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Predictors of fifty days in-hospital mortality in decompensated cirrhosis patients with spontaneous bacterial peritonitis

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World Journal of Hepatology 2016年第12期8卷 566-572页

作者： Chinmaya Kumar Bal Ripu Daman Vikram Bhatia depart-ment of Hepatology Institute of Liver and Biliary Science

AIM: To determine the predictors of 50 d in-hospital mortality in decompensated cirrhosis patients with spontaneous bacterial peritonitis(SBP).METHODS: Two hundred and eighteen patients admitted to an intensive care unit in a tertiary care hospital between June 2013 and June 2014 with the diagnosis of SBP(during hospitalization) and cirrhosis were retrospectively analysed. SBP was diagnosed by abdominal paracentesis in the presence of polymorphonuclear cell count ≥ 250 cells/mm3 in the peritoneal fluid. Student's t test, multivariate logistic regression, cox proportional hazard ratio(HR), receiver operating characteristics(ROC) curves and Kaplan-Meier survival analysis were utilized for statistical analysis. Predictive abilities of several variables identified by multivariate analysis were compared using the area under ROC curve. P < 0.05 were considered statistical significant. RESULTS: The 50 d in-hospital mortality rate attributable to SBP is 43.11%(n = 94). Median survival duration for those who died was 9 d. In univariate analysis acute kidney injury(AKI), hepatic encephalopathy, septic shock, serum bilirubin, international normalized ratio, aspartate transaminase, and model for end-stage liver disease- sodium(MELD-Na) were significantly associated with in- hospital mortality in patients with SBP(P ≤ 0.001). Multivariate coxproportional regression analysis showed AKI(HR = 2.16, 95%CI: 1.36-3.42, P = 0.001) septic shock(HR = 1.73, 95%CI: 1.05-2.83, P = 0.029) MELD-Na(HR = 1.06, 95%CI: 1.02-1.09, P ≤ 0.001) was significantly associated with 50 d in-hospital mortality. The prognostic accuracy for AKI, MELD-Na and septic shock was 77%, 74% and 71% respectively associated with 50 d inhospital mortality in SBP ***: AKI, MELD-Na and septic shock were predictors of 50 d in-hospital mortality in decompensated cirrhosis patients with SBP.

关键词： Decompensated cirrhosis Acute kidney injury Model for end-stage liver disease sodium Septic shock Spontaneous bacterial peritonitis

Effect of carbon addition on microstructure and mechanical properties of Ti-based bulk metallic glass forming alloys

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中国有色金属学会会刊：英文版 2005年第4期15卷 727-732页

作者：孙玉峰王育人魏炳忱李维火石灿鸿 National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences depart ment of Physics and Materials Science City University of Hong Kong

A kind of novel Ti-based composites was developed by introducing different amounts of carbon element to the Ti50Cu23Ni20Sn7 bulk metallic glass forming alloys. The thermal stability and microstructural evolution of the composites were investigated. Room temperature compression tests reveal that the composite samples with 1% and 3%（mass fraction） carbon additions have higher fracture strength and obvious plastic strain of 2195MPa, 3.1% and 1913MPa, 1.3% respectively, compared with those of the corresponding carbon-free Ti50Ni20Cu23Sn7 alloys. The deformation mechanisms of the composites with improved mechanical properties were also discussed.

关键词：钛铸造工艺合金机械结构

Role of Kupffer cells in the pathogenesis of liver disease

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World Journal of Gastroenterology 2006年第46期12卷 7413-7420页

作者： George Kolios Vassilis Valatas Elias Kouroumalis depart-ment of Gastroenterology and Hepatology University Hospital and Medical School University of Crete Heraklion Greece

Kupffer cells, the resident liver macrophages have long been considered as mostly scavenger cells responsible for removing particulate material from the portal circulation. However, evidence derived mostly from animal models, indicates that Kupffer cells may be implicated in the pathogenesis of various liver diseases including viral hepatitis, steatohepatitis, alcoholic liver disease, intrahepatic cholostasis, activation or rejection of the liver during liver transplantation and liver fibrosis. There is accumulating evidence, reviewed in this paper, suggesting that Kupffer cells may act both as effector cells in the destruction of hepatocytes by produdng harmful soluble mediators as well as antigen presenting cells during viral infections of the liver. Moreover they may represent a significant source of chemoattractant molecules for cytotoxic CD8 and regulatory T cells. Their role in fibrosis is well established as they are one of the main sources of TGFβ1 production, which leads to the transformation of stellate cells into myofibroblasts. Whether all these variable functions in the liver are mediated by different Kupffer cell subpopulations remains to be evaluated. In this review we propose a model that demonstrates the role of Kupffer cells in the pathogenesis of liver disease.

关键词： Kupffer cells Liver disease Hepatic injury Liver fibrosis Hepatocellular carcinoma Hepatitis Steatohepatitis

A Support Vector Machine-based Evaluation Model of Customer Satisfaction Degree in Logistics

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Journal of Donghua University(English Edition) 2007年第4期24卷 519-522,528页

作者：孙华丽谢剑英 College of International Business &Management Shanghai University depart ment of Automation Shanghai Jiaotong University

This paper presents a novel evaluation model of the customer satisfaction degree （CSD） in logistics based on support vector machine （SVM）. Firstly, the relation between the suppliers and the customers is analyzed. Seondly, the evaluation index system and fuzzy quantitative methods are provided. Thirdly, the CSD evaluation system including eight indexes and three ranks based on one-against-one mode of SVM is built, last simulation experint is presented to illustrate the theoretical results.

关键词： Logistics Evaluation model Fuzzy membership function Pairuise comparison Support vector machine Customer satisfaction degree

Extracapsular invasion as a risk factor for disease recurrence in colorectal cancer

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World Journal of Gastroenterology 2011年第15期17卷 2003-2006页

作者： Takaaki Fujii Yuichi Tabe Reina Yajima Satoru Yamaguchi Soichi Tsutsumi Takayuki Asao Hiroyuki Kuwano depart ment of General Surgical Science Graduate School of Medicine Gunma University Gunma 371-8511 Japan

AIM: To evaluate the presence of extracapsular invasion (ECI) in positive nodes as a predictor of disease recurrence disease in colorectal cancer. METHODS: Two hundred and twenty-eight consecutive patients who underwent colorectal resection were identified for inclusion in this study, of which 46 had positive lymph nodes. Among 46 cases with stage Ⅲcolorectal cancer, 16 had ECI at positive nodes and 8 had disease recurrence. The clinical and pathological features of these cases were reviewed. RESULTS: In the univariate analysis, the number of positive lymph nodes and depth of tumor invasion were significantly associated with the presence of ECI at positive nodes. Multivariate analysis demonstrated that only ECI was a predictor of recurrence. The recurrence-free interval differed significantly among patients with ECI at positive ***: Our results suggest that ECI at metastatic nodes can identify which cases are at high risk of short-term disease recurrence in colorectal cancer.

关键词： Extracapsular invasion Lymph node Metastasis Colorectal cancer Risk factor Adjuvant therapy

Numerical simulation of copper based filler metal droplets spreading under arc brazing

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中国有色金属学会会刊：英文版 2005年第4期15卷 818-822页

作者：于治水李瑞峰祁凯周方明 College of Materials Engineering Shanghai University of Engineering Science depart ment of Materials Science and Engineering Jiangsu University of Science and Technology

The spreading behavior of copper filler metal droplets under arc brazing was studied by numerical simulation method using Surface Evolver software. The mathematical model in which arc pressure force acceleration was added to the droplet microelement as the form of gravity acceleration was used in numerical simulation. Then the 3D filler metal droplet profile for different welding currents was simulated. The results show that the simulation results and the experimental results are in good accordance. And it can be seen that the spreading height decreases and diameter increases with the increasing welding current in an approximate linear relation.

关键词：铜金属加工焊接工艺电弧焊

Endoscopic sphincterotomy in patients with stenosis of ampulla of Vater:Three-year follow-up of exocrine pancreatic function and clinical symptoms

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World Journal of Gastroenterology 2007年第6期13卷 901-905页

作者： Nils Ewald Axel Michael Marzeion Reinhard Georg Bretzel Hans Ulrich Kloer Philip Daniel Hardt Third Medical depart-ment and Policlinic University Hospital Giessen and Marburg Giessen Site D-35392 Giessen Germany

AIM: To investigate retrospectively the long-term effect of endoscopic sphincterotomy (ES) including exocrine pancreatic function in patients with stenosis of ampulla of Vater. METHODS: After diagnostic endoscopic retrograde cholangiopancreatography (ERCP) and ES because of stenosis of the ampulla of Vater (SOD Type Ⅰ), follow-up examinations were performed in 60 patients (mean follow-up time 37.7 mo). Patients were asked about clini-cal signs and symptoms at present and before interven-tion using a standard questionnaire. Before and after ES exocrine pancreatic function was assessed by determina-tion of immunoreactive fecal elastase 1. Serum enzymes indicating cholestasis as well as serum lipase and amy-lase were measured. RESULTS: Eighty percent of patients reported an im-provement in their general condition after ES. The fecal elastase 1 concentrations (FEC) in all patients increased significantly after ES. This effect was even more marked in patients with pathologically low concentrations (ment of clinical symptoms and cholestasis but also by improvement of exocrine pancreatic function.

关键词： Endoscopic sphincterotomy Fecal elastase Chronic pancreatitis Papillary stenosis Oddi dysfunction

ON THE SEVERAL IDENTITIES OF RIEMANN ZETA-FUNCTION

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Chinese Science Bulletin 1991年第22期36卷 1852-1856页

作者：张文鹏 depart ment of Mathe matics Northwest University Xi'an 710069. PRC

Ⅰ. INTRODUCTION For any complex number s, let ζ(s)denote Riemann zeta-function defined by ζ(s)=sum from n=1 to ∞ 1/n^s for Re (s)>1 and by its analytic continuation. The main purpose of this report is to study the... 详细信息

关键词： Riemann zeta-function identity series

Effects of Total Flavonoids ofHippophae *** Intracellular Free Calciumin Cultured Vascular Smooth Muscle Cells of Spontaneously Hypertensive Rats and Wistar-Kyoto Rats

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Chinese Journal of Integrative Medicine 2005年第4期11卷 287-292页

作者：朱福黄波胡春燕蒋庆渊卢振国陆铭王美华龚敏乔春萍陈维黄盼华 Cardiovascular depart ment Nanhui District CentralHospital Shanghai 201300 Cardiovascular depart-ment Shanghai Renhe Hospital Internal Medicine De-part ment Longhua Hospital Shanghai University of Tradi-tional Chinese Medicine

Objective: To explore the effects of total flavonoids of Hippophae rhamnoides L. (TFH), quercetin (Que) and isorhamnetin (Isor) on the intracellular free calcium (Ca~ 2+ _ i) in vascular smooth muscle cells (VSMC) of spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY).Methods: Fluo 3-acetoxymethylester(Fluo-3/AM) was used to observe the effects of TFH (100mg/L) and its essential monomers, namely Que (10~ -4 mol/L) and Isor (10~ -4 mol/L) on changes of Ca~ 2+ _ i in cultured SHR and WKY VSMC (abbr. to Ca-SHR & Ca-WKY) following exposure to high K~+, norepinephrine (NE) and angiotensin Ⅱ(AngⅡ), and to compare with the effects of verapamil (Ver). Results: (1) TFH, Que and Isor had inhibitory effects on resting Ca-SHR (P0.05). (2) High K~+ could increase Ca-SHR more significantly than Ca-WKY (P<0.05); TFH, Que and Isor could inhibit the elevation of Ca~ 2+ _ i induced by high K~+-depolarization, with the effects similar to that of Ver, and the effect on Ca-SHR was more significant than that on Ca-WKY (P<0.05). (3) NE and AngⅡcould increase Ca-SHR more significantly than Ca-WKY (P<0.05), TFH, Que and Isor had remarkably inhibitory effect on the elevation of Ca-SHR and Ca-WKY induced by NE or AngⅡ. (4) In the absence of extracellular Ca~ 2+ , TFH, Que and Isor also had certain inhibitory effect on Ca-SHR and Ca-WKY induced by NE, and the effect on the former was more significant than that on the latter(P<0.05). Conclusion: TFH, Que and Isor might decrease the levels of Ca~ 2+ _ i in VSMCs by blocking both voltage-dependent calcium channels (VDC) and receptor-operated calcium channels (ROC) in physiological or pathological state, which may be one of the important mechanisms of their hypotensive and protective effects on target organs in patients with hypertension.

关键词： total flavonoids of Hippophae rhamnoides L. spontaneously hypertensive rats Wistar-Kyoto rats vascular smooth muscle cells intracellular free calcium