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Toward quantum unmanned systems

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Science China(Technological Sciences) 2024年第7期67卷 2277-2280页

作者： CHENG ShuMing QI HongSheng SUN Yue LIU LiJun XIE ShaoRong REN XiaoQiang Department of Control Science and Engineering Tongji UniversityShanghai 200092China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China Cipher Cloud core ltd. Beijing 100085China College of Mathematics and Computer Science Shanxi Normal UniversityLinfen 041081China School of Computer Engineering and Science Shanghai UniversityShanghai 200444China School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200444China

1 Quantum information technology Quantum information technology utilizes physical systems at the microscopic level, such as photon, atom, ion, and superconducting, to accomplish information-processing tasks that are impossible for the classical macroscopic world. During the past decade, significant process has been achieved in the pursuit of quantum technology into practical applications,generating great research interest from various domains, with the potential to radically change our information infrastructure [1–3].

关键词： quantum utilize generating

TOF–SIMS surface analysis of chemical components of size–fractioned urban aerosols in a typical heavy air pollution event in Beijing

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Journal of Environmental Sciences 2018年第7期30卷 61-76页

作者： Wenjun Li Hong Li Jinjuan Li Xueli Cheng Zhengzheng Zhang Fahe Chai Hao Zhang Ting Yang Pengli Duan Defeng Lu Yizhen Chen College of Resource and Environmental Engineering Guizhou University Guiyang 550025 China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences Beijing 100012 China Collaborative Innovation Center on Atmospheric Environment and Equipment Technology Nanjing University of Information Science andTechnology Nanjing 210044 China SAE Technology Development (Dongguan) Co. ltd. Guangdong 523087 China Environment Research Institute Shandong University Jinan 250100 China College of Earth Sciences Jilin University Changchun 130061 China Institute of Environment Science Shanxi University Shanxi 030001 China core Tech Integrated (Beijing) Pty. ltd. Beijing 100086 China

Size–fractioned atmospheric aerosol particles were collected during a typical heavy air pollution event in Beijing. The organic and inorganic components on the surfaces of the samples were analyzed using time–of–flight secondary ion mass spectrometry（TOF–SIMS）.The variation characteristics of the surface chemical composition and influencing factors were studied, and the possible sources of these chemical compositions were identified through principal component analysis. The results showed that inorganic components such as crustal elements and sulfate, and organic components such as aliphatic hydrocarbons and oxygen–containing organic groups were present. Some surface components, such as polycyclic aromatic hydrocarbons, heavy metals and fluorides may exert adverse effects on human health. The species and relative percentages of the chemical components varied with particle size, diurnal and pollution progress. During a heavy pollution event, the species and relative percentages of secondary components such as oxygen–containing organic groups and sulfurous compounds increased, indicating that particles aged during this event. The surface chemical composition of the aerosol particles was affected mainly by emissions from coal combustion and motor vehicles. In addition, air pollution, meteorological factors, and air mass transport also exerted a significant effect on the surface chemical composition of aerosol particles.

关键词： Atmospheric aerosol particles Air pollution event Surface chemical composition Influence factor Static Time-of-flight secondary ion mass spectrometry Beijing

A preliminary analysis of the surface chemistry of atmospheric aerosol particles in a typical urban area of Beijing

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Journal of Environmental Sciences 2016年第9期28卷 71-81页

作者： Zhengzheng Zhang Hong Li Hongyan Liu Runxiang Ni Jinjuan Li Liqun Deng Defeng Lu Xueli Cheng Pengli Duan Wenjun Li College of Resource and Enuironmental Engineering Guizhou Uniuersity Guiyang 550025 China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences Beijing 110012China Collaborative Innovation Center on Atmospheric Environment and Equipment Technology Nanfing University of Information Science andTechnology Nanjing 210044 China Institute of Geographic Sciences and Natural Resources Research CAS Beijing lO0101 China core Tech Integrated (Beijing) Pry. ltd. Beijing 100086 China Sichuan Academy of Environmental Sciences Sichuan 610042 China SAE Technology Development (Don99uan) Co. ltd. Guanfdong 523087 China Institute of Environment Science Shaanxi University Shaanxi 030006 China

Atmospheric aerosol particle samples were collected using an Ambient Eight Stage（Non-Viable） Cascade Impactor Sampler in a typical urban area of Beijing from 27 th *** 5th Oct.,*** surface chemistry of these aerosol particles was analyzed using Static Time of Flight-Secondary Ion Mass Spectrometry（Static TOF-SIMS）.The factors influencing surface compositions were evaluated in conjunction with the air pollution levels,meteorological factors,and air mass transport for the sampling *** results show that a variety of organic ion groups and inorganic ions/ion groups were accumulated on the surfaces of aerosol particles in urban areas of Beijing;and hydrophobic organic compounds with short-or middle-chain alkyl as well as hydrophilic secondary inorganic compounds were *** these compounds have the potential to affect the atmospheric behavior of urban aerosol ***1.1–2.1and PM3.3–4.7had similar elements on their surfaces,but some molecules and ionic groups demonstrated differences in Time of Flight-Secondary Ion Mass Spectrometry *** suggests that the quantities of elements varied between PM1.1–2.1and PM3.3–*** particular,more intense research efforts into fluoride pollution are required,because the fluorides on aerosol surfaces have the potential to harm human *** levels of air pollution had the most significant influence on the surface compositions of aerosol particles in our ***,heavier air pollution was associated with more complex surface compositions on aerosol *** addition,wind,rainfall,and air masses from the south also greatly influenced the surface compositions of these urban aerosol particles.

关键词： Atmospheric aerosol Surface chemistry Influential factors TOF-SIMS Beijing

Compound Danshen Dripping Pill inhibits hypercholesterolemia/atherosclerosis-induced heart failure in ApoE and LDLR dual deficient mice via multiple mechanisms

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1036-1052页

作者： Yanfang Yang Ke Feng Liying Yuan Yuxin Liu Mengying Zhang Kaimin Guo Zequn Yin Wenjia Wang Shuiping Zhou He Sun Kaijing Yan Xijun Yan Xuerui Wang Yajun Duan Yunhui Hu Jihong Han College of Life Sciences State Key Laboratory of Medicinal Chemical BiologyKey Laboratory of Bioactive Materials of Ministry of EducationNankai UniversityTianjin 300071China Department of Physiology Binzhou Medical UniversityYantai 264003China Cloudphar Pharmaceuticals Co. Ltd.Shenzhen 518000China Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes Hefei University of TechnologyHefei 230009China The State Key Laboratory of core Technology in Innovative Chinese Medicine Tasly AcademyTasly Holding Group Co.Ltd.Tianjin 300410China Tasly Pharmaceutical Group Co. Ltd.Tianjin 300410China Department of Cardiology the First Affiliated Hospital of USTCDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230001China

Heart failure is the leading cause of death *** Danshen Dripping Pill(CDDP)or CDDP combined with simvastatin has been widely used to treat patients with myocardial infarction and other cardiovascular diseases in ***,the effect of CDDP on hypercholesterolemia/atherosclerosis-induced heart failure is *** constructed a new model of heart failure induced by hypercholesterolemia/atherosclerosis in apolipoprotein E(ApoE)and LDL receptor(LDLR)dual deficient(ApoE^(–/–)LDLR^(–/–))mice and investigated the effect of CDDP or CDDP plus a low dose of simvastatin on the heart *** or CDDP plus a low dose of simvastatin inhibited heart injury by multiple actions including anti-myocardial dysfunction and ***,both Wnt and lysine-specific demethylase 4A(KDM4A)pathways were significantly activated in mice with heart ***,CDDP or CDDP plus a low dose of simvastatin inhibited Wnt pathway by markedly up-regulating expression of Wnt *** the anti-inflammation and anti-oxidative stress by CDDP were achieved by inhibiting KDM4A expression and *** addition,CDDP attenuated simvastatin-induced myolysis in skeletal *** together,our study suggests that CDDP or CDDP plus a low dose of simvastatin can be an effective therapy to reduce hypercholesterolemia/atherosclerosis-induced heart failure.

关键词： Compound danshen dripping pill Heart failure Hypercholesterolemia Atherosclerosis Simvastatin ApoE^(-/-)LDLR^(-/-)mice Inflammation Oxidative stress

A 10-bit 80-MS/s opamp-sharing pipelined ADC with a switch-embedded dual-input MDAC

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Journal of Semiconductors 2011年第2期32卷 102-107页

作者：尹睿廖友春张卫唐长文 ASIC & System State Key Laboratory Fudan University China Ratio Microelectronics Co. Ltd Ratio Microelectronics Co.ltd

A 10-bit 80-MS/s opamp-sharing pipelined ADC is implemented in a 0.18μm CMOS. An opamp- sharing MDAC with a switch-embedded dual-input opamp is proposed to eliminate the non-resetting and successive-stage crosstalk problems observed in the conventional opamp-sharing technique. The ADC achieves a peak SNDR of 60.1 dB （ENOB = 9.69 bits） and a peak SFDR of 76 dB, while maintaining more than 9.6 ENOB for the full Nyquist input bandwidth. The core area of the ADC is 1.1 mm2 and the chip consumes 28 mW with a 1.8 V power supply.

关键词： pipelined ADC opamp-sharing low power switch-embedded dual-input MDAC

Work-function-induced interfacial electron redistribution of MoO_(2)/WO_(2) heterostructures for high-efficiency electrocatalytic hydrogen evolution reaction

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Rare Metals 2024年第2期43卷 489-499页

作者： Tong-Fei Li Jing Li Lu-Ping Zhang Jia-Wei Ke Meng-Xing Fan Li-Fang Zhang Cheng-Wei Deng Yi Sun Tao Qian Cheng-Lin Yan School of Chemistry and Chemical Engineering Nantong UniversityNantong226019China Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Centre of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing210023China Aerospace Hydrogen Energy Technology(Shanghai)Co.ltd. Shanghai201800China Key Laboratory of core Technology of High Specific Energy Battery and Key Materials for Petroleum and Chemical Industry College of EnergySoochow UniversitySuzhou215006China Light Industry Institute of Electrochemical Power Sources Suzhou215006China

The engineering of the electronic configurations of active sites,together with the production of more accessible active sites through heterostructure design,has been established as a forceful methodology for boosting water electrolysis ***,a facile approach is developed to fabricate well-dispersed MoO_(2) and WO_(2) nanoparticles with abundant heterointerfaces entrapped in N,P-doped carbon nanofibers(referred to as MoO_(2)/WO_(2)@N,P-CNFs hereafter)as hydrogen evolution reaction(HER)electrocatalysts in alkaline and acidic *** spectroscopic analyses and theoretical findings manifest that the heterointerface formed by the work function modulation of MoO_(2)/WO_(2) triggers the spontaneous electron redistribution from MoO_(2)to WO_(2) and a built-in electric field,which is essential to promote water adsorption,optimize the H-intermediate adsorption energy,result in the enhanced charge transfer efficiency,and ultimately increase the intrinsic HER ***,the intimate confinement of MoO_(2)/WO_(2) heterostructures in the porous carbon substrate can restrain the active sites from unfavorable coarsening and detachment,thus ensuring facilitated HER kinetics and outstanding structural *** a result,MoO_(2)/WO_(2)@N,P-CNFs exhibit superior catalytic HER performance in acidic and basic solutions,requiring 118 and 95 mV overpotentials to achieve 10 mA·cm^(−2),respectively,surpassing a number of reported non-noble metal-based *** work provides guidelines for the rational design and construction of special metallic heterocomponents with optimized interfacial electronic structure for various electrochemical technologies.

关键词： Electrospinning MoO_(2)/WO_(2) heterostructure Work function Hydrogen evolution reaction

Karstification characteristics of the Cenomanian-Turonian Mishrif Formation in the Missan Oil Fields,southeastern Iraq,and their effects on reservoirs

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Frontiers of Earth Science 2022年第2期16卷 435-445页

作者： Peiyuan CHEN Lina GUO Chen LI Yi TONG CNOOC International ltd. Beijing 100028China CNOOC Research Institute Co. Ltd.Beijing 100028China

The Middle Cretaceous Mishrif Formation of the Cenomanian-Turonian age is an important Middle Eastern *** studies have shown that carbonates in the Mishrif Formation are affected by karstification and are concentrated at the top of the ***,there is a lack of systematic research on the effects of karstification on the formation’s reservoir *** on core samples,scanning electron microscopy of thin sections,and geochemical analysis of C,O,and Sr isotopes from wells in the Missan Oil Fields,unconformity was identified at the top of the B21 subzone of the Mishrif *** and cast-thin-section observations indicate that there is a significant lithological difference above and below the unconformity,and dissolution pores and voids are well-developed beneath *** silt fills the intragranular pores and geopetal fabric is developed inside some mouldic pores beneath the unconformity *** isotopic values of ^(87)Sr/^(86)Sr(0.707270-0.707722)and δ^(18)O(−5.94‰—−2.32‰)suggest that the top of the B21 subzone of the Mishrif Formation has been severely affected by syngenetic *** is the key to high-quality reservoir formation and the reservoir’s oil-bearing *** study will inform oil and gas exploration in the Missan Oil Fields and in other areas with similar reservoir characteristics.

关键词： unconformity karstification carbonate reservoir Mishrif Formation Missan Oil Fields southeastern Iraq

TDP-43 regulates cancer-associated microRNAs

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Protein & Cell 2018年第10期9卷 848-866页

作者： Xiaowei Chen Zhen Fan Warren McGee Mengmeng Chen Ruirui Kong Pushuai Wen Tengfei Xiao Xiaomin Chen Jianghong Liu Li Zhu Runsheng Chen Jane Y. Wu CAS Key Laboratory of RNA Biology Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Research Network of Computational Biology RNCB Beijing 100101 China core Facility for Protein Research institute of Biophysics Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences Beijing 100101China Department of Neurology Center for Genetic Medicine Lurie Cancer Center Northwestern University Feinberg School ofMedicine Chicago IL 60611 USA Guangdong Geneway Decoding Bio-Tech Co. ltd Foshan 528316 China

regulation of miRNA genes contributes to pathogenesis of a wide range of human diseases, including cancer. The TAR DNA binding protein 43 （TDP- 43）, a RNAJDNA binding protein associated with neu- rodegeneration, is involved in miRNA biogenesis. Here, we systematically examined miRNAs regulated by TDP- 43 using RNA-Seq coupled with an siRNA-mediated knockdown approach. TDP-43 knockdown affected the expression of a number of miRNAs. In addition, TDP-43 down-regulation led to alterations in the patterns of dif- ferent isoforms of miRNAs （isomiRs） and miRNA arm selection, suggesting a previously unknown role of TDP- 43 in miRNA processing. A number of TDP-43 associ- ated miRNAs, and their candidate target genes, are associated with human cancers. Our data reveal highly complex roles of TDP-43 in regulating different miRNAs and their target genes. Our results suggest that TDP-43 may promote migration of lung cancer cells by regulat- ing miR-423-3p. In contrast, TDP-43 increases miR-500a- 3p expression and binds to the mature miR-500a-3p sequence. Reduced expression of miR-500a-3p is associated with poor survival of lung cancer patients,suggesting that TDP-43 may have a suppressive role in cancer by regulating miR-500a-3p. Cancer-associated genes LIF and PAPPA are possible targets of miR-500a- 3p. Our work suggests that TDP-43-regulated miRNAs may play multifaceted roles in the pathogenesis of cancer.

关键词： TDP-43 miRNA cancer migration prognosis

Design and implementation of China Hydrogen Price Index system

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Clean Energy 2023年第1期7卷 148-156页

作者： Wei Liu Yanming Wan Yan Zhang Qi Liu China Hydrogen Alliance Research Institute Co. LtdBeijing100007China Guohua Energy Investment Co. LtdBeijing100007China

Hydrogen will be an important part of China’s energy system in the future and an important carrier for energy-using terminals to realize green and low-carbon *** is important to establish a nationwide hydrogen market to promote the healthy and orderly development of the hydrogen industry *** core is to form a complete hydrogen price mechanism and play a decisive role in the process of resource allocation by the *** this paper,we have developed the framework of the‘China Hydrogen Price Index’system by establishing the‘Assessment+Collection’model,which covers four types of hydrogen:hydrogen,clean hydrogen,renewable hydrogen and high-purity *** model considers the raw materials required for hydrogen production,fixed equipment,engineering construction costs and carbon prices,and conducts sensitivity analysis on the trends and influencing factors of national and regional hydrogen prices of multiple categories since *** results show that,with respect to the level of hydrogen prices,fossil-energy-rich and renewable-energy-rich areas have more advantages than other *** price of raw materials is the main factor of the hydrogen price change,and the utilization hours of renewable energy and hydrogen production equipment have a key influence on the price of renewable ***,by establishing an index update mechanism,improving the standard system and building a trading platform,we can further exert the role of price signals and continue to promote the efficient and smooth expansion of the domestic hydrogen market.

关键词： hydrogen price index market price