Bergamottin reduces liver damage by suppressing inflammation, endoplasmic reticulum and oxidative stress in cafeteria diet-fed mice

作     者：Ebru Yazıcı Elif Sahin Elif Alvuroglu Esin Yulug Ahmet Mentese 

作者机构：Deparment of ObesityDiabetes and Atherosclerosis MetabolismGraduate School of Health SciencesKaradeniz Technical University61080TrabzonTurkiye Deparment of Medical BiochemistryGraduate School of Health SciencesKaradeniz Technical University61080TrabzonTurkiye Deparment of Histology ad EmbrylogyFaculty of MedicineKaradeniz Technical University61080TrabzonTurkiye Deparment of Medical BiochemistryKaradeniz Technical University61080TrabzonTurkiye 

出 版 物：《Food Bioscience》 (食品生物科学（英文）)

年 卷 期：2023年第52卷第2期

页      面：290-297页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 083201[工学-食品科学] 

基　　金：This work was supported by Office of Scientific Research Projects of Karadeniz Technical University under Project number:TDK-2021-9315 

主　　题：Bergamottin Cafeteria diet ER stress Inflammation Liver damage Oxidative stress 

摘      要：Cafeteria diet is known to induce excessive endoplasmic reticulum stress(ERS),oxidative stress(OS),and inflammation that could cause metabolic changes and liver ***(BGM)is a natural furanocoumarin that is known to have various biological *** present study,for the first time,assessed the reducing effect of BGM on the development of liver damage in cafeteria diet fed mice.48 male C57BL/6 mice were fed an experimental diets diet for 16 weeks and BGM(0.05 mg/kg and 0.22 mg/kg)was administered for the last four *** serum samples and liver homogenates were assessed for markers of ERS,OS,and ***,histopathological analyzes were *** study demonstrated that the CAF diet caused metabolic changes,ERS,OS,and inflammation in serum and liver ***,BGM exerts anti-oxidant,anti-ER stress anti-inflammatory effects in CAF-induced liver ***,BGM may potentially be a novel therapeutic compound to ameliorate liver damage.