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Prevalence of sarcopenia using different methods in patients with non-alcoholic fatty liver disease

World Journal of Hepatology 2022年第8期14卷 1643-1651页

作者： Naiade Silveira Almeida Raquel Rocha Claudineia Almeida de Souza Ana Carolina Sirelli da Cruz Bruna dos Reis Ribeiro Luiza Valois Vieira Carla daltro Rafael Silva Manoel Sarno Helma Pinchemel Cotrim Programa de Pós-Graduação em Medicina e Saúde Universidade Federal da BahiaSalvador 40110-060BABrazil departamento de ciência da nutrição Escola de NutriçãoUniversidade Federal da BahiaSalvador 40110-060Brazil Caliper Clínica e Escola de Imagem Salvador 41810-012Brazil

BACKGRoUND Sarcopenia is a clinical condition associated with several liver diseases and it includes non-alcoholic fatty liver disease(NAFLD)in its broad spectrum as steatosis,steatohepatitis and ***,the criteria to define sarcopenia are diverse,and even those established in consensus have been discussed regarding their performance in making an accurate *** To evaluate the prevalence of sarcopenia,using different methods,in patients with NAFLD,and its association with clinical-anthropometric *** This was an observational study of outpatients with *** was defined by the European Working Group Consensus on Sarcopenia in older People of 2010(EWGSoP1)and 2018(EWGSoP2).The skeletal muscle index was used to estimate muscle mass,handgrip strength was assessed using the dynamometer and physical performance by walking a distance of four meters at usual walking *** non-invasive fibrosis scores,fibrosis-4(FIB-4)index and Aspartate aminotransferase to platelet ratio index(APRI),were used to assess the absence and presence of *** Fifty-seven individuals with NAFLD were evaluated,the mean age(SD)was 52.7(11.3)years and 75.4%were *** assessed by FIB-4 and APRI was observed in 3.7%and 16.6%of patients with NAFLD,*** diagnosis of sarcopenia was identified only by EWGSoP1 in 3.5%of NAFLD patients,and the prevalence of probable/pre-sarcopenia was higher using the EWGSoP2 consensus at 26.3%,when compared to 1.8%with *** defined by EWGSoP1,was associated with grade I steatosis,but without overweight(Pociation between sarcopenia and fibrosis was not observed(P>0.05).EWGSoP2 showed a greater number of patients with probable sarcopenia,and who were overweight(12(80.0%)),with a higher degree of steatosis[11(73.3%)and presence of fibrosis(1(6.7%),FIB-4 and 3(20.0%),APRI]compared to EWGSoP1[1(100%),0(0.0%),0(0.0%),FIB-4 and 0(0.0%),APRI,respectively].CoNCLUSIoN The presen

关键词： Non-alcoholic fatty liver disease Sarcopenia Muscle strength Physical performance Liver fibrosis

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Crohn's disease of esophagus,stomach and duodenum

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2019年第2期10卷 35-49页

作者： Andréa Maia Pimentel Raquel Rocha Genoile oliveira Santana Programa de Pós gradua??o em Medicina e Saúde Universidade Federal da Bahia departamento de ciências da nutri??o Universidade Federal da Bahia

Crohn's disease with involvement of the esophagus, stomach and duodenum has a prevalence of 0.5% to 4% in symptomatic adult patients, but some studies have shown that these results may be underestimated, since upper gastrointestinal endoscopy is not performed routinely in the initial evaluation of the disease in adult patients, as it is in the pediatric population. In general, involvement of the upper gastrointestinal tract in Crohn's disease occurs concomitantly with involvement of the lower gastrointestinal tract. The diagnosis depends on clinical,endoscopic, histological and radiological evaluation. The presence of aphthoid ulcers, longitudinal ulcers, bamboo-joint-like appearance, stenoses and fistulas are endoscopic findings suggestive of the disease, and it is important to exclude the presence of Helicobacter pylori infection. The primary histological findings,which facilitate the diagnosis, are the presence of a chronic inflammatory process with a predominance of lymphoplasmacytic cells and active focal gastritis. The presence of epithelioid granuloma, although less frequent, is highly suggestive of the disease in the absence of chronic granulomatous disease. Treatment should include the use of proton pump inhibitors associated with corticosteroids,immunomodulators and biological therapy according to the severity of the disease.

关键词： Crohn’s disease Upper gastrointestinal tract Upper digestive endoscopy Esophagus Stomach Duodenum Chronic gastritis Focal gastritis Epithelioid granuloma

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overweight and abdominal fat are associated with normal bone mineral density in patients with ulcerative colitis

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2022年第4期13卷 57-66页

作者： Mirella Brasil Lopes Andre Castro Lyra Raquel Rocha Fernanda Gomes Coqueiro Carla Andrade Lima Carolina Cunha de oliveira Genoile oliveira Santana Programa de Pós-graduação em Medicina e Saúde Universidade Federal da BahiaSalvador 40110-060Brazil departamento ciências da nutrição Universidade Federal da BahiaSalvador 40110-060Brazil departamento de nutrição Universidade Federal de SergipeLagarto 49060-110Brazil departamento ciências da Vida Universidade do Estado da BahiaSalvador 41.150-000Brazil

BACKGRoUND Low bone mineral density(BMD)is common in patients with inflammatory bowel ***,nutritional risk factors for low BMD in the ulcerative colitis(UC)population are still poorly *** To investigate the association of anthropometric indicators and body composition with BMD in patients with *** This is a cross-sectional study on adult UC patients of both genders who were followed on an outpatient basis.A control group consisting of healthy volunteers,family members,and close people was also *** nutritional indicators evaluated were body mass index(BMI),total body mass(TBM),waist circumference(WC),body fat in kg(BFkg),body fat in percentage(BF%),trunk BF(TBF),and also lean *** composition and BMD assessments were performed by dual-energy X-ray *** The sociodemographic characteristics of patients with UC(n=68)were similar to those of healthy volunteers(n=66)(P>0.05).Most patients(97.0%)were in remission of the disease,58.8%were eutrophic,33.8%were overweight,39.0%had high WC,and 67.6%had excess BF%.However,mean BMI,WC,BFkg,and TBF of UC patients were lower when compared to those of the control group(Pof patients with UC(38.2%with osteopenia and 2.9%with osteoporosis)and 3.0%in the control group(Pow BMD had lower BMI,TBM,and BFkg values than those with normal BMD(Pore likely to have low BMD(prevalence ratio[PR]=1.86;95%confidence interval[ci]:1.07-3.26).Those with excess weight(PR=0.43;95%ci:0.19-0.97)and high WC(PR=0.44;95%ci:0.21-0.94)were less likely to have low *** Patients with UC in remission have a high prevalence of metabolic bone *** fat appears to protect against the development of low BMD in these patients.

关键词： Ulcerative colitis Bone mineral density Body composition Fat body Abdominal fat

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Non-alcoholic fatty liver disease: What the clinician needs to know

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World Journal of Gastroenterology 2014年第36期20卷 12956-12980页

作者： Mariana Verdelho Machado Helena Cortez-Pinto departamento de Gastrenterologia Laboratório de Nutri??o Hospital Universitário de Santa Maria Lisbon 1649-035 Portugal

Non-alcoholic fatty liver disease(NAFLD) is the most frequent cause of liver disease in the Western world. Furthermore, it is increasing worldwide, paralleling the obesity pandemic. Though highly frequent, only about one fifth of affected subjects are at risk of developing the progressive form of the disease, non-alcoholic steatohepatitis with fibrosis. Even in the latter, liver disease is slowly progressive, though, since it is so prevalent, it is already the third cause of liver transplantation in the United States, and it is predicted to get to the top of the ranking in few years. of relevance, fatty liver is also associated with increased overall mortality and particularly increased cardiovascular mortality. The literature and amount of published papers on NAFLD is increasing as fast as its prevalence, which makes it difficult to keep updated in this topic. This review aims to summarize the latest knowledge on NAFLD, in order to help clinicians understanding its pathogenesis and advances on diagnosis and treatment.

关键词： Non-alcoholic fatty liver disease Metabolic syndrome Insulin resistance Epidemiology Pathogenesis Genetics Diagnosis Prognosis Management

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Iron homeostasis and H63D mutations in alcoholics with and without liver disease

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World Journal of Gastroenterology 2009年第1期15卷 106-111页

作者： Mariana Verdelho Machado Paula Ravasco Alexandra Martins Maria Rosário Almeida Maria Ermelinda Camilo Helena Cortez-Pinto Unidade de nutrio e Metabolismo Instituto de Medicina Molecular Faculdade de Medicina da Universidade de Lisboa1649-035 departamento de Gastrenterologia do Hospital de Santa Maria 1649-035 Lisboa Portugal Genomed Instituto de Medicina Molecular1649-035 Portugal

MM： To evaluate the prevalence of HFE gene mutation and indices of disturbed iron homeostasis in alcoholics with and without liver disease. METHoDS： one hundred and fifty-three heavy drinkers （defined as alcohol consumption 〉 80 g/d for at least 5 years） were included in the study. These comprised 78 patients with liver disease [liver disease alcoholics （Lda）] in whom the presence of liver disease was confirmed by liver biopsy or clinical evidence of hepatic decompensation, and 75 subjects with no evidence of liver disease, determined by normal liver tests on two occasions [non-liver disease alcoholics （NLda）], were consecutively enrolled. Serum markers of iron status and HFE C282Y and H63D mutations were determined. HFE genotyping was compared with data obtained in healthy blood donors from the same geographical area. RESULTS： Gender ratio was similar in both study groups. Lda patients were older than NLda patients （52 ± 10 years vs 48 ± 11 years, P = 0.03）. one third and one fifth of the study population had serum transferrin saturation （TS） greater than 45% and 60% respectively. Serum iron levels were similar in both groups. However, Lda patients had higher TS （51 ± 27 vs 36 ± 13, P 〈 0.001） and ferritin levels （559 ± 607 ng/mL vs 159 ± 122 ng/mL, P 〈 0.001）, and lower total iron binding capacity （TIBC）（241 ± 88 μg/dL vs 279 ± 40 μg/dL, P = 0.001）. The odds ratio for having liver disease with TS greater than 45% was 2.20 （95% confidence interval （ci）： 1.37-3.54）. There was no difference in C282Y allelic frequency between the two groups. However, H63D was more frequent in Lda patients （0.25 vs 0.16, P = 0.03）. Lda patients had a greater probability of carrying at least one HFE mutation than NLda patients （49.5% vs 31.6%, P = 0.02）. The odds ratio for Lda in patients with H63D mutation was 1.57 （95% ci： 1.02-2.40）. CoNCLUSIoN： The present study confirms the presence of iron overload in alcoholics, which was more severe in the subset of subjects with liver disease,

关键词： Alcoholic liver disease Iron lIFE gene H63D Hemochromatosis

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Use of Agaricus bisporus mushroom in beef burgers:antioxidant,flavor enhancer and fat replacing potential

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食物生产加工与营养(英文) 2019年第1期1卷 64-78页

作者： Iliani Patinho Erick Saldaña Miriam Mabel Selani Adriano Costa de Camargo Thais Cardoso Merlo Beatriz Schmidt Menegali Anna Paula de Souza Silva Carmen J.Contreras-Castillo departamento de Agroindústria Alimentos e Nutrição(LAN)Escola Superior de Agricultura“Luiz de Queiroz”(ESALQ)Universidade de São Paulo(USP)Avenida Pádua Dias11PiracicabaSP 13418-900Brazil Centro de ciências da Natureza Campus Lagoa do SinoUniversidade Federal de São CarlosRod.Lauri Simões de BarrosKm 12BuriSPBrazil departamento de ciencias Vegetales Facultad de Agronomía e Ingeniería ForestalPontificia Universidad Católica de ChileCasilla306-22 SantiagoChile Facultad de Ingeniería Agroindustrial Universidad Nacional de Moquegua(UNAM)MoqueguaPeru

This study aimed to evaluate the potential use of Agaricus bisporus mushroom as a natural antioxidant,fat/salt substitute and flavor enhancer in beef *** treatments were considered using a fractional factorial design(salt[0.5,1.25 and 2.0%],fat[10,15 and 20%]and mushroom content[0,15 and 30%]).Treatments were characterized by instrumental and sensory *** statistical design indicated that fat content had little influence on the *** principal component analysis showed that the incorporation of mushrooms and salt modified the texture,moisture and water *** stability decreased as the salt content increased,at a low-fat ***,the sensory profile was affected by the mushroom and salt contents,with the fat content exerting the least ***,mushroom incorporation in beef burger may be a feasible strategy to reduce the fat content of beef burgers.

关键词： Beef burger Agaricus bisporus Lipid oxidation Texture profile analysis descriptive analysis

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Characterization of goat whey proteins and their bioactivity and toxicity assay

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Food Bioscience 2022年第2期46卷 833-843页

作者： Maria Isabel Ferreira Campos Paula Perazzo de Souza Barbosa Laura Junqueira Camargo Luciano da Silva Pinto Bianca Mataribu Catarina Serr˜ao Luis Fernando Marques-Santos Jos´e Hon´orio Lopes Julia Mariano Caju de oliveira Carlos Alberto de Almeida Gadelha Tatiane Santi-Gadelha Programa de P´os-Graduaç˜ao em ciˆencia e Tecnologia de Alimentos Universidade Federal da ParaíbaJo˜ao PessoaParaíbaBrazil departamento de Biologia Molecular Universidade Federal da ParaíbaJo˜ao PessoaParaíbaBrazil Centro de desenvolvimento Tecnol´ogico Universidade Federal de PelotasRio Grande do SulBrazil Programa de P´os-Graduaç˜ao em ciˆencias da nutriç˜ao Universidade Federal da ParaíbaJo˜ao PessoaParaíbaBrazil

Goat whey is an industry-discarded dairy by-product that has interesting nutritional value and a nutrient composition with important functional potential,where proteins have a high biological value and play an important role in the organism’s ***,the aim of this study was to identify,quantify,concentrate and investigate the capacity of goat whey proteins to perform different biological activities and to evaluate their acute *** proteins were quantified and identified by Bradford,Kjehdal and SDS-PAGE *** activity was performed against Listeria monocytogenes,Salmonella spp.,Staphylococcus aureus,Pseudomonas aeruginosa and Escherichia coli microorganisms and showed MIC ranging from 15 to 120μg mL-1,with the highest inhibition for *** *** activity was performed against human malignant melanoma cells and their proliferation inhibition was up to 66.8%within 72 h of *** highest antioxidant capacity was obtained at concentration 2 mg that showed 29.69%of inhibition of DPPH radical *** acute toxicity test was performed using Artemia franciscana larvae in which whey proteins were able to preserve larval survival throughout ***,we can conclude that goat’s whey has proteins that can play a positive effect on health,with antimicrobial activity and without *** present study highlights the great potential of goat’s whey to be developed as a safe biopreservative or as a functional ingredient in the food industry.

关键词： Goat whey proteins Malignant cells Antimicrobial Antioxidant capacity Whey protein functionality

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Food and nutritional Security in the Refugee Women’s Life Narratives

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Food and nutrition Sciences 2023年第11期14卷 1031-1042页

作者： Juliana Vidal Vieira Guerra Valdecyr Herdy Alves Brenda Caroline Martins da Silva Tatiana do Socorro dos Santos Calandrini Giovanna Rosario Soanno Marchiori Ediane de Andrade Ferreira Maria Bertilla Lutterbach Riker Branco Diego Pereira Rodrigues departamento de nutriç &#227o Aplicada Instituto de Nutri&#231&#227o Universidade do Estado do Rio de Janeiro Rio de Janeiro Brasil Programa Acadêmico em ciências do Cuidado em Saúde Escola de Enfermagem Aurora de Afonso Costa Universidade Federal Fluminense Niterói Brasil Instituto de ciências da Saúde Universidade Federal do Pará Belém Brasil Centro de ciências da Saúde Universidade Federal de Roraima Boa Vista Brasil

objective: To understand, based on the life narratives of refugee women, food and nutritional security. Method: Qualitative, descriptive, exploratory study, Narratives of life method, by daniel Bertaux. Conducted with 11 participants, refugee women residing in the state of Rio de Janeiro, Brazil. Results: The meanings and feelings evidenced in the life narratives of refugee women expressed the insecurities and weaknesses with food in the resettlement. Final Considerations: Given the meanings and feelings regarding food in the refuge, it is expected that the present study will contribute to the elaboration of new action plans and intersectoral public policies of agile action to meet the demands of the refugee population, in the attempt to mitigate starvation, poverty, social differences and the compromised health status of the refugee population.

关键词： Food Security Feeding Behavior Refugees Human Migration Human Right to Adequate Food

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Essential amino acid ratios and mToR affect lipogenic gene networks and miRNA expression in bovine mammary epithelial cells

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Journal of Animal Science and Biotechnology 2016年第4期7卷 612-622页

作者： Shanshan Li Afshin Hosseini Marina danes Carolina Jacometo Jianxin Liu Juan J.Loor Institute of dairy Science College of Animal SciencesZhejiang University department of Animal Sciences Mammalian Nutri Physio GenomicsUniversity of Illinois department of Animal Science University of Lavras NUPEEC Departamento de Clínicas VeterináriaPrograma de Pós-Gradua??o em BiotecnologiaUniversidade Federal de Pelotas

Background： The objective of this study was to study how changing the ratio of Lys to Thr, Lys to His, and Lys to Val affects the expression of lipogenic genes and microRNA （miRNA） in bovine mammary epithelial cells. Results： Triplicate cultures with the respective ＂optimal＂ amino acid （AA） ratio （oPAA = Lys：Met 2.9：1; Thr：Phe 1.05：1; Lys：Thr 1.8：1; Lys：His 2.38：1; Lys：Val 1.23：1） plus rapamycin （oPAARMC; positive control）, oPAA, Lys：Thr 2.1：1 （LT2.1）, Lys：Thr 1.3：1 （LT1.3）, Lys：His 3.05：1 （LH3.0）, or Lys：Val 1.62：1 （LV1.6） were incubated in lactogenic medium for 12 h. The expression of 15 lipogenic genes and 7 miRNA were evaluated. Responses to LT2.1, LT1.3, LH3.0, and LV1.6 relative to the control （oPAARMC） included up-regulated expression ofACSS2, FABP3, ACACA, FASN, SCD, LPIN1, INSIG1, SREBF1, PPARD, and NR1H3 （commonly known as LXR-a）. Furthermore, LV1.6 up-regulated expression of ACSL1, DGAT1, and RXRA and down-regulated PPARG expression. Although no effect of oPAA on expression of PPARG was observed, compared with the control, oPAA up-regulated expression of the PPAR targets ACSS2, FABP3, ACACA, FASN, SCD, LPIN1, INSIG1, and SREBF1. Compared with the control, the expression of the anti-lipogenic MIR27AB was down-regulated by oPAA, LT2.1, LT1.3 and LH3.0. In contrast, compared with the control, the expression of the pro-lipogenic MIR21 was up-regulated by LT2.1, LT1.3, LH3.0, and LV1.6. Conclusions： The observed up-regulation of lipogenic gene networks and the changes in expression of key miRNA involved in the control of lipogenic balance are indicative of a potentially important role of EAA ratios and mToR signaling in the regulation of milk fat synthesis.

关键词： Amino acids Milk fat synthesis mToR nutrigenomics

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Association of residual feed intake with abundance of ruminal bacteria and biopolymer hydrolyzing enzyme activities during the peripartal period and early lactation in Holstein dairy cows

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Journal of Animal Science and Biotechnology 2018年第3期9卷 717-726页

作者： Ahmed A.Elolimy José M.Arroyo FernANda Batistel Michael A.Iakiviak Juan J.Loor Mammalian nutri Physio Genomics Department of Animal SciencesUniversity of Illinois department of Animal Sciences University of Illinois departamento de nutrición Animal Instituto de Producción Animal Facultad de Veterinaria Universidad de la Republica Division of nutritional Sciences Illinois Informatics Institute University of Illinois

Background: Residual feed intake(RFI) in dairy cattle typically calculated at peak lactation is a measure of feed efficiency independent of milk production level. The objective of this study was to evaluate differences in ruminal bacteria, biopolymer hydrolyzing enzyme activities, and overall performance between the most-and the leastefficient dairy cows during the peripartal period. Twenty multiparous Holstein dairy cows with daily ad libitum access to a total mixed ration from d-10 to d 60 relative to the calving date were used. Cows were classified into most-efficient(i.e. with low RFI, n = 10) and least-efficient(i.e. with high RFI, n = 10) based on a linear regression model involving dry matter intake(DMI), fat-corrected milk(FCM), changes in body weight(BW), and metabolic ***: The most-efficient cows had ~ 2.6 kg/d lower DMI at wk 4, 6, 7, and 8 compared with the least-efficient cows. In addition, the most-efficient cows had greater relative abundance of total ruminal bacterial community during the peripartal period. Compared with the least-efficient cows, the most-efficient cows had 4-fold greater relative abundance of Succinivibrio dextrinosolvens at d-10 and d 10 around parturition and tended to have greater abundance of Fibrobacter succinogenes and Megaspheara elsdenii. In contrast, the relative abundance of Butyrivibrio proteoclasticus and Streptococcus bovis was lower and Succinimonas amylolytica and Prevotella bryantii tended to be lower in the most-efficient cows around calving. During the peripartal period, the most-efficient cows had lower enzymatic activities of cellulase, amylase, and protease compared with the least-efficient ***: The results suggest that shifts in ruminal bacteria and digestive enzyme activities during the peripartal period could, at least in part, be part of the mechanism associated with better feed efficiency in dairy cows.

关键词： dairy cows Enzyme activity Peripartal period RFI Rumen bacteria

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