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Performance of the Enhanced Liver Fibrosis Score,Comparison with Vibration-controlled Transient Elastography Data,and Development of a Simple Algorithm to Predict Significant Liver Fibrosis in a Community-based Liver Service:A Retrospective Evaluation

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Journal of Clinical and Translational Hepatology 2023年第4期11卷 800-808页

作者： Tina Reinson Janisha Patel Mead Mathews Derek Fountain Ryan M.Buchanan Christopher DByrne Nutrition and Metabolism Faculty of MedicineUniversity of SouthamptonSouthamptonUK National Institute for Health and Care Research Southampton Biomedical Research CenterUniversity Hospital SouthamptonSouthamptonUK Hepatology Department University Hospital SouthamptonSouthamptonUK St Mary’s Surgery SouthamptonUK core minutes ltd RingwoodUK Clinical and Experimental Sciences Faculty of MedicineUniversity of SouthamptonSouthamptonUK

Background and Aims:Liver fibrosis is a key risk factor for cirrhosis,hepatocellular carcinoma and end stage liver *** National Institute for Health and Care Excellence guidelines for assessment for advanced(≥F3)liver fibrosis in people with nonalcoholic fatty liver disease recommend the use of enhanced liver fibrosis(ELF)test,followed by vibration-controlled transient elastography(VCTE).Performance of ELF at predicting significant(≥F2)fibrosis in real-world practice is *** assess the accuracy of ELF using VCTE;investigate the optimum ELF cutoff value to identify≥F2and≥F3;and develop a simple algorithm,with and without ELF score,for detecting≥***:Retrospective evaluation of patients referred to a Community Liver Service for VCTE,Jan-Dec *** included:body mass index(BMI),diabetes status,alanine aminotransferase(ALT)levels,ELF score and biopsy-validated fibrosis stages according to ***:Data from 273 patients were available.n=110 patients had *** showed fair performance for≥F2 and≥F3,area under the curve(AUC)=0.70,95%confidence interval(CI)0.64-0.76 and AUC=0.72,95%CI:0.65-0.79 ***≥F2 Youden's index for ELF=9.85 and for≥F3,ELF=*** ALT,BMI,and HbA1c(ALBA algorithm)to predict≥F2 showed good performance(AUC=0.80,95%CI:0.69-0.92),adding ALBA to ELF improved performance(AUC=0.82,95%CI:0.77-0.88).Results were independently ***:Optimal ELF cutoff for≥F2 is 9.85 and 9.95 for≥***,BMI,and HbA1c(ALBA algorithm)can stratify patients at risk of≥*** is improved by adding ALBA.

关键词： Primary health care Retrospective evaluation Liver disease Diabetes Nonalcoholic fatty liver disease

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^(27)Al MAS-NMR study of inorganic polymer formation at ambient temperature

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 182-187页

作者： Sang-Wook AHN Hee-Soo LEE Wan-Hee YANG Jung-Woo LEE Young-Keun JEONG National core Research Center for Hybrid Materials Solution Pusan National University School of Material Science and Engineering Pusan National University INTChem Co. Ltd.

Inorganic polymers are a novel class of materials formed by the polymerization of silicon, aluminium and oxygen species to form an amorphous three-dimensional framework structure. The basis of this process is the alkaline solutions to induce a certain amount of Si and AI atoms to dissolve from a feedstock such as aluminosilicate. A study of 27A1 MAS-NMR was carried out in an attempt to understand the reaction mechanism of the inorganic polymerization at ambient temperature. Scanning electron microscopy （SEM） and X-ray diflYactometry （XRD） were also employed to establish the composition and microstructure of the inorganic polymerization. Specimens were prepared with different A1/Si mole ratios from the starting materials. The higher the AI content, the more sufficient the AI atoms that can combine with SiO4, and the longer the reaction time, the more the bonded Si--O--A1--O polymer structure, and then the higher the A1 content, the fewer the octahedral A1 with a uniform Si--O--A1--O structure in four directions, because four AI atoms are combined with SiO4, resulting in a uniform Si--O--AI--O structure in four directions. The results show that they have an amorphous microstructure.

关键词： inorganic polymer amorphous tetrahedral

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MEMS development focusing on collaboration using common facilities:a retrospective view and future directions

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Microsystems & Nanoengineering 2021年第4期7卷 25-33页

作者： Masayoshi Esashi MEMS core Co.ltd.(CTO) Sendai 981-3206Japan Micro System Integration Center(pSIC)(senior research fellow) Tohoku UniversitySendai 980-0845Japan

I have been developing MEMS(microelectromechanical systems)technology and supporting the industry through collaboration.A facility was built in house on a 20 mm square wafer for use in prototyping MEMS and ICs(integrated circuits).The constructed MEMS devices include commercialized integrated capacitive pressure sensors,electrostatically levitated rotational gyroscopes,and two-axis optical *** integration,which is a MEMS on an LSI(large-scale integration),was developed for sophisticated systems using LSI made in a *** technology was applied for tactile sensor networks for safe robots,multi FBAR filters on LSI,active-matrix multielectron emitter arrays,and so *** facility used to produce MEMS on 4-and 6-inch wafers was developed based on an old semiconductor factory and has been used as an open hands-on access facility by many *** directions of MEMS research are discussed.

关键词： scanner directions companies

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Exploring the underlying mechanism of action of a traditional Chinese medicine formula,Youdujing ointment,for cervical cancer treatment

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Quantitative Biology 2021年第3期9卷 292-303页

作者： Lei Zhang Ji Lv Ming Xiao Li Yang Le Zhang College of Computer Science Sichuan UniversityChengdu 610065China Sichuan Asia-core Gene Technology Co. LtdChengdu 610045China

Background:A traditional Chinese medicine formula,Youdujing(YDJ)ointment,is widely used for treatment of human papilloma virus-related diseases,such as cervical ***,the underlying mechanisms by which active compounds of YDJ alleviates cervical cancer are still ***:We applied a comprehensive network pharmacology approach to explore the key mechanisms of YDJ by integrating potential target identification,network analysis,and enrichment analysis into classical molecular docking ***,we used network and enrichment analyses to identify potential therapeutic ***,we performed molecular docking to investigate the potential active compounds of ***,we carried out a network-based analysis to unravel potentially effective drug ***:Network analysis yielded four potential therapeutic targets:ESRI,NFKB1,TNF,and *** docking highlighted that these proteins may interact with four potential active compounds of YDJ:E4,Y2,Y20,and ***,we found that Y2 or Y21 can act alone or together with E4 to trigger apoptotic cascades via the mitochondrial apoptotic pathway and estrogen ***:Our study not only explained why YDJ is effective for cervical cancer treatment,but also lays a strong foundation for future clinical studies based on this traditional medicine.

关键词： Youdujing cervical cancer traditional Chinese medicine network pharmacological molecular docking synergy effect

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Sea-surface reflection-aided underwater localization with unknown sound speed

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Science China(Information Sciences) 2019年第4期62卷 209-211页

作者： Bingbing ZHANG Yongchang HU Hongyi WANG Zhaowen ZHUANG School of Electronic Science National University of Defense Technology Xi'an Research Center Cloud Core Network Product Line/R&D Mgmt Huawei Technologies Co. Ltd

Dear editor,The problem of underwater localization has drawn considerable attention in recent years [1]. However, it is quite challenging due to a lack of measurements and the unknown sound propagation speed(SPS), eve... 详细信息

关键词： Sea-surface reflection-aided underwater localization with unknown sound speed

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A DISTRIBUTED CLUSTERING METHOD TO SEGMENT MICRO-BLOG USERS ON CLOUD ENVIRONMENTS

A DISTRIBUTED CLUSTERING METHOD TO SEGMENT MICRO-BLOG USERS ...

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第25届中国控制与决策会议

作者： Hui Liu Wu Qu Jin Yi Junhe Wang Chenghao Sun China Information Technology Security Evaluation Center Tsinghua University core Research Institute Beijing Venustech Cybervision Co. Ltd.

ISBN: (纸本)9781467355339

With the rapid development of social network analysis （SNA for short）, people increasingly pay attention to segment micro-blog users in the SNAs. It’s a new trend on classic marketing technique segmentation. In the case of micro-blog, it’s useful to get a group of users with a common set of characters and learn what’s on their mind. As is usually the case, the standard for measuring the category of the micro-blog users is multi-objective, i.e., the data is high dimensional. If you have a personal micro-blog account, it’s easy enough to create the lists that might be most meaningful to you by using generic clustering algorithms. And if your business has Tens of millions of users, the near real-time requirement and the lack of efficient clustering algorithms to identify and distinguish them limits the power and scalability of this approach. To overcome these limitations, in this paper we introduce a novel distributed high dimensional data clustering algorithm based on Map-Reduce framework to distinguish the different communities from the entire social network, called CDGM-Clu. Extensive experiments on real and synthetic datasets show that the CDGM-Clu algorithm is significantly efficient and scalable, and useful for analyzing a large social network data.

关键词： Clustering Map-Reduce Social Network Analysis CDGM-Clu

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Geochemistry of Pore Water and Associated Diagenetic Reactions in the Diapiric Area of Yinggehai Basin, Northwestern South China Sea

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Journal of Earth Science 2015年第3期26卷 306-316页

作者： Tao Jiang Xinong Xie Hui Chen Zhenfeng Wang Xushen Li Key Laboratory of Tectonics and Petroleum Resources of Ministry of Education China University of Geosciences Kochi Institute for core Sample Research Japan Agency for Marine-Earth Science and Technology China National Offshore Oil Zhanjiang ltd. Corporation

This study examined the geochemical features of pore water in the diapiric area of the Yinggehai Basin, northwestern South China Sea, and illuminated the origin and evolution of basin fluids. Pore water with low salinity occurs in marine sediments in the diapiric area even without meteoric water infiltration. The presence of low-salinity water within deep, overpressured compartments is assumed to be due to smectite-illite transformation. Howerver, in shallow portions（less than 2 000 m） of diapiric areas with normal pressure, pore water has a much wider variation and much lower salinity than that in the overpressured intervals. Its total dissolved solid（TDS） content is ~5 336 to 35 939 mg/L. Moreover, smectite and chlorite content sharply decreases as kaolinite and illite content increase in shallower intervals. The geochemical variation of pore water in diapiric structures indicates the expulsion of low-salinity, overpressured fluids along vertical faults. Strong injection of hot fluids from deep overpressured sediments results in rapid clay mineral transformation in shallow reservoirs. Consequently, fluid mixing due to fluid expulsion from deeper overpressured deposits leads to variation in salinity and ionic composition as well as some diagenetic reactions. This includes transformation of clay minerals caused by the higher temperatur of deeper hot fluids, e.g., the transfromation of smectite to illite and chlorite to kaolinite. Therefore, variations in salinity and ionic compositions in various pressured systems provide a clue to flow pathways and associated diagenetic reactions.

关键词： pore water diagenetic reaction clay mineral transformation overpressured system Yinggehai Basin

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New AES Dual Ciphers Based on Rotation of Columns

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Wuhan University Journal of Natural Sciences 2019年第2期24卷 93-97页

作者： YANG Min XIAO Benchang MENG Qingshu The Key Laboratory of Aerospace Information and Trusted Computing Ministry of Education School of Cyber Science and Engineering Wuhan University Suzhou C* core Technology Co. Ltd

Based on the different representations of the finite field GF(256), there are different Advanced Encryption Standard(AES) implementations, which is called dual ciphers. They have the same encryption process as AES, but with parameters modified. The research of dual ciphers initially aims to find more efficient AES implementations, and later it is found that they can be used to resist side-channel attacks and for white box ciphers. In this paper, based on the rotation of columns, we propose new AES dual ciphers, which use AES directly, but with the input matrices(plaintexts and keys) and output matrix rotated. The key expansion algorithm only needs some change on the computation sequence. Because of these features, there is almost no extra cost in implementing dual ciphers and it is easy for new dual ciphers to work with other side-channel protection methods to protect AES in more dimensions.

关键词： AES dual cipher side channel security differential power analysis template attack

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Systematic review and Meta-analysis of 26 randomized controlled clinical trials of Compound Danshen Dripping Pill for non-proliferating diabetic retinopathy

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Chinese Herbal Medicines 2022年第1期14卷 142-153页

作者： Yu Wang Lei Hao Zhipeng Huo Yuanxue Liu Yujing Sun Zhaohui Song State Key Laboratory of core Technology in Innovative Chinese Medicine Tasly AcademyTasly Holding Group Co.Ltd.Tianjin 300410China

Objective:Diabetic retinopathy(DR) is the retinal consequence of chronic progressive diabetic microvascular leakage and ***-proliferating diabetic retinopathy(NPDR) is the early stage of *** eventually occurs to some degree in all patients with diabetes *** recent years,many clinical trials have shown that Compound Danshen Dripping Pill(CDDP) may be associated with the improvement of NPDR *** aim of this study was to quantitatively summarize the association between CDDP and the therapeutic effects of ***:It was conducted that a systematic literature search of Pub Med,Web of Science,CNKI,VIP and Wanfang Data updated in June 2020 with the following search terms:"diabetic retinopathy° or"retinopathy° or "DR° or "NPDR°,in combination with "Compound Danshen Dripping Pill° or "Salvia miltiorrhiza° or "Danshen°.Risk ratio(RR) and weighted mean difference(WMD) with their 95% confidence interval(CI) was calculated between treatment and control *** sensitivity analyses were undertaken by removing each individual study when high heterogeneity *** analysis,Metaregression,and publication bias analysis were also *** strength of evidence was evaluated with the Grading of Recommendation,Assessment,Development,and Evaluation(GRADE) ***:Twenty-six RCTs involving 2047 subjects were included to conduct a Meta-analysis after screening the studies,extracting the data,and assessing the study *** Stata15.0 software was utilized for ***-analysis indicated that curative effects of treatment group with CDDP was significantly better than control [RR = 0.54,95% CI(0.40,0.73);moderate-quality evidence].In addition,the results showed that CDDP was significantly associated with improving retinal hemorrhages[WMD =-0.62,95% CI(-0.78,-0.46);low-quality evidence],the vision [WMD = 0.14,and 95% CI(0.09,0.19),low-quality evidence],fundus fluorescence angiography [RR = 0.37 and 95% CI(0.23,0.60);low-qualit

关键词： Compound Danshen Dripping Pill diabetic retinopathy Meta-analysis randomized controlled clinical trial systemic review

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Fabrication of UV-Curing Linalool-Polysiloxane Hybrid Films with High Refractive Index and Transparency

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Journal of Renewable Materials 2024年第3期12卷 569-583页

作者： Wenqing Xiao Lewen Tan Xunjun Chen Qiaoguang Li Yunqing Ruan College of Chemistry and Chemical Engineering Zhongkai University of Agriculture and EngineeringGuangzhou510225China R&D Department Guangzhou Silicon Core Material Technology Co.Ltd.Guangzhou510220China

In this article,a series of high refractive indices(1.50-1.53)thiol phenyl polysiloxane(TPS)were synthesized via hydrolytic sol-gel *** Fourier transform infrared spectra(FT-IR)and nuclear magnetic resonance spectra(NMR)results showed that TPS conformed to the predicted *** terpene linalool was exploited as photocrosslinker to fabricate UV-curing linalool-polysiloxane hybrid films(LPH)with TPS via photoinitiated thiol-ene *** rapidly cured under UV irradiation at the intensity of 80 mW/cm^(2) in 30 s,exhibiting good UV-curing *** optical transmittance of LPH in the wavelength of 300-800 nm was over 90%,exhibiting good optical *** water contact angle and water vapor permeability results showed that the introduction of phenyl groups enhance the hydrophobicity and water vapor barrier properties of *** results indicated the potential of LPHs in the applications of optical functional coatings.

关键词： UV-curing polysiloxane hybrid films high refractive index transparency

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