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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria S.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdiSNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan Mario Villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez Francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

Green ionic metal-organic frameworks as nanocatalysts for CO_(2)fixation

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Nano Research 2025年第1期18卷 260-269页

作者： Nuria Martín Miguel Maireles-Porcar Julián Sánchez Velandia Belén Altava Francisco G.Cirujano Eduardo García-Verdugo departamento de Química Inorgánica y Orgánica Universidad Jaume IAv.Sos Baynats/nCastellóde la PlanaCastellón 12071Spain

Co,Ni,and Zn iso-reticular coordination polymers of 2,5-dihydroxyterphthalic acid(H_(2)dot)can be rapidly obtained under room temperature and aqueous conditions using either sodium or ammonium hydroxide as the bases to deprotonate the *** use of metal bromides and tetrabutylammonium hydroxide(TBAOH)as the base allows the green synthesis of ionic metal-organic frameworks(MOFs),characterized by X-ray diffraction(XRD),Fourier transform infrared(FTIR),scanning electron microscopy(SEM),thermo gravimetric analysis(TGA),H-nuclear magnetic resonance(NMR),elemental analysis,and X-ray photoelectron spectroscopy(XPS),and employed in the pressure,solvent,and additive-free CO_(2)fixation to epoxides by its cycloaddition to epichlorohydrin,exhibiting a cooperative behavior between the MOF and the ionic liquid formed within the framework,achieving TONs of the confined tetrabutylammonium bromide(TBABr)up to 700.

关键词： metal-organic frameworks(MOFs) ionic liquids heterogeneous catalysis CO_(2)conversion

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.G.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Does cypermethrin affect enzyme activity, respiration rate and walking behavior of the maize weevil （Sitophilus zeamais）？

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Insect Science 2013年第3期20卷 358-366页

作者： Ronnie Von Santos Veloso Eliseu Jose G. Pereira Raul Narciso C. Guedes Maria Goreti A. Oliveira departamento de Entomologia departamento de Bioquimica e biologia Molecular Universidade Federal de Vicosa Brazil

Insecticides cause a range of sub-lethal effects on targeted insects, which are frequently detrimental to them. However, targeted insects are able to cope with insecti- cides within sub-lethal ranges, which vary with their susceptibility. Here we assessed the response of three strains of the maize weevil Sitophilus zeamais Motschulsky （Coleoptera.＂ Curculionidae） to sub-lethal exposure to the pyrethoid insecticide cypermethrin. We ex- pected enzyme induction associated with cypermethrin resistance since it would aid the resistant insects in surviving such exposure. Lower respiration rate and lower activity were also expected in insecticide-resistant insects since these traits are also likely to favor survivorship under insecticide exposure. Curiously though, cypermethrin did not affect ac- tivity of digestive and energy metabolism enzymes, and even reduced the activity of some enzymes （particularly for cellulase and cysteine-proteinase activity in this case）. There was strain variation in response, which may be （partially） related to insecticide resistance in some strains. Sub-lethal exposure to cypermethrin depressed proteolytic and mainly cellulolytic activity in the exposed insects, which is likely to impair their fitness. However, such exposure did not affect respiration rate and walking behavior of the insects （except for the susceptible strain where walking activity was reduced）. Walking activity varies with strain and may minimize insecticide exposure, which should be a concern, particularly if associated with （physiological） insecticide resistance.

关键词： insecticides insecticide resistance pyrethroids stored grain insect sub-lethal effects

Vertical stratification of bat assemblages in flooded and unflooded Amazonian forests

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Current Zoology 2010年第4期56卷 469-478页

作者： Maria Joo Ramos PEREIRA Joo Tiago MARQUES Jorge M.PALMEIRIM Centro de biologia Ambiental Departamento de Biologia Animal Faculdade de Ciências da Universidade de Lisboa Instituto de desenvolvimento Sustentvel Mamirau

Tropical rainforests usually have multiple strata that results in a vertical stratification of ecological opportunities foranimals. We investigated if this stratification influences the way bats use the vertical space in flooded and unflooded forests of theCentral Amazon. Using mist-nets set in the canopy (17 to 35 m high) and in the understorey (0 to 3 m high) we sampled four sitesin upland unflooded forests (terra firme), three in forests seasonally flooded by nutrient-rich water (varzea), and three in forestsseasonally flooded by nutrient-poor water (igapo). Using rarefaction curves we found that species richness in the understorey andcanopy were very similar. An ordination analysis clearly separated the bat assemblages of the canopy from those of the understorey inboth flooded and unflooded habitats. Gleaning carnivores were clearly associated with the understorey, whereas frugivores wereabundant in both strata. Of the frugivores, Carollinae and some Stenodermatinae were understorey specialists, but several Stenodermatinaemostly used the canopy. The first group mainly includes species that, in general, feed on fruits of understorey shrubs,whereas the second group feed on figs and other canopy fruits. We conclude that vertical stratification in bat communities occurseven within forests with lower canopy heights, such as Amazonian seasonally flooded forests, and that the vertical distribution ofbat species is closely related to their diet and foraging behaviour.

关键词： Amazon Bats Chiroptera Vertical stratification Floodplain

Immunohistochemical study of the digestive tract of Oligosarcus hepsetus

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World Journal of Gastroenterology 2013年第12期19卷 1919-1929页

作者： Danielle A Vieira-Lopes Nadja L Pinheiro Armando Sales Adriana Ventura Francisco G Araújo Iracema D Gomes Aparecida A Nascimento departamento de biologia Animal Instituto de Biologia Universidade Federal Rural do Rio de Janeiro

AIM: To describe the histology of the digestive tract and to investigate the occurrence of endocrine cells in Oligosarcus hepsetus (O. hepsetus ). METHODS: The digestive tract (DT) of O. hepsetus was divided into esophagus, two stomach regions (glandular and non-glandular) and two intestinal regions (anterior and posterior). These specimens were processed by routine histological techniques and stained with hematoxylin-eosin, Gomori's trichrome, periodic acid Schiff (PAS) and Alcian blue (AB). An immunohistochemical method using avidin-biotin-peroxidase was ***: The esophagus is lined with a non-keratinized stratified squamous epithelium that is reactive to PAS and AB. The stomach has a mucosa lined with a simple columnar epithelium with mucus-secreting cells that are reactive only to PAS. The intestine has a simple columnar epithelium with a brush border and goblet cells that are reactive to PAS and AB. Somatostatin, serotonin and cholecystokinin immunoreactive cells were identified throughout the ***: This study revealed adaptations for the species' diet and showed that the distribution and relative frequency of immunoreactive cells are similar to those of other fish.

关键词： Fish Esophagus Stomach Intestine Endocrine cells

Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

The unusual life history of a southern Iberian Peninsula population of Torleya major （Ephemeroptera： Ephemerellidae）

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Insect Science 2011年第5期18卷 583-589页

作者： M. J. Lopez-Rodriguez J. M. Tierno de Figueroa J. Alba-Tercedor departamento de biologia Animal Facultad de Ciencias Universidad de Granada Granada Spain

The nymphal biology of a population of Torleya major （Klapalek） in southem Iberian Peninsula was studied. An atypical life cycle pattern is described, with eggs hatching in August producing a fast-developing cohort with adults emerging in autumn and a second slow-developing cohort with adults emerging in spring of the following year. Nymphal growth occurred primarily in summer-autumn （in the first cohort） and in spring （in the second）. The origin of such a life history is discussed. Nymphs were collector-gatherers, consuming mainly detritus. Although ontogenetic shifts on the use of trophic resources were detected, similar food was utilized during the months when both cohorts cohabited, eliminating the possibility that the rapid growth of the first cohort could be related to the utilization of different food resources.

关键词： collector-gatherer life cycle mayfly nymphal feeding southern Iberian Peninsula

Using dung beetles to evaluate the effects of urbanization on Atlantic Forest biodiversity

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Insect Science 2013年第3期20卷 393-406页

作者： Vanesca Korasaki Jose Lopes George Gardner Brown Julio Louzada departamento de Agronomia departamento de biologia Animal e Vegetal Universidade Estadual de Londrina Londrina-PR Empresa Brasileira de Pesquisa Agropecu~ria Embrapa Florestas Colombo-PR departamento de biologia Setor de Ecologia Universidade Federal de Lavras Lavras Minas Gerais Brazil

We used dung beetles to evaluate the impact of urbanization on insect biodi- versity in three Atlantic Forest fragments in Londrina, Parana, Brazil. This study provides the first empirical evidence of the impact of urbanization on richness, abundance, compo- sition and guild structure of dung beetle communities from the Brazilian Atlantic Forest. We evaluated the community aspects （abundance, richness, composition and food guilds） of dung beetles in fragments with different degrees of immersion in the urban matrix using pitfall traps with four alternative baits （rotten meat, rotten fish, pig dung and decaying ba- nana）. A total of 1 719 individuals were collected, belonging to 29 species from 11 genera and six Scarabaeinae tribes. The most urban-immersed fragment showed a higher species dominance and the beetle community captured on dung presented the greatest evenness. The beetle communities were distinct with respect to the fragments and feeding habits. Except for the dung beetle assemblage in the most urbanized forest fragment, all others exhibited contrasting differences in species composition attracted to each bait type. Our results clearly show that the degree of urbanization affects Atlantic Forest dung beetle communities and that the preservation of forest fragments inside the cities, even small ones, can provide refuges for Scarabaeinae.

关键词： bioindicator coprophagous beetles food preference fragmentation habitat loss urban matrix