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Science China(Life Sciences) 2024年第6期67卷 1321-1324页

作者： Baoman Li Yanyan Tian Puyue Wang Department of Life Sciences National Natural Science Foundation of ChinaBeijing 100085China

Immunology,a biomedical discipline with an ancient history of maintaining thriving research vitality to date,refers to the study of the structure and function of the immune system of the body,the pathogenesis of immune-related diseases,immunological diagnoses,and prevention mechanisms(National Natural Science foundation of China,2023).Immunological research is the foundation of research in biology,as well as basic and clinical medicine(Kubli et al.,2021).

关键词： prevention foundation Natural

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Knowledge-Enhanced Conversational Agents

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Journal of Computer Science & Technology 2024年第3期39卷 585-609页

作者： Fabio Caffaro Giuseppe Rizzo LINKS foundation 10138 TurinItaly

Humanity has fantasized about artificial intelligence tools able to discuss with human beings fluently for *** efforts have been proposed ranging from ELIZA to the modern vocal *** the large interest in this research and innovation field,there is a lack of common understanding on the concept of conversational agents and general over expectations that hide the current limitations of existing *** work proposes a literature review on the subject with a focus on the most promising type of conversational agents that are powered on top of knowledge bases and that can offer the ground knowledge to hold conversation autonomously on different *** describe a conceptual architecture to define the knowledge-enhanced conversational agents and investigate different domains of *** conclude this work by listing some promising research pathways for future work.

关键词： conversational agent dialogue system knowledge enhancing artificial agent intelligent conversation

Optimised hybrid classification approach for rice leaf disease prediction with proposed texture features

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Journal of Control and Decision 2024年第1期11卷 84-97页

作者： Sakhamuri Sridevi K.Kiran Kumar Department of Computer Science and Engineering Koneru Lakshmaiah Education FoundationVaddeswaramIndia

This paper aims to frame a new rice disease prediction model that included three major ***,median filtering(MF)is deployed during pre-processing and then‘proposed Fuzzy Means Clustering(FCM)based segmentation’is *** that,‘Discrete Wavelet Transform(DWT),Scale-Invariant Feature Transform(SIFT)and low-level features(colour and shape),Proposed local Binary Pattern(LBP)based features’are extracted that are classified via‘MultiLayer Perceptron(MLP)and Long Short Term Memory(LSTM)’and predicted outcomes are *** exact prediction,this work intends to optimise the weights of LSTM using Inertia Weighted Salp Swarm Optimisation(IW-SSO)***,the development of IW-SSO method is established on varied metrics.

关键词： Rice disease improved fuzzy hybrid classifiers optimised LSTM IW-SSO algorithm

Quest for Equitable Education in Phases:Insights From an NGO in China

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ECNU Review of Education 2024年第2期7卷 230-240页

作者：潘江雪王博 Adream foundation Shandong Women's University&Adream foundation No.2399Daxue RoadChangqing DistrictJinan 250300Shandong ProvinceChina

Highlights Among the East Asian nations,a recurring predicament faced by educational institutions is that of providing inclusive but high-quality *** involvement of non-governmental organizations(NGOs)in education is valuable in *** was such an NGO on education in China,established in 2008 with a singular and noble objective:promotion of equitable access to quality education within the disadvantaged regions of China.

关键词： Educational improvement educational NGO in China equitable and quality education

Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies

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Neural Regeneration Research 2025年第3期20卷 803-804页

作者： Glenn A.Harris Lauren R.Hirschfeld Rainwater Charitable foundation Fort WorthTXUSA

Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(MAPT) and can be classified as either 3-repeat(3R) or 4-repeat(4R) based on the number of repeat domains from alternative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

Time-Aware LSTM Neural Networks for Dynamic Personalized Recommendation on Business Intelligence

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Tsinghua Science and Technology 2024年第1期29卷 185-196页

作者： Xuan Yang James A.Esquivel Graduate School Angeles University FoundationAngeles City 2009Philippines Shandong Provincial University Laboratory for Protected Horticulture Weifang University of Science and TechnologyWeifang 262700China

Personalized recommendation plays a critical role in providing decision-making support for product and service analysis in the field of business ***,deep neural network-based sequential recommendation models gained considerable ***,existing approaches pay litle attention to users'dynamically evolving interests,which are influenced by product attributes,especially product *** overcome these challenges,we propose a dynamic personalized recommendation model:***,we first embed product information and attribute information into a unified data ***,we exploit long short-term memory(LsTM)networks to characterize sequential behavior over multiple time periods and seize evolving interests by hierarchical LSTM ***,similarity values between users are measured through pairwise interest features,and personalized recommendation lists are generated.A series of experiments reveal the superiority of the proposed method compared withotheradvanced methods.

关键词： personalized recommendations evolving interests embedding LsTM networks

Testosterone replacement therapy and vascular thromboembolic events: a systematic review and meta-analysis

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Asian Journal of Andrology 2024年第2期26卷 144-154页

作者： Rossella Cannarella Carmelo Gusmano Claudia Leanza Vincenzo Garofalo Andrea Crafa Federica Barbagallo Rosita A Condorelli Sandro La Vignera Aldo E Calogero Department of Clinical and Experimental Medicine University of CataniaCatania 95123Italy Glickman Urological&Kidney Institute Cleveland Clinic FoundationClevelandOH44195USA

To evaluate the relationship between testosterone replacement therapy(TRT)and arterial and/or venous thrombosis in patients with pre-treatment total testosterone(TT)<12 nmol I^(-1),we performed a meta-analysis following the Population Intervention Comparison Outcome ***:men with TT<12 nmol I^(-1) or clear mention of hypogonadism in the inclusion criteria of patients;intervention:TRT;comparison:placebo or no therapy;outcomes:arterial thrombotic events(stroke,myocardial infarction[MI],upper limbs,and lower limbs),VTE(deep vein thrombosis[DVT],portal vein thrombosis,splenic thrombosis,and pulmonary embolism),and mortality.A total of 2423 abstracts were assessed for ***-four studies,including 14 randomized controlled trials(RCTs),were finally included,with a total of 4027 and 310288 hypotestosteronemic male patients,from RCTs and from observational studies,*** on RCT-derived data,TRT did not influence the risk of arterial thrombosis(odds ratio[OR]=1.27,95%confidence interval[CI]:0.47-3.43,P=0.64),stroke(OR=1.34,95%CI:0.09-18.97,P=0.83),MI(OR=0.51,95%CI:0.11-2.31,P=0.39),VTE(OR=1.42,95%CI:0.22-9.03,P=0.71),pulmonary embolism(OR=1.38,95%CI:0.27-7.04,P=0.70),and mortality(OR=0.70,95%CI:0.20-2.38,P=0.56).Meanwhile,when only observational studies are considered,a significant reduction in the risk of developing arterial thrombotic events,Ml,venous thromboembolism,and mortality was *** risk for DVT remains uncertain,due to the paucity of RCT-based *** in men with TT<12 nmol I^(-1) is safe from the risk of adverse cardiovascular *** studies specifically assessing the risk of DVT in men on TRT are needed.

关键词： hypogonadism testosterone testosterone replacement therapy thromboembolism thrombosis TRT

Gut flora in multiple sclerosis:implications for pathogenesis and treatment

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Neural Regeneration Research 2024年第7期19卷 1480-1488页

作者： Weiwei Zhang Ying Wang Mingqin Zhu Kangding Liu Hong-Liang Zhang Department of Neurology the First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Department of Life Sciences National Natural Science Foundation of ChinaBeijingChina

Multiple sclerosis is an inflammatory disorder chara cterized by inflammation,demyelination,and neurodegeneration in the central nervous *** current first-line therapies can help manage symptoms and slow down disease progression,there is no cure for multiple *** gut-brain axis refers to complex communications between the gut flo ra and the immune,nervous,and endocrine systems,which bridges the functions of the gut and the *** in the gut flora,termed dys biosis,can lead to systemic inflammation,leaky gut syndrome,and increased susceptibility to *** pathogenesis of multiple sclerosis involves a combination of genetic and environmental factors,and gut flora may play a pivotal role in regulating immune responses related to multiple scle *** develop more effective therapies for multiple scle rosis,we should further uncover the disease processes involved in multiple sclerosis and gain a better understanding of the gut-brain *** review provides an overview of the role of the gut flora in multiple scle rosis.

关键词： gut flora gut-brain axis multiple sclerosis pathogenesis treatment

Neural membrane repair at the core of regeneration

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Neural Regeneration Research 2024年第7期19卷 1399-1400页

作者： Catarina Dias Jesper Nylandsted Danish Cancer Institute Membrane IntegrityCopenhagenDenmark Champalimaud Research Champalimaud FoundationLisbonPortugal Department of Molecular Medicine University of Southern DenmarkOdenseDenmark

Loss of plasma membrane integrity can compromise cell functioning and *** countera ct this eminent threat,euka ryotic cells have developed efficient repair mechanisms,which seem to have co-evolved with the emergence of vital membrane processes(Cooper and McNeil,2015).This relationship between basic cellular functioning and membrane repair highlights the fundamental significance of preserving membrane integrity for cellular life.

关键词： repair preserving integrity

Challenges and opportunities in rare cancer research in China

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Science China(Life Sciences) 2024年第2期67卷 274-285页

作者： Jianxin Xue Qunyan Lyu Division of Thoracic Tumor Multimodality Treatment Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China National Natural Science foundation of China Beijing 100085China

Cancer is one of the major public health challenges in *** cancers collectively account for a considerable proportion of all *** lack of awareness of rare cancers among healthcare professionals and the general public,the typically complex and delayed diagnosis,and limited access to clinical trials are key *** years have witnessed an increase in funding for research related to rare cancers in *** this review,we provide a comprehensive overview of rare cancers and summarize the status of research on rare cancers in China and overseas,including the trends of funding and *** also highlight the challenges and perspectives regarding rare cancers in China.

关键词： rare cancers basic research clinical research preclinical model funding scheme