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Considerations for determining optimal mouse caging density

中国比较医学杂志 2008年第1期18卷 26-26页

作者： Charmaine Foltz Larry Carbone David DeLong Bernard E. Rollin Pascalle Van Loo Julia Whitaker Axel Wolff Division of Veterinary Resources National Institutes of Health Bethesda MD. University of California San Francisco San Francisco CA. Veterinary Medical Unit VA Medical Center Minneapolis MN. Colorado State University Fort Collins CO. Utrecht University The Netherlands. Department of pathology and Laboratory Medicine Division of Laboratory Animal Medicine University of North Carolina Chapel Hill NC. Division of Compliance Oversight OLAW National Institutes of Health Bethesda MD. Correspondence should be addressed to Charmaine Foltz DVM

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Transplantation of stem cells from human exfoliated deciduous teeth for bone regeneration in the dog mandibular defect

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World Journal of Stem Cells 2014年第4期6卷 505-510页

作者： Ali Behnia Abbas Haghighat Ardeshir Talebi Nosrat Nourbakhsh Fariba Heidari Member of Students’ Research Center Isfahan Uni-versity of Medical Sciences81745-319 IsfahanIran Department of Oral and Maxillofacial Surgery Shahid Saddooghi University of Medical SciencesYazd Dental School*** YazdIran Department of Oral and Maxillofacial Surgery Alzahra HospitalIsfahan University of Medical SciencesIsfahan Dental School81746-73461 IsfahanIran Torabinejad Research Center Department of PathologyFaculty of Medical SciencesIsfahan University81746-73461 IsfahanIran Torabinejad Research Center Department of Pediatric DentistryIsfahan University of Medical SciencesIsfahan Dental School81746-73461 IsfahanIran Torabinejad Research Center Isfahan University of Medical SciencesIsfahan Dental School81746-73461 IsfahanIran

AIM: To investigate the effect of stem cells from human exfoliated deciduous teeth(SHED) transplanted for bone regeneration in the dog mandibular ***: In this prospective comparative study, SHEDs had been isolated 5 years ago from human exfoliated deciduous teeth. The undifferentiated stem cells were seeded into mandibular bone through-andthrough defects of 4 dogs. Similar defects in control group were filled with cell-free collagen scaffold. After 12 wk, biopsies were taken and morphometric analysis was performed. The percentage of new bone formation and foreign body reaction were measured in each case. The data were subject to statistical analysis using the Mann-Whitney U and Kruskalwalis statistical tests. Differences at P < 0.05 was considered as significant ***: There were no significant differences between control and SHED-seeded groups in connective tissue(P = 0.248), woven bone(P = 0.248) and compact bone(P = 0.082). There were not any side effects in transplanted SHED group such as teratoma or malignancy and abnormalities in this ***: SHEDs which had been isolated and characterized 5 years ago and stored with cryopreservation banking were capable of proliferation and osteogenesis after 5 years, and no immune response was observed after three months of seeded SHEDs.

关键词： Bone regeneration Isolation Stem cells from human exfoliated deciduous teeth

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Human genetic and immunological determinants of critical COVID-19 pneumonia

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四川生理科学杂志 2021年第11期43卷 1947-1947页

作者： Qian Zhang St Giles Laboratory of Human Genetics of Infectious Diseases Rockefeller Branch The Rockefeller University New York NY USA Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France University of Paris Imagine Institute Paris France Howard Hughes Medical Institute Paris France The Rockefeller University & Howard Hughes Medical Institute New York NY USA Necker Hospital for Sick Children & INSERM Paris France Department of Pediatrics Necker Hospital for Sick Children Paris France Cemil Taşcıoglu City Hospital Istanbul Turkey Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France Imagine Institute University of Paris Paris France Al Jalila Children’s Hospital Dubai United Arab Emirates San Raffaele Telethon Institute for Gene Therapy IRCCS Ospedale San Raffaele and Vita Salute San Raffaele University Milan Italy Hospices Civils de Lyon Lyon France Helix San Mateo CA USA Department of Intensive Care Medicine Critical Care Center CHU Lille Lille France Univ. Lille CNRS Inserm CHU Lille Institut Pasteur de Lille U1019-UMR9017-CIIL-Centre d’Infection et d’Immunité deLille Lille France Shupyk National Medical Academy for Postgraduate Education Kiev Ukraine Department of Medical Microbiology University Medical Center Utrecht Utrecht The Netherlands Sidra Medicine Doha Qatar Primary Immunodeficiencies Group Department of Microbiology and Parasitology School of Medicine University of Antioquia Medellín Colombia School of Microbiology University of Antioquia Medellín Colombia IIBB-CSIC IDIBAPS Barcelona Spain Department of Immunology Second Faculty of Medicine Charles University University Hospital in Motol Prague Czech Republic Department of Immunology Dmitry Rogachev National Medical Research Center of Pediatric Hematology Oncology and Immunology Moscow Russia Pulmonology Department Cliniques Universitaire

SARS-CoV-2 infection is benign in most individuals but,in-10%of cases,it triggers hypoxemic COVID-19 pneumonia,which becomes critical in-3%of *** ensuing risk of death(-1%)doubles every five years from childhood onward and is-1.5 times greater in men than in *** are the molecular and cellular determinants of critical COVID-19 pneumonia?Inborn errors of type I IFNs,including autosomal TLR3 and X-linked TLR7 deficiencies,are found in-1-5%of patients with critical pneumonia under 60 years old.

关键词： pneumonia critical cases

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