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Dietary supplementation in patients with alcoholic liver disease: a review on current evidence

Hepatobiliary & Pancreatic Diseases International 2016年第4期15卷 348-360页

作者： Zeinab Ghorbani Masoomeh Hajizadeh Azita Hekmatdoost Department of Clinical nutrition and Dietetics Faculty of Nutrition and Food TechnologyNational Nutrition and Food TechnologyResearch Institute Shahid Beheshti University of Medical Sciences

BACKGROUND：Alcoholic liver disease（ALD）is one of the main causes of liver disease *** the pathogenesis of ALD has not yet been well elucidated,the oxidative metabolites of ethanol such as acetaldehyde and reactive oxygen species play a pivotal role in the clinical and pathological spectrum of the *** review summarizes the existing evidences on dietary supplements considered to have antioxidant,and/or anti-inflammatory properties,and their role in the management of ALD and the proposed *** SOURCES：The present study reviewed all studies published in Pub Med,Science Direct and Scopus,from 1959 to2015,indicating the role of different dietary supplementation in attenuation of many pathophysiological processes involved in development and progression of ***-texts of citations were used except for those that were published in languages other than ***：Significant progress has been made to understand the key events and molecular players for the onset and progression of ALD from both experimental and clinical studies;however,there is no successful treatment currently *** present review discussed the role of a variety of dietary supplements（*** A,carotenoids,vitamins B3,C and E,in addition to antioxidants and anti-inflammatory agents）in treating *** has been shown that supplementation with some carotenoids,vitamin B3,vitamin C,silymarin,curcumin,probiotics,zinc,S-adenosylmethionine and garlic may havepotential beneficial effects in animal models of ALD;however,the number of clinical studies is very *** addition,supplementation should be accompanied with alcohol ***：Since oxidative stress and inflammation are involved in the pathogenesis of ALD,dietary supplements that can modulate these pathologies could be useful in the treatment of *** addition to alcohol cessation,these supplements have shown beneficial effects on animal models of *** trials are needed to validate t

关键词： alcoholic liver disease fatty liver dietary supplements antioxidants nutrition diet

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Dendrobium officinale polysaccharide attenuates type 2 diabetes in mice model by modulating gut microbiota and alleviating intestinal mucosal barrier damage

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food Science and Human Wellness 2025年第1期14卷 112-123页

作者： Xiaoxia Chen Chun Chen Changyang Ma Wenyi Kang Junlin Wu Xiong Fu Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety Guangzhou 510640China SCUT-Zhuhai Institute of Modern Industrial Innovation School of Food Science and EngineeringSouth China University of TechnologyGuangzhou 510640China Guangzhou Institute of Modern Industrial Technology Guangzhou 511458China Overseas Expertise Introduction Center for Discipline Innovation of food nutrition and Human Health(111 Center) Guangzhou 510640China National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Guangzhou Wondfo Health Science and Technology Co. Ltd.Guangzhou 510640China

The purpose of this study was to investigate the hypoglycemic effect and mechanism of D endrobium officinale polysaccharide(DOP)on type 2 diabetes mellitus(T2DM)mice established by high-fat diet and *** results showed that DOP improved glycolipid metabolism and serum inflammation levels,and inhibited intestinal-derived lipopolysaccharide(LPS)translocation,suggesting that inhibiting LPS-mediated intestinal barrier damage may be a key target for DOP to alleviate ***,the study found that DOP reduced intestinal inflammation and oxidative stress levels,significantly up-regulated the mRNA expression of tight junction proteins Claudin-1,Occludin and zonula occluden-1(ZO-1),and ameliorated intestinal epithelial *** addition,DOP strongly inhibited the intestinal pathogenic bacteria and LPS-producing bacteria Helicobacter,Enterococcus and Desulfovibrio with a reduction rate of 95%,73% and 9%,respectively,and promoted the proliferation of anti-inflammatory bacteria Bifidobacterium and Lactobacillus by 139% and 8%,*** together,the hypoglycemic effect of DOP was related to the protection of intestinal mucosal barrier,and its underlying mechanism lied in its excellent anti-inflammatory and gut microbiotamodulatory effects,providing a theoretical basis for developing DOP as a novel prebiotic in functional food for diabetes.

关键词： Dendrobium officinale polysaccharide Hypoglycemic Mechanism Lipopolysaccharide Gut microbiota

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Effects of probiotics,prebiotics and synbiotics supplementation on cardiovascular risk factors in patients with type 2 diabetes mellitus:a GRADE-assessed systematic review and meta-analysis of randomized controlled trials

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food Science and Human Wellness 2025年第1期14卷 29-49页

作者： Yanyan Tian Jiayue Xia Lihua Li Ligang Yang Hua Xiao Guoping Gao Yuanyuan Wang Chen Zhang Tiange Bu Guiju Sun Key Laboratory of Environmental Medicine and Engineering of Ministry of Education Department of Nutrition and Food HygieneSchool of Public HealthSoutheast UniversityNanjing 210009China Lianshui People’s Hospital Affi liated to Kangda College of Nanjing Medical University Huai’an 223400China Gong’an County People’s Hospital Jingzhou 434300China Department of nutritional Sciences University of TorontoToronto M5S 1A1Canada

A systematic review and meta-analysis study was conducted to assess the effectiveness of probiotic/prebiotic/synbiotic supplementation on the effects of cardiovascular risk factors in patients with type 2 diabetes mellitus(T2DM)based on data from randomized controlled trials(RCTs).We searched electronic databases including PubMed,Cochrane Library,Embase,and Web of Science to identify clinical trials published up to 31 March *** was pooled using a random-effects model if significant heterogeneity(I2>50%),otherwise use a fixed-effects ***-six trials that included 3317 patients were enrolled for ***-analysis reported that probiotic/prebiotic/synbiotic supplementation significantly reduced systolic blood pressure(SBP)(weighted mean difference(WMD):-3.57 mmHg,95% confidence interval(CI):-5.36,-1.78;P=0.000),diastolic blood pressure(DBP)(WMD:-2.05 mmHg,95%CI:-3.07,-1.04;P=0.000),triglycerides(TG)(WMD:-16.10 mg/dL,95%CI:-20.16,-12.05;P=0.000),total cholesterol(TC)(WMD:-14.00 mg/dL,95%CI:-20.46,-7.55;P=0.000),low-density lipoprotein cholesterol(LDL-C)(WMD:-7.03 mg/dL,95%CI:-9.25,-4.81;P=0.000),fasting plasma glucose(FPG)(WMD:-16.57 mg/dL,95%CI:-20.39,-12.74;P=0.000),hemoglobin A1c(HbA1c)(WMD:-0.44%,95%CI:-0.68,-0.20;P=0.000),insulin(standardized mean difference(SMD):-0.37,95%CI:-0.53,-0.21;P=0.000),homeostatic model assessment of insulin resistance(HOMA-IR)(WMD:-1.05,95%CI:-1.56,-0.54;P=0.000),C-reactive protein(CRP)(SMD:-0.35,95%CI:-0.57,-0.13;P=0.002),tumor necrosis factor-α(TNF-α)(SMD:-1.07,95%CI:-1.57,-0.56;P=0.000),interleukin-6(IL-6)(SMD:-0.37,95%CI:-0.61,-0.13;P=0.003)levels,they also increased the high-density lipoprotein cholesterol(HDL-C)(WMD:3.70 mg/dL,95%CI:1.80,5.60;P=0.000)levels in T2DM patients,as compared to the placebo *** meta-analysis supports the use of probiotic/prebiotic/synbiotic supplementation as an adjunctive therapy to improve blood pressure,glycemic control parameters,lipid profile and inflammatory markers in pati

关键词： Probiotic Prebiotic Synbiotic Type 2 diabetes mellitus Cardiovascular risk factors Systematic review and meta-analysis

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Lipids and Fatty Acid Composition of Dried Edible Red and Black Ants

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Agricultural Sciences in China 2010年第7期9卷 1072-1077页

作者： Oranut Sihamala Subhachai Bhulaidok Department of food Science and nutrition Zhejiang University

Total lipid contents,lipid classes and fatty acid compositions of hot-air dried edible black ants（Polyrhachis vicina Roger） from Wenzhou and Guizhou,China,and edible red ant（Oecophylla smaragdina Fabricius） from Thailand were *** major lipid components were triacylglycerol（43.4-79.4% of total lipid）,followed by phospholipids（6.1-21.5%）,diacylglycerol（6.1-18.1%） and cholesterol ester（4.9-13.5%） while free fatty acids（1.8-2.9%） and sterol（0.5-0.8%） were the minor *** acid（C18：1） was the most predominant fatty acid,accounting for 3 407.8,9 098.8 and 3 790.1 mg 100 g-1 in Wenzhou and Guizhou black ants,and Thai red ant,*** by palmitic acid（C16：0）,922.9,2 523.3 and 1 511.8 mg 100 g-1;linoleic acid（C18：2n-6）,133.7,305.2 and 506.4 mg 100 g-1;α-linolenic acid（C18：3n-3）,35.1,138.0 and 52.5 mg 100 g-1;eicosapentaenoic acid（C20：5n-3） was 19.1,15.0 and 20.0 mg 100 g-1 in Wenzhou and Guizhou black ants,and Thai red ant,*** acid（C22：5n-3） was only found in black ants,7.0 and 7.3 mg 100 g-1 for Wenzhou and Guizhou ants,*** edible black and red ants were shown to be a good source of unsaturated fatty acid.

关键词： Polyrhachis vicina Roger Oecophylla smaragdina Fabricius edible black ant edible red ant polyunsaturated fatty acid (PUFA)

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Anthocyanin attenuates disturbance of intestinal barrier in high fat-high cholesterol diet-challenged mice through regulating the response of T helper 17 cells

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food Science and Human Wellness 2025年第1期14卷 332-344页

作者： Qiannan Liu Juan Pang Yi Tang Yiran You Jiaxin Mi Jinghe Xiao Yu Chen Wenhua Ling Department of nutrition School of Public HealthSun Yat-sen UniversityGuangzhou 510000China Laboratory of Clinical Pharmacy and Adverse Drug Reaction West China HospitalSichuan UniversityChengdu 610000China Department of nutrition The First People's Hospital of ZhaoqingZhaoqing 526000China Guangdong Provincial Key Laboratory of food Nutrition and HealthGuangzhou 510000China

Anthocyanin,as a typical food bioactive molecule,is capable of reversing inflammatory,oxidative and allergic condition thus contributes to intestinal *** were wondering whether anthocyanin has influence on the infiltration of inflammatory cells into the intestinal mucosa and thus help enhancing intestinal barrier which could be damaged in some metabolic *** this study,the influence of anthocyanin(administered orally)on the alterations(including structure and permeability)of the intestinal mucosa in mice in response to a high fat-high cholesterol(HFHC)diet was *** T helper 17(Th17)cells were isolated from mouse intestine tissues to observe the modulatory role of anthocyanin through the transcription phosphorylated STAT 3(p-STAT3).The results indicated that anthocyanin significantly alleviated HFHC-induced impairment in the intestinal structures and permeability in a dose-dependent manner;moreover,anthocyanin appeared to inhibit HFHC induced the expression of p-STAT3,thereby disturbing Th17 cell *** high-fat diet(HFD,cholesterol level non-modified)-challenged mice selective p-STAT3 inhibitor significantly reversed the effects of anthocyanin,which were decreased amount of interleukin(IL)-17A(produced and released from Th17 cells)and the protected intestinal structure/*** summary,the results of this study suggest that anthocyanin may attenuate the damage of intestinal barrier in HFHC mice through regulating intestinal STAT3-Th17-IL-17A signal transduction pathway.

关键词： Anthocyanin Intestinal barrier dysfunction STAT3 T helper 17(Th17)cell interleukin(IL)-17A

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Batch and fed-batch production of butyric acid by Clostridium butyricum ZJUCB

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2005年第11期6卷 1076-1080页

作者：何国庆孔青陈启和阮晖 Department of food Science and nutrition Zhejiang University

The production of butyric acid by Clostridium butyricum ZJUCB at various pH values was investigated. In order to study the effect of pH on cell growth, butyric acid biosynthesis and reducing sugar consumption, different cultivation pH values ranging from 6.0 to 7.5 were evaluated in 5-L bioreactor. In controlled pH batch fermentation, the optimum pH for cell growth and butyric acid production was 6.5 with a cell yield of 3.65 g/L and butyric acid yield of 12.25 g/L. Based on these results, this study then compared batch and fed-batch fermentation of butyric acid production at pH 6.5. Maximum value (16.74 g/L) of butyric acid concentration was obtained in fed-batch fermentation compared to 12.25 g/L in batch fermentation. It was concluded that culti- vation under fed-batch fermentation mode could enhance butyric acid production significantly (P<0.01) by C. butyricum ZJUCB.

关键词： Clostridium butyricum Batch fermentation Fed-batch fermentation pH Butyric acid production Acetic acid

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Optimization of conditions for supercritical fluid extraction of flavonoids from hops (Humulus lupulus L.)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2005年第10期6卷 999-1004页

作者：何国庆熊皓平陈启和阮晖王肇悦 TRAORé Lonseny Department of food Science and nutrition Zhejiang University Hangzhou 310029 China Department of food Science and nutrition University of Conakry PB 1147 Guinea

Waste hops are good sources of flavonoids. Extraction of flavonoids from waste hops (SC-CO2 extracted hops) using supercritical fluids technology was investigated. Various temperatures, pressures and concentrations of ethanol (modifier) and the ratio (w/w) of solvent to material were tested in this study. The results of single factor and orthogonal experiments showed that at 50 °C, 25 MPa, the ratio of solvent to material (50%), ethanol concentration (80%) resulted in maximum extraction yield fla- vonoids (7.8 mg/g). HPLC-MS analysis of the extracts indicated that flavonoids obtained were xanthohumol, the principal prenylflavonoid in hops.

关键词： Carbon dioxide Carbon disulfide Ethanol food processing Medicine Optimization Pressure Solvents Temperature

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Quantitative Structure-activity Relationship Studies on the Antioxidant Activity and Gap Junctional Communication of Carotenoids

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Chinese Journal of Structural Chemistry 2010年第9期29卷 1362-1372页

作者：孙玉敬吴丹刘东红陈健初沈妍叶兴乾 Department of food Science and nutrition School of Biosystems Engineering and Food ScienceZhejiang University

The antioxidant and gap junctional communication（GJC） activities of carotenoids are known to be the two main anticancer *** structure-activity relationship（QSAR） models of the two activities were developed using stepwise regression and multilayer perceptron neural network based on the calculated descriptors of quantum *** results showed that the significant molecular descriptor related to the antioxidant activity of carotenoids was the HOMO-LUMO energy gap（EHL） and the molecular descriptor related to the GJC was the lowest unoccupied molecular orbital energy（ELUMO）.The two models of antioxidant activity both showed good predictive power,but the predictive power of the neural network QSAR model of antioxidant activity was *** addition,the two GJC models have similar,moderate predictive *** possible mechanisms of antioxidant activity and GJC of carotenoids were discussed.

关键词： carotenoids antioxidant activity gap junctional communication multilayer perceptron neural network quantitative structure-activity relationship

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Ligustroside derived from Ligustrum japonicum inhibits melanogenesis via blocking the MAPK and PKA/CREB signaling pathways

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Asian Pacific Journal of Tropical Biomedicine 2025年第2期15卷 65-74,I0004,I0005页

作者： Xian-Rong Zhou Fatih Karadeniz Jung Hwan Oh Youngwan Seo Chang-Suk Kong Department of Bioscience Silla UniversityBusan 46958Korea Collaborative Innovation Center for Child nutrition and Health Development Chongqing University of EducationChongqing 400067China Marine Biotechnology Center for Pharmaceuticals and foods Silla UniversityBusan 46958Korea nutritional Education Graduate School of EducationSilla UniversityBusan 46958Korea Division of Convergence on Marine Science Korea Maritime&Ocean UniversityBusan49112Korea Department of food and nutrition Silla UniversityBusan 46958Korea

Objective:To investigate the anti-melanogenic potential of ligustroside isolated from Ligustrum ***:The cytotoxicity of ligustroside was tested via MTT ***,the effects of ligustroside on the expression of critical melanogenic markers such as tyrosinase,tyrosinase related proteins(TRPs),and microphthalmia-associated transcription factor(MITF)were analyzed at both mRNA and protein levels via RT-qPCR and Western blot,respectively,inα-melanocyte stimulating hormoneinduced B16F10 *** addition,phosphorylation of p38,ERK and JNK proteins was *** analysis of MITF was also ***:Ligustroside significantly reduced intracellular tyrosinase activity and melanin content by 37.11%and 29.12%,respectively,compared to untreated ***,it downregulated the expression of MITF,tyrosinase,TRP-1,and TRP-2 at the mRNA and protein levels by regulating both the mitogen-activated protein kinase(MAPK)and protein kinase A(PKA)/cAMP response element-binding protein(CREB)signaling *** also suppressed the nuclear protein expression of MITF,β-catenin,and p-CREB,and decreased immunofluorescence intensity of nuclear ***:Ligustroside derived from Ligustrum japonicum shows a significant anti-melanogenesis effect via suppression of the MAPK and PKA/CREB signaling pathways.

关键词： Ligustrum japonicum Ligustroside MAPK Melanogenesis CREB PKA

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Ultrasound particle sizing:A review

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Particuology 2013年第2期11卷 135-147页

作者： Malcolm J.W.Povey School of food Science and nutrition The University of Leeds

Ultrasound spectrometry is one of very few methods that can size particles over the range 10 nm to I mm for optically opaque, undiluted materials. It has in-line, non-invasive capabilities which make it a serious contender for use in industrial process monitoring, with the potential for 100% inspection. In aqueous systems, it is more sensitive to nanoparticles than to particles in the micrometre range upwards because the scattering power varies as the inverse square of particle diameter, making it suitable for the detec- tion of nanoparticles in concentrated, mixed systems. Future development of ultrasound spectrometers suitable for widespread laboratory and industrial use depends on meeting the challenges of complex data interpretation and the need for considerable know how. In this review we provide a brief account of ultrasound propagation and scattering theory which underlies the ultrasound spectrometer, describe several types of spectrometer and demonstrate its successful use in the characterization of colloidal silica, whole milk and protein solutions.

关键词： Ultrasound Particle size Measurement instrumentation Review Acoustics Particle size distribution (PSD) Nanoparticles Colloids Ultrasound spectrometry

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