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Dose escalation of adalimumab as a strategy to overcome anti-drug antibodies:A case report of infantile-onset inflammatory bowel disease

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World Journal of Gastroenterology 2023年第38期29卷 5428-5434页

作者： Silvana Ancona Sara Signa Chiara Longo Giuliana Cangemi Roberta Carfora Enrico Drago Alessandro La Rosa Marco Crocco Andrea Chiaro Paolo Gandullia Serena Arrigo Dipartimento di Neuroscienze RiabilitazioneOftalmologiaGenetica e Scienze Materno-Infantili(DINOGMI)Universitàdegli Studi di GenovaGenova 16126Italy Pediatric Gastroenterology and Endoscopy Unit IRCCS Istituto Giannina GasliniGenova 16147Italy Chromatography and Mass Spectrometry Section Central Laboratory of AnalysisIRCCS Istituto Giannina GasliniGenova 16147Italy

BACKGROUND Treatment of infantile-onset inflammatory bowel disease(IO-IBD)is often challenging due to its aggressive disease course and failure of standard therapies with a need for *** loss of response is frequently caused by the production of anti-drug antibodies,a well-known problem in IBD patients on biologic *** present a case of IO-IBD treated with therapeutic drug monitoring(TDM)-guided high-dose anti-tumor necrosis factor therapy,in which dose escalation monitoring was used as a strategy to overcome anti-drug *** SUMMARY A 5-mo-old boy presented with a history of persistent hematochezia from the 10th d of life,as well as relapsing perianal abscess and growth ***,anemia,and elevated inflammatory markers were also *** assessment revealed skip lesions with deep colic ulcerations,inflammatory anal sub-stenosis,and deep fissures with persistent abscess.A diagnosis of IO-IBD Crohn-like was *** patient was initially treated with oral steroids and *** the perianal abscess healed,adalimumab(ADA)was administered with concomitant gradual tapering of *** and biochemical steroid-free remission was achieved with good trough *** 3 mo,antibodies to ADA(ATA)were found with undetectable trough levels;therefore,we optimized the therapy schedule,first administering 10 mg weekly and subsequently up to 20 mg weekly(2.8 mg/kg/dose).After 2 mo of high-dose treatment,ATA disappeared,with concomitant high trough levels and stable clinical and biochemical remission of the *** TDM-guided high-dose ADA treatment as a monotherapy overcame ATA *** strategy could be a good alternative to combination therapy,especially in very young patients.

关键词： Infantile-onset inflammatory bowel disease Adalimumab Loss of response Dose escalation Anti-drug antibodies Case report

Oral mucositis induced by risperidone:rare side effect of a frequently prescribed medication

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General Psychiatry 2020年第5期33卷 366-368页

作者： Andrea Aguglia Andrea Amerio Luca Proietti Alessandra Costanza Gianluca Serafini Mario Amore Department of Neuroscience RehabilitationOphthalmologyGeneticsMaternal and Child Health(DiNOGMI)Section of PsychiatryUniversity of GenoaGenoaItaly IRCCS Ospedale Policlinico San Martino GenoaItaly Mood Disorders Program Tufts Medical CenterBostonMAUSA Department of Psychiatry Faculty of MedicineUniversity of Geneva(UNIGE)GenevaSwitzerland Department of Psychiatry ASO Santi Antonio e Biagio e Cesare Arrigo HospitalAlessandriaItaly

Risperidone is a safe second-generation antipsychotic which is rarely associated with the emergence of a few adverse effects,such as oral lesions and *** report the case of a 77-year-old woman affected by a neurocognitive disorder with psychotic features and treated with risperidone 2 mg/*** 1 week,she showed a burning mouth syndrome with oral lesions and risperidone was ***-induced oral ulcerations may be caused by the reduction of saliva protection with minor adverse effects related to oral movement disorders or impairment of the bacterial flora of saliva.

关键词： frequent medication impairment

Associations among depression, suicidal behavior, and quality of life in patients with human immunodeficiency virus

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World Journal of Virology 2015年第3期4卷 303-312页

作者： Gianluca Serafini Franco Montebovi Dorian A Lamis Denise Erbuto Paolo Girardi Mario Amore Maurizio Pompili Department of Neuroscience RehabilitationOphthalmologyGeneticsMaternal and Child Health (DINOGMI)Section of PsychiatryUniversity of Genoa Department of Neurosciences Suicide Prevention CenterSant’Andrea Hospital Department of Psychiatry and Behavioral Sciences Emory University School of Medicine

AIM: To investigate the potential associations among major depression, quality of life, and suicidal behavior in human immunodeficiency virus(HIV) patients. METHODS: A detailed MEDLINE search was carried out to identify all articles and book chapters in English published from January 1995 to January 2015. RESULTS: Based on the main findings, the prevalence of major depressive disorder(MDD) ranged from 14.0% to 27.2%. Furthermore, the prevalence of suicidal ideation varied from 13.6% to 31.0% whereas, attempted suicides were reported to range from 3.9% to 32.7%. Interestingly, various associated risk factors for both depression and suicide were identified in HIV patients. Finally, consistent associations were reported among MDD, suicidal ideation, and poor quality of life in individuals living with HIV. CONCLUSION: Although additional studies are needed to elucidate this complex association, our results suggest the importance of early detection of both MDD and suicidality in patients living with HIV.

关键词： Major depression Suicidal behavior Quality of life Human immunodeficiency virus infection

Nanotechnology meets atopic dermatitis: Current solutions, challenges and future prospects. Insights and implications from a systematic review of the literature

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Bioactive Materials 2019年第1期4卷 380-386页

作者： Giovanni Damiani Roberto Eggenhöffner Paolo Daniele Maria Pigatto Nicola Luigi Bragazzi Clinical Dermatology IRCCS Istituto Ortopedico GaleazziMilanItaly Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilanItaly Department of Dermatology Case Western Reserve UniversityClevelandOHUSA Young Dermatologists Italian Network Centro Studi GISEDBergamoItaly Department of Surgical Sciences and Integrated Diagnostics University of GenoaGenoaItaly Postgraduate School of Public Health Department of Health SciencesUniversity of GenoaGenoaItaly Laboratory for Industrial and Applied Mathematics(LIAM) Department of Mathematics and StatisticsYork UniversityTorontoOntarioCanada Department of Neuroscience RehabilitationOphthalmologyGenetics and Maternal/Child Sciences(DINOGMI)University of GenoaGenoaItaly

Atopic dermatitis is a chronic,relapsing,non-contiguous,exudative eczema/dermatitis,which represents a complex,multi-factorial disorder,due to an impairment of the stratum corneum *** available drugs have a low skin bioavailability and may give rise to severe adverse ***,including nanoparticles,liposomes,nano-gels,nano-mixtures,nano-emulsions and other nano-carriers,offer unprecedented solutions to these issues,enabling:i)the management of different clinical forms of atopic dermatitis,especially the recalcitrant ones,i)a better bio-availability and trans-dermal drug targeted delivery at the inflammation site,ii)dose control,iii)significant improvements both in clinical symptoms and immune responses,iv)with less adverse events being reported and a better safety ***,some nano-sized structures could amplify and even worsen symptoms in particularly susceptible ***,most studies included in the present systematic review have been conducted in-vitro or in-vivo,with few randomized controlled clinical trials(RCTs).Future investigations should adopt this design in order to enable scholars achieving robust findings and ***,given the above-mentioned shortcomings,further research in the field is urgently warranted.

关键词： Nanodermatology Nanobiotechnologies Atopic dermatitis

多发性硬化T1-SE与T1-GE序列上低信号病变的微结构变化程度:与“黑洞”定义的相关性

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国际医学放射学杂志 2020年第5期 622-622页

作者： C.Lapucci N.Romano S.Schiavi L.Saitta A.Uccelli G.Boffa 白晓燕 Department of Neuroscience Rehabilitation OphthalmologyGenetics Maternal and Child Health (DINOGMI) University of Genoa

摘要目的回顾性分析T-SE和T-GE序列在检测多发性硬化(MS)低信号病变中的不同表现,量化病变内微结构损伤的程度,并分析其与病人临床表现的相关性。方法共

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Cerebellum and neurodegenerative diseases:Beyond conventional magnetic resonance imaging

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World Journal of Radiology 2017年第10期9卷 371-388页

作者： Enricomaria Mormina Maria Petracca Giulia Bommarito Niccolò Piaggio Sirio Cocozza Matilde Inglese Department of Neurology Icahn School of Medicine at Mount Sinai Neuroradiology Unit Department of Biomedical Sciences and Morphological and Functional ImagesUniversity of Messina Department of Neuroscience Reproductive Sciences and OdontostomatologyUniversity of Naples Federico Ⅱ Depart-ment of Neuroscience RehabilitationOphthalmologyGenetics and Maternal and Child Health (DINOGMI)University of Genoa Department of Neuroradiology San Martino Hospital Department of Advanced Biomedical Sciences University of Naples Federico Ⅱ

The cerebellum plays a key role in movement control and in cognition and cerebellar involvement is described in several neurodegenerative *** conventional magnetic resonance imaging(MRI) is widely used for brain and cerebellar morphologic evaluation,advanced MRI techniques allow the investigation of cerebellar microstructural and functional ***,voxel-based morphometry,diffusion MRI based fiber tractography,resting state and task related functional MRI,perfusion,and proton MR spectroscopy are among the most common techniques applied to the study of *** the present review,after providing a brief description of each technique's advantages and limitations,we focus on their application to the study of cerebellar injury in major neurodegenerative diseases,such as multiple sclerosis,Parkinson's and Alzheimer's disease and hereditary ataxia.A brief introduction to the pathological substrate of cerebellar involvement is provided for each disease,followed by the review of MRI studies exploring structural and functional cerebellar abnormalities and by a discussion of the clinical relevance of MRI measures of cerebellar damage in terms of both clinical status and cognitive performance.

关键词： Cerebellum Neurodegenerative disease Ataxia Multiple sclerosis Parkinson’s disease Diffusion magnetic resonance imaging Tractography Volumetry Functional magnetic resonance imaging Alzheimer’s disease

一项临床可行的7 T方案用于多发性硬化皮质病变的识别

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国际医学放射学杂志 2020年第5期 629-629页

作者： S.Cocozza M.Cosottini A.Signori L.Fleysher M.M.El Mendili F.Lublin 白晓燕 Department of Neuroscience Rehabilitation OphthalmologyGenetics Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research (CEBR) University of Genoa

摘要目的旨在评估在适合临床研究的时间和解剖覆盖范围内,7 T MRI扫描序列用于识别多发性硬化(MS)病人皮质病变(CL)的能力。此外,通过研究确认CL的临床意义,检

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Inflammation in the anterior visual pathway in multiple sclerosis:what do the animal models teach us?

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Neuroimmunology and Neuroinflammation 2021年第3期8卷 185-202页

作者： Christian Cordano Claudia Ramos Sam Arnow Andrés Cruz-Herranz Caroline Guglielmetti MicheleIester Fabio Bandini UCSF Weill Institute for Neurosciences Department of NeurologyUniversity of CaliforniaSan FranciscoCA 94158USA Neurosciences Group of Antioquia School of MedicineUniversidad de AntioquiaMedellín050010Colombia Department of Physical Therapy and Rehabilitation Science University of CaliforniaSan Francisco-San FranciscoCA 94158USA Department of Neurosciences RehabilitationOphthalmologyGeneticsMaternal and Child Health(DiNOGMI)University of GenoaGenoa 16132Italy IRCCS Ospedale Policlinico San Martino Genoa 16132Italy Department of Neurology S.Paolo HospitalSavona 17100Italy

A provocative and overly reductive mantra is that"the back of the eye is the front of the brain".Retinal imaging techniques that take advantage of this"window"to the central nervous system can provide valuable information regarding injury to the nervous system with relative ease and with a limited burden to *** retina develops embryonically as part of the neuroectoderm,is made up principally of neurons and their supporting cells,and is synaptically tied to the central nervous system(CNS).This has led to significant interest in using retinal health as a biomarker for brain health-given the relatively limited accessibility of brain tissue in chronic neurodegenerative diseases that progress over *** retina is not truly part of the CNS,and as with much of brain imaging-the grounds for asserting the pathological specificity of retinal imaging is ***-based methods such as optical coherence tomography indirectly provide an opportunity to evaluate retinal neurodegeneration,while autopsy studies,histology and immunohistochemistry predominate as the methods that collect direct pathological *** understanding of pathological retinal lesions characteristic of demyelinating diseases,specifically diseases showing anterior visual pathway involvement,has grown significantly in recent ***,much of the underlying pathobiology of injury remain *** review aims to highlight the major pathological features of the retina in multiple sclerosis,and its most used animal models(experimental autoimmune encephalomyelitis and cuprizone),with a particular focus on n the role of inflammation.

关键词： Anterior visual pathway multiple sclerosis optical coherence tomography experimental autoimmune encephalomyelitis