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Microstructure and Shear Properties Evolution of Minor Fe-doped SAC/Cu Substrate Solder Joint under Isothermal Aging

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1279-1290页

作者： Quanzhen Li Chengming Li Xiaojing Wang Shanshan Cai Jubo Peng Shujin Chen Jiajun Wang Xiaohong Yuan Jiangsu University of Science and Technology Zhenjiang212003China r&d center Yunnan Tin Group(Holding)Co.LtdKunming650000China The 58 Research Institute of China Electronics Technology Group CorporationWuxi214100China Yunnan Precious Metals Lab Sino-Platinum Metals Co.LtdKunming650156China

different amounts of Fe(0.005,0.01,0.03,0.05,and 0.07 wt%)were added to SAC305 to study the shear behavior damage of Fe-doped SAC solder joints under thermal loading(170℃,holding time of 0,250,500,and 750 h).The results show that during isothermal aging at 170℃,the average shear force of all solder joints decreases with increasing aging time,while the average fracture energy first increases and then decreases,reaching a maximum at 500 *** Fe doping could both increase shear forces and related fracture energy,with the optimum Fe doping amount being 0.03 wt%within the entire aging *** is because the doping Fe reduces the undercooling of the SAC305 alloy,resulting in the microstructure refining of solder *** in turn causes the microstructure changing from network structure(SAC305 joint:eutectic network+β-Sn)to a single matrix structure(0.03Fe-doped SAC305 joint:β-Sn matrix+small compound particles).Specifically,Fe atoms can replace some Cu in Cu_(6)Sn_(5)(both inside the solder joint and at the interface),and then form(Cu,Fe)_(6)Sn_(5) compounds,resulting in an increase in the elastic modulus and nanohardness of the ***,the growth of Cu_(6)Sn_(5) and Cu_(3)Sn intermetallic compounds(IMC)layer are inhibited by Fe doping even after the aging time prolonging,and Fe aggregates near the interface compound to form FeSn_(2).This study is of great significance for controlling the growth of interfacial compounds,stabilizing the microstructures,and providing strengthening strategy for solder joint alloy design.

关键词： SAC305 solder Fe doping Shear mechanical behavior Isothermal aging Interfacial intermetallic compounds(IMC)

recent Advances in deciphering the Mechanisms and Biological Functions of dNA demethylation

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Chinese Journal of Chemistry 2024年第6期42卷 645-651页

作者： Yang Feng Sheng-Jun Chen Bi-Feng Yuan Key Laboratory of Aquatic Product Processing Ministry of Agriculture and Rural AffairsNational R&D Center for Aquatic Product ProcessingSouth China Sea Fisheries Research InstituteChinese Academy of Fishery SciencesGuangzhouGuangdong510300 China School of Public Health Research Center of Public HealthRenmin Hospital of Wuhan UniversityWuhan UniversityWuhanHubei430071 China

5-Methylcytosine (5mC) is a dynamic and reversible epigenetic modification in genomic dNA of higher *** has been well-established that the demethylation of 5mC occurs through the ten-eleven translocation (TET)-mediated oxidation of 5mC followed by thymine dNA glycosylase (TdG)-initiated base excision repair (BEr).recent findings also have identified an alternative pathway of dNA *** this pathway,TET enzymes directly oxidize 5mC to form 5-formylcytosine (5fC) or 5-carboxylcytosine (5caC).These modified bases can undergo direct deformylation or decarboxylation,***,dNA demethylation can also occur through the deamination of 5mC and 5hmC,resulting in the production of thymine and 5-hydroxymethyluracil (5hmU),*** dNA demethylation pathways possess critical functional implications and roles in biological *** recent Advances article will focus on the studies of mechanisms and biological functions of dNA demethylation,shedding light on the reversible nature of the epigenetic modification of 5mC.

关键词： Epigenetics dNA dNA methylation 5-Methylcytosine demethylation Mechanisms Biological functions C—C bond cleavage Mass spectrometry

The AaBBX21–AaHY5 module mediates light-regulated artemisinin biosynthesis in Artemisia annua L.

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Journal of Integrative Plant Biology 2024年第8期66卷 1735-1751页

作者： Weizhi He Hang Liu Zhangkuanyu Wu Qing Miao Xinyi Hu Xin Yan Hangyu Wen Yaojie Zhang Xueqing Fu Li ren Kexuan Tang Ling Li Frontiers Science center for Transformative Molecules Joint International ResearchLaboratory of Metabolic and Developmental SciencesKey Laboratory of Urban Agriculture(South)Ministry of AgriculturePlant Biotechnology Research CenterFudan-SJTU-Nottingham Plant Biotechnology R&D CenterSchool of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Institute for Agri-Food Standards and Testing Technology Shanghai Academy of Agricultural SciencesShanghai 201403China

The sesquiterpene lactone artemisinin is an important anti-malarial component produced by the glandular secretory trichomes of sweet wormwood(Artemisia annua L.).Light was previously shown to promote artemisinin production,but the underlying regulatory mechanism remains *** this study,we demonstrate that ELONGATEd HYPOCOTYL5(HY5),a central transcription factor in the light signaling pathway,cannot promote artemisinin biosynthesis on its own,as the binding of AaHY5 to the promoters of artemisinin biosynthetic genes failed to activate their *** analysis and yeast two-hybrid screening revealed the B-box transcription factor AaBBX21 as a potential interactor with ***21 showed a trichome-specific expression ***,the AaBBX21–AaHY5 complex cooperatively activated transcription from the promoters of the downstream genes AaGSW1,AaMYB108,and AaOrA,encoding positive regulators of artemisinin ***,AaHY5 and AaBBX21 physically interacted with the *** E3 ubiquitin ligase CONSTITUTIVELY PHOTOMOrPHOGENIC 1(COP1).In the dark,AaCOP1 decreased the accumulation of AaHY5 and AaBBX21 and repressed the activation of genes downstream of the AaHY5–AaBBX21 complex,explaining the enhanced production of artemisinin upon light *** study provides insights into the central regulatory mechanism by which light governs terpenoid biosynthesis in the plant kingdom.

关键词： AaBBX21 AaHY5 AaCOP1 Artemisia annua L. artemisinin biosynthesis light

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Oncology research 2024年第2期32卷 421-432页

作者： SEUNG-HEE GWAK JUHYUN LEE EUNJI OH dOHYUN LEE WONSHIK HAN JONGMIN KIM KYONG-TAI KIM department of Life Sciences Pohang University of Science and TechnologyPohang37673Korea r&d center NovMetaPharma Co.Ltd.Pohang37668Korea department of Surgery and Cancer research Institute Seoul National University College of MedicineSeoul03080Korea Generative Genomics research center Global Green Research&Development CenterHandong Global UniversityPohang37554Korea

Genetic information is transcribed from genomic dNA to mrNA,which is then translated into threedimensional *** can undergo various post-transcriptional modifications,including rNA editing that alters mrNA sequences,ultimately affecting protein *** this study,rNA editing was identified at the 499th base(c.499)of human vaccinia-related kinase 2(VrK2).This rNA editing changes the amino acid in the catalytic domain of VrK2 from isoleucine(with adenine base)to valine(with guanine base).Isoleucine-containing VrK2 has higher kinase activity than the valine-containing VrK2,which leads to an increase in tumor cell *** we reported that VrK2 directly interacts with dystrobrevin-binding protein(dysbindin)and results in reducing its ***,we demonstrate that isoleucine-containing VrK2 decreases the level of dysbindin than valinecontaining *** interacts with cyclin d and thereby regulates its expression and *** reduction in the level of dysbindin by isoleucine-containing VrK2 further enhances the cyclin d expression,resulting in increased tumor growth and reduction in survival *** has also been observed that in patient samples,VrK2 level was elevated in breast cancer tissue compared to normal breast ***,the isoleucine form of VrK2 exhibited a greater increase in breast cancer ***,it is concluded that VrK2,especially dependent on the 167th variant amino acid,can be one of the indexes of tumor progression and proliferation.

关键词： VrK2 Kinase activity Breast cancer Tumor rNA editing Cell proliferation Cell growth

droplet morphology analysis of drop-on-demand inkjet printing

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China Foundry 2024年第1期21卷 20-28页

作者： Hu-xiang Xia Takechi Kensuke Tajima Shin Kawamura Yoshiumi Qing-yan Xu Key Laboratory for Advanced Materials Processing Technology(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Toyota Central r&d Labs. Inc.41-1 Yokomichi NagakuteAichi 480-1192Japan Frontier research center Toyota Motor Corporation1 Toyota-ChoToyotaAichi 471-8572Japan

As an accurate 2d/3d fabrication tool,inkjet printing technology has great potential in preparation of micro electronic *** morphology of droplets produced by the inkjet printer has a great impact on the accuracy of *** this study,the drop-on-demand(dod)inkjet simulation model was established,and the accuracy of the simulation model was verified by corresponding *** simulation result shows that the velocity of the droplet front and tail,as well as the time to disconnect from the nozzle is mainly affected by density(ρ),viscosity(μ)and surface tension(σ)of *** the liquid filament is about to disconnect from the nozzle,the filament length and filament front velocity are found to have a linear correlation withσ/ρμand ln(ρ/(μσ1/2)).

关键词： microdevice fabrication inkjet printing droplet morphology modeling and simulation

Extraction and bioactivities of the chemical composition from Pleurotus ostreatus:a review

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Journal of Future Foods 2024年第2期4卷 111-118页

作者： Qingchun Zhao Xiaopeng Liu Lili Cui Changyang Ma National r&d center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Functional Food Engineering Technology research center Kaifeng 475004China Joint International research Laboratory of Food&Medicine resource Function Kaifeng 475004China

Pleurotus ostreatus as an edible mushroom with pharmacological potential,belonging to class basidiomycetes of kingdom Mycota is known to have immense therapeutic *** contains polysaccharides,proteins,sterols,volatile oils and *** has a variety of biological activities,including anti-oxidant,anti-hyperlipidemic,anti-tumor,immunoregulatory and *** paper summarizes the extraction methods,chemical components and biological activities of ***,and find it is good resources to develop medicine and health food.

关键词： Pleurotus ostreatus Extraction methods Chemical components Biological activities

development and formation of wing cuticle based on transcriptomic analysis in Locusta migratoria during metamorphosis

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Journal of Integrative Agriculture 2024年第4期23卷 1285-1299页

作者： Jing Zhang Zhaochen Wu Shuo Li He Huang Suning Liu Weimin Liu Xiaoming Zhao Jianzhen Zhang Shanxi Key Laboratory of Nucleic Acid Biopesticides Institute of Applied BiologyShanxi UniversityTaiyuan 030006China College of Life Science Shanxi UniversityTaiyuan 030006China Guangmeiyuan r&d center/Guangdong Provincial Key Laboratory of Insect developmental Biology and Applied Technology South China Normal UniversityMeizhou 514779China

Wings are an important flight organ of *** development is a complex process controlled by a series of *** flightless wing pad transforms into a mature wing with the function of migratory flight during the nymphto-adult ***,the mechanism of wing morphogenesis in locusts is still *** study analyzed the microstructures of the locust wing pads at pre-eclosion and the wings after eclosion and performed the comparative transcriptome ***-seq identified 25,334 unigenesand 3,430 differentially expressed genes(dEGs)(1,907 up-regulated and 1,523 down-regulated).The dEGs mainly included cuticle development(LmACPs),chitin metabolism(Lm Idgf4),lipid metabolism-related genes,cell adhesion(Integrin),zinc finger transcription factors(LmSalm,LmZF593 andLmZF521),and *** analysis based on rNA interference and hematoxylin and eosin(H&E)staining showed that the three genes encoded zinc finger transcription factors are essential for forming wing cuticle and maintaining morphology in Locusta ***,the study found that the LmSalm regulates the expression of LmACPs in the wing pads at pre-eclosion,and LmZF593 and LmZF521 regulate the expression of LmIntegrin/LmIdgf4/LmHMT420 in the wings after *** study revealed that the molecular regulatory axis controls wing morphology in nymphal and adult stages of locusts,offering a theoretical basis for the study of wing development mechanisms in hemimetabolous insects.

关键词： Locusta migratoria wing development metamorphosis rNA-seq

3-Epi-betulinic acid 3-O-β-d-glucopyranoside(eBAG)induces autophagy by activation of AMP-activated protein kinase in hepatocellular carcinoma

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Food Science and Human Wellness 2024年第3期13卷 1453-1464页

作者： Mengjie Liu Xuqiang Liu Kaiyue He Yongping Jian Yujia Li Jinrong Guo Jingyu Yang Zhixiang Xu Wenyi Kang School of Life Sciences Henan UniversityKaifeng 475004China National r&d center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Joint International research Laboratory of Food&Medicine resource Function Kaifeng 475004China Shenzhen research Institute of Henan University Shenzhen 518000China

3-Epi-betulinic acid 3-O-β-d-glucopyranoside(eBAG)is a pentacyclic triterpene mainly distributed in food and medicinal plants,which exhibits various pharmacological ***,whether these functions are attributed to eBAG or additional components in these plants remain ***,we report that eBAG exerted an inhibitory activity against hepatocellular carcinoma and esophageal cancer *** induced non-apoptotic cell death in hepatocellular carcinoma *** eBAG-induced cell death was inhibited by knock-down of autophagy related gene(ATG)5 and ATG7,by administration of 3-methyladenine,a selective autophagy inhibitor that suppresses phosphoinositide 3-kinase(PI3K),and by chloroquine,a classic autophagy flux *** demonstrated that eBAG induced an autophagy-mediated cell *** of eBAG mimicked cellular bioenergetics depletion leading to the reduction of intracellular ATP,activation of AMP-activated protein kinase(AMPK),and inhibition of ***-treatment with compound C,an AMPK inhibitor,abrogated cell death induced by *** further validated the anti-tumor effect of eBAG in the murine xenograft model of hepatocellular carcinoma and found that eBAG treatment promoted the induction of autophagy and reduction of tumor growth in *** a functional food ingredient,eBAG is a potential therapeutic agent for the treatment of hepatocellular carcinoma and esophageal cancer.

关键词： eBAG Autophagy ATP AMPK Hepatocellular carcinoma

Study on Skin Care Efficacy of the Active Ingredients in Camellia Japonica Flowers at High and Low Altitudes

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China detergent & Cosmetics 2024年第1期9卷 76-80页

作者： Cao Yimiao Gao Hongqi Gao Cong deng Quanzhi r&d center Shanghai Forest Cabin Bio-tech Co.Ltd.China

The active ingredients of Camellia japonica flowers(CJF)at high and low altitudes,as well as their skin care efficacy were *** dried red CJF at high and low altitudes were ultrasonically extracted with 70%ethanol,and these extracts were concentrated and then diluted to a constant *** content of total flavonoids,total polyphenols and total proteins was tested and *** addition,dPPH free radical scavenging,inhibition of the formation of advanced glycation end products,and inhibitory activity against elastase was measured to compare their skin care efficacy in anti-oxidation,anti-glycation,anti-wrinkling and *** results showed that,based on the dry weight of CJF,the content of total flavonoids and total proteins of the CJF at high altitude was approximately 1.5 times of the CJF at low altitude,while the content of total polyphenols was approximately 2.4 times that of the CJF at low *** skin care efficacy of CJF at high altitude was significantly better than that of the CJF at low *** work could provide theoretical basis for the selection and application of Camellia japonica flowers in the field of cosmetics.

关键词： camellia japonica flowers at high and low altitudes active ingredients skin care efficacy