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Chemical Research in Chinese Universities 2004年第6期20卷 694-697页

作者： LUYao GUOLi-ping MAJian-fang YANGJin WUDong-mei FacultyofChemistry NortheastNormalUniversityChangchun130024China collegeofchemistry＆pharmocology JiamusiUniversityJiamusi154002China

The electrochemical properties of eight new divalent transition metal benzenesulphonate complexes with 1,10-phenanthroline in different solvents and supporting electrolytes were investigated by means of cyclic voltammetry(CV). Based on the CV data the influences of various coordination modes on the electrochemical behavior of the complexes were discussed. The diffusion coefficient D c and rate constant k s of those complexes in DMF systems were estimated according to CV and the results show that these processes were all quasi-reversible.

关键词： Benzenesulphonate 1,10-Phenanthroline Transition metal complex Cyclic voltammetry

INHIBITORY EFFECTS OF THE ALKALOIDS FROM Radix Caulophylli ON THE PROLIFERATION OF HUMAN VASCULAR ENDOTHELIAL CELL

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Journal of Pharmaceutical Analysis 2005年第2期17卷 91-93,98页

作者：李义平贺浪冲 Department of pharmocology Medical School of Xi'an Jiaotong University X''an 710061 China

Objective To find an angiogenetic inhibitor from Radix Caulophylli (RC). Methods The extract of Radix Caulophylli was obtained by using 95% alcohol in water as solvent. Then, the total alkaloids of Radix Caulophylli was isolated from the extract by using a positive ion exchange resin column. An active part was found by a screening model of cell membrane chromatography (CMC) and further tested by the MTT method with emodin as a control. Results The total alkaloids of Radix Caulophylli was the active part by CMC and could significantly inhibit proliferation of ECV304 cells in MTT test. The inhibitory rate was 56.06% while the concentration of the total alkaloids of Radix Caulophylli was 19.63μg/mL. Conclusion The total alkaloids from Radix Caulophylli may be a new angiogenetic inhibitor, and mechanism of the total alkaloids on inhibitory angiogenesis still need to be further investigated.

关键词： Radix Caulophylli cell membrane chromatography MTT angiogenetic inhibitor

Pharmacokinetic study about compatibility of Eucommia ulmoides and Psoralea corylifolia

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Chinese Herbal Medicines 2023年第2期15卷 263-270页

作者： Yuxing Huang Erwei Liu Xuhua Huang Jia Hao Siyuan Hu Xiumei Gao Tianjin University of Traditional Chinese Medicine Tianjin 301617China Tianjin Key Laboratory of Phytochemistry and Pharmaceutical Analysis Tianjin University of Traditional Chinese MedicineTianjin 301617China Tianjin Key Laboratory of Chinese Medicine pharmocology Tianjin University of Traditional Chinese MedicineTianjin 301617China First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300193China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300193China

Objective:The compatibility of Eucommia ulmoides(Eu)and Psoralea corylifolia(Pc)on the pharmacokinetic(PK)properties in the rat was explored in this ***:Eu extract,Pc extract and the combined extracts(crude drug ratio was 2:1)was administered by gavage,*** PK experiments were *** first one,the blood samples were collected via the occuli chorioideae vein to get the PK properties of the *** second one,the blood samples were simultaneously collected via the internal jugular vein or portal vein at different time points and the concentrations of target ingredients were detected by LC/MS/MS to clear the location where the interaction of Eu and Pc took place in ***:Eight of 11 ingredients in Eu and Pc extract were determined in rat *** exposure levels of geniposidic acid(GPA),aucubin(AU),geniposide(GP),pinoresinol diglucoside(PDG),psoralen glycosides(PLG)and isopsoralen glycosides(IPLG)were decreased 1/5–2/3 after administration of combined *** to the combined administration,the exposure of GPA and AU in plasma of single Eu administration collected via the portal vein were decreased 1/3–2/3,and the values of AUC0-24h and AUC0-∞ of GP collected from the portal vein or internal jugular vein were double *** other components’parameters were not significantly ***:In summary,the Pc and Eu combined administration could affect the exposure of the main components of Eu extract in rats due to the changed intestinal *** research on the compatibility of Pc and Eu was helpful to guide the clinical administration of Eu and Pc simultaneously.

关键词： double intubation drug interaction Eucommia ulmoides Oliver LC/MS/MS pharmacokinetic properties Psoralea corylifolia L

The role of peripheral anionic sites in the regulation of the spatial structure of acetylcholinesterase tetramer for high efficiency

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中国药理通讯 2011年第2期28卷 49-50页

作者： Shuang Jiang Xiaobo Wang Ronggang Xi Yingge Zhang Institute of pharmocology and Toxicology Academy of Military Medical Sciences Beijing 100850 210th Hospital of People Liberation Army Dalian 116021

To study how acetylcholinesterase (ACHE) (solve the paradox between its high efficiency and the narrow active center gorge (ACG), and to explore the role of peripheral anionic site

关键词：英文摘要内容介绍编辑工作期刊

Impact of Paneth Cell Autophagy on Inflammatory Bowel Disease

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Impact of Paneth Cell Autophagy on Inflammatory Bowel Diseas...

病理条件下的神经可塑性及在针灸研究中的可能应用

首届东方药理论坛暨2018年全国心脑血管药理学术会议、上海市药理学会第十九届学术年会

作者： Shu-Ling Wang Bo-Zong Shao Chao-Yu Miao Department of Gastroenterology Changhai HospitalSecond Military Medical University/Naval Medical University Department of pharmocology Second Military Medical University/Naval Medical University

Intestinal mucosal barrier,mainly consisting of the mucus layer and epithelium,functions in absorbing nutrition as well as prevention of the invasion of pathogenic *** cell,an important component of mucosal barrier,plays a vital role in maintaining the intestinal homeostasis by producing antimicrobial materials and controlling the host-commensal *** evidence shows that the dysfunction of intestinal mucosal barrier,especially Paneth cell,participates in the onset and progression of inflammatory bowel disease(IBD).Autophagy,a cellular stress response,involves various physiological processes,such as secretion of proteins,production of antimicrobial peptides and degradation of aberrant organelles or *** the recent years,the roles of autophagy in the pathogenesis of IBD have been increasingly *** in this review,we mainly focus on describing the roles of Paneth cell autophagy in IBD as well as several popular autophagy-related genetic variants in Penath cell and the related therapeutic strategies against IBD.

关键词： autophagy Paneth cell inflammatory bowel disease unfolded protein response endoplasmic reticulum stress

来源： cnki会议评论

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针刺研究 2008年第1期33卷 41-46页

作者：赵慧英牟萍董岩西北农林科技大学陕西杨陵712100 兰州大学兰州730000 Department of Vet.and Comparative Anatomy Pharmocology and PhysiologyWashington State UniversityPullmanWA 99164USA

大脑由可塑性极强的神经元组成。许多病理因素通过神经可塑性的分子细胞学机制诱导出特异性的神经活动模式,从而在细胞学水平引起脑的病理生理变化。这一逐步完善的理论不仅为理解诸多极为复杂的神经系统疾病提供了理论依据,亦为将来的... 详细信息

大脑由可塑性极强的神经元组成。许多病理因素通过神经可塑性的分子细胞学机制诱导出特异性的神经活动模式,从而在细胞学水平引起脑的病理生理变化。这一逐步完善的理论不仅为理解诸多极为复杂的神经系统疾病提供了理论依据,亦为将来的临床治疗提供了可行的途径。针灸效应的生物学机制目前尚不十分清楚,有证据表明:经穴信息可能直接或间接地传入中枢神经系统,并通过重塑神经元活动模式(可塑性)达到某些治疗效果。由于这方面的研究尚处于起步阶段,这里以药物成瘾中神经可塑性作为范例,论述外周刺激如何利用神经可塑性改变脑的功能。药物成瘾是一种中枢神经系统性疾病,通常被定义为无法自拔的药物使用。充分证据表明:反复使用某种依赖性药物后,中脑边缘多巴胺(DA)系统的神经回路会发生一系列病理性的持久变化,从而导致动物情绪上的巨大变化。发现、鉴定和总结成瘾性药物在中脑边缘DA系统引发的长时程细胞学变化,是目前揭开成瘾的神经学机制的一条可行之路。突触可塑性变化是长时程神经变化中进展最快、最深入的研究领域。因此,本文以药物成瘾为例,阐明在特定病理条件下神经系统中可塑性的普遍机制和在针灸研究中的可能应用。

关键词：药物成瘾中脑边缘多巴胺系统神经可塑性针灸

川芎嗪对D-半乳糖损伤模型小鼠学习记忆及胆碱能系统的影响

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中国医学科学院学报 2003年第5期25卷 553-556页

作者：张春王世真左萍萍崔旭蔡炯中国医学科学院中国协和医科大学北京协和医院核医学科北京100730 Department of pharmocology Institute of Basic Medical SciencesCAMS and PUMCBeijing Institute of Geronotology and Geriatrics General Hospital of PLABeijing

目的探讨川芎嗪对D-半乳糖(D-galactose,D-gal)损伤模型学习记忆和胆碱能系统功能的影响。方法C57BL/6J小鼠颈背部皮下注射2%D-gal100mg·kg-1·d-1,连续40d制造D-gal损伤模型。第3周起各组分别用生理盐水(正常对照组、模型组)、川芎嗪... 详细信息

目的探讨川芎嗪对D-半乳糖(D-galactose,D-gal)损伤模型学习记忆和胆碱能系统功能的影响。方法C57BL/6J小鼠颈背部皮下注射2%D-gal100mg·kg-1·d-1,连续40d制造D-gal损伤模型。第3周起各组分别用生理盐水(正常对照组、模型组)、川芎嗪(高、低剂量组)和哈伯因(阳性对照组)灌胃。第6周起进行Morris水迷宫测试,连续5d。行为测试结束后,进行大脑皮层乙酰胆碱酯酶(acetylcholinesterase,AchE)活性测定和M受体的放射性配基结合分析。结果与正常对照组相比,D-gal模型组学习记忆能力、AchE活性和M受体含量均明显下降(P<0.05),川芎嗪尤其是在100mg·kg-1·d-1剂量时可明显改善学习记忆功能,增强胆碱酯酶活性(P<0.05),上调M受体数目(P<0.005)。结论川芎嗪可明显提高模型小鼠的学习记忆能力,改善中枢胆碱能系统功能。

关键词：川芎嗪 D-半乳糖阿尔茨海默病痴呆模型胆碱能系统

从人胚胎干细胞畸胎瘤中有效获取间充质干细胞和神经前体细胞(英文)

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生物化学与生物物理进展 2008年第12期35卷 1417-1424页

作者：曾桥安世民潘乾夏昆夏家辉张灼华孙毅范国平中南大学医学遗传学国家重点实验室长沙410008 Department of Human Genetics David Geffen School of Medicine University of California at Los Angeles 695 Charles Young Drive South Los Angeles CA 90095 USA Mental Retardation Research Center University of California at Los Angeles 695 Charles Young Drive South Los Angeles CA 90095 USA Department of Molecalar and Medical pharmocology Department of Psychiatry and Behavioral Sciences and Semel Institute of Neuroscience and Human Behavior University of California at Los Angeles 695 Charles Young Drive South Los Angeles CA 90095 USA Burnham Institute for Medical Research 10901 North Torrey Pines Road La Jolla CA 92037 USA

通过人胚胎干细胞(human embryonic stem cells,hESC)体外分化方法和畸胎瘤形成可以分化获得多种成体细胞.但目前尚不清楚是否可以从 hESCs 畸胎瘤中分离某些特异性细胞.通过体外筛选方法,有效地从 hESCs 畸胎瘤中分离出神经前体细胞(ne... 详细信息

通过人胚胎干细胞(human embryonic stem cells,hESC)体外分化方法和畸胎瘤形成可以分化获得多种成体细胞.但目前尚不清楚是否可以从 hESCs 畸胎瘤中分离某些特异性细胞.通过体外筛选方法,有效地从 hESCs 畸胎瘤中分离出神经前体细胞(neural progenitor cells,NPCs)和间充质干细胞(mesenchymal stem cells,MSCs).这种 hESCs 畸胎瘤来源的 NPCs 和MSCs 与体内神经前体细胞和间充质干细胞有着相似的分子标记和特性,并具有进一步的分化潜能——分别可以诱导成为神经元、神经胶质细胞、脂肪细胞和骨骼细胞等.根据人胚胎干细胞畸胎瘤中含有不同分化阶段的外胚层、中胚层和内胚层的组织或细胞,认为人胚胎干细胞畸胎瘤可以作为另一个细胞来源以获取多种(包括人胚胎干细胞体外分化难以得到的)各种前体 / 干细胞和终末分化细胞.

关键词：人胚胎干细胞畸胎瘤间充质干细胞神经前体细胞