Exploring the underlying mechanism of action of a traditional Chinese medicine formula,Youdujing ointment,for cervical cancer treatment

作     者：Lei Zhang Ji Lv Ming Xiao Li Yang Le Zhang Lei Zhang;Ji Lv;Ming Xiao;Li Yang;Le Zhang

作者机构：College of Computer ScienceSichuan UniversityChengdu 610065China Sichuan Asia-core Gene Technology Co.LtdChengdu 610045China 

出 版 物：《Quantitative Biology》 (定量生物学（英文版）)

年 卷 期：2021年第9卷第3期

页      面：292-303页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 100214[医学-肿瘤学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：This research received funding support from the National Science and Technology Major Project(2018ZX10201002) 

主　　题：Youdujing cervical cancer traditional Chinese medicine network pharmacological molecular docking synergy effect 

摘      要：Background:A traditional Chinese medicine formula,Youdujing(YDJ)ointment,is widely used for treatment of human papilloma virus-related diseases,such as cervical ***,the underlying mechanisms by which active compounds of YDJ alleviates cervical cancer are still ***:We applied a comprehensive network pharmacology approach to explore the key mechanisms of YDJ by integrating potential target identification,network analysis,and enrichment analysis into classical molecular docking ***,we used network and enrichment analyses to identify potential therapeutic ***,we performed molecular docking to investigate the potential active compounds of ***,we carried out a network-based analysis to unravel potentially effective drug ***:Network analysis yielded four potential therapeutic targets:ESRI,NFKB1,TNF,and *** docking highlighted that these proteins may interact with four potential active compounds of YDJ:E4,Y2,Y20,and ***,we found that Y2 or Y21 can act alone or together with E4 to trigger apoptotic cascades via the mitochondrial apoptotic pathway and estrogen ***:Our study not only explained why YDJ is effective for cervical cancer treatment,but also lays a strong foundation for future clinical studies based on this traditional medicine.