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Progress toward understanding the contribution of alkali generation in dental biofilms to inhibition of dental caries

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International Journal of Oral Science 2012年第3期4卷 135-140页

作者： Ya-Ling Liu Marcelle Nascimento Robert A Burne Depa rtment of Oral Biology College of Dent stry University of Florida Gainesville USA Department of Restorative dental Sciences Division of Operative Dentistry College of Dentistry University of Florida Gainesville USA

Alkali production by oral bacteria is believed to have a major impact on oral microbial ecology and to be inibitory to the initiation and progression of dental caries. A substantial body of evidence is beginning to accumulate that indicates the modulation of the alkalinogenic potential of dental biofilms may be a promising strategy for caries control. This brief review highlights recent progress toward understanding molecular genetic and physiologic aspects of important alkali-generating pathways in oral bacteria, and the role of alkali production in the ecology of dental biofilms in health and disease.

关键词： arginine biofilm dental caries microbial ecology urea

Non-surgical management of dens invaginatus type IIIB in maxillary lateral incisor with three root canals and 6-year follow-up:A case report and review of literature

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World Journal of Clinical Cases 2022年第33期10卷 12240-12256页

作者： Suraj Arora Gurdeep Singh Gill Shahabe Abullais Saquib Priyanka Saluja Suheel M Baba Shafait Ullah Khateeb Anshad M Abdulla Shashit Shetty Bavabeedu Ahmed Babiker Mohamed Ali Mohamed Fadul A Elagib Department of Restorative dental Sciences College of DentistryKing Khalid UniversityAbha 61421Saudi Arabia Department of Conservative Dentistry and Endodontics JCD Dental CollegeSirsa 125055India Department of Periodontics and Community dental Sciences King Khalid UniversityAbha 61421Saudi Arabia Department of Pediatric Dentistry and Orthodontic Sciences King Khalid UniversityAbha 61421Saudi Arabia

BACKGROUND The presence of dens invaginatus(DI)complicates treatment of any tooth,from diagnosis to access cavity and biomechanical preparation and *** of successful non-surgical management of DI type IIIB in maxillary lateral incisor are ***,we report such a case,with three root canals and a long *** SUMMARY A 13-year-old female patient presented with mild pain in the maxillary right lateral incisor(#7)for 10-15 *** examination,the tooth was slightly rotated,with slight tenderness on percussion and grade I mobility but with no caries,pockets or restorations and non-vital pulp(via vitality tests).Radiographic examination revealed unusual configuration of the tooth’s root canals,with an enamel-lined invagination extending to the apex,suggesting the possibility of DI Oehler’s type IIIB and a periapical *** the access cavity lingually revealed one distinct buccal orifice and two distinct palatal orifices;under higher magnification of a dental operating microscope(DOM),the mesio palatal and disto-palatal orifices were observed as connected by a C-shaped *** root canals were prepared with hand K-files following a step-back technique,and obturated using a combination technique of lateral condensation and vertical *** the 6-year follow-up,the patient was asymptomatic,and the periapical radiography displayed significant healing around the apical end of the *** Proper knowledge of unusual root canal anatomy is required in treating *** methods of root canal treatment can successfully resolve such complex cases,facilitated by DOM and cone-beam computed tomography.

关键词： Dens invaginatus Maxillary lateral incisor Three root canals Root canal Anatomy Treatment Case report

Knowledge,attitude and anxiety pertaining to basic life support and medical emergencies among dental interns in Mangalore City,India

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World Journal of Emergency Medicine 2017年第2期8卷 131-135页

作者： Vinej Somaraj Rekha P Shenoy Ganesh Shenoy Panchmal Praveen S Jodalli Laxminarayan Sonde Ravichandra Karkal Department of Public Health Dentistry Rajas Dental College&HospitalTirunelveliTamil NaduIndia Department of Public Health Dentistry Yenepoya Dental CollegeMangaloreKarnatakaIndia Department of Psychiatry Yenepoya Medical CollegeMangaloreKarnataka 575018India

BACKGROUND: This cross-sectional study aimed to assess the knowledge, attitude and anxiety pertaining to basic life support(BLS) and medical emergencies among interns in dental colleges of Mangalore city, Karnataka, ***: The study subjects comprised of interns who volunteered from the four dental colleges. The knowledge and attitude of interns were assessed using a 30-item questionnaire prepared based on the Basic Life Support Manual from American Heart Association and the anxiety of interns pertaining to BLS and medical emergencies were assessed using a State-Trait Anxiety Inventory(STAI) Questionnaire. Chi-square test was performed on SPSS 21.0(IBM Statistics, 2012) to determine statistically signifi cant differences(Pdental interns with respect to Basic Life Support procedures.

关键词： Basic life support Cardiopulmonary resuscitation dental interns Medical emergencies State-Trait anxiety inventory

Periodontal conditions and treatment in urban and rural population of West Bengal,India

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Asian Pacific Journal of Tropical Medicine 2010年第2期3卷 152-157页

作者： Mehta R Kundu D Chakrabarty S Bharati P Department of Periodontia Dr.R.Ahmed Dental College & Hospital Biological Anthropology Unit Indian Statistical Institute

Objective:To search adequate epidemiological data on periodontal conditions for the planning of oral health programs in Indian population,and to determine the prevalence of periodontal diseases,in regards to age and gender of urban and rural population in West ***. Methods:22 542 subjects aged 15 years onwards,representative of rural and urban areas of West Bengal were examined for their periodontal conditions using the community periodontal index(CPI).Results:Supra and/or sub gingival calculus dominated as the most frequent score (score 2) among males(76.51%) and females(76.58%),which was least affected in young age group and higher in rural *** of highest score were significant(P<0.001) according to their gender,age group and habitation and had independent effects(P<0.001) on it. Mean number of sextants affected by scores 1,2,3,& 4 were more in the rural *** treatment needed was predominantly typeⅡ(Scaling and improved oral hygiene).Conclusions: The severe periodontal condition(Score 2,3 and 4) is observed among rural males in older age group more than its urban counterparts of West Bengal,India.

关键词： Periodontal diseases Treatment needs Urban and rural population Age group Gender

Dissecting the theranostic potential of exosomes in autoimmune disorders

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Cellular & Molecular Immunology 2019年第12期16卷 935-936页

作者： Vijayashree Priyadharsini Jayaseelan Paramasivam Arumugam Biomedical Research Unit and Laboratory Animal Centre-dental Research Cell Saveetha Dental CollegeSaveetha Institute of Medical and Technical Sciences(SIMATS)Saveetha UniversityChennaiTamil Nadu 600077India

The biology of exosomes is a fascinating field of science that has attracted much attention from clinical researchers due to the plethora of associated *** biological cargoes serve as a hub of information about the health status of a cell or a group of *** reports on exosome-derived biomolecules in relation to diseases such as cancer,neurodegenerative diseases,and infectious diseases have spurred interest in exploring their role in the pathogenesis of other debilitating disease *** research into autoimmune disorders(ADs)in relation to exosome biology has identified novel therapeutic leads aiming to improve the life expectancy of individuals suffering from such disorders.1 One such important,notable contribution was recently shared by Guay et *** provided concreate evidence on the mechanism ofβcell apoptosis induced by the transfer of exosomal miRNAs derived from T cells,which eventually leads to type I diabetes *** crucial mediators of the process were T-lymphocyte-derived exosomes harboring miR-142-3p,miR-142-5p,and ***-miRs designed to block the interactions of miRNAs with their target genes insideβcells prevented the process of apoptosis,eventually rescuingβcells.2 Thus,targeting the mediators of crosstalk or blocking the function of exosomal miRNAs could serve as an interesting therapeutic strategy for type I diabetes mellitus(Fig.1).Consistent with the above report,this review highlights the contribution of exosomes to the development of autoimmune *** addition,this review also reveals the possible“theranostic”markers(therapeutic and diagnostic biomarkers)associated with ADs.

关键词： disorders autoimmune eventually

Antimicrobial effect of alexidine and chlorhexidine against Enterococcus faecalis infection

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International Journal of Oral Science 2013年第1期5卷 26-31页

作者： Hyun-Shik Kim Seok Woo Chang Seung-Ho Baek Seung Hyun Han Yoon Lee Qiang Zhu Kee-Yeon Kum Department of Conservative Dentistry Dental Research Institute and BK21 ProgramSeoul National University Dental HospitalSeoul National University School of Dentistry Department of Conservative Dentistry School of DentistryKyung Hee University Department of Oral Microbiology and Immunology Dental Research Institute and BK21 ProgramSeoul National University Dental HospitalSeoul National University School of Dentistry Department of Dentistry Wonju college of Medicine Yonsei University Division of Endodontology School of Dental MedicineUniversity of Connecticut Health Center

A previous study demonstrated that alexidine has greater affinity for the major virulence factors of bacteria than *** aim of this study was to compare the antimicrobial activity of 1%alexidine with that of 2%chlorhexidine using Enterococcus faecalis-infected dentin *** bovine dentin blocks were prepared and randomly divided into six groups of 10 *** was inoculated on 60 dentin blocks using the Luppens apparatus for 24 h and then the dentin blocks were soaked in 2%chlorhexidine or 1%alexidine solutions for 5 and 10 min,*** saline was used as a *** antimicrobial efficacy was assessed by counting the number of bacteria adhering to the dentin surface and observing the degradation of bacterial shape or membrane rupture under a scanning electron *** fewer bacteria were observed in the 2%chlorhexidine-or 1%alexidine-soaked groups than in the control group(P0.05).Ruptured or antiseptic-attached bacteria were more frequently observed in the 10-min-soaked chlorhexidine and alexidine groups than in the 5-min-soaked chlorhexidine and alexidine *** conclusion,10-min soaking with 1%alexidine or 2%chlorhexidine can be effective against *** infection.

关键词： alexidine antibacterial effect chlorhexidine Enterococcus faecalis Luppens apparatus root canal soaking scanning electron microscope

Innovation leading development:a glimpse into three-dimensional bioprinting in Israel

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Bio-Design and Manufacturing 2024年第3期7卷 358-382页

作者： Lujing Gao Zixuan Liu Daniel Dikovsky Jiqian Wang Deqing Mei Lihi Adler-Abramovich Ehud Gazit Kai Tao State Key Laboratory of Heavy Oil Processing and Centre for Bioengineering and Biotechnology College of Chemistry and Chemical EngineeringChina University of Petroleum(East China)Qingdao 266580China Future Science Research Institute Hangzhou Global Scientific and Technological Innovation CentreHangzhou 311200China Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials Hangzhou 311200China Redefine Meat Ltd. Rehovot 7670110Israel State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310058China Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou 310058China Department of Oral Biology The Maurice and Gabriela Goldschleger School of Dental MedicineFaculty of Medical&Health SciencesTel Aviv UniversityTel Aviv 6997801Israel The Center for Nanoscience and Nanotechnology Tel Aviv UniversityTel Aviv 6997801Israel Department of Materials Science and Engineering Iby and Aladar FleischmanTel Aviv UniversityTel Aviv 6997801Israel The Shmunis School of Biomedicine and Cancer Research George S.Wise Faculty of Life SciencesTel Aviv UniversityTel Aviv 6997801Israel

Three-dimensional(3D)printing has attracted increasing research interest as an emerging manufacturing technology for devel-oping sophisticated and exquisite architecture through hierarchical *** has also been employed in various advanced industrial *** development of intelligent biomedical engineering has raised the requirements for 3D printing,such as flexible manufacturing processes and technologies,biocompatible constituents,and alternative ***,state-of-the-art 3D printing mainly involves inorganics or polymers and generally focuses on traditional industrial fields,thus severely limiting applications demanding biocompatibility and *** this regard,peptide architectonics,which are self-assembled by programmed amino acid sequences that can be flexibly functionalized,have shown promising potential as bioinspired inks for 3D ***,the combination of 3D printing and peptide self-assembly poten-tially opens up an alternative avenue of 3D bioprinting for diverse advanced ***,a small but innovative nation,has significantly contributed to 3D bioprinting in terms of scientific studies,marketization,and peptide architectonics,including modulations and applications,and ranks as a leading area in the 3D bioprinting *** review summarizes the recent progress in 3D bioprinting in Israel,focusing on scientific studies on printable components,soft devices,and tissue *** paper further delves into the manufacture of industrial products,such as artificial meats and bioinspired supramolecular architectures,and the mechanisms,physicochemical properties,and applications of peptide ***,Israel contributes significantly to the field of 3D bioprinting and should thus be appropriately recognized.

关键词： Israel 3D bioprinting Biomanufacturing Peptide self-assembly Integration of industry,education and research

Ocular prosthesis incorporating IPS e-max press scleral veneer and a literature review on non-integrated ocular prosthesis

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International Journal of Ophthalmology(English edition) 2017年第1期10卷 148-156页

作者： Godwin Clovis Da Costa Meena Ajay Aras Paul Chalakkal Michelle Clovis Da Costa Department of Prosthodontics Goa Dental College and HospitalBambolimGoa 403202India Department of Pedodontics and Preventive Dentistry Goa Dental College and HospitalBambolimGoa 403202India Primary DNB(Ophthalmology) West Lion's Super Specialty Eye HospitalBangaloreKarnataka 560002India

The article highlights a new method for the fabrication of an ocular prosthesis by the incorporation of a ceramic scleral veneer. The steps of fabrication include impression making, wax try-in, performing a “cut-back” on a selected stock eye, insertion of the IPS e-max press scleral veneer, finishing and insertion. It also includes a detailed review on non-integrated ocular prostheses.

关键词： IPS e-max press ceramic eye prosthesis ocular prosthesis

Effects of TiN film coating on electrochemical behaviors of nanotube formed Ti-xHf alloys

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中国有色金属学会会刊：英文版 2009年第4期19卷 857-861页

作者： Kang LEE Won-Gi KIM Joo-Young CHO Sang-Won EUN Han-Cheol CHOE Department of dental Materials & Research Center of Nano-Interface Activation for Biomaterials College of DentistryChosun University Department of Applied Advanced Materials Korea Polytechnic Ⅴ Colleges

Ti-xHf(x=10%,20%,30% and 40%,mass fraction) alloys were prepared by arc melting,and the microstructure was controlled for 24 h at 1 000 ℃ in argon *** formation of nanotube was conducted by anodizing on Ti-Hf alloys in 1.0 mol/L H3PO4 electrolytes with small amounts of NaF at room *** then TiN coatings were coated by DC-sputtering on the anodized *** and nanotube morphology of the alloys were examined by field emission scanning electron microscopy(FE-SEM) and X-ray diffractometry(XRD).The corrosion properties of the specimens were examined through potentiodynamic test(potential range from -1 500 to 2 000 mV) in 0.9 % NaCl solution by *** microstructure shows the acicular phase and α' phase with Hf *** amorphous oxide surface is transformed to crystalline anatase *** coated nanotube surface has a good corrosion resistance.

关键词：氮化钛涂层合金制备纳米管电化学行为薄膜包衣 0.9%NaCl溶液扫描电子显微镜微观结构