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Aquaculture and Fisheries 2024年第3期9卷 455-485页

作者： Urmi Mukherjee Sudipta Maitra Molecular and Cellular endocrinology Laboratory Department of ZoologyVisva-Bharati UniversitySantiniketan731235India

Endocrine-disrupting chemicals(EDCs)may mimic the endogenous neuroendocrine and endocrine messengers and interfere with developmental,reproductive,immune,metabolic and other physiological *** of basal metabolic rate,energy metabolism,food intake and engorgement by endocrine disruptors may lead to loss of metabolic ***-induced loss of metabolic homeostasis and obesity gave rise to the concept of metabolic-disrupting chemicals(MDC)and environmental *** oxidative stress,alterations in the circadian clock,and energy-sensing homeostasis are some of the major pathophysiological conditions implicated in promoting metabolic ***,fish are the most vulnerable candidate due to their direct exposure to metabolic disruptors in aquatic *** limited,studies conducted using piscine models have helped to identify MDCs in the aquatic ***,the molecular mechanisms through which MDCs can negatively influence the metabolism of hormones,epigenetic alteration,gut dysbiosis,and changes in endocrine and metabolic receptor expression and functions have recently gained considerable *** this review,we provide an update on the impact of MDCs on the initiators,cellular mediators,and hormone receptors related to the maintenance of metabolic homeostasis,with particular emphasis on fish models.

关键词： Reactive oxygen species SIRT1/AMPK/PGC PPAR Estrogen receptor Hormone metabolism Metabolic disruption

From liver to hormones:The endocrine consequences of cirrhosis

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World Journal of Gastroenterology 2024年第9期30卷 1073-1095页

作者： Juan Eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio María del Carmen Durand-Vásquez Luciana del Pilar Rafael-Robles Jhean Gabriel Gonzáles-Yovera María Alejandra Quispe-Flores Luis Alberto Concepción-Urteaga Alejandro Román-González José Paz-Ibarra Marcio José Concepción-Zavaleta Non-communicable Diseases Endocrinology Research LineHospital de Apoyo ChepénChepén 13871Peru department of endocrinology Hospital Víctor Lazarte EchegarayTrujillo 13006Peru department of endocrinology Clínica Javier PradoLima 15046Peru department of Gastroenterology Hospital Nacional Guillermo Almenara IrigoyénLima 15018Peru department of endocrinology Hospital de Emergencias GrauLima 15001Peru Internal Medicine Hospital Regional Docente de TrujilloTrujillo 13011Peru department of endocrinology Hospital Universitario de San Vicente FundaciónMedellin 050010Colombia Internal Medicine Universidad de AntioquiaMedellín 050010Colombia School of Medicine Universidad Nacional Mayor de San MarcosLima 15081Peru department of endocrinology Hospital Nacional Edgardo Rebagliati MartinsLima 15072Peru Carrera de Medicina Humana Universidad Científica del SurLima 15067Peru

Hepatocrinology explores the intricate relationship between liver function and the endocrine *** liver diseases such as liver cirrhosis can cause endocrine disorders due to toxin accumulation and protein synthesis *** its importance,assessing endocrine issues in cirrhotic patients is frequently *** article provides a comprehensive review of the epidemiology,pathophysiology,diagnosis,and treatment of endocrine disturbances in liver *** review was conducted using the PubMed/Medline,EMBASE,and Scielo databases,encompassing 172 *** cirrhosis is associated with endocrine disturbances,including diabetes,hypoglycemia,sarcopenia,thyroid dysfunction,hypogonadotropic hypogonadism,bone disease,adrenal insufficiency,growth hormone dysfunction,and secondary *** optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and continuous glucose monitoring system,*** can be assessed through imaging and functional tests,while other endocrine disorders are evaluated using hormonal assays and imaging *** options include metformin,glucagon-like peptide-1 analogs,sodium-glucose co-transporter-2 inhibitors,and insulin,which are effective and safe for diabetes *** standards are followed for managing hypoglycemia,and hormone replacement therapy is often necessary for other endocrine *** transplantation can address some of these problems.

关键词： diabetes mellitus Hypoglycemia Thyroid diseases Hypogonadism Metabolic bone diseases Liver cirrhosis

Long noncoding RNA protein-disulfide isomerase-associated 3 regulated high glucose-induced podocyte apoptosis in diabetic nephropathy through targeting miR-139-3p

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World Journal of diabetes 2024年第2期15卷 260-274页

作者： Yin-Xi He Ting Wang Wen-Xian Li Yan-Xia Chen department of Orthopaedic Trauma The Third Hospital of ShijiazhuangShijiazhuang 050000Hebei ProvinceChina department of endocrinology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina department of endocrinology The First Hospital of ZhangjiakouZhangjiakou 075000Hebei ProvinceChina

BACKGROUND Podocyte apoptosis plays a vital role in proteinuria pathogenesis in diabetic nephropathy(DN).The regulatory relationship between long noncoding RNAs(lncRNAs)and podocyte apoptosis has recently become another research hot spot in the DN *** To investigate whether lncRNA protein-disulfide isomerase-associated 3(Pdia3)could regulate podocyte apoptosis through miR-139-3p and revealed the underlying *** Using normal glucose or high glucose(HG)-cultured podocytes,the cellular functions and exact mechanisms underlying the regulatory effects of lncRNA Pdia3 on podocyte apoptosis and endoplasmic reticulum stress(ERS)were *** Pdia3 and miR-139-3p expression were measured through quantitative real-time polymerase chain *** cell viability was detected through the cell counting kit-8 colorimetric *** podocyte apoptosis rate in each group was measured through flow *** interaction between lncRNA Pdia3 and miR-139-3p was examined through the dual luciferase reporter ***,western blotting was performed to detect the effect of lncRNA Pdia3 on podocyte apoptosis and ERS via *** The expression of lncRNA Pdia3 was significantly downregulated in HG-cultured ***,lncRNA Pdia3 was involved in HG-induced podocyte ***,the dual luciferase reporter assay confirmed the direct interaction between lncRNA Pdia3 and *** Pdia3 overexpression attenuated podocyte apoptosis and ERS through miR-139-3p in HG-cultured *** Taken together,this study demonstrated that lncRNA Pdia3 overexpression could attenuate HG-induced podocyte apoptosis and ERS by acting as a competing endogenous RNA of miR-139-3p,which might provide a potential therapeutic target for DN.

关键词： Long noncoding RNAs Diabetic nephropathy Podocyte apoptosis Endoplasmic reticulum stress Competing endogenous RNA

Dengue causing relapse of minimal change disease: A double-edged sword

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Asian Pacific Journal of Tropical Medicine 2024年第5期17卷 237-238页

作者： Sourabh Sharma Himanshu Verma Sanjay Kalra department of Nephrology VMMC&Safdarjung HospitalNew DelhiIndia department of endocrinology Bharti HospitalKarnalIndia

Dengue virus infection is endemic in India with seasonal *** can lead to lethal consequences with plasma leakage and/or bleeding[1,2].Dengue shock syndrome has high mortality in developing countries like *** can cause functional proteinuria and even heavy proteinuria[3-6].Though dengue has been implicated to cause glomerulonephritis[7],to the best of our knowledge,dengue as a cause of relapse of minimal change disease(MCD)has not been reported.

关键词： relapse mortality bleeding

Evaluation of teplizumab's efficacy and safety in treatment of type 1 diabetes mellitus:A systematic review and meta-analysis

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World Journal of diabetes 2024年第7期15卷 1615-1626页

作者： Xiao-Lan Ma Dan Ge Xue-Jian Hu department of endocrinology and Metabolism The Second Affiliated Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Islets of Langerhans beta cells diminish in autoimmune type 1 diabetes mellitus(T1DM).Teplizumab,a humanized anti-CD3 monoclonal antibody,may help *** long-term implications on clinical T1DM development,safety,and efficacy are *** To assess the effectiveness and safety of teplizumab as a therapeutic intervention for individuals with *** A systematic search was conducted using four electronic databases(PubMed,Embase,Scopus,and Cochrane Library)to select publications published in peerreviewed journals written in *** odds ratio(OR)and risk ratio(RR)were calculated,along with their 95%*** assessed heterogeneity using Cochrane Q and I2 statistics and the appropriate P *** There were 8 randomized controlled trials(RCTs)in the current meta-analysis with a total of 1908 T1DM patients from diverse age cohorts,with 1361 patients receiving Teplizumab and 547 patients receiving a *** was found to have a substantial link with a decrease in insulin consumption,with an OR of 4.13(95%CI:1.72 to 9.90).Teplizumab is associated with an improved Cpeptide response(OR 2.49;95%CI:1.62 to 3.81)and a significant change in Glycated haemoglobin A1c(HbA1c)levels in people with type 1 diabetes[OR 1.75(95%CI:1.03 to 2.98)],and it has a RR of 0.71(95%CI:0.53 to 0.95).CONCLUSION In type 1 diabetics,teplizumab decreased insulin consumption,improved C-peptide response,and significantly changed HbA1c levels with negligible side *** appears to improve glycaemic control and diabetes management with good safety and efficacy.

关键词： Type-1 diabetes mellitus Teplizumab Anti-CD3 monoclonal antibody Insulin Glycated haemoglobin A1c Cpeptide

Cut-off value of glycated hemoglobin A1c for detecting diabetic retinopathy in the Chinese population

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World Journal of diabetes 2024年第7期15卷 1531-1536页

作者： Yan Wen Qing Wang department of endocrinology China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

BACKGROUND Glycated hemoglobin A1c(HbA1c)is considered the most suitable for diabetes mellitus diagnosis due to its accuracy and ***,the effect of HbA1c on diabetic retinopathy(DR)in the Han and Korean populations in Jilin,China,remains *** To determine the best cut-off of HbA1c for diagnosing DR among the *** This cross-sectional study included 1933 participants from the Yanbian area of Jilin Province,*** investigators employed a questionnaire-based survey,physical examination,laboratory tests,and fundus photography for the *** best cut-off value for HbA1c was established via the receiver operating characteristic *** factors associated with HbA1c-associated risk factors were determined via linear *** The analysis included 887 eligible Chinese Han and Korean participants,591 of whom were assigned randomly to the training set and 296 to the validation *** prevalence of DR was 3.27% in the total ***1c of 6.2% was the best cut-off value in the training set,while it was 5.9% in the validation *** both Chinese Han and Korean populations,an HbA1c level of 6.2% was the best cut-off *** optimal cut-off values of fasting blood glucose(FBG)≥7 mmol/L and<7 mmol/L were 8.1% and 6.2% respectively in Han populations,while those in Korean populations were 6.9%and 5.3%,***,body mass index,and FBG were determined as the risk factors impacting HbA1c *** HbA1c may serve as a useful diagnostic indicator for *** HbA1c level of 6.2% may be an appropriate cut-off value for DR detection in the Chinese population.

关键词： Diabetic retinopathy Glycated hemoglobin A1c Cut-off value Age Body mass index Fasting blood glucose

Triceps skinfold thickness trajectories and the risk of all-cause mortality:A prospective cohort study

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World Journal of Clinical Cases 2024年第15期12卷 2568-2577页

作者： Na Yang Li-Yun He Zi-Yi Li Yu-Cheng Yang Fan Ping Ling-Ling Xu Wei Li Hua-Bing Zhang Yu-Xiu Li department of endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

BACKGROUND The measurement of triceps skinfold(TSF)thickness serves as a noninvasive metric for evaluating subcutaneous fat *** its clinical utility,the TSF thickness trajectories and their correlation with overall mortality have not been thoroughly *** To explore TSF thickness trajectories of Chinese adults and to examine their associations with all-cause *** This study encompassed a cohort of 14747 adults sourced from the China Health and Nutrition *** class trajectory modeling was employed to identify distinct trajectories of TSF *** were classified into subgroups reflective of their respective TSF thickness *** utilized multivariate Cox regression analyses and mediation examinations to explore the link between TSF thickness trajectory and overall mortality,including contributory *** Upon adjustment for multiple confounding factors,we discerned that males in the‘Class 2:Thin-stable’and‘Class 3:Thin-moderate’TSF thickness trajectories exhibited a markedly reduced risk of mortality from all causes in comparison to the‘Class 1:Extremely thin’*** the mediation analyses,the Geriatric Nutritional Risk Index was found to be a partial intermediary in the relationship between TSF thickness trajectories and *** females,a lower TSF thickness pattern was significantly predictive of elevated all-cause mortality risk exclusively within the non-elderly *** In males and non-elderly females,lower TSF thickness trajectories are significantly predictive of heightened mortality risk,independent of single-point TSF thickness,body mass index,and waist circumference.

关键词： Triceps skinfold thickness Trajectory All-cause mortality Body mass index Geriatric Nutritional Risk Index

diabetes remission and nonalcoholic fatty pancreas disease

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World Journal of diabetes 2024年第7期15卷 1390-1393页

作者： Wen-Jun Wu department of endocrinology Jinshan Branch of Shanghai Sixth People’s HospitalShanghai 201500China

This editorial focuses on the relationship between nonalcoholic fatty pancreas disease(NAFPD)and the development and remission of type 2 diabetes(T2D).NAFPD is characterized by intrapancreatic fatty deposition associated with obesity and not associated with alcohol abuse,viral infections,and other *** fat deposition in the pancreas is associated with the development of T2D,and the underlying mechanism is lipotoxicβ-cell ***,the results on the relationship between intrapancreatic fat deposition(IPFD)andβ-cell function are *** of the therapeutic approach,weight loss improves IPFD,glycemia,andβ-cell *** imaging is valuable for clinically monitoring and evaluating the management of T2D.

关键词： diabetes remission Type 2 diabetes Pancreatic fat content βcell function Weight loss

Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

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Bone Research 2024年第1期12卷 180-198页

作者： Morten S.Hansen Kaja Madsen Maria Price Kent Søe Yasunori Omata Mario M.Zaiss Caroline M.Gorvin Morten Frost Alexander Rauch Molecular endocrinology Laboratory(KMEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark department of Clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of Metabolism and Systems Research(IMSR)and Centre for diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for Membrane Proteins and Receptors(COMPARE) Universities of Birmingham and NottinghamBirmingham B152TTUK department of Molecular Medicine University of Southern DenmarkDK-5000 Odense CDenmark department of Orthopedic Surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan department of Internal Medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Steno diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment *** study aimed to provide an overview of transcriptional reprogramming during human osteoclast *** were differentiated from CD14+monocytes from eight female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across *** patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the monocyte stage,such as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of mature *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density SNPs,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5AR1),somatostatin receptor 2(SSTR2),and free fatty acid receptor 4(FFAR4/GPR120).Activating C5AR1 enhanced osteoclast formation,while activating SSTR2 decreased the resorptive activity of mature osteoclasts,and activating FFAR4 decreased both the number and resorptive activity of mature *** conclus

关键词： osteoclast programming identif

Establishment and Validation of a Four-stress Granule-related Gene Signature in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 1-14页

作者： Mengzhu Li Xiude Fan Jiajun Zhao Dawei Wang department of endocrinology Shandong Provincial HospitalShandong UniversityJinanShandongChina Key Laboratory of Endocrine Glucose&Lipids Metabolism and Brain Aging Ministry of EducationDepartment of EndocrinologyShandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina Shandong Key Laboratory of endocrinology and Lipid Metabolism JinanShandongChina Shandong Institute of Endocrine and Metabolic Diseases JinanShandongChina

Background and Aims:Stress granules(SGs)as membrane-less cytoplasmic foci formed in response to unfavorable external stimuli could promote cancer cells to adapt to hostile *** carcinoma(HCC)is prone to be highly aggressive once diagnosed,which markedly reduces patient survival ***,it is crucial to develop valid diagnostic markers to prognosticate HCC patient prognosis,which promotes individualized precision therapeutics in *** the pro-tumorigenic activity of SGs,it is of great potential value to construct a prognostic tool for HCC based on the expression profiles of SG-related genes(SGGs).Methods:Bioinformatic analysis was employed to establish an SGG-based prognostic *** blotting and realtime polymerase chain reaction assays were used to assess the expression patterns of the related ***-of-function experiments were performed to analyze the effect of the SGGs on SG formation and cell ***:A four-SGG signature(KPNA2,MEX3A,WDR62,and SFN)targeting HCC was established and validated to exhibit a robust performance in predicting HCC ***,all four genes were further found to be highly expressed in human HCC *** important,we demonstrated that individually knocking down the four SGGs significantly reduced HCC cell proliferation and metastasis by compromising the SG formation ***:We developed an SGG-based predictive signature that can be used as an independent prognostic tool for *** strong predictive power of this signature was further elucidated by the carcinogenic activity of KPNA2,MEX3A,WDR62,and SFN in HCC cells by regulating SG formation.

关键词： Hepatocellular carcinoma Stress granules Prognostic factor G3BP1