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Insecticidal Potential of α-Pinene and β-Caryophyllene against Myzus persicae and Their Impacts on Gene Expression

Phyton-International Journal of Experimental Botany 2023年第7期92卷 1943-1954页

作者： Talha Ali Chohan Tahir Ali Chohan Muhammad Zahid Mumtaz Muhammad Waqar Alam Salah ud Din Iqra Naseer Ayesha Riaz Tayyeba Naseem Areeba Iftikhar Dur ENajaf Ali Mubashir Hassan Hayssam M.Ali Institute of Molecular Biology and Biotechnology(IMBB) The University of LahoreLahore54000Pakistan Institute of Pharmaceutical Sciences University of Veterinary and Animal SciencesLahore54000Pakistan deparment of Plant Pathology University of OkaraOkara56300Pakistan deparment of bioinformatics University of OkaraOkara56300Pakistan Department of Soil Science The Islamia University of BahawalpurBahawalpur63100Pakistan Department of Zoology The Islamia University of BahawalpurBahawalpur(Bahawalnagar Campus)63100Pakistan The Steve and Cindy Rasmussen Institute for Genomic Medicine Nationwide Children’s HospitalColumbusOhio43205USA Department of Botany and Microbiology College of ScienceKing Saud UniversityRiyadh11451Saudi Arabia

Myzus persicae(***)is now considered a threat to agricultural crops due to economic *** synthetic insecticides applied every year against ***,are reported to be unsafe for environment,humans,and beneficial ***,several species of Myzus have been found to develop resistance due to over application of these ***,it is required to find some novel insecticide that would be safe for the environment as well as for *** the current study,two major pure constituentsα-pinene andβ-caryophyllene were evaluated for their insecticidal potential against *** using a fumigant toxicity ***,impact ofα-pinene andβ-caryophyllene on expression of five different genes,e.g.,HSP 60,FPPS I,OSD,TOL and ANT responsible for reproduction,dispersion,and growth of *** has also been *** perform fumigant toxicity assay,five different concentrations(3.5,4,4.5,5 and 6μL L−1)ofα-pinene andβ-caryophyllene were *** concentration(LC)was calculated,and gene expression studies were executed through qRT PCR at LC30 ofα-pinene andβ-*** constituents demonstrated excellent fumigant toxicity effects against *** at all five ***,α-pinene shows significantly better results(98%)as compared toβ-caryophyllene(80%)after 72 h at 6μL L−1 of *** highest upregulation in expression was demonstrated at LC30 dose ofα-pinene in five in three out of five genes understudy(TOL,ANT,and FPPS I).Conversely,two genes HSP 60 and OSD demonstrated downregulation at LC30 dose ofβ-***,our results highlighted the promising insecticidal potential of both compoundsα-pinene andβ-caryophylleneby interfering with the reproduction and development related processes in ***,allowing us to recommend the phytoconstituents under investigation as an ecofriendly alternative to synthetic insecticides.

关键词： Fumigation M.persicae gene expression real time PCR α-pinene β-caryophyllene

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Identification of mecciRNAs and their roles in the mitochondrial entry of proteins

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Science China(Life Sciences) 2020年第10期63卷 1429-1449页

作者： Xu Liu Xiaolin Wang Jingxin Li Shanshan Hu Yuqi Deng Hao Yin Xichen Bao Qiangfeng Cliff Zhang Geng Wang Baolong Wang Qinghua Shi Ge Shan deparment of Clinical Laboratory The Firs Ajiaued Hospital of USICHefei National Laborarory for Physical Sciences an Microscalethe CAS Key Laboratory of Inmate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230027China Department of Neurosurgery The First Afiliated Hospial of University of Science and Technology of China Hefei 230001China Key Laboratory of Regeneralive Biology of the Chinese Academy of Sciences Joint School of Life SciencesGuangzhou Medical Untiversily and Guangzhou Institutes of Biomedicine and HealhChinese Academy of SciencesGuangzhou 510530China MOE Key Laboratory of bioinformatics School of Life SciencesTsinghua UniversiyBeiing 100084.China CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China

Mammalian mitochondria have small genomes encoding very limited numbers of *** one thousand proteins and noncoding RNAs encoded by the nuclear genome must be imported from the cytosol into the ***,we report the identification of hundreds of circular RNAs(mecciRNAs)encoded by the mitochondrial *** provide both in vitro and in vivo evidence to show that mecciRNAs facilitate the mitochondrial entry of nuclear-encoded proteins by serving as molecular chaperones in the folding of imported *** components involved in mitochondrial protein and RNA importation,such as TOM40 and PNPASE,interact with mecciRNAs and regulate protein *** expression of mecciRNAs is regulated,and these transcripts are critical for the adaption of mitochondria to physiological conditions and diseases such as stresses and cancers by modulating mitochondrial protein *** and their associated physiological roles add categories and functions to the known eukaryotic circular RNAs and shed novel light on the communication between mitochondria and the nucleus.

关键词： mitochondria circRNA mecciRNA mitochondrial protein import

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Screening of GJB2 mutations in Chinese population

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Journal of Otology 2007年第1期2卷 18-22页

作者： HAN Ming-kun1, HAN Dong-yi1, GUO Yu-fen2, LI Qing-zhong3, ZHAO Ya-li1, 4, RAO Shao-qi1, 5, 6, YUAN Hu1, ZONG Liang1, GUAN Jing2, XU Bai-cheng2, WANG Da-yong1, LAN lan1, WANG Qiu-ju1, 7 1 Department of Otorhinolaryngology/ Head and Neck Surgery, and Institute of Otolaryngology, China People Liberation Army General Hospital, Beijing, China 2 Department of Otorhinolaryngology/ Head and Neck Surgery, the Second Affiliated Hospital of LanZhou University, Lanzhou, China 3 deparment of Otlolaryngology, Eye and ENT Hospital of Fudan University, Shanghai, China 4 Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China 5 Departments of Cardiovascular Medicine and Molecular Cardiology, the Cleveland Clinic Foundation, Cleveland, Ohio, USA 6 Department of bioinformatics, Harbin Medical University, Harbin, China 7 China National Human Genome Center, Beijing, China Department of Otorhinolaryngology/ Head and Neck Surgery and Institute of Otolaryngology China People Liberation Army General Hospital Beijing China Department of Otorhinolaryngology/ Head and Neck Surgery the Second Affiliated Hospital of LanZhou University Lanzhou China deparment of Otlolaryngology Eye and ENT Hospital of Fudan University Shanghai China Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Departments of Cardiovascular Medicine and Molecular Cardiology the Cleveland Clinic Foundation Cleveland Ohio USA Department of bioinformatics Harbin Medical University Harbin China China National Human Genome Center Beijing China

The GJB2 gene(connexin 26) has been shown to be responsible for DFNB1 and DFNA3. We screened the GJB2 gene in 488 patients with prelingual deafness(Group 1), 124 with postlingual deafness(Group 2), and 117 normal hearing subjects(Group 3). We found that, in Group 1, 65 patients(13.32%) were homozygotes or compound heterozygotes and 51 patients (10.45%) carried a single pathogenic mutation. The 235delC mutation was the most frequent mutation, accounting for 73.22% of the known pathogenic alleles in Group 1. No homozygotes or compound heterozygotes were detected in Group 2 or Group 3. Some postlingual deaf patients (2.42%) and normal hearing subjects(4.27%) were 235delC carriers. Our preliminary data indicate that 235delC, the most frequent mutation identified in this study, is a major cause for prelingual deafness.

关键词： prelingual deafness postlingual deafness, GJB2 235delC Chinese

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