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Bergamottin reduces liver damage by suppressing inflammation, endoplasmic reticulum and oxidative stress in cafeteria diet-fed mice

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Food Bioscience 2023年第2期52卷 290-297页

作者： Ebru Yazıcı Elif Sahin Elif Alvuroglu Esin Yulug Ahmet Mentese deparment of obesity Diabetes and Atherosclerosis MetabolismGraduate School of Health SciencesKaradeniz Technical University61080TrabzonTurkiye deparment of Medical Biochemistry Graduate School of Health SciencesKaradeniz Technical University61080TrabzonTurkiye deparment of Histology ad Embrylogy Faculty of MedicineKaradeniz Technical University61080TrabzonTurkiye deparment of Medical Biochemistry Karadeniz Technical University61080TrabzonTurkiye

Cafeteria diet is known to induce excessive endoplasmic reticulum stress(ERS),oxidative stress(OS),and inflammation that could cause metabolic changes and liver ***(BGM)is a natural furanocoumarin that is known to have various biological *** present study,for the first time,assessed the reducing effect of BGM on the development of liver damage in cafeteria diet fed mice.48 male C57BL/6 mice were fed an experimental diets diet for 16 weeks and BGM(0.05 mg/kg and 0.22 mg/kg)was administered for the last four *** serum samples and liver homogenates were assessed for markers of ERS,OS,and ***,histopathological analyzes were *** study demonstrated that the CAF diet caused metabolic changes,ERS,OS,and inflammation in serum and liver ***,BGM exerts anti-oxidant,anti-ER stress anti-inflammatory effects in CAF-induced liver ***,BGM may potentially be a novel therapeutic compound to ameliorate liver damage.

关键词： Bergamottin Cafeteria diet ER stress Inflammation Liver damage Oxidative stress

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Risk Factors for Adverse Pregnancy Outcomes among Zhuang Ethnic Pregnant Women:A Cohort Study in Guangxi,China

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Current Medical Science 2021年第2期41卷 219-227页

作者： Bao-ying FENG Yang PENG Jun LIANG Li WU Qun-jiao JIANG Shun LIU Xiao-yun ZENG Dong ping HUANG Xiao-qiang QIU Han LI Department of Sanitary Chemistry School of Public HealthGuangxi Medical UniversityNanning 530021China Department of Environmental and Occupational Health School of Public HealthGuangxi Medical UniversityNanning 530021China deparment of Epidemiology and Health Statistics School of Public HealthGuangxi Medical UniversityNanning 530021China

Risk factors for adverse pregnancy outcomes among Zhuang ethnic pregnant women are *** study analyzed the incidence and risk factors related to preterm birth(PB),low birth weight(LBW)and macrosomia in Zhuang *** conducted a prospective cohort study of 9965 Zhuang pregnancy women in Guangxi,*** on mothers and newborns was obtained by using questionnaires and referring to medical *** logistic regression analyses were used to evaluate the association between related factors and adverse pregnancy *** results showed that the incidence of PB,LBW and macrosomia in Zhuang people was 5.55%,5.64%and 2.19%,*** age≥36 years(OR=2.22,95%CI:1.51-3.27)was related to a higher incidence of *** with pre-pregnancy body mass index(BMI)obesity(OR=1.79,95% CI:1.15-2.80)were associated with a higher risk of *** protective factors of macrosomia were maternal pre-pregnancy BMI<18.5 kg/㎡(OR=0.30,95% CI:0.15-0.60)and female fetus(OR=0.41,95% CI:0.28-0.59).Our study provided a reference for maternal and childcare administration among Zhuang population.

关键词： Zhuang ethnic cohort study low birth weight preterm birth macrosomia risk factors

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Hyperuricemia Accompanied with Changes in the Retinal Microcirculation in a Chinese High-risk Population for Diabetes

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Biomedical and Environmental Sciences 2011年第2期24卷 146-154页

作者： YUAN YuanZhi M. Kamran IKRAM JIANG SunFang LIN HuanDong REN LiMin YAN HongMei SHENG JianHua CHEN XuSheng GAO Xin deparment of Ophthalmology Zhongshan Hospital Fudan University Shanghai 200032 China Department of Epidemiology Department of Ophthalmology and Department of Neurology Erasmus Medical Center Rotterdam The Netherlands Department of General Practice Zhongshan Hospital Fudan University Shanghai 200032 China Department of Endocrinology and Metabolism Zhongshan Hospital Fudan University Shanghai 200032 China Changfeng Comnunity Health Service Center of Shanghai Putuo District Shanghai 200062 China

Objective To investigate the association of retinal vascular calibers with hyperuricemia in a middle‐aged and elderly population. Methods A cross‐sectional design was applied in this study and 869 participants aged ≥40 years from a high‐risk group for diabetes were recruited. All participants received the anthropometrical measurements and laboratory tests. Retinal arteriolar and venular caliber of the participants were measured with a semi‐automated system. Hyperuricemia was defined as a serum uric acid level 420 μmol/L in men and 360 μmol/L in women. Linear regression models were used to assess the association of hyperuricemia with retinal vascular calibers. These models were additionally adjusted for age, central obesity, hypertension, dyslipidemia, weekly activity, smoking status, and education. Results Among the 869 participants, 133 （15.3%） suffered from hyperuricemia. The crude mean serum uric acid level was 312.3 μmol/L （Standard Deviation 79.5）; mean concentration was 355.0 μmol/L （SD 75.5） in male participants, and 288.0 μmol/L （SD 71.1） in female participants （age‐adjusted difference 58.1 μmol/L, 95% Confidence Internal 48.5, 67.6）. After adjusting for additional covariates, male participants with hyperuricemia had 3.77 μm （95% CI ‐0.46, 8.00） smaller arteriolar caliber and 6.20 μm （95% CI 0.36, 12.04） larger venule than those without hyperuricemia; the corresponding numbers among female participants were 1.57 μm （95% CI ‐1.07, 4.21） for retinal arteriolar caliber and 2.28 μm （95% CI ‐1.72, 6.27） for retinal venular caliber. Conclusion Hyperuricemia was associated with smaller retinal arteriolar caliber and larger venular caliber mainly in male participants in this study.

关键词： Cardiovascular disease Hypertension Hyperuricemia Metabolic syndrome Retinal photograph Retinal vessels Uric acid

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