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Journal of Energy and Power Engineering 2013年第10期7卷 1957-1965页

作者： RUdiger Rebstock Junnai Zhai Alois P. Schaffarczy German-Dutch Wind Tunnels DNW-KKK Linder Hoehe Cologne D-51147 Germany Department of Mechanical Engineering University of Applied Sciences Kiel Kiel D-24149 Germany

Wind turbine size has increased continuously and correspondingly also its Reynolds numbers. The Reynolds number effect can therefore no longer be ignored in design and optimization of wind turbines. Reliable profile test data should be available. A suitable facility for testing wind turbine profiles at high Reynolds numbers is the Cryogenic Wind Tunnel cologne DNW-KKK. By means of injecting liquid nitrogen the tunnel can be cooled down to 100 K and the Reynolds number therefore can be raised accordingly. The maximum Reynolds number for 2D profile tests can reach 27x10^6. In this paper the test uncertainty and the flow quality of DNW-KKK were analyzed. Then some test results on the Reynolds number effect of the wind turbine profiles will be presented. The Reynolds number effect is different from model to model. Especially for thick profiles and flow control devices the Reynolds number effect is not always like the description in literature.

关键词： Aerodynamics of wind turbine profiles Reynolds number effect cryogenic wind tunnel test.

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al Kabbani Christoph Köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology

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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： Daniel Adam Felix Langerscheidt Hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

High-throughput base editing:a promising technology for precision medicine and drug discovery

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Signal Transduction and Targeted Therapy 2021年第7期6卷 1937-1938页

作者： Agapios Sachinidis Faculty of Medicine Institute of NeurophysiologyUniversity of CologneCologneGermany Center for Molecular Medicine cologne(CMMC) University of CologneCologneGermany

Recently,two resource papers(Hanna et al.1 and Cuella-Martin et al.2)were published describing high-throughput large-scale functional assessment of tens of thousands of human singlenucleotide variants(SNVs)across mult... 详细信息

关键词： base editing

Suppression of mature TAU isoforms prevents Alzheimer's disease-like amyloid-beta oligomer-induced spine loss in rodent neurons

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Neural Regeneration Research 2024年第8期19卷 1655-1657页

作者： Sarah Buchholz Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine cologne(CMMC) Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany

Introduction:TAU isoforms as disease mediators:The microtubule-associated protein TAU is predominantly present in the axons of neurons under physiological *** Alzheimer’s disease(AD)and related tauopathies,TAU also mislocalizes("TAU missorting")to the soma and the dendrites,where it eventually forms aggregates,the so-called neurofibrillary tangles(for review see Zimmer-Bensch and Zempel,2021;Zempel,2023).

关键词： Alzheimer Zimmer tau

Neuronal trafficking as a key to functional recovery in immune-mediated neuropathies

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Neural Regeneration Research 2024年第11期19卷 2331-2332页

作者： Felix Kohle Michael Schroeter Department of Neurology University of Cologne and University Hospital CologneCologneGermany

Immune-mediated neuropathies are rare diseases of the peripheral nervous system(PNS),substantially affecting patients’functionality and quality of *** are amenable to immunomodulatory treatments,which in many cases stabilize disease progression,but long-term deficits persist in many *** long-term deficits are particularly observed in monophasic autoimmune neuropathies like Guillain-Barrésyndrome and also in chronic variants,e.g.,chronic inflammatory demyelinating neuropathy(Fadia et al.,2019).

关键词： diseases autoimmune

The role of LIN28B in tumor progression and metastasis in solid tumor entities

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Oncology Research 2023年第2期31卷 101-115页

作者： TABEA GEWALT KA-WON NOH LYDIA MEDER Department I of Internal Medicine Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine cologne University of CologneCologneGermany Institute for Pathology Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Mildred Scheel School of Oncology Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany

LIN28B is an RNA-binding protein that targets a broad range of microRNAs and modulates their maturation and *** normal conditions,LIN28B is exclusively expressed in embryogenic stem cells,blocking differentiation and promoting *** addition,it can play a role in epithelial-to-mesenchymal transition by repressing the biogenesis of let-7 *** malignancies,LIN28B is frequently overexpressed,which is associated with increased tumor aggressiveness and metastatic *** this review,we discuss the molecular mechanisms of LIN28B in promoting tumor progression and metastasis in solid tumor entities and its potential use as a clinical therapeutic target and biomarker.

关键词： Cancer Metastasis LIN28B Let-7 Stemness EMT Resistance

A simple human cell model for TAU trafficking and tauopathy-related TAU pathology

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Neural Regeneration Research 2022年第4期17卷 770-772页

作者： Michael Bell Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCenter for Molecular Medicine Cologne(CMMC)University of CologneCologneGermany

The microtubule(MT)-associated protein TAU is highly abundant in the axon of human brain neurons,where it binds to and stabilizes MT ***,TAU regulates the dynamic(dis)assembly of MT strands and is involved in a wide range of neuronal *** Alzheimer's disease(AD)and other tauopathies,TAU is missorted into the somatodendritic *** missorting is accompanied by(or leads to)abnormal TAU phosphorylation,MT destabilization,and loss of dendritic spines and mitochondria,eventually resulting in TAU aggregation,neuronal dysfunction and cell death(Arendt et al.,2016).Strikingly,the mechanisms of TAU sorting,and the detrimental cascade upon its failure,are still not fully understood.

关键词： tau sorting eventually

Predicting the next move: tracking the complexity of lung cancer evolution and metastasis

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Signal Transduction and Targeted Therapy 2023年第9期8卷 3885-3887页

作者： Carina Lorenz Axel M.Hillmer Johannes Brägelmann University of cologne Faculty of Medicine and University Hospital CologneDepartment of Translational GenomicsCologneGermany University of cologne Faculty of Medicine and University Hospital CologneMildred Scheel School of Oncology CologneCologneGermany University of cologne Faculty of Medicine and University Hospital CologneCenter for Molecular Medicine CologneCologneGermany University of cologne Faculty of Medicine and University Hospital CologneInstitute of PathologyCologneGermany

In a series of seven papers in Nature and Nature Medicine,the TRACERx study group presents multi-omic analyses of 421 non-small cell lung cancer(NSCLC)patients,which have yielded a comprehensive map of intratumor heterogeneity(ITH)and lung cancer evolutionary trajectories at an unprecedented level of detail.1–7 The in-depth molecular data,and their subsequent integrated analyses,hold the potential to not only shine light on lung cancer progression but also influence a broad spectrum of scientific disciplines,research fields,and clinical oncology,thereby enhancing our understanding of cancer in general.

关键词： lung cancer metastasis

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亚洲高山流域千年尺度地表剥蚀的制约因素

中国科学:地球科学 2025年第1期 75-94页

作者：杨业 Steven A.BINNIE 徐胜刘丛强 Tibor J.DUNAI 天津大学地球系统科学学院表层地球系统科学研究院 Institute of Geology and Mineralogy University of Cologne

本研究利用前人1233个亚洲高山流域沉积物宇宙成因核素10Be数据统一计算了地表剥蚀速率,以约束构造、气候和地形如何影响和控制地表剥蚀过程.基于高程数据逐个像元的核素产率,使用蒙特卡洛模拟方法重新计算了10Be流域剥蚀速率.剥蚀速率... 详细信息

本研究利用前人1233个亚洲高山流域沉积物宇宙成因核素10Be数据统一计算了地表剥蚀速率,以约束构造、气候和地形如何影响和控制地表剥蚀过程.基于高程数据逐个像元的核素产率,使用蒙特卡洛模拟方法重新计算了10Be流域剥蚀速率.剥蚀速率变化范围从（7.4±0.7）mm ka-1（1σ;青藏高原内部）到（9,646744+777）mm ka-1（1σ;青藏高原南部）跨四个数量级,中位数为186mm ka-1.逐个像元计算的核素产率与传统模型使用质心坐标和平均高程计算的核素产率相比,后者96.6%核素产率被低估,其中高程差越大越被低估.两种方法计算的产率偏差可达40%,究其原因可能是流域高程分布不均和核素产率随海拔和纬度呈非线性变化.通过量化地表剥蚀速率与构造、气候、地形和岩性之间的相关性将有助于推演未知流域的剥蚀速率.从局部小尺度分析,亚热带台湾岛地区剥蚀速率可能主要受降水和新构造驱动的山体滑坡影响,而降水变化范围较窄的青藏高原东部的剥蚀速率主要受控于地形;冰川覆盖的高原地区剥蚀速率受冰川作用影响,如帕米尔、青藏高原内部和南部地区;青藏高原内部剥蚀速率较低是因为较低的降水和较高的侵蚀基准面,从而限制了河流的下切和地表起伏度演化.与局部小尺度强调单一主控因素不同,本研究对亚洲高山流域宏观大尺度进行量化分析发现:（1）地形指标（包括坡度、地形起伏度和河道陡峭指数）与剥蚀速率在千年尺度呈现一致的幂函数关系,而非简单线性;（2）剥蚀速率与气候（包括与海拔相关的降水、温度和植被覆盖度）和新构造活动（地震核密度分布）呈近似幂函数关系,为次要控制因素;（3）岩性与剥蚀速率没有明显的相关性,可能受限于流域复杂的岩性混合和低分辨率的可侵蚀指数数据.

关键词： 10Be剥蚀速率气候变化构造抬升地形梯度亚洲高山流域

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