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Submicron Ag-coated Cu particles as filler in sintering paste: Suppression of Ag dewetting and improvement of sinterability by surface modification using stearic acid

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Transactions of Nonferrous Metals Society of China 2024年

作者： Yeongjung Kim Yong-Sung Eom Kwang-Seong Choi Jong-Hyun Lee Department of Materials Science and Engineering， Seoul National University of Science and Technology， 232 Gongneung-ro Low-Carbon Integration Tech， creative research section， ETRI， 218 Gajeong-ro Materials research Institute for Future Convergence， Seoul National University of Science and Technology， 232 Gongneung-ro

Four types of submicron Ag-coated Cu particles with different Ag contents were prepared as sintering paste fillers， and the Ag contents of the particles were measured to be 10， 20， 30， and 40 wt%. Four types of particles （in order of increasing Ag content: A10， A20， A30， and A40） were surface-modified with stearic acid， to suppress the Ag shell dewetting and improve sinterability. The surface-modified particles were mixed with a polyol-based solvent to fabricate a resin-free paste. Subsequently， the pastes were screen-printed onto a slide glass and sintered at 250 ℃ in a nitrogen atmosphere for 1–10 min to form an electrode. The electrical resistivity of the sintered film as a function of sintering time was measured using a four-point probe. All the four surface-modified Cu@Ag particles with different Ag contents exhibited decreased electrical resistivity. Particularly， the largest difference in values after and before the surface modification was observed for A40 with the highest Ag content; the electrical resistivities of the initial and surface-modified particles were 1.51×10-4and 6.67×10-5Ω·cm， respectively， after sintering for 10 min. The findings of this study confirmed that the surface modification using stearic acid effectively suppressed the dewetting of the Ag shell and improved the sinterability of the submicron Cu@Ag particles.

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High-temperature corrosion of sintered RE_(2)Si_(2)O_(7)(RE=Yb and Ho)environmental barrier coating materials by volcanic ash

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1628-1638页

作者： Ayahisa Okawa Son Thanh Nguyen Tadachika Nakayama Thi-Mai-Dung Do Hisayuki Suematsu Shu Yin Takuya Hasegawa Tsuneo Suzuki Takashi Goto Koichi Niihara Institute of Multidisciplinary research for Advanced Materials Tohoku UniversitySendai 980-8577Japan Department of creative Engineering National Institute of TechnologyKushiro 084-0916Japan Extreme Energy-Density research Institute Nagaoka University of TechnologyNagaoka 940-2188Japan Advanced Institute for Materials research(WPI-AIMR) Tohoku UniversitySendai 980-8577Japan

Rare-earth silicates are promising environmental barrier coatings(EBCs)that can protect SiC_(f)/Si C_(m)substrates in next-genera tion gas turbine ***,RE_(2)Si_(2)O_(7)(RE=Yb and Ho)shows potential as an EBC due to its coefficient of thermal expansion(CTE)compatible with substrates and high resistance to water vapor *** target operating temperature for next-generation tur bine blades is 1400°*** is inevitable during adhesion to molten volcanic ash,and thus,understanding the corrosion behavior o the material is crucial to its *** study investigates the high-temperature corrosion behavior of sintered RE_(2)Si_(2)O_(7)(RE=Yb and Ho).Samples were prepared using a solid-state reaction and hot-press *** were then exposed to volcanic ash at 1400°C for 224,and 48 *** 48 h of exposure,volcanic ash did not react with Yb_(2)Si_(2)O_(7)but penetrated its interior,causing *** Ho_(2)Si_(2)O_(7)was partially dissolved in the molten volcanic ash,forming a reaction zone that prevented volcanic ash melts from penetrating the *** increasing heat treatment time,the reaction zone expanded,and the thickness of the acicular apatite grains increased The Ca:Si ratios in the residual volcanic ash were mostly unchanged for Yb_(2)Si_(2)O_(7)but decreased considerably over time for Ho_(2)Si_(2)O_(7).Th Ca in volcanic ash was consumed and formed apatite,indicating that RE^(3+)ions with large ionic radii(Ho>Yb)easily precipitated apatit from the volcanic ash.

关键词： environmental barrier coating volcanic ash rare-earth disilicate corrosion

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Investigating epithelial-neuronal signaling contribution in visceral pain through colon organoid-dorsal root ganglion neuron co-cultures

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Neural Regeneration research 2024年第6期19卷 1199-1200页

作者： Francesco Margiotia Lorenzo Di Cesare Mannelli Antonino Morabito Carla Ghelardini Elena Lucarini Department of Neuroscience Psychology Drug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology Section University of Florence Department of Neuroscience Psychology Drug Research and Child Health-NEUROFARBA University of Florence 3. Meyer Children's Hospital IRCCS

Abdominal pain is a common symptom associated with irritable bowel syndrome and inflammatory bowel diseases(IBDs), affecting about 20% of the global population(Grundy et al., 2019). Current pain therapies are poorly effective on visceral pain of intestinal origin and present several side effects, hence the need to identify novel molecular and cellular targets for drug development. The pathophysiology of visceral-abdominal pain,

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Improving Network Availability through Optimized Multipath Routing and Incremental Deployment Strategies

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Computers, Materials & Continua 2024年第7期80卷 427-448页

作者： Wei Zhang Haijun Geng Computer Application Teaching and research section China University of Labor RelationsBeijing100048China School of Automation and Software Engineering Shanxi UniversityTaiyuan030006China

Currently,distributed routing protocols are constrained by offering a single path between any pair of nodes,thereby limiting the potential throughput and overall network *** approach not only restricts the flow of data but also makes the network susceptible to failures in case the primary path is *** contrast,routing protocols that leverage multiple paths within the network offer a more resilient and efficient *** routing,as a fundamental concept,surpasses the limitations of traditional shortest path first *** not only redirects traffic to unused resources,effectively mitigating network congestion,but also ensures load balancing across the *** optimization significantly improves network utilization and boosts the overall performance,making it a widely recognized efficient method for enhancing network *** further strengthen network resilience against failures,we introduce a routing scheme known as Multiple Nodes with at least Two Choices(MNTC).This innovative approach aims to significantly enhance network availability by providing each node with at least two routing *** doing so,it not only reduces the dependency on a single path but also creates redundant paths that can be utilized in case of failures,thereby enhancing the overall resilience of the *** ensure the optimal placement of nodes,we propose three incremental deployment *** algorithms carefully select the most suitable set of nodes for deployment,taking into account various factors such as node connectivity,traffic patterns,and network *** deployingMNTCon a carefully chosen set of nodes,we can significantly enhance network reliability without the need for a complete overhaul of the existing *** have conducted extensive evaluations of MNTC in diverse topological spaces,demonstrating its effectiveness in maintaining high network availability with minimal path *** results are impressive,sh

关键词： Multipath routing network availability incremental deployment schemes genetic algorithm

DNBP-CCA:A Novel Approach to Enhancing Heterogeneous Data Traffic and Reliable Data Transmission for Body Area Network

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Computers, Materials & Continua 2024年第5期79卷 2851-2878页

作者： Abdulwadood Alawadhi Mohd.Hasbullah Omar Abdullah Almogahed Noradila Nordin Salman A.Alqahtani Atif M.Alamri InterNetWorks research Laboratory School of ComputingUniversiti Utara MalaysiaSintok06010Malaysia Faculty of Computer Science and Information Technology Universiti Tun Hussein Onn MalaysiaParit RajaJohor86400Malaysia School of Games&creative Technology University for the Creative ArtsFarnhamGU97DSUK Computer Engineering Department College of Computer and Information SciencesKing Saud UniversityRiyadh11543Saudi Arabia Software Engineering Department College of Computer and Information SciencesKing Saud UniversityRiyadh11543Saudi Arabia

The increased adoption of Internet of Medical Things (IoMT) technologies has resulted in the widespread use ofBody Area Networks (BANs) in medical and non-medical domains. However, the performance of IEEE 802.15.4-based BANs is impacted by challenges related to heterogeneous data traffic requirements among nodes, includingcontention during finite backoff periods, association delays, and traffic channel access through clear channelassessment (CCA) algorithms. These challenges lead to increased packet collisions, queuing delays, retransmissions,and the neglect of critical traffic, thereby hindering performance indicators such as throughput, packet deliveryratio, packet drop rate, and packet delay. Therefore, we propose Dynamic Next Backoff Period and Clear ChannelAssessment (DNBP-CCA) schemes to address these issues. The DNBP-CCA schemes leverage a combination ofthe Dynamic Next Backoff Period (DNBP) scheme and the Dynamic Next Clear Channel Assessment (DNCCA)scheme. The DNBP scheme employs a fuzzy Takagi, Sugeno, and Kang (TSK) model’s inference system toquantitatively analyze backoff exponent, channel clearance, collision ratio, and data rate as input parameters. Onthe other hand, the DNCCA scheme dynamically adapts the CCA process based on requested data transmission tothe coordinator, considering input parameters such as buffer status ratio and acknowledgement ratio. As a result,simulations demonstrate that our proposed schemes are better than some existing representative approaches andenhance data transmission, reduce node collisions, improve average throughput, and packet delivery ratio, anddecrease average packet drop rate and packet delay.

关键词： Internet of Medical Things body area networks backoff period tsk fuzzy model clear channel assessment media access control

RNA modifications in the progression of liver diseases: from fatty liver to cancer

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Science China Life Sciences 2024年第10期67卷 2105-2119页

作者： Simiao Li Wajahat Z Mehal Xinshou Ouyang Department of Internal Medicine Section of Digestive DiseasesYale University School of Medicine

Non-alcoholic fatty liver disease（NAFLD） has emerged as a prominent global health concern associated with high risk of metabolic syndrome, and has impacted a substantial segment of the population. The disease spectrum ranges from simple fatty liver to non-alcoholic steatohepatitis（NASH）, which can progress to cirrhosis and hepatocellular carcinoma（HCC） and is increasingly becoming a prevalent indication for liver transplantation. The existing therapeutic options for NAFLD, NASH, and HCC are limited, underscoring the urgent need for innovative treatment strategies. Insights into gene expression, particularly RNA modifications such as N6methyladenosine（m6A）, hold promising avenues for interventions. These modifications play integral roles in RNA metabolism and cellular functions, encompassing the entire NAFLD-NASH-HCC progression. This review will encompass recent insights on diverse RNA modifications, including m6A, pseudouridine（Ψ）, N1-methyladenosine（m1A）, and 5-methylcytidine（m5C） across various RNA species. It will uncover their significance in crucial aspects such as steatosis, inflammation, fibrosis, and tumorigenesis. Furthermore, prospective research directions and therapeutic implications will be explored, advancing our comprehensive understanding of the intricate interconnected nature of these pathological conditions.

关键词： m6A RNA modification NASH NAFLD HCC fatty liver

DNA-delivered monoclonal antibodies targeting the p53 R175H mutant epitope inhibit tumor development in mice

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Genes & Diseases 2024年第4期11卷 368-380页

作者： Dafei Chai Xu Wang Praveen Neeli Shan Zhou Xingfang Yu Kanaga Sabapathy Yong Li Department of Medicine Section of Epidemiology and Population SciencesDan L Duncan Comprehensive Cancer CenterBaylor College of MedicineHoustonTX 77030USA Division of Cellular&Molecular research Humphrey Oei Institute of Cancer ResearchNational Cancer Centre SingaporeSingapore 168583Singapore

tThe tumor suppressor p53 is the most common mutated gene in cancer,with the R175H as the most frequent p53 missense ***,there are currently no approved targeted therapies or immunotherapies against mutant ***,we characterized and inves-tigated a monoclonal antibody(mAb)that recognizes the mutant p53-R175H for its affinity,specificity,and activity against tumor cells in *** then delivered DNA plasmids expres-sing the anti-R175H mAb or a bispecific antibody(BsAb)into mice to evaluate their therapeutic *** results showed that the anti-R175H mAb specifically bound to the p53-R175H an-tigen with a high affinity and recognized the human mutant p53-R175H antigen expressed on HEK293T or MC38 cells,with no cross-reactivity with wild-type *** cultured cells,the anti-R175H mAb showed higher cytotoxicity than the control but did not induce antibody-dependent cellular *** made a recombinant MC38 mouse cell line(MC38-p53-R175H)that overexpressed the human p53-R175H after knocking out the endogenous mutant p53 *** vivo,administration of the anti-R175H mAb plasmid elicited a robust anti-tumor effect against MC38-p53-R175H in *** administration of the anti-R175H BsAb plasmid showed no therapeutic effects,yet potent anti-tumor activity was observed in combination with the anti-PD-1 *** results indicate that targeting specific mutant epitopes using DNA-delivered mAbs or BsAbs presents a form of improved natural immunity derived from tumor-infiltrating B cells and plasma cells against intracellular tumor antigens.

关键词： BsAb Cytotoxicity mAb Mutant p53 PD-1 R175H

Stoichiometric Ti3C2Tx Coating for Inhibiting Dendrite Growth in Anode-Free Lithium Metal Batteries

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Energy & Environmental Materials 2024年第4期7卷 153-162页

作者： Xiangrong Zeng Manmatha Mahato Woong Oh Hyunjoon Yoo Van Hiep Nguyen Saewoong Oh Geetha Valurouthu Soon-Ki Jeong Chi Won Ahn Yury Gogotsi Il-Kwon Oh National creative research Initiative for Functionally Antagonistic Nano-Engineering Department of Mechanical Engineering Korea Advanced Institute of Science and Technology (KAIST) Department of Materials Science & Engineering and A. J. Drexel Nanomaterials Institute Drexel University Department of Energy Engineering Soonchunhyang University National Nanofab Center (NNFC) Korea Advanced Institute of Science and Technology (KAIST)

Lithium metal batteries (LMBs) and anode-free LMBs (AFLMBs) present a solution to the need for batteries with a significantly superior theoretical energy ***,their adoption is hindered by low Coulombic efficiency (CE) and rapid capacity fading,primarily due to the formation of unstable solid electrolyte interphase (SEI) layer and Li dendrite growth as a result of uneven Li plating.

关键词： anode-free lithium metal batteries stoichiometric MXene solid electrolyte interphase surface terminations

Anoctamin 4 defines glucose-inhibited neurons in the ventromedial hypothalamus

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Neural Regeneration research 2024年第6期19卷 1177-1178页

作者： Longlong Tu Yanlin He Yong Xu Children's Nutrition research Center Department of Pediatrics Baylor College of Medicine Department of Molecular and Cellular Biology Section of Endocrinology Diabetes and Metabolism Department of Medicine Baylor College of Medicine Brain Glycemic and Metabolism Control Department Pennington Biomedical Research Center Louisiana State University

Glucose is the primary fuel source of the brain,and therefore glucose levels need to be tightly regulated and maintained within a small physiological ***,the body necessitates a stable supply of energy mainly provided by glucose for various bodily *** or low blood glucose levels would impair the physiological functions of various organs of the *** high blood glucose(i.e.,

关键词： HYPOGLYCEMIA