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Biomedical and Environmental Sciences 2022年第3期35卷 270-275页

作者： LI Wen Long LI Yuan Yuan LI Yu Xin FU Yu HE Xian Zhi TAO Fei Yan YOU Ruo Lan ZHANG Ruo Yu ZHONG Ming Qing CHI Hui Min ZHAI Qing Feng School of Public Health Weifang Medical UniversityWeifang 261042ShandongChina community healthcare center of baoshan street office Health Bureau of Licheng DistrictJinan 250000ShandongChina Weifang Maternal and Child health Hospital Weifang 261042ShandongChina

Experimental evidence has demonstrated that environmental hazards can induce neurodegeneration such as Alzheimer's disease(AD)^([1]).The pathogenesis of AD,characterized by a gradual cognitive decline,overproduction ofβ-amyloid(Aβ),and hyperphosphorylated tau in specific brain areas,is considered to involve the interaction of several internal(individual)and external environmental factors.

关键词： Alzheimer Aβ tau

Veterans utilizing a federally qualified health center: a clinical snapshot

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Military Medical Research 2023年第1期10卷 134-136页

作者： Thad E.Abrams Bruce Alexander Antonio Flores M.Bryant Howren VHA office of Rural Health Veterans Rural Health Resource CenterIowa CityIA 52246USA Carver College of Medicine The University of IowaIowa CityIA 52242USA center for Access Delivery Research and Evaluation(CADRE) VA Iowa City Healthcare SystemIowa CityIA 52246USA community Health centers of Southeastern Iowa West BurlingtonIA 52655USA Department of Behavioral Sciences and Social Medicine College of MedicineFlorida State UniversityTallahasseeFL 32306USA Florida Blue center for Rural Health Research and Policy College of MedicineFlorida State UniversityTallahasseeFL 32306USA

Dear Editor,Te Veterans Health Administration(VHA)provides healthcare for over 9 million enrolled veterans with approximately 2.7 million of those residing in rural areas[1].Te MISSION Act of 2018 emphasizes VHA collaboration with Federally Qualifed healthcare centers(FQHC)to serve rural residing veterans and nearly all existing collaborations involve arrangement of payment for community-based care by VHA to ***,there is a paucity of descriptive clinical data on existing cross-system collaborations which may help characterize these veterans and aid understanding of conditions for which they may receive treatment across *** data has implications for workforce training,development,and resource allocation[2].Te objective of this report is to describe diferent clinical profles between two mutually exclusive samples:veterans engaged in FQHC only use,and VHA-enrolled veterans engaged in dual VHA and FQHC use.

关键词： Veterans Federally qualified healthcare centers healthcare utilization Dual use Mental health

Study on the relationship between the structure of bacterial flora onthe tongue and types of tongue coating in patients with type 2diabetes mellitus

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Traditional Medicine Research 2019年第6期4卷 326-337页

作者： Yu-Hong Ding# Xing-Yu Zheng Wei-Wei Chen Xin-Fu Lin Xiao Yang Jie-Wei Luo Fang-Meng Huang Yong-Xi Wu Shi-Chao Wei community healthcare Services center of Gudong street FuzhouChina Provincial Clinical Medical College Fujian Medical UniversityFuzhouChina Department of Traditional Chinese Medicine Fujian Provincial HospitalFuzhouChina Department of Paediatrics Fujian Provincial HospitalFuzhouChina Teaching and Research office of Medical Cosmetology Department of ManagementFujian Health CollegeFuzhouChina.

Objective:To analyze the characteristics of bacterial flora on the tongue and types of tongue coating between healthy individuals and patients with type 2 diabetes mellitus(T2DM)via detecting 16S rDNA of oral tongue coating microbial ***:A total of 42 patients with T2DM were recruited,including 6 with thin white coating,9 with mirror-like coating,27 with yellow thick coating(YTC),and 28 healthy *** V4 region of 16S rDNA from the tongue coating microbiota was sequenced using the Linux ubuntu sequencing platform,and the structure of bacterial flora in the tongue was *** construction,principal coordinates analysis,redundancy analysis,and linear discriminant analysis were conducted using R software to analyze the differences of bacterial flora in the tongue coating in each ***:A total of 8131 different operational taxonomic units(OTUs)were obtained via sequencing,of which 719 OTU samples showed significant differences(PNeisseria>Veillonella>Streptococcus>Fusobacterium>Leptotrichia and so *** order of dominant bacteria of group 2 were Neisseria>Prevotella>Fusobacterium>Streptococcus>porphyromonas and so *** dominant bacteria of group 3 were Prevotella>Fusobacterium>Streptococcus>Neisseria>Leptotrichia>Rothia>Veil

关键词： Type 2 diabetes mellitus Oral flora 16S rDNA sequence Yellow thick coating

The Long-Term Impacts of COVID-19 on Physical and Psychological Health—Beijing Municipality,China,December 2022–April 2023

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China CDC weekly 2023年第40期5卷 894-899页

作者： Tian Tian Chuan Yang Xiaoyu Long Fei Kong Yu Fu Fang Liu Ling Tuo Xiujun Guo Lei Li Xingxing Zhao Qun Wang Guangti Yuan Huiqing Wang Yuanyuan Wang Jie Qiao center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijingChina State Key Laboratory of Female Fertility Promotion BeijingChina National Clinical Research center for Obstetrics and Gynecology(Peking University Third Hospital) BeijingChina Key Laboratory of Assisted Reproduction(Peking University) Ministry of EducationBeijingChina Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology BeijingChina Personnel Department Peking University Third HospitalBeijingChina office of Hospital Management Peking University Health Science CenterBeijingChina The Second Outpatient Department of Peking University Third Hospital BeijingChina Capital Airport sub-district DongPingLi community Health center BeijingChina Zizhuyuan community Service Station in Haidian District BeijingChina Beijing Advanced Innovation center for Genomics BeijingChina Peking-Tsinghua center for Life Sciences Peking UniversityBeijingChina.

Summary What is already known about this topic?Reports detailing the clinical presentation of coronavirus disease 2019(COVID-19)are extensive in ***,data remains limited regarding the long-term effects of the 2022 outbreak on the community and healthcare workers(HCWs).What is added by this report?In the follow-up study conducted with 1,069 community members and 3,309 HCWs infected with COVID-19,we observed that five months postoutbreak,39.2%of community members and 28.7%of HCWs reported experiencing at least one *** symptoms most frequently reported included fatigue or muscle weakness,insomnia,cognitive dysfunction,hair loss,joint or muscle pain,and persistent *** tended to experience fewer long-term physical consequences and their symptoms had an expedited recovery time compared to the community ***,HCWs displayed a higher prevalence of moderate to severe depression and anxiety.

关键词： clinical consequences COV

Hesitant adopters:COVID-19 vaccine hesitancy among diverse vaccinated adults in the United States

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Infectious Medicine 2023年第2期2卷 89-95页

作者： Sharon Reece Sheena CarlLee Aaron J.Scott Don E.Willis Brett Rowland Kristin Larsen Ijanae Holman-Allgood Pearl A.McElfish College of Medicine University of Arkansas for Medical Sciences NorthwestFayettevilleAR 72703USA office of community Health and Research University of Arkansas for Medical Sciences NorthwestSpringdaleAR 72703USA College of Medicine University of Arkansas for Medical Sciences NorthwestSpringdaleAR 72703USA

Background:Despite the United States(US)having an abundant supply of COVID-19 vaccines,vaccination rates lag behind other high-income countries,suggesting that vaccine hesitancy and attitudes play a greater role in public health measures than pure supply and *** the acknowledgment that vaccination attitudes and status may or may not be correlated,this study examined COVID-19 vaccine hesitancy among vaccinated US adults by asking:(1)What is the prevalence of COVID-19 vaccine hesitancy among the vaccinated?(2)Does COVID-19 vaccine hesitancy vary across sociodemographic characteristics?(3)Does COVID-19 vaccine hesitancy vary by healthcare access and influenza vaccination over the past 5 years?Methods:Data were collected through an online survey of 2022 US adults with a final analytic sample of 1383 vaccinated ***:Overall,48.8%of vaccinated adults reported some level of hesitancy,while a slight majority reported they were“not at all hesitant”.Younger respondents,women,and Black and American Indian or Alaska Native participants had greater adjusted odds of being more hesitant towards receiving the COVID-19 ***-dents who had a primary care physician had greater adjusted odds than those who did not have a primary care physician of being more hesitant towards receiving the COVID-19 ***:This is the first population-based national sample study examining COVID-19 vaccine hesitancy among vaccinated individuals from subgroups of distinctive backgrounds in order to inform targeted strategies for reducing vaccine *** can assist in efforts to increase vaccination rates and also decrease vaccine hesitancy at the national level.

关键词： COVID-19 vaccine Vaccine hesitancy Hesitant adopters US adults

Diagnostic Analysis of Mechanical Conditions of Small-Scale Incinerators in the healthcare Facilities in Tanzania

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Journal of Environmental Protection 2022年第11期13卷 895-912页

作者： Samwel Manyele Mahir Said Honest Anicetus Adolf Kiyunge Josephat Saria Michael Habtu Grace Saguti Department of Chemical and Mining Engineering University of Dar es Salaam Dar es Salaam Tanzania Ministry of Health Community Development Gender Elderly and Children Dodoma Tanzania Department of Environmental Studies The Open University of Tanzania Dar es Salaam Tanzania World Health Organization Dar es Salaam Country Office Dar es salaam Tanzania

This paper provides analytical diagnosis of mechanical conditions of medical waste incinerators used for healthcare waste (HCW) treatment in Tanzania. The main features assessed were types of incinerators, features of incinerators and incinerator house. The assessment was conducted in three levels of health care facilities (HCFs), that is, Regional, district hospitals and health centers, existed in 26 regions of Tanzania. Questionnaires, interview and checklists were used as tools for data collection. It was observed that High-Tech incinerators are mainly used in regional hospitals, while district hospital and health center use both High-Tech and De-Montfort incinerators. About 60% of the incinerators have defective doors. More than 55% of incinerators are corroded in regional and district hospitals. The chimney, top plates and grate which are good condition are 55.6% and 60% in regional hospitals and health centers, respectively. The situation is below 50% in district hospitals. The leakage of the roof and loose structures were observed in district hospitals and health center to be more than 50% of the incinerator houses. On other hand, the performance of burners and incinerator housing cleanliness are generally good. It was concluded that the incinerators in the HCFs are in bad conditions, necessitating maintenance.

关键词： Small-Scale Incinerators healthcare Waste Mechanical Conditions Waste Generation Rate Operation and Maintenance Environmental Cleanliness

A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)

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Military Medical Research 2020年第1期7卷 1-22页

作者： Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Hospital Management Wuhan UniversityWuhan 430071China Department of Respiratory Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Pharmacy Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Evidence-Based Medicine and Knowledge Translation Henan UniversityKaifeng 475000China China Academy of Chinese Medical Sciences Beijing 100700China China center for Evidence Based Traditional Chinese Medicine(CCEBTCM) Beijing 100700China Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Clinical Laboratory Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Infectious Diseases Zhongnan Hospital of Wuhan UniversityWuhan 430071China Division of Medical Affairs Zhongnan Hospital of Wuhan UniversityWuhan 430071China Division of Nursing Affairs Zhongnan Hospital of Wuhan UniversityWuhan 430071China office of Nosocomial Infection Control Zhongnan Hospital of Wuhan UniversityWuhan 430071China Emergency center Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Health Research Methods Evidenceand ImpactMcMaster UniversityHamiltonON L8S 4L8Canada Department of Traditional Chinese Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Global Health Institute Wuhan UniversityWuhan 430072China the Zhongnan Hospital of Wuhan University Novel Coronavirus Management and Research Team Evidence-Based Medicine Chapter of China International Exchange and Promotive Association for Medical and Health Care(CPAM)

In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named "2019 novel coronavirus(2019-nCoV)" by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV.

关键词： 2019 novel coronavirus 2019-nCoV Respiratory disease Pneumonia Infectious diseases Rapid advice guideline Clinical practice guideline Evidence-based medicine

Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission

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四川生理科学杂志 2022年第6期44卷 1118-1118页

作者： Smruthi Karthikeyan Department of Pediatrics University of California San Diego La Jolla CA USA Department of Biomedical Informatics University of California San Diego La Jolla California USA Department of Computer Science and Engineering University of California San Diego La Jolla CA USA Department of Bioengineering University of California San Diego La Jolla CA USA Department of Immunology and Microbiology The Scripps Research Institute La Jolla CA USA Expedited COVID Identification Environment (EXCITE) Laboratory Department of Pediatrics University of California San Diego La Jolla CA USA Department of Obstetrics Gynecology and Reproductive Sciences University of California San Diego La Jolla CA USA COVID-19 Detection Investigation Surveillance Clinical and Outbreak Response California Department of Public Health Richmond CA USA Sanford Consortium of Regenerative Medicine University of California San Diego La Jolla CA USA Department of Cellular and Molecular Medicine University of California San Diego La Jolla CA USA Student Health and Well-Being University of California San Diego La Jolla CA USA center for Computational Biology and Bioinformatics University of California San Diego La Jolla CA USA Institute for Genomic Medicine University of California San Diego La Jolla CA USA Operational Strategic Initiatives University of California San Diego La Jolla CA USA Return to Learn University of California San Diego La Jolla CA USA Student Affairs University of California San Diego La Jolla CA USA Academic Affairs University of California San Diego La Jolla CA USA Department of Pathology University of California San Diego La Jolla CA USA Scripps Health San Diego La Jolla CA USA Rady Children’s Institute for Genomic Medicine San Diego CA USA Sharp healthcare San Diego CA USA Helix San Mateo CA USA County of San Diego Health and Human Services Agency San Diego CA USA Herbert Wertheim School of Public Health and Human Longevity Science Univers

As SARS-CoV-2 continues to spread and evolve,detecting emerging variants early is critical for public health *** lineage prevalence by clinical testing is infeasible at scale,especially in areas with limited resources,participation,or testing/sequencing capacity,which can also introduce ***-CoV-2 RNA concentration in wastewater successfully tracks regional infection dynamics and provides less biased abundance estimates than clinical testing4,*** virus genomic sequences in wastewater would improve community prevalence estimates and detect emerging variants.

关键词： wastewater Wastewater testing

Feasibility, acceptability, and effectiveness of non-pharmaceutical interventions against infectious diseases among crisis-affected populations: a scoping review

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Infectious Diseases of Poverty 2022年第1期11卷 8-26页

作者： Jonathan A.Polonsky Sangeeta Bhatia Keith Fraser Arran Hamlet Janetta Skarp Isaac J.Stopard Stéphane Hugonnet Laurent Kaiser Christian Lengeler Karl Blanchet Paul Spiegel World Health Organization GenevaSwitzerland Institute of Global Health Faculty of MedicineUniversity of GenevaGenevaSwitzerland MRC Centre for Global Infectious Disease Analysis Department of Infectious Disease EpidemiologyImperial College LondonLondonUK Abdul Latif Jameel Institute for Disease and Emergency Analytics Imperial College LondonLondonUK Swiss Tropical and Public Health Institute BaselSwitzerland University of Basel BaselSwitzerland Geneva Centre of Humanitarian Studies University of GenevaGenevaSwitzerland center for Humanitarian Health Johns Hopkins Bloomberg School of Public HealthBaltimoreUSA

Background:Non-pharmaceutical interventions(NPIs)are a crucial suite of measures to prevent and control infectious disease *** being particularly important for crisis-affected populations and those living in informal settlements,who typically reside in overcrowded and resource limited settings with inadequate access to healthcare,guidance on NPI implementation rarely takes the specific needs of such populations into *** therefore conducted a systematic scoping review of the published evidence to describe the landscape of research and identify evidence gaps concerning the acceptability,feasibility,and effectiveness of NPIs among crisis-affected populations and informal ***:We systematically reviewed peer-reviewed articles published between 1970 and 2020 to collate available evidence on the feasibility,acceptability,and effectiveness of NPIs in crisis-affected populations and informal *** performed quality assessments of each study using a standardised *** analysed the data to produce descriptive summaries according to a number of categories:date of publication;geographical region of intervention;typology of crisis,shelter,modes of transmission,NPI,research design;study design;and study ***:Our review included 158 studies published in 85 peer-reviewed *** research used low quality study *** acceptability,feasibility,and effectiveness of NPIs was highly context *** general,simple and cost-effective interventions such as community-level environmental cleaning and provision of water,sanitation and hygiene services,and distribution of items for personal protection such as insecticide-treated nets,were both highly feasible and ***,financial,and human resource constraints affected both the implementation and sustainability of *** engagement emerged as a strong factor contributing to the effectiveness of ***,measures that involve po

关键词： Disease outbreaks Communicable disease control Prevention & control Vulnerable populations Warfare and armed conflicts Disasters Relief work Poverty areas