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Psychological distress in Moroccan Patients with Hematological Malignancies and Its Impact on Their Quality of Life

Psycho-Oncologie 2023年第4期17卷 235-244页

作者： Maha Ouazzani Zineb El Khammar Nawal Oubelkacem Youssef Aboussaleh Hajar Masrour Moncef Maiouak Rhizlane Berrady Laboratoire de Nutrition Santéet EnvironnementDépartement de BiologieFacultédes SciencesUniversitéIbn TofailKenitra14000Maroc Service de Médecine Interne et d’oncohématologie CHU Hassan IIFès30050Maroc Laboratoire d’épidémiologie Facultéde Médecine et de Médecine DentaireFès30050Maroc

Introduction:la qualitéde vie des patients suivis pour une hémopathie maligne dépend non seulement du type de la maladie,de ses caractéristiques cliniques,biologiques et thérapeutiques,mais aussi de la santémentale du patient.L’objectif de notreétude est d’évaluer l’état psychologique des patients au diagnostic,de rechercher les facteurs associésàson altération et de préciser son impact sur la qualitéde vie des patients.Méthode:nous avons menéuneétude monocentrique transversale quiévalue la dépression,l’anxiétéet la qualitéde vie d’une population de patients atteints de syndromes lymphoprolifératifs sur une période de *** questionnaires ontétéutilisés au moment du diagnostic:le HAdS pour rechercher la dépression et l’anxiétéet le SF12échelle pourévaluer la qualitéde vie liéeàla santé.Résultat:Les cent patients ont acceptéde répondre aux *** patients sont suivis pour un lymphome malin non hodgkinien,une maladie de Hodgkin,et une leucémie lymphoïde *** sex-ratio(H/F)est de 1,*** prévalence des symptômes anxieux est de 70%avec 95%CI(61,01%;78,99%)et des symptômes dépressifs de 76%avec 95%CI(49,4%;82,6%)des *** analyse univariée,le caractère féminin est associéaux symptômes anxieux(p=0,008),etàl’altération de qualitéde vie mentale(p=0,02).Alors qu’en analyse multivariée,Les symptômes anxio-dépressifs sont significativement associésàun score de qualitéde vie faible aussi bien mentale que *** plus les symptômes anxieux sont corrélés au sexe féminin(ORA=20,50;95%CI[1,58–264,48]);et la douleur(ORA=12,33;95%CI[1,07–141,77]).Conclusion:la recherche de comorbidités psychologiques doit faire partie du diagnostic initial de cette population vulnérable pour une meilleure qualitéde vie.

关键词： dépression anxiété qualitéde vie liéàla santé lymphome

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Testing for hepatitis B virus alone does not increase vaccine coverage in non-immunized persons

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World Journal of Gastroenterology 2017年第38期23卷 7037-7046页

作者： Anders Boyd Julie Bottero Fabrice Carrat Joel Gozlan Hayette Rougier Pierre-Marie Girard Karine Lacombe Institute Pierre Louis d’épidémiologie et de SantéPublique(IPLESP UMRS 1136) INSERMSorbonne Universités Service de maladies infectieuses Hopital Saint-AntoineAP-HP département de santépublique Hopital Saint-AntoineAP-HP Laboratoire de Virologie Hopital Saint-AntoineAP-HP INSERM UMR_S1135 CIMI

AIM To determine whether hepatitis B virus(HBV)-testing could serve as a gateway to vaccinate non-immunized individuals in a low-prevalent *** Non-immunized subjects participating in a multi-center, HBV-testing campaign in Paris, France were identified and contacted via telephone 3-9 mo after testing in order to determine vaccination status. Vaccination coverage was evaluated in per-protocol(for all respondents) and intent-to-treat analysis(assuming all non-responders did not vaccinate).RESULTS In total, 1215/4924(24.7%) enrolled subjects with complete HBV serology were identified as nonimmunized and eligible for analysis. There were 99/902 successfully contacted subjects who had initiated HBV vaccination after screening: per-protocol, 11.0%(95%CI: 9.0-13.2); intent-to-treat, 8.2%(95%CI: 6.7-9.8). In multivariable analysis, vaccination was more likely to be initiated in individuals originating from moderate or high HBV-endemic countries(P d healthcare coverage(P = 0.01) and men who have sex with men(P = 0.02). When asked about the reasons for not initiating HBV vaccination, the most frequent response was "will be vaccinated later"(33.4%), followed by "did not want to vaccinate"(29.8%), and "vaccination was not proposed by the physician"(21.5%). Sub-group analysis indicated a stark contrast in vaccination coverage across centers, ranging from 0%-56%.CONCLUSION HBV-vaccination after HBV screening was very low in this study, which appeared largely attributed to physician-patient motivation towards vaccination. Increased vaccination coverage might be achieved by emphasizing its need at the organizational level.

关键词： Health service organization Hepatitis B virus vaccination Public health Testing intervention Vaccine coverage

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Interendoscopist variability in proximal colon polyp detection is twice higher for serrated polyps than adenomas

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World Journal of Gastroenterology 2016年第38期22卷 8549-8557页

作者： Jean-François Bretagne Stéphanie Hamonic Christine Piette Jean-François Viel Guillaume Bouguen Service des maladies de l'appareil digestif hopital PontchaillouCentre hospitalo-universitaire de Rennes35033 RennesFrance Service d'épidémiologie et de santé publique Centre hospitalo-universitaire de Rennes35033 Rennes France Association pour le dépistage des cancers en Ille et Vilaine 35033 RennesFrance

AIM To assess the interendoscopist variability in the detection of colorectal polyps according to their location and histological *** This study was a retrospective analysis of prospectively collected data from a regional colorectal cancer(CRC) screening program; 2979 complete colonoscopies from 18 endoscopists were included. Variability in performance between endoscopists for detection of at least one adenoma(A), one proximal adenoma(PA), one distal adenoma(dA), and one proximal serrated polyp(PSP) was assessed by using multilevel logistic regression *** The observed detection rates among the 18 endoscopists ranged from 24.6% to 47.6%(mean = 35.7%) for A, from 19.1% to 39.0%(mean = 29.4%) for dA, from 6.0% to 22.9%(mean = 12.4%) for PA, and from 1.3% to 19.3%(mean = 6.9%) for *** adjusting for patient-level variables(sex, age), the interendoscopist detection rates variability achieved a significant level for A, PA, and PSP but not for dA(P = 0.03, P = 0.02, P = 0.02 and P = 0.08, respectively). This heterogeneity, as measured by the variance partition coefficient, was approximately threefold higher for PA(6.6%) compared with A(2.1%), and twofold higher for PSP(12.3%) compared with *** These results demonstrate significant interendoscopist variability for proximal polyp particularly for serrated p o l y p s, b u t n o t f o r d i s t a l a d e n o m a d e t e c t i o n. These findings contribute to explain the decreased effectiveness of complete colonoscopies at preventing proximal CRCs and the need to carefully assess the proximal colon during scope procedure.

关键词： Colonoscopy Colorectal cancer Adenoma Serrated polyp Proximal polyp detection rate Quality performance

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How French general practitioners adapt their care to patients with social difficulties?

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Family Medicine and Community Health 2019年第4期7卷 10-17页

作者： Annie de Oliveira Barbara Chavannes Magali Steinecker Mady denantes Julie Chastang Gladys Ibanez department of General Practice Medicine Sorbonne UniversityParisFrance Sorbonne Université INSERMInstitut Pierre Louis d’Épidémiologie et de SantéPublique(IPLESP)F75012ParisFrance

Objective Several studies have shown the role of the primary care system in access to care and in reducing social inequalities in *** objective of this study was to describe the practices of general practitioners(GPs)in taking into account the social environment of their patient,and the ways they adapted to social *** Qualitative study comprising interviews and focus *** French primary care *** Twenty semistructured interviews and two focus groups were conducted with 33 *** were audio recorded,transcribed verbatim and analysed using thematic *** reporting of findings was guided by consolidated criteria for reporting qualitative *** This study identified adaptations at three levels:in the individual management of patients(alert system,full involvement in prevention,better communication,prioritised additional examinations,financial facilities,help in administrative tasks),in the collective management of patients in an office(consultation without appointment,pay-for performance indicators,medical staffs,multidisciplinary protocols,medical practice in group,medical student),and in the community management(patients description,cooperation with associations,public health sector and politics).Conclusion In France,GPs can take into account the social determinants of health in practice through simple or more complex actions.

关键词： patients prevention collective

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Evaluation of the Quality of Hospital-Based Management of Severe Acute Malnutrition in Children under 5 in Benin

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Food and Nutrition Sciences 2017年第11期8卷 1012-1021页

作者： Tchasso Serge Kenao Charles Sossa Jerome Yolaine Glèlè Ahanhanzo Ghislain Emmanuel Sopoh Patrick Makoutodé Victoire damienne Agueh département de Promotion de la Santé Institut Régional de Santé Publique Université d’Abomey-Calavi Abomey Calavi Bénin département d’épidémiologie et de biostatistique Institut Régional de Santé Publique Université d’Abomey-Calavi Abomey Calavi Bénin département de Santé et Environnement Institut Régional de Santé Publique Université d’Abomey-Calavi Abomey Calavi Bénin département de Politique et Système de Santé Institut Régional de Santé Publique Université d’Abomey-Calavi Abomey Calavi Bénin

Introduction: The aim of the study was to assess the quality of the management of severe acute malnutrition in the Mono departmental Hospital Center (CHd) in Benin. Methods: This was a cross-sectional and evaluative study which took place from 03 February to 20 July 2016. The study was carried out in the mono departmental hospital of Lokossa. The non-probabilistic sampling method was used to select all our study materials and all our targets were systematically selected. Our study materials involved observation checklist, guidelines documents and questionnaires to collect data. The assessment of the quality of the hospital management of severe acute malnutrition was based on national and international standards like Benin’s national protocol of acute malnutrition management. Results: In our study, 27 cases of severe acute malnutrition (SAM) in children were considered. The median age of those children was 12 months. The rates of the components inputs, process and results were 25% (poor), 58.33% (acceptable) and 40% (poor), respectively. The sub components with respect to the norms were all related to the management of severe acute malnutrition like, availability of therapeutic foods ready for use, availability of management protocol, availability of trained and supervised staff in the management of the severe acute malnutrition and the proportion of dead and cured children. The study showed that the quality of the management of severe acute malnutrition at the mono departmental hospital of Lokossa was poor with a rate of 41.38%. Conclusion: The quality of the management of severe acute malnutrition at the mono departmental hospital of Lokossa was poor. The sub components that need to improve were the availability of therapeutic foods ready for use, availability of management protocol, along with the training and supervision of staff in charge of the management of severe acute malnutrition.

关键词： Evaluation Severe Acute Malnutrition Benin

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Validity of the French version of Catquest-9SF and use of an electronic notepad for entering patient-reported outcome measures

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Eye and Vision 2021年第1期8卷 92-100页

作者： Gregory Katz Alexandra Rouquette François Lignereux Thierry Mourgues Michel Weber Mats Lundström Chair of Innovation&Value in Health University of Paris School of MedicineParisFrance Value-Based Health Care Consortium ParisFrance Prom-Time ParisFrance Service de SantéPublique et d’Épidémiologie AP-HP Paris-SaclayLe Kremlin-BicêtreFrance Centre de recherche enÉpidémiologie et Santédes Populations InsermUniversitéParis-SaclayVillejuifFrance Ophtalmologie Chénieux Polyclinique de LimogesLimogesFrance Institut Ophtalmologique Sourdille-Atlantique Elsan SantéAtlantiqueNantesFrance Ophthalmology department Centre Hospitalier-Universitaire de NantesNantesFrance department of Clinical Sciences OphthalmologyFaculty of MedicineLund UniversityLundSweden

Background:The Catquest-9SF questionnaire is a patient reported outcome measure that quantifies the visual benefits from cataract *** purpose of this study was to translate and adapt the Catquest-9SF questionnaire for France,to assess its psychometric properties via Rasch analysis,and to assess its validity when completed using an electronic ***:The Catquest-9SF questionnaire was translated following the guidelines of the International Society for Pharmacoeconomics and Outcomes ***-9SF and clinical data were collected from patients before and after routine cataract *** questionnaire data were collected via an electronic *** analysis was performed to assess psychometric properties,and sensitivity to change was analysed for patients with complete paired pre-and post-operative ***:A complete filled-in preoperative questionnaire was obtained for 848 *** analysis showed good precision(person separation:2.32,person reliability:0.84),ordered category probability curves,no item misfit,and *** respondents were slightly more able than the level of item difficulty(targeting:−1.12 logits).Sensitivity was analysed on 211 paired questionnaires,and the postoperative questionnaires showed a clear ceiling *** effect size was *** use of an electronic notepad for completing the questionnaire worked out very well after some ***:The French version of Catquest-9SF has good psychometric properties and is suitable for use in French-speaking *** use of the Catquest-9SF questionnaire in an electronic format showed good validity.

关键词： Cataracts Patient-related outcome measures Quality of life Questionnaire Value-based health care Catquest-9SF

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From Research data to Intervention Models: Intervening with All Stakeholders

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Psycho-Oncologie 2023年第3期17卷 109-112页

作者： Louise Potvin Grégory Ninot Sabine dutheil Anne-Fleur Guillemin Jérôme Foucaud department de Médecine sociale et préventive Ecole de santépublique de l’Universitéde MontréalMontréalQuébecQCH3N 1X7Canada Institut desbrest d’Epidémiologie et de santéPublique(Universitéde Montpellier-INSERM) Montpellier34093France Institut du Cancer de Montpellier Montpellier34298France Institut du Sein d’Aquitaine Clinique TivoliBordeaux33000France department recherche en sciences humaines et sociales Épidémiologie et santépubliqueInstitut national du cancer(INCa)Boulogne-Billancourt92513France

[French version]En tant que dispositif de recherche innovant pour développer et mettre en oeuvre les préventions,la recherche interventionnelle en santédes populations(RISP)occupe une place particulière dans le d... 详细信息

关键词： les dis des

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2010—2013年法国的大学附属医院儿科儿童接受的个体CT辐射暴露的调查

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国际医学放射学杂志 2018年第2期 244-245页

作者： N.M.Y.Journy S.dreuil N.Boddaert J.F.Chateil d.defez H.ducoule-Pointe 张文杰 Laboratoire d’épidémiologie des rayonnements ionisants Unité Radioprotection de l ’Homme Institut de Radioprotection et de Sureté Nucléaire

摘要目的描述CT在儿科实践中的扫描参数、CT容积剂量指数(CTdIvol)和剂量长度乘积（dLP）,并将其与当前的CT诊断参考水平（dRL）进行比较。方法 2010—2013年期

关键词：扫描参数 dLP 大学附属医院 CT

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Hypofractionated Radiation Therapy for the Treatment of Breast Cancer: Experience of National Institute of Oncology, Rabat, Morocco

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Journal of Cancer Therapy 2016年第10期7卷 773-783页

作者： A. S. Koné A. diakité S. Ahid I. M. diarra K. diabaté R. Abouqal Y. Cherrah N. Benjaafar Service de Radiothérapie Institut National d’Oncologie de Rabat Rabat Morocco Laboratoire de Pharmacologie & Toxicologie Faculté de Médecine et de pharmacie de Rabat Rabat Morocco Laboratoire de biostatistique de Recherche Clinique et d’Epidémiologie Faculté de Médecine et de pharmacie de Rabat Rabat Morocco

Hypofractionated radiation therapy has proven effective on locoregional control and tolerance in the adjuvant treatment of breast cancer. The aim of this study is to compare the results of hypofractionated radiation therapy versus conventional radiation therapy in terms of local control and tolerance. It was a retrospective study of patients observations collected from January 2007 to december 2008 in department of Radiation Therapy in Institut National d’Oncologie de Rabat. The treatment results were evaluated by the rate of locoregional recurrence, distant recurrence and research of late toxicities. Radiotherapy was delivered using the same technique in both groups, by gamma photons of cobalt 60 with an energy of 1.25 MeV. They were 2 groups: the first group treated with standard dose rate and the second group treated by hypofractionated radiation therapy. The mean age of the patients was 42.8 ± 6.9 years old in the standard group and 43.22 ± 7.2 years old in the hypofractionation group. We noted a predominance of infiltrating ductal carcinoma. The majority of patients were pT2, pN0 and pN1. The majority of patients had radical surgery and chemotherapy with anthracyclines in both groups. We noted a statistically significant difference in the irradiation of chest wall between the standard (89.2%) and hypofractionated group (70.3%), with p = 0.043. The median duration of radiation therapy was statistically different in both groups: 39 days in the standard and 23 days in the hypofractionated group (p 0.001). The local recurrences were statistically identical to 12 and 24 months (p = 0.999). Concerning toxicities, the frequency of adverse event was similar in both groups. Hypofractionated radiation therapy with a total dose of 42 Gy at 2.8 Gy per fraction in 5 fractions weekly is comparable to standard radiotherapy in terms of local control and tolerance and is therefore a very good alternative to standard treatment.

关键词： Hypofractionated Radiation Therapy Breast Cancer Local Control Tolerance

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Phenotipic Prevalence of Antibiotic Resistance in Gabon

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Open Journal of Medical Microbiology 2021年第2期11卷 100-118页

作者： Annicet-Clotaire dikoumba Richard Onanga Pierre Philippe Mbehang Nguema Laurette G. Mangouka Berthe Amélie Iroungou Fabrice Kassa Kassa Berthold Bivigou Mboumba Elvire Mbongo Kama Jean-Fabrice Yala Edgard-Brice Ngoungou Sylvain Godreuil Hô pital d’Instruction des Armées Omar Bongo Ondimba Département de biologie médicale Libreville Gabon Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF) Laboratoire de Bactériologie de Recherche Unité de recherche et d’Analyses Médicales (URAM) Franceville Gabon Centre Hospitalier Universitaire de Montpellier Laboratoire de Bactériologie France Institut de Recherche en Ecologie Tropicale (IRet/CENAREST) Département Ecologie animale Libreville Gabon Hô pital d’Instruction des Armées Omar Bongo Ondimba Département de Médecine Libreville Gabon Unité mixte de Recherche Santé Militaire/CIRMF Libreville Gabon Université des sciences et techniques de Masuku (USTM) Laboratoire de Biologie Moléculaire et Cellulaire équipe de Microbiologie et Immunologie Franceville Gabon Université des Sciences de la Santé Faculté de Médecine Département d’Epidémiologie Biostatistiques et Informatique Médicale (DEBIM)/Unité de Recherche en Epidémiologie des Maladies Chroniques et Santé Environnement (UREMCSE) Libreville Gabon MIVEGEC IRD CNRS Université de Montpellier Montpellier France

Background: The increasing phenomenon of bacterial resistance to antibiotics is a real public health problem. The main causes are poor management of hygiene and water quality, but also the use of antibiotics without precaution. The objective of this study was to isolate and determine the antibiotic resistance profile of the different bacteria found in the main hospitals and bacteriology laboratories in Gabon. Methods: 6034 samples were taken from hospitals in seven main cities of Gabon, and analyzed according to the usual techniques. The pathogenic strains were identified by Matrix-Assisted Laser Desorption Ionization-Time Of Flight Mass Spectrometry. Antimicrobial susceptibility testing was performed by the agar disc diffusion method, according to the Antibiogram Committee of the French Society for Microbiology guidelines. Results: 974 pathogenic bacterial strains were found, including 890/974 (91.4%) Gram-negative bacilli. The systematic antimicrobial susceptibility testings identified 160/974 (16.4%) multi-resistant strains. Escherichia coli was the most represented species. 12.5% - 25% of Escherichia coli, Klebsiel

关键词： Gabon Antibiotic Resistance Profiles Methicillin-Resistant S. aureus (MRSA) Extended Spectrum Beta-Lactamase-Producing Enterobacteriaceae (ESBL-PE) Carbapenems

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