检索结果-南通市图书馆

Transient receptor potential vanilloid 1 involved in the analgesic effects of total flavonoids extracted from Longxuejie(Resina Dracaenae Cochinchinensis)

引用

Journal of Traditional Chinese Medicine 2024年第3期44卷 437-447页

作者： MO Xiaoqiang CHEN Yating YIN Qian CHEN Haibo BAN Qiang LI Jun CHEN Su YAO Jinguang Department of Stomatology Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000China college of General Practitioners Youjiang Medical University for NationalitiesBaise 533000China college of Biomedical Engineering South-Central Minzu UniversityKey Laboratory of Cognitive Science of State Ethnic Affairs CommissionHubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis and TreatmentWuhan 430074China college of pharmacy South-Central Minzu UniversityWuhan 430074China

OBJECTIVE: To evaluate the analgesic effects of total flavonoids of Longxuejie(Resina Dracaenae Cochinchinensis)(TFDB) and explore the possible analgesic mechanism associated with transient receptor potential vanilloid 1(TRPV1).METHODS: Whole-cell patch clamp technique was used to observe the effects of TFDB on capsaicin-induced TRPV1 currents. Rat experiments in vivo were used to observe the analgesic effects of TFDB. Western blot and immunofluorescence experiments were used to test the change of TRPV1 expression in DRG neurons induced by ***: Results showed that TFDB inhibited capsaicin-induced TRPV1 receptor currents in acutely isolated dorsal root ganglion(DRG) neurons of rats and the half inhibitory concentration was(16.7 ± 1.6) mg/***(2-20 mg/kg) showed analgesic activity in the phase Ⅱ of formalin test and(0.02-2 mg per paw)reduced capsaicin-induced licking times of rats. TFDB(20 mg/kg) was fully efficacious on complete Freund's adjuvant(CFA)-induced inflammatory thermal hyperalgesia and capsaicin could weaken the analgesic effects. The level of TRPV1 expressions of DRG neurons was also decreased in TFDB-treated CFA-inflammatory pain ***: All these results indicated that the analgesic effect of TFDB may contribute to their modulations on both function and expression of TRPV1 channels in DRG neurons.

关键词： Freund's adjuvant formaldehyde capsaicin flavonoids Longxuejie(Resina Dracaenae Cochinchinensis) transient receptor potential vanilloid 1 inflammatory pain

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Binary Hybrid Artificial Hummingbird with Flower Pollination Algorithm for Feature Selection in Parkinson’s Disease Diagnosis

引用

Journal of Bionic Engineering 2024年第2期21卷 1003-1021页

作者： Liuyan Feng Yongquan Zhou Qifang Luo college of Artificial Intelligence Guangxi University for NationalitiesNanning530006China Xiangsihu college of Guangxi university for nationalities Nanning532100GuangxiChina Guangxi Key Laboratories of Hybrid Computation and IC Design Analysis Nanning530006China

Parkinson’s disease is a neurodegenerative disorder that inflicts irreversible damage on *** experimental data regarding Parkinson’s patients are redundant and irrelevant,posing significant challenges for disease ***,there is a need to devise an effective method for the selective extraction of disease-specific information,ensuring both accuracy and the utilization of fewer *** this paper,a Binary Hybrid Artificial Hummingbird and Flower Pollination Algorithm(FPA),called BFAHA,is proposed to solve the problem of Parkinson’s disease diagnosis based on speech ***,combining FPA with Artificial Hummingbird Algorithm(AHA)can take advantage of the strong global exploration ability possessed by FPA to improve the disadvantages of AHA,such as premature convergence and easy falling into local ***,the Hemming distance is used to determine the difference between the other individuals in the population and the optimal individual after each iteration,if the difference is too significant,the cross-mutation strategy in the genetic algorithm(GA)is used to induce the population individuals to keep approaching the optimal individual in the random search process to speed up finding the optimal ***,an S-shaped function converts the improved algorithm into a binary version to suit the characteristics of the feature selection(FS)*** this paper,10 high-dimensional datasets from UCI and the ASU are used to test the performance of BFAHA and apply it to Parkinson’s disease *** with other state-of-the-art algorithms,BFAHA shows excellent competitiveness in both the test datasets and the classification problem,indicating that the algorithm proposed in this study has apparent advantages in the field of feature selection.

关键词： Artificial Hummingbird Algorithm Flower pollination algorithm Feature selection Parkinson’s disease Meta-heuristic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aluminum exposure impairs oocyte quality via subcellular structure disruption and DNA damage-related apoptosis in mice

引用

Journal of Environmental Sciences 2024年第5期139卷 308-319页

作者： Hongge Li Jingcai Liu Weihua Nong Mengying Shen Sheng Dou Shaochen Sun Junli Wang The Affiliated Hospital of Youjiang Medical university for nationalities Guangxi 533000China college of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China School of Medical Laboratory Youjiang Medical University for NationalitiesGuangxi 533000China Industrial college of Biomedicine and Health Industry Youjiang Medical University for NationalitiesGuangxi 533000China Reproductive Medicine Guangxi Medical and Health Key Discipline Construction ProjectThe Affiliated Hospital of Youjiang Medical University for NationalitiesGuangxi 533000China

Aluminum(Al)can lead to an exposure of creature in varieties ways for its universality,and it could disturb normal physiological metabolism,with the damage to multisystem including *** the oocyte quality is critical for female reproduction,we inspected the toxicity of Al on mouse oocyte *** constructed in vitro exposure mouse model,and we found that 5 mmol/L Al had adverse effects on oocyte maturation by impairing organelle and *** spindle and misaligned chromosomes which might be considered to be caused by elevated levels of acetylation,as well as abnormal distribution of actin dynamics could hinder normal meiosis of *** dysfunction indicated that Al affected proteins synthesis,transport and digestion,which would further damage oocyte *** order to explore the mechanism of Al toxicity,our further investigation demonstrated that Al caused mitochondrial dysfunction and imbalance calcium homeostasis,resulting in limited energy ***,high level of reactive oxygen species,DNA damage and apoptosis caused by oxidative stress were also the manifestation of Al toxicity on *** conclusion,our study provided the evidence that Al exposure affected oocyte quality through its effects on spindle organization,actin dynamics,organelle function and the induction of DNA damage-related apoptosis with mouse model.

关键词： Aluminum Oocyte Cytoskeleton Organelle DNA damage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Orange-red emitting Sr_3LaTa_3O_(12):Sm^(3+) phosphors with perovskite structure and high thermal stability for w-LEDs

引用

Journal of Rare Earths 2024年第3期42卷 464-472,I0002页

作者： Xiaopeng Hu Anlin Zhang Yufeng Du Li Zhou Changlin Li Jingjing Lian Zhequan Zou Xuan Ouyang Bin Deng Lianwu Xie Ruijin Yu college of Chemistry Biology and Environmental Engineering Xiangnan UniversityChenzhou423043China college of Sciences Central South University of Forestry and TechnologyChangsha410004China college of Chemistry&pharmacy Northwest A&F UniversityYangling712100China Hunan Provincial Key Laboratory of Xiangnan Rare-Precious Metals Compounds Research and Application Xiangnan UniversityChenzhou423043China

A novel layered perovskite tantalate phosphor Sr_(3)LaTa_(3)O_(12):Sm^(3+)(SLTO:Sm^(3+)) with orange-red emission was obtained for the first time via the solid-phase synthetic method. The phase purity, surface morphology,element distribution and luminescent properties of the SLTO:xSm^(3+)(x= 0.01 mol%-0.30 mol%) phosphors were investigated. Under 408 nm excitation, the optimum doped SLTO:0.10Sm^(3+) phosphor emits orangered light at 598 nm with the highest emission peak(4G_(5/2)→6H_(7/2)). The critical energy transfer distance is 1.687 nm. The prepared SLTO:0.10Sm^(3+)phosphor has excellent thermal stability with temperature quenching temperature(T_(0.5)> 500 K) and high activation energy(E_(a)= 0.25 e V). Through calculation, the chromaticity coordinates of all samples are concentrated in the orange-red area, and the color purity reaches 99%. The fabricated white light-emitting diode(w-LED) has a good correlated color temperature(5132 K), a high R_(a)(89), and the CIE chromaticity coordinates(0.340, 0.327). Consequently, the superiority of orange-red-emitting tantalate SLTO:Sm^(3+) phosphors for w-LEDs is demonstrated.

关键词： Tantalate Sr_(3)LaTa_(3)O_(12) Sm^(3+) Luminescence LED Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nanotherapeutics targeting autophagy regulation for improved cancer therapy

引用

Acta Pharmaceutica Sinica B 2024年第6期14卷 2447-2474页

作者： Yunmeng Liu Yaxin Wang Jincheng Zhang Qikai Peng Xingdong Wang Xiyue Xiao Kai Shi college of pharmacy Nankai UniversityTianjin 300350China

The clinical efficacy of current cancer therapies falls short,and there is a pressing demand to integrate new targets with conventional ***,a highly conserved self-degradation process,has received considerable attention as an emerging therapeutic target for *** the rapid development of nanomedicine,nanomaterials have been widely utilized in cancer therapy due to their unrivaled delivery ***,considering the potential benefits of integrating autophagy and nanotechnology in cancer therapy,we outline the latest advances in autophagy-based *** on a brief background related to autophagy and nanotherapeutics and their impact on tumor progression,the feasibility of autophagy-based nanotherapeutics for cancer treatment is ***,emerging nanotherapeutics developed to modulate autophagy are reviewed from the perspective of cell signaling pathways,including modulation of the mammalian target of rapamycin(mTOR)pathway,autophagy-related(ATG)and its complex expression,reactive oxygen species(ROS)and mitophagy,interference with autophagosome-lysosome fusion,and inhibition of hypoxia-mediated *** addition,combination therapies in which nano-autophagy modulation is combined with chemotherapy,phototherapy,and immunotherapy are also ***,the prospects and challenges of autophagy-based nanotherapeutics for efficient cancer treatment are envisioned.

关键词： Autophagy regulation Nanotherapeutic Combination strategies Cancer therapy Signal transduction pathway Delivery strategies Dual effects Nanomaterials

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Elucidating the Degradation Pathways of Human Insulin in the Solid State

引用

Journal of Analysis and Testing 2024年第03期8卷 288-299页

作者： Andrew Fagan Lorraine M.Bateman Joseph P.O'Shea Abina M.Crean SSPC the SFI Centre for Pharmaceutical Research School of Pharmacy University College Cork School of pharmacy University College Cork Analytical and Biological Chemistry Research Facility (ABCRF) University College Cork School of Chemistry University College Cork

While there have been significant advances in the development of peptide oral dosage forms in recent years, highlighted by the clinical and commercial success of approved peptides such as Rybelsus?, there remain several barriers in the way of broad range applicability of this approach to peptide delivery. One such barrier includes the poor physical and chemical stability inherent to their structures, which persists in the solid state although degradation typically occurs at different rates and via different pathways in comparison to the solution state. Using insulin as a model peptide, this work sought to contribute to the development of analytical techniques for investigating common insulin degradation pathways. Chemically denatured,deamidated and aggregated samples were prepared and used to benchmark circular dichroism spectroscopy, reverse phase HPLC and size exclusion chromatography methods for the investigation of unfolding, chemical modifications and covalent aggregation of the insulin molecule respectively. Solid state degraded samples were prepared by heating insulin powder at 60 °C and 75% relative humidity for 1, 3, 5 and 7 d, and the degradation profiles of the samples were evaluated and compared with those observed in solution. While no unfolding was observed to occur, significant deamidation and covalent aggregation were detected. Reductive disulfide bond cleavage using dithiothreitol allowed for separation of the insulin A-and B-chains,offering a facile yet novel means of assessing the mechanisms of deamidation and covalent aggregation occurring in the solid state.

关键词： Biopharmaceutical analysis Covalent aggregation Deamidation Disulfide cleavage Insulin Solid state Stability

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Olfactory dysfunction and its related molecular mechanisms in Parkinson’s disease

引用

Neural Regeneration Research 2024年第3期19卷 583-590页

作者： Yingying Gu Jiaying Zhang Xinru Zhao Wenyuan Nie Xiaole Xu Mingxuan Liu Xiaoling Zhang college of pharmacy Nantong UniversityNantongJiangsu ProvinceChina

Changes in olfactory function are considered to be early biomarkers of Parkinson’s *** dysfunction is one of the earliest non-motor features of Parkinson’s disease,appearing in about 90%of patients with early-stage Parkinson’s disease,and can often predate the diagnosis by ***,olfactory dysfunction should be considered a reliable marker of the ***,the mechanisms responsible for olfactory dysfunction are currently *** this article,we clearly explain the pathology and medical definition of olfactory function as a biomarker for early-stage Parkinson’s *** the basis of the findings of clinical olfactory function tests and animal model experiments as well as neurotransmitter expression levels,we further characterize the relationship between olfactory dysfunction and neurodegenerative diseases as well as the molecular mechanisms underlying olfactory dysfunction in the pathology of early-stage Parkinson’s *** findings highlighted in this review suggest that olfactory dysfunction is an important biomarker for preclinical-stage Parkinson’s ***,therapeutic drugs targeting non-motor symptoms such as olfactory dysfunction in the early stage of Parkinson’s disease may prevent or delay dopaminergic neurodegeneration and reduce motor symptoms,highlighting the potential of identifying effective targets for treating Parkinson’s disease by inhibiting the deterioration of olfactory dysfunction.

关键词： biomarker early-stage olfactory disorders olfactory dysfunction Parkinson’s disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Kármán vortex street in a spin–orbit-coupled Bose–Einstein condensate with PT symmetry

引用

Chinese Physics B 2024年第6期33卷 289-296页

作者：邵凯花席保龙席忠红涂朴王青青马金萍赵茜石玉仁 college of Physics and Electronic Engineering Northwest Normal UniversityLanzhou 730070China college of Physics and Hydropower Engineering Gansu Normal College For NationalitiesHezuo 747000China college of Intelligent Manufacturing Sichuan University of Arts and ScienceDazhou 635000China

The dynamics of spin–orbit-coupled Bose–Einstein condensate with parity-time symmetry through a moving obstacle potential is simulated numerically. In the miscible two-component condensate, the formation of the Kármán vortex street is observed in one component, while ‘the half-quantum vortex street' is observed in the other component. Other patterns of vortex shedding, such as oblique vortex dipoles, V-shaped vortex pairs, irregular turbulence, and combined modes of various wakes, can also be found. The ratio of inter-vortex spacing in one row to the distance between vortex rows is approximately0.18, which is less than the stability condition 0.28 of classical fluid. The drag force acting on the obstacle potential is simulated. The parametric regions of Kármán vortex street and other vortex patterns are calculated. The range of Kármán vortex street is surrounded by the region of combined modes. In addition, spin–orbit coupling disrupts the symmetry of the system and the gain-loss affects the local particle distribution of the system, which leads to the local symmetry breaking of the system, and finally influences the stability of the Kármán vortex street. Finally, we propose an experimental protocol to realize the Kármán vortex street in a system.

关键词： Kármán vortex street Bose–Einstein condensate spin–orbit-coupled parity-time symmetry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tetramic acid-motif natural products from a marine fungus Tolypocladium cylindrosporum FB06 and their anti-Parkinson activities

引用

Marine Life Science & Technology 2024年第1期6卷 84-92页

作者： Yuna Jung Chaesun Kwon Taeyeon Kim Jin Woo Lee Min-Kyoo Shin Sang Hee Shim Natural Products Research Institute College of PharmacySeoul National UniversitySeoul 08826Republic of Korea college of pharmacy and Research Institute of Pharmaceutical Sciences Seoul National UniversitySeoul 08826Republic of Korea college of pharmacy Duksung Women’s UniversitySeoul 01369Republic of Korea

Tetramic acid-containing natural products are attracting significantly increasing attention from biologists and chemists due to their intriguing structures and biological *** the present study,two new tetramic acid alkaloids tolypyridone I(1)and tolypyridone J(2),together with five known ones(3–7),were isolated from cultures of a marine fungus Tolypocladium cylindrosporum FB06 isolate obtained from a marine sediment in Beaufort sea of North *** structures were elucidated using 1D,2D NMR,and *** configurations were established on the basis of 1H coupling constants,ROESY correlations and DP4 *** 2 was isolated as mixtures of rotational isomers with C-3 to C-7 axis between 4-hydroxy-2-pyridone and 1-ethyl-3,5-dimethylcyclohexane,hindering *** our unbiased screening to discover neuroprotective compounds in an in vitro Parkinson’s disease(PD)model,SH-SY5Y dopaminergic cells were treated with isolated compounds followed by treatment with 1-methyl-4-phenylpyridinium(MPP^(+)),a parkinsonian *** tested compounds,F-14329(7)significantly protected cells from MPP^(+)-induced ***^(+)-mediated cell death is known to be related to the regulation of Bcl-2 family proteins,specifically the down-regulation of anti-apoptotic Bcl-2 and the up-regulation of pro-apoptotic Bax *** with 2 mmol/L of MPP^(+)for 24 h significantly reduced Bcl-2 levels compared to control treated with ***,treatment with F-14329(7)attenuated such *** study demonstrates that tetramic acid-motif compounds could be potential lead compounds for treating PD.

关键词： Tolypocladium cylindrosporum Tetramic acid Tolypyridone Parkinson’s disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modulating the electrode–electrolyte interface enables switchable selectivity in electrocatalytic furfural reduction

引用

Science China Chemistry 2024年第10期67卷 3193-3194页

作者： Jingfang Zhang Yi Huang Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education School of Chemical Engineering & PharmacyWuhan Institute of Technology college of Chemistry Central China Normal University

Furfural(FF), an important bio-based platform molecule, can be valorized to high-value-added chemicals(e.g., furfuryl alcohol(FA) or 2-methylfuran(MF)) through catalytic hydrogenation [1]. The traditional thermocatalytic transformation of FF always requires high-temperature and highpressure conditions [2]. Accordingly, electrocatalytic hydrogenation is emerging as a promising approach for the selective reduction of FF to FA or MF under environmentally friendly and benign conditions.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：