A.Syazwan department of forest Management Faculty of ForestryUniversiti Putra Malaysia (UPM) Faculty of Veterinary Medicine University Malaysia Kelantan Institute of Tropical forestry and forest Products Universiti Putra Malaysia (UPM) mycology and pathology Laboratory Forest Biodiversity Division Forest Research Institute Malaysia

The entomopathogenic fungus Isaria fumosorosea Wize, formerly known as Paecilomyces fumosoroseus is reported as a promising biocontrol agent for controlling subterranean termites, particularly those belonging to the family Rhinotermitidae. In Malaysia, the family Rhinotermitidae includes two species of subterranean termites with extremely high economic importance; namely Coptotermes curvignathus Holmgren, and the Asian SLubterranean Termite (Coptotermes gestroi Wasmann). To comprehend the potential control of this soil-dwelling fungus against these subterranean termites in Malaysia, an investigation was carried out by testing the pathogenecity of 11 isolates against these termite species. All isolates showed pathogenic potential against the termite (Mortality rate of C. curvignathus:84.4%; C. gestroi:67.3%). IsolatePF49 was the most effective against both species of termites and was further tested for its virulence and *** LC_(50) values of PF49 against C. curvignathus and *** were 7.55×103 and 1.09×102 conidia/ml,respectively. The average number of days required to complete the mycosis process in C. curvignathus and *** were 4.7 and 8 days, respectively. These fungi are believed useful for protecting living trees, plants, wood,wood structures, and other cellulosic materials susceptible to termite infestation and damage.

关键词： Biological control Entomopathogenic fungus Subterranean termites Lethal concentration

Ligninolytic enzymes production by endophytic fungus Diaporthe phaseolorum(Desm.)*** the influence of different carbon and nitrogen sources

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Studies in Fungi 2021年第1期6卷 531-542页

作者： Kumar V Prasher IB mycology and plant pathology Lab. Department of BotanyPanjab University ChandigarhChandigarh-160014India

Endophytic fungi are being investigated for their ability to create industrially relevant secondary *** recent years,there has been a surge in interest in these fungi as a source of novel enzymes,particularly hydrolytic *** present study investigated the effect of different carbon,organic and inorganic nitrogens on the growth and ligninolytic enzyme production by the endophytic fungus Diaporthe *** fungus was isolated from the leaves of Dillenia indica and analyzed by morpho-molecular *** fungus showed promising results for in vitro production of ligninolytic *** was the most favorable carbon compound for growth among all the carbon compounds *** displayed maximum lignin peroxidase(Lip)activity in fructose(3.5 U/ml),followed by pectin(2.60 U/ml)and glucose(2.53 U/ml).Glucose gave the highest manganese peroxidase(MnP)activity i.e.,6.88 U/ml followed by starch,sucrose and ***,the maximum laccase activity was 44.5 U/ml in *** nitrate and L-asparagine were the best inorganic and organic nitrogen for *** the case of ligninolytic enzyme production,ammonium acetate and ammonium phosphate were the best media for LiP and MnP,whereas laccase production was highest in ammonium nitrate supplemented *** organic nitrogen sources,medium supplemented with DL-tryptophan gave the highest Lip production,whereas MnP and laccase production was observed in the medium containing L-tyrosine and *** the best of our knowledge,this is the first report related to the growth and ligninolytic enzyme production by Diaporthe *** findings from the study will assist researchers in improving the production of ligninolytic enzymes by this fungus under in vitro conditions on an industrial scale.

关键词： Hydrolytic enzymes Industrially In vitro Manganese peroxidase Morpho molecular analysis