检索结果-南通市图书馆

Neural Regeneration Research 2024年第6期19卷 1199-1200页

作者： Francesco Margiotta Lorenzo Di Cesare Mannelli Antonino Morabito Carla Ghelardini Elena Lucarini department of Neuroscience PsychologyDrug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology SectionUniversity of FlorenceFlorenceItaly department of Neuroscience PsychologyDrug Research and Child Health-NEUROFARBAUniversity of FlorenceFlorenceItaly Meyer Children’s Hospital IRCCS FlorenceItaly

Abdominal pain is a common symptom associated with irritable bowel syndrome and inflammatory bowel diseases(IBDs),affecting about 20%of the global population(Grundy et al.,2019).Current pain therapies are poorly effective on visceral pain of intestinal origin and present several side effects,hence the need to identify novel molecular and cellular targets for drug development.

关键词： pain visceral colon

Commentary on“Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain”

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第4期19卷 728-728页

作者： Lorenzo Di Cesare Mannelli Carla Ghelardini department of Neuroscience PsychologyDrug Research and Child Health-Neurofarba-Section of Pharmacology and ToxicologyUniversity of Florence

In pat i e nt s,a s well as in animal mod e l s,hypersensitivity to external stimuli(hyperalgesia and allodynia)or spontaneous pain is often the first,and the most disabling,symptom of neuropathy(Davis et al.,2020).The increased activity of sensitive neurons drives pain development,making ion channel modulation a fundamental target for current pharmacotherapy as well as one of the most investigated by the R&D departments of pharmaceutical companies(Bennett et al.,2019).

关键词： companies pain ent

Oligodendrocyte precursor cell maturation: role of adenosine receptors

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第9期16卷 1686-1692页

作者： Federica Cherchi Anna Maria Pugliese Elisabetta Coppi department of Neuroscience PsychologyDrug Research and Child Health-Neurofarba-Division of Pharmacology and ToxicologyUniversity of FlorenceFlorenceItaly

Oligodendrocyte-formed myelin sheaths allow fast synaptic transmission in the brain and their degeneration leads to demyelinating diseases such as multiple sclerosis. Remyelination requires the differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes but, in chronic neurodegenerative disorders, remyelination fails due to adverse environment. Therefore, a strategy to prompt oligodendrocyte progenitor cell differentiation towards myelinating oligodendrocytes is required. The neuromodulator adenosine, and its receptors(A1, A(2A), A(2B) and A3 receptors: A1R, A(2A)R, A(2B)R and A3R), are crucial mediators in remyelination processes. It is known that A1Rs facilitate oligodendrocyte progenitor cell maturation and migration whereas the A3Rs initiates apoptosis in oligodendrocyte progenitor cells. Our group of research contributed to the field by demonstrating that A(2A)R and A(2B)R inhibit oligodendrocyte progenitor cell maturation by reducing voltage-dependent K^+ currents necessary for cell differentiation. The present review summarizes the possible role of adenosine receptor ligands as potential therapeutic targets in demyelinating pathologies such as multiple sclerosis.

关键词： adenosine receptors K^+channels oligodendrocyte differentiation oligodendrocyte progenitor cells remyelination

Prevention of vertical transmission of hepatitis B virus infection

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第26期27卷 4182-4193页

作者： Piero Veronese Icilio Dodi Susanna Esposito Giuseppe Indolfi department of Medicine and Surgery University of ParmaParma 43121Italy department of Pediatrics Pietro Barilla Children's HospitalParma 43121Italy department neurofarba University of FlorenceFlorence 50129Italy department neurofarba Meyer Children's University HospitalFlorence 50129Italy

Hepatitis B virus(HBV)is the leading cause of chronic viral ***,almost two million children younger than 5 years acquire the infection,mostly through vertical or horizontal transmission in early *** transmission of HBV is a high efficacy phenomenon ranging,in the absence of any preventive interventions,from 70%to 90%for hepatitis e antigen positive mothers and from 10%to 40%for hepatitis e antigen-negative *** viraemia is a preeminent risk factor for vertical transmission of *** screening is the first step to prevent vertical transmission of *** B passive and active immunoprophylaxis at birth together with antiviral treatment of highly viraemic mothers are the key strategies for global elimination of HBV *** are needed to promote implementation of birth-dose vaccination and hepatitis B immunoglobulins in low-and middle-income countries where the prevalence of the infection is at the highest.

关键词： Hepatitis B Vertical transmission Hepatitis B vaccine Hepatitis B immune globulin Neonatal immunoprophylaxis Tenofovir alafenamide fumarate

Interferon-gamma and neuropathy: balance between pain and neuroprotection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第12期17卷 2700-2701页

作者： Valentina Ferrara Alessandra Toti Carla Ghelardini Lorenzo Di Cesare Mannelli department of Neuroscience PsychologyDrug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology SectionUniversity of FlorenceFlorenceItaly

Chronic pain is sustained by a phenomenon of hyper-activation of nociceptive neurons both at peripheral(peripheral sensitization)and central(central sensitization)*** onset and maintenance of pain,however,is to be found in the interaction among the various cell populations in the nervous tissue including neurons and glia(Nam et al.,2016).The pathogenesis of neuropathic pain is extremely complex depending on the primary cause of nerve damage,*** nerve injury is associated with a robust inflammatory response while chemotherapy-induced pain is characterized by a modest phlogistic component(Di Cesare Mannelli et al.,2013).Despite these differences,a powerful common concept to explain the cellular mechanisms underlying pain is the activation of glia.

关键词： pain sustained

Neurorestoration from medicinal plants:an opportunity to treat painful neuropathies

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第3期12卷 403-404页

作者： Lorenzo Di Cesare Mannelli Carla Ghelardini department of Neuroscience PsychologyDrug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology SectionUniversity of FlorenceFlorenceItaly

Neuropathic pain originates from damages to the somatosensory nervous system（IASP-International Association for the Study of Pain-taxonomy）.Lesions（traumas,compression,iatrogenic and pharmacological causes）or dise... 详细信息

关键词： Neurorestoration from medicinal plants:an opportunity to treat painful neuropathies EFSA

Breakthroughs and challenges in the management of pediatric viral hepatitis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第20期27卷 2474-2494页

作者： Emanuele Nicastro Lorenzo Norsa Angelo Di Giorgio Giuseppe Indolfi Lorenzo D'Antiga department of Pediatric Gastroenterology Hepatology and Transplantation ASST Papa Giovanni XXIIIBergamo 24127Italy department of neurofarba Meyer Children's University Hospital of FlorenceFlorence 50137Italy

Chronic infections by hepatitis B virus(HBV)and hepatitis C virus(HCV)major causes of advanced liver disease and mortality *** regarded as benign infections in children,their persistence through adulthood is undoubtedly of *** advances in HCV treatment have restored the visibility of these conditions and raised expectations for HBV treatment,which is currently far from being *** we describe direct-acting antivirals available for pediatric HCV(sofosbuvir/ledipasvir,sofosbuvir/velpatasvir,glecaprevir/pibrentasvir)and their real-world use.A critical review of the HBV pediatric classification is ***-HBV investigational compounds are reviewed in light of the pathophysiology in the pediatric population,including capsid assembly modulators,antigen secretion inhibitors,silencing RNAs,and immune *** for screening and management of immunosuppressed children or those with other risk factors or comorbidities are also summarized.

关键词： Hepatitis C Hepatitis B Direct acting antivirals Liver cirrhosis Children

Treatment of hepatitis B virus infection in children and adolescents

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第36期27卷 6053-6063页

作者： Mariangela Stinco Chiara Rubino Sandra Trapani Giuseppe Indolfi department of Health Sciences Pediatric SectionMeyer Children’s University HospitalFlorence 50139Italy department neurofarba University of Florence and Meyer Children’s University HospitalFlorence 50139Italy

Hepatitis B virus(HBV)infection is one of the main causes of morbidity and mortality *** children acquire the infection perinatally or during early childhood and develop a chronic hepatitis characterized by a high viral replication and a low-inflammation phase of infection,with normal or only slightly raised *** a conservative approach in children is usually recommended,different therapies exist and different therapeutic approaches are *** main goals of antiviral treatment for children with chronic HBV infection are to suppress viral replication and to warn the disease progression to cirrhosis and hepatocellular carcinoma,although these complications are rare in *** United States Food and Drug Administration(USFDA)and European Medicines Agency(EMA)have approved interferon alfa-2b for children aged 1 year and older,pegylated interferon alfa-2a and lamivudine for children aged 3 years and older,entecavir for use in children aged 2 years and older,and adefovir for use in those 12 years of age and *** disoproxil fumarate is approved by EMA for children aged 2 years and older and by USFDA for treatment in children aged 12 years and ***,EMA has approved the use of tenofovir alafenamide for treatment of children aged 12 years and older or for children weighing more than 35 kg independent of *** narrative review will provide the framework for summarizing indications to antiviral therapy in the management of chronic HBV infection in children and adolescents.

关键词： Hepatitis B Children Adolescents Antiviral therapy Tenofovir disoproxil fumarate Entecavir Interferon

Ultrathin Descemet stripping automated endothelial keratoplasty versus Descemet membrane endothelial keratoplasty:a fellow-eye comparison

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Eye and Vision 2020年第1期7卷 241-249页

作者： Rita Mencucci Eleonora Favuzza Elisa Marziali Michela Cennamo Cosimo Mazzotta Ersilia Lucenteforte Gianni Virgili Stanislao Rizzo Eye Clinic Department of NeurosciencePsychologyPharmacology and Child Health(NEUROFARBA)University of FlorenceEye ClinicLargo Brambilla 350134 FlorenceItaly department of Medicine Surgery and NeurosciencesOphthalmology UnitSiena UniversitySienaItaly Siena Crosslinking Center SienaItaly department of Clinical and Experimental medicine University of PisaPisaItaly

Background:To compare the visual outcome and patients’satisfaction after ultrathin Descemet stripping automated endothelial keratoplasty(UT-DSAEK)and Descemet membrane endothelial keratoplasty(DMEK)performed on fellow eyes of the same ***:In this retrospective study,the records of 18 pseudophakic patients affected by Fuchs endothelial dystrophy who underwent DMEK in one eye and UT-DSAEK in the fellow eye were *** corrected visual acuity(BCVA),corneal pachymetry,keratometry,corneal aberrations,photopic and mesopic contrast sensitivity,and endothelial cell counts measured 12 months after surgery in either eye were analyzed and *** results of a satisfaction questionnaire were also ***:Twelve months after surgery,BCVA was not significantly different in UT-DSAEK and DMEK eyes(0.10±0.04 and 0.07±0.07 logMAR,respectively);at both 4-and 6 mm optical zones total and posterior corneal higher order aberrations(HOAs),posterior astigmatism and total coma were significantly lower after DMEK;BCVA in both groups was significantly correlated mainly with anterior corneal aberrations;contrast sensitivity was higher after DMEK especially in mesopic conditions and at medium spatial frequencies;the endothelial cell density was similar,although slightly higher in the UT-DSAEK group(p=0.10).The satisfaction questionnaire showed that although patients were highly satisfied from both procedures,more than half of them preferred DMEK and reported a more comfortable and quicker postoperative ***:DMEK and UT-DSAEK showed no evidence of difference in terms of postoperative BCVA,although DMEK had a better performance in terms of contrast sensitivity,posterior corneal aberrations and overall patient satisfaction.

关键词： DMEK UT-DSAEK DSAEK Descemet stripping automated endothelial keratoplasty Ultra-thin Descemet stripping automated endothelial keratoplasty Descemet membrane endothelial keratoplasty

Kounis syndrome:a clinical entity penetrating from pediatrics to geriatrics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2020年第5期17卷 294-299页

作者： Mattia Giovannini Ioanna Koniari Francesca Mori Silvia Ricci Luciano De Simone Silvia Favilli Sandra Trapani Giuseppe Indolfi Nicholas George Kounis Elio Novembre Allergy Unit Department of Pediatrics Meyer Children’s University Hospital Electrophysiology and Device department University Hospital of South Manchester NHS Foundation Trust department of Health Sciences University of Florence Meyer Children’s Hospital Pediatric Cardiology Unit Meyer Children’s University Hospital department of neurofarba University of Florence Meyer Children’s Hospital department of Cardiology Patras University School of Medicine

1 Introduction Kounis syndrome constitutes a coronary hypersensitivity disorder defined by the association of an anaphylactoid,anaphylactic,allergic or hypersensitivity reaction with an acute coronary syndrome,in a physiopathological context involving various interrelated and interacting inflammatory cells,such as mast-cells,eosinophils and platelets.[1,2]Similar entities to Kounis syndrome might involve cerebral and mesenteric arteries.

关键词： Age Classification Coronary artery disease Kounis syndrome Myocardial infarction