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Genetic Variations and Nonalcoholic Fatty Liver Disease:Field Synopsis,Systematic Meta-Analysis,and Epidemiological Evidence

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Biomedical and Environmental Sciences 2024年第7期37卷 762-773页

作者： Yamei Li Xiang Xiao Jie Wang Yixu Liu Xiongfeng Pan Haibin Yu Jiayou Luo Miyang Luo department of epidemiology and health statistics School of Public HealthUniversity of South ChinaHengyang 421001HunanChina department of Maternal and Child health Xiangya School of Public HealthCentral South UniversityChangsha 410008HunanChina Supervision and Inspection department of Shanghai healthcare Security Bureau Shanghai 200003China department of epidemiology and health statistics Xiangya School of Public HealthCentral South UniversityChangsha 410008HunanChina

Objective To systematically summarize the published literature on the genetic variants associated with nonalcoholic fatty liver disease(NAFLD).Methods Literature from Web of Science,PubMed,and Embase between January 1980 and September 2022 was systematically ***-analyses of the genetic variants were conducted using at least five data *** epidemiologic credibility of the significant associations was graded using the Venice *** Based on literature screening,399 eligible studies were included,comprising 381 candidate gene association,16 genome-wide association,and 2 whole-exome sequencing *** identified 465 genetic variants in 173 genes in candidate gene association studies,and 25 genetic variants in 17 genes were included in the *** meta-analysis identified 11 variants in 10 genes that were significantly associated with NAFLD,with cumulative epidemiological evidence of an association graded as strong for two variants in two genes(HFE,TNF),moderate for four variants in three genes(TM6SF2,GCKR,and ADIPOQ),and weak for five variants in five genes(MBOAT7,PEMT,PNPLA3,LEPR,and MTHFR).Conclusion This study identified six variants in five genes that had moderate to strong evidence of an association with NAFLD,which may help understand the genetic architecture of NAFLD risk.

关键词： Nonalcoholic fatty liver disease Genetic association study Genetic variant Systematic review Meta-analysis

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healthy life expectancy with cardiovascular disease among Chinese rural population based on the prospective cohort study

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Journal of Geriatric Cardiology 2024年第8期21卷 799-806页

作者： Feng JIANG Xiao-Tian LIU Ze HU Wei LIAO Shuo-Yi LI Rui-Fang ZHU Zhen-Xing MAO Jian HOU Sohail Akhtar Fayaz Ahmad Tahir Mehmood Chong-Jian WANG department of epidemiology and Biostatistics College of Public HealthZhengzhou UniversityZhengzhouChina department of Mathematics and statistics The University of HaripurHaripurPakistan School of Natural Sciences National University of Sciences and TechnologyIslamabadPakistan

BACKGROUND Limited research has explored the impact of cardiovascular disease(CVD)on healthy life expectancy(HLE)especially in resource-limited *** study aimed to investigate the association between CVD and HLE in Chinese rural *** This study included 11,994 participants aged 45 years and older from the baseline and follow-up surveys of the Henan rural cohort *** status was measured via a Visual Analogue *** multistate Markov model was applied to estimate the association between CVD and transitions in health,unhealthiness and ***-specific total life expectancy,HLE and unhealthy life expectancy were calculated by the multistate life table *** During a mean follow-up time of 3.85(3.84–3.86)years,there were 588 deaths *** individuals with CVD,the risk of switching from health to unhealthiness status was increased by 71%[hazard ratio(HR)=1.71,95%CI:1.42–2.07],the chance of recovery was reduced by 30%(HR=0.70,95%CI:0.60–0.82).Men aged 45 years without CVD could gain an extra 7.08(4.15–10.01)years of HLE and lose 4.00(1.60–6.40)years of unhealthy life expectancy compared to their peers with CVD,*** corresponding estimates among women were 8.62(5.55–11.68)years and 5.82(2.59–9.04)years,*** This study indicated that CVD was significantly associated with poorer health status and lower HLE among Chinese rural *** is an important public health policy to adopt targeted measures to reduce the CVD burden and enhance the quality of life and HLE in resource-limited areas.

关键词： healthy cardiovascular life

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Injury Mortality of Children and Adolescents Aged 0–19 Years—China,2010–2021

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China CDC weekly 2024年第14期6卷 294-299,I0001-I0006页

作者： Jingtao Zhou Min Zhao Hao Huang David C.Schwebel Peishan Ning Zhenzhen Rao Peixia Cheng Li Li Guoqing Hu department of epidemiology and health statistics Hunan Provincial Key Laboratory of Clinical EpidemiologyXiangya School of Public HealthCentral South UniversityChangsha CityHunan ProvinceChina department of Psychology University of Alabama at BirminghamBirminghamALUSA department of Child Adolescent and Women’s HealthSchool of Public HealthCapital Medical UniversityBeijingChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha CityHunan ProvinceChina

Introduction:To examine the recent trends in child injury mortality in ***:Injury mortality data of 2010–2021 for children and adolescents aged 0–19 years were from the China health statistics *** mortality disparities across urban *** locations,gender,and age groups were *** percent change(APC),average annual percent change(AAPC),and their 95%confidence intervals(95%CI)were estiamted usimg Joinpoint regression ***:The age-standardized injury mortality significantly dropped from 21.87 to 9.41 per 100,000 population among children and youth aged 0–19 years during 2010–2021,with an AAPC of−6.7%(95%CI:−8.2%,−5.2%).The urban-rural disparity and gender gap in injury mortality reduced *** 2021,drowning and road traffic crashes were the top two causes of child injury deaths,explaing 31.1%and 27.9%of total injury deaths,*** accounted for 62.3%of injury deaths among infants younger than a ***,the suicide mortality rate rose from 2.16 to 3.42 per 100,000 population between 2010 and 2021 among teenagers aged 15–19 *** analyses yielded similar ***:During 2010–2021,the injury mortality decreased significantly among Chinese children and adolescents,and the responding urbanrural disparities narrowed.

关键词： injury younger narrow

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Reproductive Characteristics and Trends of Major Pregnancy Outcomes of Women at Different Parities-Beijing Municipality,China,2013-2022

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China CDC weekly 2024年第31期6卷 786-792页

作者： Zhaoxia Jia Yongxian Zhao Lei Wang Qingqing Wu Moning Guo Jianpeng Zheng Lili Huang Junhua Wang Zhao Wang Di Zhang Minghui Wu department of information and statistics Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing Maternal and Child Health Care HospitalBeijingChina department of data resources and statistics Beijing Municipal Health Big Data and Policy Research CenterBeijingChina

Summary What is already known about this topic?With socioeconomic development,the increase of older pregnancies and multiparas has brought risks to mothers and *** is added by this report?As parities increased,the proportion of women of advanced maternal age(AMA)and non-local domicile increased,while the proportion of women with higher education levels *** with≥3 parities are more likely to have preterm birth(PTB)and *** are the implications for public health practice?A comprehensive analysis of pregnancy traits among women at different parities offers a robust foundation for tailored strategies against adverse pregnancy outcomes.

关键词： mother pregnancy likely

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Understanding the educational inequalities in suicide attempts and their mediators:a Mendelian randomisation study

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General Psychiatry 2024年第1期37卷 133-142页

作者： Jiahao Zhu Houpu Liu Rui Gao Lilu Ding Jing Wang Ye Yang Dan Zhou Yingjun Li department of epidemiology|and health statistics School of Public HealthHangzhou Medical CollegeHangzhouZhejiangChina Vanderbit Genetics Institute Vanderbilt University Medical CenterNashvilleTennesseeUSA School of Public health and the Second Afliated Hospital Zhejiang University Schol of MedicineHangzhouZhejiangChina

Background Educational inequalities in suicide have become increasingly prominent over the past *** modifiable risk factors that serve as intermediaries in the impact of low educational attainment on suicide has the potential to reduce health *** To examine the risk factors that mediate the relationship between educational attainment and suicide attempts and quantify their contributions to the mediation *** We conducted a two-sample Mendelian randomisation(MR)analysis to estimate the causal effect of educational attainment on suicide attempts,utilising genome-wide association study summary statistics from the Integrative Psychiatric Research(iPSYCH;6024 cases and 44240 controls)and FinnGen(8978 cases and 368299 controls).We systematically evaluated 42 putative mediators within the causal pathway connecting reduced educational attainment to suicide attempts and employed two-step and multivariable MR to quantify the proportion of the mediated *** In the combined analysis of iPSYCH and FinnGen,each standard deviation(SD)decrease in genetically predicted educational attainment(equating to 3.4 years of education)was associated with a 105%higher risk of suicide attempts(odds ratio(OR):2.05;95%confidence interval(Cl):1.81 to 2.31).0f the 42 risk factors analysed,the two-step MR identified five factors that mediated the association between educational attainment and suicide *** respective proportions of mediation were 47%(95%Cl:29%to 66%)for smoking behaviour,36%(95%Cl:0%to 84%)for chronic pain,49%(95%Cl:36%to 61%)for depression,35%(95%Cl:12%to 59%)for anxiety and 26%(95%Cl:18%to 34%)for *** MR implicated these five mediators collectively,accounting for 68%(95%Cl:40%to 96%)of the total *** This study identified smoking,chronic pain and mental disorders as primary intervention targets for attenuating suicide risk attributable to lower educational levels in the European population.

关键词： effect. random inequalities

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health benefits from the rapid reduction in ambient exposure to air pollutants after China's clean air actions:progress in efficacy and geographic equality

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National Science Review 2024年第2期11卷 103-113页

作者： Tao Xue Ruohan Wang Meng Wang Yanying Wang Dan Tong Xia Meng Conghong Huang Siqi Ai Fangzhou Li Jingyuan Cao Mingkun Tong Xueqiu Ni Hengyi Liu Jianyu Deng Hong Lu Wei Wan Jicheng Gong Shiqiu Zhang Tong Zhu Institute of Reproductive and Child health National Health Commission Key Laboratory of Reproductive Health/Department of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Epidemiology of Major Diseases(PKU) School of Public Health Peking University Health Science Centre State Environmental Protection Key Laboratory of Atmospheric Exposure and Health Risk Management and Center for Environment and Health Peking University Advanced Institute of Information Technology Peking University department of epidemiology and Environmental health School of Public Health and Health ProfessionsUniversity at Buffalo State Key Joint Laboratory of Environment Simulation and Pollution Control College of Environmental Sciences and EngineeringPeking University department of Earth System Science Tsinghua University School of Public health Key Laboratory of Public Health Safety of the Ministry of Education and Key Laboratory of Health Technology Assessment of the Ministry of HealthFudan University College of Land Management Nanjing Agricultural University National&Local Joint Engineering Research Center for Rural Land Resources Use and Consolidation Clean Air Asia

Clean air actions （CAAs） in China have been linked to considerable benefits in public ***,whether the beneficial effects of CAAs are equally distributed geographically is *** high-resolution maps of the distributions of major air pollutants (fine particulate matter[PM2.5]and ozone[O3]) and population,we aimed to track spatiotemporal changes in health impacts from,and geographic inequality embedded in,the reduced exposures to PM2.5and O3from 2013 to *** used a method established by the Global Burden of Diseases *** analyzing the changes in loss of life expectancy（LLE） attributable to PM2.5and O3,we calculated the gain of life expectancy （GLE） to quantify the health benefits of the air-quality ***,we assessed the geographic inequality embedded in the GLE using the Gini index （GI）.Based on risk assessments of PM2.5and O3,during the first stage of CAAs（2013 to 2017）,the mean GLE was 1.87 *** of the sum of the GLE was disproportionally distributed in about one quarter of the population exposed （GI 0.44）.During the second stage of CAAs（2017 to 2020）,the mean GLE increased to 3.94 months and geographic inequality decreased （GI 0.18）.According to our assessments,CAAs were enhanced,from the first to second stages,in terms of not only preventing premature mortality but also ameliorating health *** enhancements were related to increased sensitivity to the health effects of air pollution and synergic control of PM2.5and *** findings will contribute to optimizing future CAAs.

关键词： clean air action public health inequality fine particulate matter ozone

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Measurement,associations,patterns,and promotion:Unveiling vital areas in physical activity epidemiology

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Journal of Sport and health Science 2024年第5期13卷 605-607页

作者： Kara M.Whitaker Guest editor Michael J.LaMonte department of health&Human Physiology University of IowaIowa CityIA 52242USA department of epidemiology and Environmental health University of BuffaloBuffaloNY 14214 USA

Physical activity(PA)epidemiology first emerged as a new field of study around the 1950s with publication of seminal investigations on London civil servants1 and has continued to evolve as a scientific discipline to present *** subdiscipline of epidemiology studies the frequencies,distributions,and dynamics of PA and its impact on human health,morbidity,and *** over the past 75 years has demonstrated numerous health benefits of *** on these research findings,the World health Organization recommends adults aged 18-64 years engage in at least 150-300 min of moderate-intensity aerobic PA per week,or at least 75-150 min of vigorous-intensity aerobic PA per week,or a combination of both intensities.

关键词： epidemiology promotion continued

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Plant-based dietary patterns and risk of esophageal cancer:A prospective cohort study spanning 17 years

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Chinese Journal of Cancer Research 2024年第1期36卷 36-45页

作者： Xiaorui Zhang Feifan He Jiayue Li Ru Chen Xinqing Li Li Li Fen Liu Shaoming Wang Wenqiang Wei department of epidemiology and health statistics School of Public HealthBeijing Municipal Key Laboratory of Clinical EpidemiologyCapital Medical UniversityBeijing 100069China National Central Cancer Registry office National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China department of Cancer epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective: Plant-based diets have multiple health benefits for cancers;however, little is known about the association between plant-based dietary patterns and esophageal cancer(EC).This study presents an investigation of the prospective associations among three predefined indices of plant-based dietary patterns and the risk of ***: We performed endoscopic screening for 15,709 participants aged 40-69 years from two high-risk areas of China from January 2005 to December 2009 and followed the cohort until December 31, 2022. The overall plant-based diet index(PDI), healthful plant-based diet index(h PDI), and unhealthful plant-based diet index(u PDI), were calculated using survey responses to assess dietary patterns. We applied Cox proportional hazard regression to estimate the multivariable hazard ratios(HRs) and 95% confidence intervals(95% CIs) of EC across 3plant-based diet indices and further stratified the analysis by ***: The final study sample included 15,184 participants in the cohort. During a follow-up of 219,365person-years, 176 patients with EC were identified. When the highest quartile was compared with the lowest quartile, the pooled multivariable-adjusted HR of EC was 0.50(95% CI, 0.32-0.77) for h PDI. In addition, the HR per 10-point increase in the h PDI score was 0.42(95% CI, 0.27-0.66) for ECs. Conversely, u PDI was positively associated with the risk of EC, and the HR was 1.80(95% CI, 1.16-2.82). The HR per 10-point increase in the u PDI score was 1.90(95% CI, 1.26-2.88) for ECs. The associations between these scores and the risk of EC were consistent in most subgroups. These results remained robust in sensitivity ***: A healthy plant-based dietary pattern was associated with a reduced risk of EC. Emphasizing the healthiness and quality of plant-based diets may be important for preventing the development of EC.

关键词： Esophageal cancer diet dietary pattern epidemiology nutrition prospective cohort study

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Optimal Model Average Prediction in Orthogonal Kriging Models

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Journal of Systems Science & Complexity 2024年第3期37卷 1080-1099页

作者： WANG Jun HE Jiabei LIANG Hua LI Xinmin School of Mathematics and statistics Qingdao UniversityQingdao 266071China department of statistics George Washington UniversityWashington DC 20052USA

The main objective of this paper is to consider model averaging methods for kriging *** paper proposes a Mallows model averaging procedure for the orthogonal kriging model and demonstrate the asymptotic optimality of the model averaging estimators in terms of mean square *** studies are conducted to evaluate the performance of the proposed method and compare it with the competitors to demonstrate its *** authors also analyse a real dataset for an illustration.

关键词： Asymptotic optimality Mallows criterion optimal model averaging orthogonal kriging model

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Changes in the Non-targeted Metabolomic Profile of Three-year-old Toddlers with Elevated Exposure to Polycyclic Aromatic Hydrocarbons

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Biomedical and Environmental Sciences 2024年第5期37卷 479-493页

作者： LI Yang LIN Dan ZHANG Xiu Qin JU Guang Xiu SU Ya ZHANG Qian DUAN Hai Ping YU Wei Sen WANG Bing Ling PANG Shu Tao department of epidemiology and health statistics School of Public HealthQingdao UniversityQingdao 266021ShandongChina department of Environmental health Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Physicochemical Laboratory Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Section of Child health Care Huangdao Maternity and Child Health Care Hospital of QingdaoQingdao 266499ShandongChina Qingdao Blood Center Qingdao 266071ShandongChina

Objective To investigate changes in the urinary metabolite profiles of children exposed to polycyclic aromatic hydrocarbons(PAHs)during critical brain development and explore their potential link with the intestinal *** Liquid chromatography-tandem mass spectrometry was used to determine ten hydroxyl metabolites of PAHs(OH-PAHs)in 36-month-old ***,37 children were categorized into low-and high-exposure groups based on the sum of the ten ***-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was used to identify non-targeted metabolites in the urine ***,fecal flora abundance was assessed by 16S rRNA gene sequencing using Illumina *** The concentrations of 21 metabolites were significantly higher in the high exposure group than in the low exposure group(variable importance for projection>1,P<0.05).Most of these metabolites were positively correlated with the hydroxyl metabolites of naphthalene,fluorine,and phenanthrene(r=0.336–0.531).The identified differential metabolites primarily belonged to pathways associated with inflammation or proinflammatory states,including amino acid,lipid,and nucleotide ***,these distinct metabolites were significantly associated with specific intestinal flora abundances(r=0.34–0.55),which were mainly involved in *** Higher PAH exposure in young children affected metabolic homeostasis,particularly that of certain gut microbiota-derived *** investigation is needed to explore the potential influence of PAHs on the gut microbiota and their possible association with neurodevelopmental outcomes.

关键词： Child Gut microbiota Non-targeted metabolomics Polycyclic aromatic hydrocarbons Urinary metabolite profile

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