Compound Danshen Dripping Pill inhibits hypercholesterolemia/atherosclerosis-induced heart failure in ApoE and LDLR dual deficient mice via multiple mechanisms

作     者：Yanfang Yang Ke Feng Liying Yuan Yuxin Liu Mengying Zhang Kaimin Guo Zequn Yin Wenjia Wang Shuiping Zhou He Sun Kaijing Yan Xijun Yan Xuerui Wang Yajun Duan Yunhui Hu Jihong Han Yanfang Yang;Ke Feng;Liying Yuan;Yuxin Liu;Mengying Zhang;Kaimin Guo;Zequn Yin;Wenjia Wang;Shuiping Zhou;He Sun;Kaijing Yan;Xijun Yan;Xuerui Wang;Yajun Duan;Yunhui Hu;Jihong Han

作者机构：College of Life SciencesState Key Laboratory of Medicinal Chemical BiologyKey Laboratory of Bioactive Materials of Ministry of EducationNankai UniversityTianjin 300071China Department of PhysiologyBinzhou Medical UniversityYantai 264003China Cloudphar Pharmaceuticals Co.Ltd.Shenzhen 518000China Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education InstitutesHefei University of TechnologyHefei 230009China The State Key Laboratory of Core Technology in Innovative Chinese MedicineTasly AcademyTasly Holding Group Co.Ltd.Tianjin 300410China Tasly Pharmaceutical Group Co.Ltd.Tianjin 300410China Department of Cardiologythe First Affiliated Hospital of USTCDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230001China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2023年第13卷第3期

页      面：1036-1052页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the China NSFC grants 82173807 to Yajun Duan and 81973316 to Jihong Han Tianjin Municipal Science and Technology Commission of China Grant 20JCZDJC00710 the Fundamental Research Funds for the Central Universities(Nankai University,China)63211045 to Jihong Han 

主　　题：Compound danshen dripping pill Heart failure Hypercholesterolemia Atherosclerosis Simvastatin ApoE^(-/-)LDLR^(-/-)mice Inflammation Oxidative stress 

摘      要：Heart failure is the leading cause of death *** Danshen Dripping Pill(CDDP)or CDDP combined with simvastatin has been widely used to treat patients with myocardial infarction and other cardiovascular diseases in ***,the effect of CDDP on hypercholesterolemia/atherosclerosis-induced heart failure is *** constructed a new model of heart failure induced by hypercholesterolemia/atherosclerosis in apolipoprotein E(ApoE)and LDL receptor(LDLR)dual deficient(ApoE^(–/–)LDLR^(–/–))mice and investigated the effect of CDDP or CDDP plus a low dose of simvastatin on the heart *** or CDDP plus a low dose of simvastatin inhibited heart injury by multiple actions including anti-myocardial dysfunction and ***,both Wnt and lysine-specific demethylase 4A(KDM4A)pathways were significantly activated in mice with heart ***,CDDP or CDDP plus a low dose of simvastatin inhibited Wnt pathway by markedly up-regulating expression of Wnt *** the anti-inflammation and anti-oxidative stress by CDDP were achieved by inhibiting KDM4A expression and *** addition,CDDP attenuated simvastatin-induced myolysis in skeletal *** together,our study suggests that CDDP or CDDP plus a low dose of simvastatin can be an effective therapy to reduce hypercholesterolemia/atherosclerosis-induced heart failure.