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Kinetic analysis of p53 gene network with time delays and PIDD

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International Journal of Biomathematics 2024年第3期17卷 57-88页

作者： Ruimin Huo Nan Liu Hongli Yang Liangui Yang School of Mathematical Sciences Inner Mongolia University Hohhot 010021P.R.China faculty of Mathematics Baotou Teachers College Baotou 014030P.R.China timuyhl@***

p53 kinetics plays a key role in regulating cell *** on the p53 gene regulatory network composed by the core regulatory factors ATM,Mdm2,Wipl,and PIDD,the effect of the delays in the process of transcription and translation of Mdm2 and Wipl on the dynamics of p53 is studied theoretically and *** results show that these two time delays can affect the stability of the positive *** the increase of delays,the dynamics of p53 presents an oscillating ***,we also study the effects of PIDD and chemotherapeutic drug etoposide on the kinetics of *** model indicates that(i)PIDD low-level expression does not significantly affect p53 oscillatory behavior,but high-level expression could induce two-phase kinetics of p53;(ii)Too high and too low concentration of etoposide is not conducive to p53 *** results are in good agreement with experimental ***,we consider the infuence of internal noise on the system through Binomial r-leap *** simulations reveal that high-intensity noise completely destroys p53 dynamics in the deterministic model,whereas low-intensity noise does not alter p53 ***,for the stable focus,the internal noise with appropriate intensity can induce quasi-limit cycle oscillations of the *** work may provide the useful insights for the development of anticancer therapy.

关键词： PIDD time delay p53 gene regulatory network Hopf bifurcation stochastic simulation.

LKB1 depletion-mediated epithelial-mesenchymal transition induces fibroblast activation in lung fibrosis

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Genes & Diseases 2024年第3期11卷 417-426页

作者： Zijian Xu Elizabeth R.Davies Liudi Yao Yilu Zhou Juanjuan Li Aiman Alzetani Ben G.Marshall David Hancock Tim Wallis Julian Downward Rob M.Ewing Donna E.Davies Mark G.Jones Yihua Wang Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and Experimental Sciences Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biomedical Research Centre University Hospital SouthamptonSouthampton SO166YDUK University Hospital Southampton Southampton SO166YDUK Oncogene Biology The Francis Crick InstituteLondon NW11ATUK

The factors that determine fibrosis progression or normal tissue repair are largely *** previously demonstrated that autophagy inhibition-mediated epithelial-mesenchymal transition(EMT)in human alveolar epithelial type Il(ATIl)cells augments local myofibroblast differentiation in pulmonary fibrosis by paracrine ***,we report that liver kinase B1(LKB1)inactivation in ATIl cells inhibits autophagy and induces EMT as a *** IPF lungs,this is caused by the down-regulation of CAB39L,a key subunit within the LKB1 complex.3D co-cultures of ATIl cells and MRC5 lung fibroblasts coupled with RNA sequencing(RNA-seq)confirmed that paracrine signaling between LKB1-depleted ATIl cells and fibroblasts augmented myofibroblast ***,these data suggest that reduced autophagy caused by LKB1 inhibition can induce EMT in ATIl cells and contribute to fibrosis via aberrant epithelial-fibroblast crosstalk.

关键词： CAB39L Crosstalk EMT LKB1 Pulmonary fibrosis

A Hybrid Machine Learning Framework for Security Intrusion Detection

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Computer Systems Science & Engineering 2024年第3期48卷 835-851页

作者： Fatimah Mudhhi Alanazi Bothina Abdelmeneem Elsobky Shaimaa Aly Elmorsy Mathematics and Computer Science Department Faculty of ScienceAlexandria UniversityAlexandriaEgypt

Proliferation of technology,coupled with networking growth,has catapulted cybersecurity to the forefront of modern security *** this landscape,the precise detection of cyberattacks and anomalies within networks is crucial,necessitating the development of efficient intrusion detection systems(IDS).This article introduces a framework utilizing the fusion of fuzzy sets with support vector machines(SVM),named *** core strategy of FSVM lies in calculating the significance of network features to determine their relative *** with minimal significance are prudently disregarded,a method akin to feature *** process not only curtails the computational burden of the classification algorithm but also ensures the preservation of high accuracy *** ascertain the efficacy of the FSVM model,we have employed a publicly available dataset from Kaggle,which encompasses two distinct decision *** evaluation methodology involves a comprehensive comparison of the classification accuracy of the processed dataset against four contemporary models in the *** performance metrics scores are meticulously calculated for each *** comparative analysis reveals that the FSVM model demonstrates a marked superiority over its counterparts,enhancing classification accuracy by a minimum of 3%.These findings underscore the FSVM model’s robustness and reliability,positioning it as a highly effective tool in the realm of cybersecurity.

关键词： Cybersecurity fuzzy sets classification internet of things

Optimization of extraction process for total fl avonoids of Sophorae Flos for the treatment of hyperlipidemia based on network pharmacology and molecular docking

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Journal of Polyphenols 2024年第3期6卷 117-129页

作者： Jiale Mao Aijinxiu Ma Lingling Wang Xu Zhao faculty of Functional Food and Wine Shenyang Pharmaceutical UniversityShenyang 110016China

This study aimed to investigate the mechanism of action of Sophora Flos(SF)in the treatment of hyperlipidemia(HLP)using network pharmacology and molecular docking methods,and to optimize the extraction process of the predicted active *** STRING database was used for protein interaction analysis and PPI network construction via Cytoscape *** was employed for docking and *** extensive review of SF identifi ed 6 active ingredients,297 related objectives,84 disease objectives,and 57 total *** protein interaction and topology analysis,18 core targets were identifi *** included 146 gene function entries(P<0.05).Active compounds,mainly fl avonoids,can modulate the expression of various proteins such as TNF,IL-6,IL-1β,PPARG,and TGFB1 to achieve therapeutic eff ects on *** network pharmacology and molecular docking results suggested that the active fl avonoids component in SF may be related to the treatment of ***,the orthogonal experiment method was used to optimize the extraction process of total fl avonoid from SF using ethanol refl ux extraction,based on a single factor *** eff ects of refl ux time,solid-liquid ratio,ethanol concentration,and other factors on the extraction of total fl avonoid from SF were *** optimum process conditions were refl ux time of 1.25 h,solid-liquid ratio of 1:15 g/mL and ethanol concentration of 60%.Using these conditions,the purity of total fl avonoid extracted from SF was 70.33±0.22%.

关键词： Sophorae Flos total fl avonoid process optimization network pharmacology hyperlipidemia

Dysregulated bidirectional epithelial-mesenchymal crosstalk:A core determinant of lung fibrosis progression

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第1期2卷 27-33页

作者： Liudi Yao Zijian Xu Donna E.Davies Mark G.Jones Yihua Wang Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK Clinical and Experimental Sciences Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biomedical Research Centre University Hospital SouthamptonSouthampton SO166YDUK

Progressive lung fibrosis is characterized by dysregulated extracellular matrix(ECM)***-ing of disease pathogenesis remains limited and has prevented the development of effective *** an abnormal wound-healing response is strongly implicated in lung fibrosis initiation,factors that determine why fi-brosis progresses rather than regular tissue repair occur are not fully *** human lung fibrosis,there is evidence of altered epithelial and mesenchymal populations as well as cells undergoing epithelial-mesenchymal transition(EMT),a dynamic and reversible biological process by which epithelial cells lose their cell polarity and down-regulate cadherin-mediated cell-cell adhesion to gain migratory *** review will focus on the role of EMT and dysregulated epithelial-mesenchymal crosstalk in progressive lung fibrosis.

关键词： Lung fibrosis Epithelial-mesenchymal transition(EMT) Crosstalk

The role of melatonin receptor 1B gene(MTNR1B)in the susceptibility to depression and type 2 diabetes comorbidity

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Genes & Diseases 2024年第3期11卷 113-115页

作者： Mutaz Amin Benjamin Rafla Rongling Wu Teodor T.Postolache Cclaudia Gragnoli INSERM US14-OrphanetParis 75014France Department of Biochemistry and Molecular Biology Faculty of MedicineAl-Neelain UniversityKhartoum 11121Sudan Division of Endocrinology Department of MedicineCreighton University School of MedicineOmahaNE 68124USA Department of Public Health Sciences Penn State College of MedicineHersheyPA 17033USA Department of Statistics Penn State College of MedicineHersheyPA 17033USA Mood and Anxiety Program Department of PsychiatryUniversity of Maryland School of MedicineBaltimoreMD 21201USA Rocky Mountain Mental llness Research Education and Clinical Center(MIRECC) Veterans Integrated Service Network(VISN)19Military and Veteran Microbiome:Consortium for Research and Education(MVM-CoRE)DenverCO 80246USA Mental Ilness Research Education and Clinical Center(MIRECC) Veterans Integrated Service Network(VISN)5VA Capitol Health Care NetworkBaltimoreMD 21090USA Molecular Biology Laboratory Bios Biotech Multi-Diagnostic Health CenterRome00197Italy

Melatonin is an endogenous monoamine hormone secreted by the pineal *** signaling has been shown to play a role in circadian rhythm regulation,lipid and glucose metabolism,and obesity,and it has anti-inflammatory and antioxidant *** melatonin receptor 1B gene(MTNR1B)is expressed in,among other tissues,the brain and pancreatic beta cells,and risk variants for T2D have been reported as impairing early insulin secretion and increasing fasting glucose levels.^(1) Variants in the MTNR1B gene also have been reported in patients with depression(MDD).

关键词： MTNR1B metabolism properties.

Zoonotic human liver flukes, a type 1 biocarcinogen, in freshwater fishes: genetic analysis and confirmation of molluscan vectors and reservoir hosts in Bangladesh

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贫困所致传染病(英文) 2024年第3期13卷 1-16页

作者： Labony Sharmin Shahid Alim Md. Abdul Hasan Muhammad Mehedi Hossain Md. Shahadat Akter Sharmin Paul Joydeep Farjana Thahsin Ali Md. Haydar Alam Mohammad Zahangir Hatta Takeshi Kawada Hayato Mizutani Keiko Tsuji Naotoshi Anisuzzaman Department of Parasitology Faculty of Veterinary Science Bangladesh Agricultural University Mymensingh Bangladesh Department of Fisheries Technology Faculty of Fisheries Bangladesh Agricultural University Mymensingh Bangladesh Department of Biotechnology School of Life Sciences &amp Biotechnology Adamas University Barasat - Barrackpore Rd Jagannathpur Kolkata West Bengal India Department of Pathology and Parasitology Hajee Mohammad Danesh Science and Technology University Dinajpur Bangladesh Department of Parasitology and Tropical Medicine Kitasato University School of Medicine-15-Kitasato Minami Sagamihara Kanagawa-0374 Japan Department of Molecular and Cellular Parasitology Kitasato University Graduate School of Medical Sciences-15-Kitasato Minami Sagamihara Kanagawa-0373 Japan

Background Opisthorchiid flukes, particularlyOpisthorchis viverrini,Opisthorchis felineus,Clonorchis sinensis, andMetorchis spp. are the most common fish-borne zoonotic human liver flukes (hLFs). Liver fluke infections are more prevalent in resource-deprived and underprivileged areas. We herein estimated the prevalence of the metacercariae (MC) of major hLFs in common large freshwater fishes (lFWF) marketed for human consumption from some selected areas of Bangladesh along with detection of their molluscan vectors and *** The current status of fish-borne zoonotic hLF infections in lFWF was investigated along with their molluscan vectors and mammalian reservoir hosts in Mymensingh and Kishoreganj in Bangladesh from July 2018–June 2022 using conventional and multiple molecular techniques, such as PCR, PCR-restriction fragment length polymorphism (RFLP), sequencing, and bioinformatic analyses. The infection rate of fishes was analyzed using theZ-test and the loads of MC were compared using the chi-squared (χ2) *** The MC ofC. sinensis,Opisthorchis spp., andMetorchis spp. were detected in 11 species of common and popular lFWF. In lFWF, the estimated prevalence was 18.7% and the mean load was 137.4 ± 149.8 MC per 100 g of fish. The prevalence was the highest (P 0.05) distributed between the head and body of fishes. The infection rate was slightly higher in cultured (19.6%) fishes. The MC ofC. sinensis,O. felineus,O. viverrini, andMetorchis orientalis in fishes were confirmed using PCR, PCR-RFLP and bioinformatics. The cercariae of opisthorchiid (Pleurolophocercus cercariae) flukes were only recovered fromBithynia spp. (3.9%, 42 out of 1089). The ova of hLFs from dogs (4.3%, 5 out of 116) and cats (6.0%, 6 out of 100), and adult flukes (***) from ducks

关键词： Human liver fluke Freshwater fish Molluscan vector Reservoir host Bangladesh

Bibliometric analysis of research challenges and trends in urban underground space

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Deep Underground Science and Engineering 2024年第2期3卷 207-215页

作者： You Zhang Liang Zheng Lingling He Yuyong Jiao Hanfa Peng Ranjith PGamage faculty of Engineering China University of GeosciencesWuhanChina Department of Civil Engineering Monash UniversityClaytonVictoriaAustralia Sinohydro Engineering Bureau Co. LtdPower ChinaXiningChina 4Wuhan Geomatic InstituteWuhanChina

The utilization and development of urban underground space play a crucial role in optimizing the layout of civic architecture and enhancing the urban ecological environment,which contributes toward increasing the overall carrying capacity and promoting sustainable development in *** delve into the research progress of urban underground space,knowledge maps were created using the information visualization software *** literature was systematically extracted from three prominent databases,namely,Web of Science,Scopus,and China National Knowledge *** to the bibliometric analysis of the co-citation and core words co-occurrence,the trends and challenges of research on urban underground space were *** highlighted by the results obtained,it still remains highly challenging to achieve interdisciplinary collaboration in urban underground space research;the research trends of urban underground space consist of collaborative planning and whole life cycle sustainable development,multisource geological data informatization and resource evaluation,infrastructure design optimization,and intelligent *** knowledge map,drawn using bibliometric methods,offers a quantitative analysis of literature retrieval across various *** is recognized as an essential tool for exploring and identifying challenges and trends in urban underground space.

关键词： bibliometric analysis knowledge groups urban underground space VOSviewer

“OMINO”: A Modern Approach to Postural Standing Reeducation through Breathing Techniques

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Health 2024年第5期16卷 383-394页

作者： Maria Chiara Patriarca Medicine and Rehabilitation Department Faculty of Medicine and Surgery Catholic University of Holy Heart Rome Italy

Postural problems are very common, which is why plenty of Techniques have been created to solve them: Mezieres Technique (including muscle chains), RPG (Global Postural Re-Education, including pelvic diaphragm), Pilates Method (including core muscles), Bobath Concept (including COG, center of gravity) and Yoga. In this work, I show a new way of treating and solving postural problems. I am basing this physiotherapy approach on a new Image I created. Every patient can use it for every correction and change in posture. I called the new Image: “OMINO (little man)”. “Postural Card” could be a good work to make “OMINO” possible. “OMINO” is immediately understandable and, using “OMINO POCKET INSTRUCTIONS”, it can be easily done. Contribution of paper: • Trunk is a vital element for any kind of rehabilitation;• “core stability” is the key to activating the trunk. • Doing “OMINO” means working on “core stability”;• “OMINO” makes rehabilitation simple for the patient.

关键词： Trunk core Stability “OMINO” Patient Rehabilitation