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Succinylation modification:a potential therapeutic target in stroke

Neural Regeneration Research 2024年第4期19卷 781-787页

作者： Jie Lian Wenwu Liu Qin Hu Xiaohua Zhang department of Neurosurgery Ren Ji HospitalShanghai Jiao Tong University School of Medicine department of diving and Hyperbaric Medicine Naval Medical CenterNaval Medical University

Stroke is a leading cause of mortality and disability *** cell death triggered by the compromised supply of blood oxygen and glucose is one of the major pathophysiology of strokeinduced brain *** mitochondrial energy metabolism is observed minutes after stroke and is closely associated with the progression of ***,a new type of posttranslational modification,known as lysine succinylation,has been recognized to play a significant role in mitochondrial energy metabolism after ***,the role of succinylation modification in cell metabolism after stroke and its regulation are not well *** aimed to review the effects of succinylation on energy metabolism,reactive oxygen species generation,and neuroinflammation,as well as Sirtuin 5 mediated desuccinylation after *** also highlight the potential of targeting succinylation/desuccinylation as a promising strategy for the treatment of *** succinylation level is dynamically regulated by the nonenzymatic or enzymatic transfer of a succinyl group to a protein on lysine residues and the removal of succinyl catalyzed by *** evidence has suggested that succinylation can regulate the metabolic pathway through modulating the activity or stability of metabolic ***,especially Sirtuin 5,are characterized for their desuccinylation activity and have been recognized as a critical regulator of metabolism through desuccinylating numerous metabolic *** between succinylation and desuccinylation has been implicated in the pathophysiology of *** agents that enhance the activity of Sirtuin 5 have been employed to promote desuccinylation and improve mitochondrial metabolism,and neuroprotective effects of these agents have been observed in experimental stroke ***,their therapeutic efficacy in stroke patients should be validated.

关键词： mitochondria metabolism neuroprotection sirtuin 5 stroke succinylation modification

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A combined nanotherapeutic approach targeting farnesoid X receptor,ferroptosis,and fibrosis for nonalcoholic steatohepatitis treatment

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2228-2246页

作者： Jiangtao Fu Pingping Zhang Zhiguo Sun Guodong Lu Qi Cao Yiting Chen Wenbin Wu Jiabao Zhang Chunlin Zhuang Chunquan Sheng Jiajun Xu Ying Lu Pei Wang The Center for Basic Research and Innovation of Medicine and Pharmacy(MOE) School of PharmacyNaval Medical UniversityShanghai 200433China National Demonstration Center for Experimental Pharmaceutical Education Naval Medical University/Second Military Medical UniversityShanghai 200433China department of diving and Hyperbaric Medicine Naval Special Medical CenterNaval Medical UniversityShanghai 200433China

Obeticholic acid(OCA),a farnesoid X receptor(FXR)agonist with favorable effects on fatty and glucose metabolism,has been considered the leading candidate drug for nonalcoholic steatohepatitis(NASH)***,its limited effectiveness in resolving liver fibrosis and lipotoxicity-induced cell death remains a major ***,a newly recognized form of cell death characterized by uncontrolled lipid peroxidation,is involved in the progression of *** oxide(NO)is a versatile biological molecule that can degrade extracellular *** this study,we developed a PEGylated thiolated hollow mesoporous silica nanoparticles(MSN)loaded with OCA,as well as a ferroptosis inhibitor liproxsatin-1 and a NO donor S-nitrosothiol(ONL@MSN).Biochemical analyses,histology,multiplexed flow cytometry,bulk-tissue RNA sequencing,and fecal 16S ribosomal RNA sequencing were utilized to evaluate the effects of the combined nanoparticle(ONL@MSN)in a mouse NASH *** with the OCA-loaded nanoparticles(O@MSN),ONL@MSN not only protected against hepatic steatosis but also greatly ameliorated fibrosis and ***@MSN also displayed enhanced therapeutic actions on the maintenance of intrahepatic macrophages/monocytes homeostasis,inhibition of immune response/lipid peroxidation,and correction of microbiota *** findings present a promising synergistic nanotherapeutic strategy for the treatment of NASH by simultaneously targeting FXR,ferroptosis,and fibrosis.

关键词： Nonalcoholic steatohepatitis Nanotherapy Farnesoid X receptor Ferroptosis Fibrosis Obeticholic acid S-Nitrosothiol Liproxstatin-1

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The anti-inflammatory effects of exercise on autoimmune diseases:A 20-year systematic review

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Journal of Sport and Health Science 2024年第3期13卷 353-367,I0001页

作者： Beibei Luo Dao Xiang Xiaorong Ji Xuan Chen Rui Li Shuxin Zhang Yujun Meng David C.Nieman Peijie Chen School of Exercise and Health Shanghai University of SportShanghai 200438China Shanghai Key Laboratory of Human Performance Shanghai University of SportShanghai 200438China department of diving and Hyperbaric Medicine Naval Medical CenterShanghai 200433China National Key Laboratory of Immunity and Inflammation Naval Medical UniversityShanghai 200433China Human Performance Laboratory Appalachian State UniversityNorth Carolina Research CampusKannapolisNC 28081USA Research Institute for Doping Control Shanghai University of SportShanghai 200438China

Background:The anti-inflammatory effect of exercise may be an underlying factor in improving several autoimmune *** aim of this systematic review was to examine the evidence on the role of exercise training in mitigating inflammation in adolescents and adults with autoimmune ***:PubMed,Web of Science,and Embase databases were systematically reviewed for related studies published between January 1,2003,and August 31,*** randomized and non-randomized controlled trials of exercise interventions with autoimmune disease study participants that evaluated inflammation-related biomarkers were *** quality of evidence was assessed using the Tool for the assEssment of Study qualiTy and reporting in EXercise scale and Cochrane bias risk ***:A total of 14,565 records were *** screening the titles,abstracts,and full texts,87 were eligible for the systematic *** studies were conducted in 25 different countries and included a total of 2779 participants(patients with autoimmune disease,in exercise or control groups).Overall,the evidence suggests that inflammation-related markers such as C-reactive protein,interleukin 6,and tumor necrosis factor a were reduced by regular exercise *** exercise interventions combined with multiple exercise modes were associated with greater ***:Regular exercise training by patients with autoimmune disease exerts an anti-inflammatory *** systematic review provides support for the promotion and development of clinical exercise intervention programs for patients with autoimmune *** patients with autoimmune disease can safely adopt moderate exercise training protocols,but changes in inflammation biomarkers will be modest at *** exercise interventions are ineffective or even modestly but transiently pro-inflammatory.

关键词： Autoimmune diseases Cytokines Inflammation Physical activity Training

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Changes of Immunoreactive β-Endorphin in Plasma, Pituitary and Hypothalamus of Rats during Oxygen-Induced Convulsions

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Journal of Medical Colleges of PLA(China) 1989年第1期4卷 85-89页

作者：陶恒沂倪国坛 department of diving physiology Faculty of Naval Medicine Second Military Medical University Shanghai

We observed for the first time the differences of immunoreactive β-endorphin(IR -β- EP) content in plasma, pituitary and hypothalamus of rats under various conditionsusing radioimmunoassay (RIA) and the effects of naloxone and β - endorphin (β- EP) antiserumon initial time of convulsions (ITC), severity of convulsions(SOC) and mortality on surface(MOS) of rats to hyperbaric oxygen(HBO). The results suggest thatβ- EP may partici-pate in the course of oxygen - induced convulsions and be one of endogenous convulsion - causingagents.

关键词： β-endorphin oxygen-induced convulsions naloxone radioimmunoassay antiserum rats

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A new neuroprotective bakkenolide from the rhizome of Petasites tricholobus

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Chinese Chemical Letters 2008年第7期19卷 841-844页

作者： Na Zhang Mei Li Guo Ge Zhang Run Ping Li department of Pharmacognosy School of Pharmacy Second Military Medical University Shanghai 200433 China department of diving Medicine Faculty of Naval Medicine Second Military Medical University Shanghai 200433 China

A new bakkenolide-type compound, bakkenolide-Va（1）, was isolated from the rhizome of Petasites tricholobus. The structure was characterized on the basis of various NMR （1H, 13C, 1H-1H COSY, HMQC, HMBC and NOESY） and mass spectrometry data. The neuroprotective activity of bakkenolide-Va was investigated in primarily cultured neurons treated by hypoxia-ghicose deprivation and various types of oxidative insults.

关键词： Petasites tricholobus Compositae Bakkenofide-Va Neuroprotection

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Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第5期14卷 382-391页

作者： Ling ZHAO You-bin WANG Shi-rui QIN Xue-mei MA Xue-jun SUN Ming-lian WANG Ru-gang ZHONG College of Life Science and Bioengineering Beijing University of Technology Peking Union Medical College Hospital department of diving Medicine Faculty of Naval Medicinethe Second Military Medical University

Objective: Skin damage induced by ischemia/reperfusion (I/R) is a multifactorial process that often occurs in plastic surgery. The mechanisms of I/R injury include hypoxia, inflammation, and oxidative damage. Hydrogen gas has been reported to alleviate cerebral I/R injury by acting as a free radical scavenger. Here, we assessed the protective effect of hydrogen-rich saline (HRS) on skin flap I/R injury. Methods: Abdominal skin flaps of rats were elevated and ischemia was induced for 3 h; subsequently, HRS or physiological saline was administered intraperitoneally 10 min before reperfusion. On postoperative Day 5, flap survival, blood perfusion, the accumulation of reactive oxygen species (ROS), and levels of cytokines were evaluated. Histological examinations were performed to assess inflammatory cell infiltration. Results: Skin flap survival and blood flow perfusion were improved by HRS relative to the controls. The production of malondialdehyde (MDA), an indicator of lipid peroxidation, was markedly reduced. A multiplex cytokine assay revealed that HRS reduced the elevation in the levels of inflammatory cytokines, chemokines and growth factors, with the exception of RANTES (regulated on activation, normal T-cell expressed and secreted) growth factor. HRS treatment also reduced inflammatory cell infiltration induced by I/R injury. Conclusions: Our findings suggest that HRS mitigates I/R injury by decreasing inflammation and, therefore, has the potential for application as a therapy for improving skin flap survival.

关键词： Hydrogen-rich saline Ischemia/reperfusion Skin flaps Oxidative damage Inflammation

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An updated inventory of marine opisthobranch(Mollusca,Gastropoda)from the territorial waters of the Republic of Mauritius

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Journal of Oceanology and Limnology 2024年第1期42卷 226-243页

作者： Lisa AH SHEE TEE Chandani APPADOO Daneshwar PUCHOOA Vishwakalyan BHOYROO department of Agricultural&Food Science Faculty of AgricultureUniversity of MauritiusRéduit 80837Mauritius department of Biosciences&Ocean Studies Pole of Research Excellence Sustainable Marine BiodiversityFaculty of ScienceUniversity of MauritiusRéduit 80837Mauritius

Island ecosystems support diverse aquatic invertebrate communities comprising endemic *** of existing species is important for *** this study,a checklist of marine opisthobranch from the Republic of Mauritius is presented.A combination of benthic surveys(50 m×5 m in triplicates),rover diving techniques and photo documentation were used over two years(2018–2020)within 35 sheltered and unsheltered *** and molecular analysis were used for *** composition within sheltered and unsheltered areas in Mauritius was estimated using the Bray-Curtis *** checklist featured 117 species belonging to 61 genera and 28families,of which 13 are new *** findings increased the knowledge of opisthobranch diversity from the Mauritius by 15.4%.Among the listed species,the distribution range of Cyerce nigra,Actinocyclus papillatus,and Phyllidia picta extended from the Western Pacific to the South Western Indian *** analysis of the undescribed Gymnodoris *** it resembled Gymnodoris *** Hawaii and were different by a genetic distance value of 10.6%.The species richness and evenness were higher within the sheltered regions of Mauritius which harboured the food resource of *** areas as compared to unsheltered regions were heavily populated,suggesting the probable influence of wave actions on opisthobranch diversity and *** order Nudibranchia was reported as most speciose,with 86 *** Sacoglossa and Nudibranchia were observed only on macroalgae and sponges *** abundance was also recorded on shipwrecks which are the most common form of artificial *** the inclusion of observations from previous studies,201species belonging to 94 genera and 36 families are now known from the Mauritius.

关键词： marine opisthobranch inventory new record occurrence Republic of Mauritius Indian Ocean

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Exercise induces tissue hypoxia and HIF-1α redistribution in the small intestine

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Journal of Sport and Health Science 2020年第1期9卷 82-89页

作者： Die Wu Wei Cao Dao Xiang Yi-Ping Hu Beibei Luo Peijie Chen School of Kinesiology Shanghai University of SportShanghai 200438China department of diving Medicine Naval Medical Research InstituteSecond Military Medical UniversityShanghai 200432China department of Cell Biology Second Military Medical UniversityShanghai 200432China

Background:Exercise induces blood flow redistribution among tissues,leading to splanchnic *** epithelial cells are positioned between the anaerobic lumen and the highly metabolic lamina propria with an oxygen ***-inducible factor(HIF)-la is pivotal in the transcriptional response to the oxygen ***:In this study,the pimonidazole hydrochloride staining was applied to observe the tissue hypoxia in different organs,which might be affected by the blood flow *** HIF-la luciferase reporter ROSA26 oxygen-dependent degradation domain(ODD)-Luc/^+mouse model(ODD domain-Luc;female,n=3-6/group) was used to detect the HIF-la expression in the *** used 3 swimming models:moderate exercise for 30 min,heavy-intensity exercise bearing 5% bodyweight for 1.5 h,and long-time exercise for 3 ***:We found that 1 session of swimming at different intensities could induce tissue hypoxia redistribution in the small intestine,colon,liver and kidney,but not in the spleen,heart,and skeletal *** data showed that exercise exacerbated the extent of physiological hypoxia in the small ***,using ODD-Luc mice,we found that moderate exercise increased the in vivo HIF-1α level in the small *** postexercise HIF-1α level was gradually decreased in a time-dependent ***,the redistribution of tissue hypoxia and the increase of HIF-la expression were not related to the exercise intensity and ***:This study provided evidence that the small intestine is the primary target organ for exercise-induced tissue hypoxia and HIF-la redistribution,suggesting that HIF-1α may be a potential target for the regulation of gastrointestinal functions after exercise.

关键词： Blood flow redistribution Hypoxia-inducible factor-1α ODD-Luc Pimonidazole HCl Swimming

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The heart rate - breathing rate relationship in aquatic mammals： A comparative analysis with terrestrial species

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Current Zoology 2015年第4期61卷 569-577页

作者： Jacopo P. MORTOLA department of physiology McGill University Montreal QC Canada H3G 1Y6

Aquatic and semi-aquatic mammals, while resting at the water surface or ashore, breathe with a low frequency （f） by comparison to terrestrial mammals of the same body size, the difference increasing the larger the species. Among various interpretations, it was suggested that the low-f breathing is a consequence of the end-inspiratory breath-holding pattern adopted by aquatic mammals to favour buoyancy at the water surface, and evolved to be part of the genetic makeup. If this interpretation was correct it could be expected that, differently from f, the heart rate （HR, beats/min） of aquatic and semi-aquatic mammals at rest would not need to differ from that of terrestrial mammals and that their HR-fratio would be higher than in terrestrial species. Literature data for HR （beats/min） in mammals at rest were gathered for 56 terrestrial and 27 aquatic species. In aquatic mammals the allometric curve （HR=191 .M^18; M= body mass, kg） did not differ from that of terrestrial species （HR=212.M^-0.22） and their HR-fratio （on average 32±5） was much higher than in terrestrial species （5±1）（P〈0.0001）. The comparison of these HR allometric curves to those forfpreviously published indicated that the HR-fratio was body size-independent in terrestrial species while it increased significantly with M in aquatic species. The similarity in HR and differences in f between aquatic and terrestrial mammals agree with the possibility that the lowfof aquatic and semi-aquatic mammals may have evolved for a non-respiratory function, namely the regulation of buoyancy at the water surface [Current Zoology 61（4）： 569-577, 2015].

关键词： Allometry Breathing pattern Control of breathing diving Cardio-respiratory coupling

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SALVAGING RATS WITH DECOMPRESSION SICKNESS BY INJECTION OF GINSENG AND LIGUSTRAZINI *** RECOMPRESSION

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Journal of Traditional Chinese Medicine 1985年第1期5卷 65-66页

作者：王超政张学虎李长亮方德恩吴咸中 PLA Tianjin Medical College department of Deep diving Medicine Naval Medical School

This experiment was intended to ascertain thepossibility of treating severe decompression sicknessby drugs without resorting to *** model animals were male SD rats withsevere artificial decompression *** screening,we found that injection of Ginseng and *** decreased the mortality rate after de-compression,or prolonged the period of *** of the 10 rats that received the injectionsurvived and were symptom-free after 72 hours *** the 3 rats that died,survivaltime of 2 was *** of the 10 controlswhich were given intraperitoneal injection of normalsaline *** results of the study showed that this modali-ty of treatment had obvious therapeutic effect on SDrats with severe decompression sickness with no useof reeompression.

关键词： decompression sickness ascertain prolonged screening minutes mortality Seven treating markedly

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