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AutoQNN: An End-to-End Framework for Automatically Quantizing Neural Networks

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Journal of Computer Science & Technology 2024年第2期39卷 401-420页

作者：龚成卢冶代素蓉邓倩杜承昆李涛 college of Software Nankai UniversityTianjin 300350China college of Computer Science Nankai UniversityTianjin 300350China State Key Laboratory of Processors Institute of Computing TechnologyChinese Academy of Sciences Beijing 100190China

Exploring the expected quantizing scheme with suitable mixed-precision policy is the key to compress deep neural networks(DNNs)in high efficiency and *** exploration implies heavy workloads for domain experts,and an automatic compression method is ***,the huge search space of the automatic method introduces plenty of computing budgets that make the automatic process challenging to be applied in real *** this paper,we propose an end-to-end framework named AutoQNN,for automatically quantizing different layers utilizing different schemes and bitwidths without any human *** can seek desirable quantizing schemes and mixed-precision policies for mainstream DNN models efficiently by involving three techniques:quantizing scheme search(QSS),quantizing precision learning(QPL),and quantized architecture generation(QAG).QSS introduces five quantizing schemes and defines three new schemes as a candidate set for scheme search,and then uses the Differentiable Neural Architecture Search(DNAS)algorithm to seek the layer-or model-desired scheme from the *** is the first method to learn mixed-precision policies by reparameterizing the bitwidths of quantizing schemes,to the best of our *** optimizes both classification loss and precision loss of DNNs efficiently and obtains the relatively optimal mixed-precision model within limited model size and memory *** is designed to convert arbitrary architectures into corresponding quantized ones without manual intervention,to facilitate end-to-end neural network *** have implemented AutoQNN and integrated it into *** experiments demonstrate that AutoQNN can consistently outperform state-of-the-art *** 2-bit weight and activation of AlexNet and ResNet18,AutoQNN can achieve the accuracy results of 59.75%and 68.86%,respectively,and obtain accuracy improvements by up to 1.65%and 1.74%,respectively,compared with state-of-the-art ***,c

关键词： automatic quantization mixed precision quantizing scheme search quantizing precision learning quan-tized architecture generation

Polystyrene microplastics disrupted physical barriers, microbiota composition and immune responses in the cecum of developmental Japanese quails

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Journal of Environmental sciences 2024年第10期144卷 225-235页

作者： Lingyang Jing Yuxin Zhang Qingyu Zhang Hongfeng Zhao college of life sciences Shaanxi Normal UniversityXi’an 710119China

Microplastics,a new type of emerging pollutant,is ubiquitous in terrestrial and water *** have become a growing concern due to their impacts on the environment,animal,and human *** also suffer from microplastics *** this study,we examined the toxic effects of polystyrene microplastics(PS-MPs)exposure on physical barrier,microbial community,and immune function in the cecum of a model bird species—Japanese quail(Coturnix japonica).The one-week-old birds were fed on environmentally relevant concentrations of 20μg/kg,400μg/kg,and 8 mg/kg PS-MPs in the diet for 5 *** results showed that microplastics could cause microstructural damages characterized by lamina propria damage and epithelial cell vacuolation and ultrastructural injuries including microvilli breakage and disarrangement aswell asmitochondrial vacuolation in the cecum of *** particular,blurry tight junctions,wider desmosomes spacing,and gene expression alteration indicated cecal tight junction ***,mucous layer breakdown andmucin decrease indicated that chemical barrier was disturbed by ***-MPs also changed cecal microbial *** addition,structural deformation of cecal tonsils and increasing proinflammatory cytokines suggested cecal immune disorder and inflammation responses by PS-MPs *** results suggested that microplastics negatively affected digestive system and might pose great health risks to terrestrial birds.

关键词： Microplastics Gut barrier Histology Inflammation Immunity Oxidative stress

The RNA m^(6)A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression

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Cellular & Molecular Immunology 2024年第1期21卷 6-18页

作者： Yang Liu Renjie Song Zhike Lu Lu Zhao Xinyi Zhan Yini Li Xuetao Cao Department of Immunology Center for ImmunotherapyInstitute of Basic Medical SciencesPeking Union Medical CollegeChinese Academy of Medical SciencesBeijingChina Suzhou Institute of Systems Medicine Chinese Academy of Medical SciencesSuzhouChina Frontier Research Center for Cell Response Institute of ImmunologyCollege of Life SciencesNankai UniversityTianjinChina School of life sciences Westlake UniversityHangzhouChina

Emergency granulopoiesis and neutrophil mobilization that can be triggered by granulocyte colony-stimulating factor(G-CSF)through its receptor G-CSFR are essential for antibacterial innate ***,the epigenetic modifiers crucial for intrinsically regulating G-CSFR expression and the antibacterial response of neutrophils remain largely unclear.N6-methyladenosine(m^(6)A)RNA modification and the related demethylase alkB homolog 5(ALKBH5)are key epigenetic regulators of immunity and inflammation,but their roles in neutrophil production and mobilization are still *** used cecal ligation and puncture(CLP)-induced polymicrobial sepsis to model systemic bacterial infection,and we report that ALKBH5 is required for emergency granulopoiesis and neutrophil ***5 depletion significantly impaired the production of immature neutrophils in the bone marrow of septic *** addition,Alkbh5-deficient septic mice exhibited higher retention of mature neutrophils in the bone marrow and defective neutrophil release into the circulation,which led to fewer neutrophils at the infection site than in their wild-type *** bacterial infection,ALKBH5 imprinted production-and mobilization-promoting transcriptome signatures in both mouse and human ***,ALKBH5 erased m^(6)A methylation on the CSF3R mRNA to increase the mRNA stability and protein expression of G-CSFR,consequently upregulating cell surface G-CSFR expression and downstream STAT3 signaling in *** RIP-qPCR results confirmed the direct binding of ALKBH5 to the CSF3R mRNA,and the binding strength declined upon bacterial infection,accounting for the decrease in G-CSFR expression on bacteria-infected *** these results collectively,we define a new role of ALKBH5 in intrinsically driving neutrophil production and mobilization through m^(6)A demethylation-dependent posttranscriptional regulation,indicating that m^(6)A RNA modification in neutrop

关键词： Emergency granulopoiesis Neutrophil mobilization ALKBH5 m^(6)A RNA modification G-CSF receptor

Selective immobilization of Pb(Ⅱ)by biogenic whewellite and its mechanism

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Journal of Environmental sciences 2024年第3期137卷 664-676页

作者： Xingxing Wang Kaiyan Ren Kairui Jiao Wenjun Nie Xiaochi An Bin Lian college of life sciences College of Marine Science and EngineeringNanjing Normal UniversityNanjing 210023China

The development of bio-adsorbents with highly selective immobilization properties for specific heavy metals is a great challenge,but has important application *** whewellite(BW)with high selectivity for Pb(Ⅱ)was synthesized by mineral microbial *** selective immobilization properties and mechanism of BW for Pb(Ⅱ)were analyzed by combining mineral characterization technology and batch adsorption research *** results indicated that BW can efficiently and selectively immobilize Pb(Ⅱ)in single or composite heavy metal adsorption solutions,and the immobilized Pb(Ⅱ)is difficult to *** undergoes monolayer adsorption on Pb(Ⅱ),Qmax≈1073.17 mg/*** immobilization of Pb(Ⅱ)by BW is a physico-chemical adsorption process with spontaneous heat absorption and an accompanying increase in *** addition,the sequestration of Pb(Ⅱ)by BW remains around 756.99 mg/g even at p H=*** excellent selective immobilization properties of BW for Pb(Ⅱ)are closely related to its smaller Ksp,electrostatic repulsion effect,organic-inorganic composite structure,acid resistance and the formation of Pb(Ⅱ)*** study provides beneficial information about the recycling of lead in acidic lead-containing wastewater and composite heavy metal contaminated water bodies.

关键词： Aspergillus niger Biogenic whewellite Pb(Ⅱ) Selective adsorption Immobilization mechanism

The autophagy protein Atg9 functions in glia and contributes to parkinsonian symptoms in a Drosophila model of Parkinson’s disease

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Neural Regeneration Research 2024年第5期19卷 1150-1155页

作者： Shuanglong Yi Linfang Wang Margaret S.Ho Shiping Zhang School of life Science and Technology ShanghaiTech UniversityShanghaiChina college of life sciences University of Chinese Academy of SciencesBeijingChina

Parkinson’s disease is a progressive neurodegenerative disease characterized by motor deficits,dopaminergic neuron loss,and brain accumulation ofα-synuclein aggregates called Lewy *** in protein degradation pathways,such as autophagy,has been demonstrated in neurons as a critical mechanism for eliminating protein aggregates in Parkinson’s ***,it is less well understood how protein aggregates are eliminated in glia,the other cell type in the *** the present study,we show that autophagy-related gene 9(Atg9),the only transmembrane protein in the autophagy machinery,is highly expressed in Drosophila glia from adult *** from immunostaining and live cell imaging analysis reveal that a portion of Atg9 localizes to the trans-Golgi network,autophagosomes,and lysosomes in ***9 is persistently in contact with these *** glial atg9 reduces the number of omegasomes and autophagosomes,and impairs autophagic substrate *** suggests that glial Atg9 participates in the early steps of autophagy,and hence the control of autophagic ***,loss of glial atg9 induces parkinsonian symptoms in Drosophila including progressive loss of dopaminergic neurons,locomotion deficits,and glial *** findings identify a functional role of Atg9 in glial autophagy and establish a potential link between glial autophagy and Parkinson’s *** results may provide new insights on the underlying mechanism of Parkinson’s disease.

关键词： Atg9 autophagy glia Parkinson’s disease

Protaetia brevitarsis larvae extract ameliorated obesity in high fat diet-fed mice by modulating gut microbiota and lipid metabolism

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Food Science and Human Wellness 2024年

作者： Zong-Qi Zhang Si-Cong Chen Qing-Lei Wang Chun-Qin Liu Jin-Hua Xiao Da-Wei Huang college of life sciences， nankai university Hebei Key Laboratory of Soil Entomology， Cangzhou Academy of Agricultural and Forestry sciences

Due to the rapid development of obesity and related metabolic diseases in the world， it is particularly important to explore the ability of novel materials in regulating obesity. In this study， C57BL/6J obese mice were used as objects， and 16S rRNA gene sequencing and lipidomics techniques were used to explore the regulatory effect and mechanism of the P. brevitarsis ethanol extract (50%， v/v) against obesity. Our results showed that P. brevitarsis extract could significantly reduce the body weight， triglyceride (TG)， total cholesterol (TC)， low-density lipoprotein cholesterol (LDL-C)， and pro-inflammatory cytokines (TNF-α， IFN-γ， and IL-6) levels of HFD-fed mice. Moreover， the P. brevitarsis extract changed the composition and relative abundance of its gut microbiota， especially increasing Akkermansia muciniphila. Meanwhile， the content of short-chain fatty acids (SCFAs) was increased， especially acetic acid and butyric acid， which leads to a decrease in the synthesis and accumulation of lipids in the liver. Furthermore， the P. brevitarsis extract also induced the difference in lipid synthesis in the liver by down-regulating the mRNA levels of SREPB-1C， FAS， and ACC. Therefore， this research provided preliminary work and reference for the development of P. brevitarsis as a functional food for anti-obesity.

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Cloning of sft-4 and its influence on vitality and virulence of pine wood nematode,Bursaphelenchus xylophilus

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Journal of Forestry Research 2024年第5期35卷 191-200页

作者： Shuisong Liu Linsong Wang Ronggui Li Mengyu Chen Wenjun Deng Chao Wang Guicai Du Qunqun Guo college of life sciences Qingdao UniversityQingdao 266071People’s Republic of China

In our previous screening of the transcriptome of the causal agent of the devastating pine wilt disease,pine wood nematode(PWN,Bursaphelenchus xylophilus),after treatment with the nematicide fomepizole,Surfeit locus gene sft-4,which encodes a regulatory factor,was found to be *** situ hybridization results showed that the sft-4 was continuously expressed from egg to adult and was especially high in the reproductive *** in a study of the effect of RNA interference(RNAi)of sft-4 and recombinant SFT-4 on PWN activity,treatment with sft-4 dsRNA inhibited feeding,reproduction,oviposition and egg hatching of PWN with the greatest inhibition on reproduction and oviposition,whereas recombinant SFT-4 had the opposite *** addition,RNAi of sft-4 changed the female–male ratio and lifespan of *** bioassays of PWNs,with RNAi of sft-4 on seedlings and 2-year-old Pinus thunbergii trees,none of the treated plants developed symp-toms during the monitoring period,indicating that virulence of PWNs was either significantly *** results indicate that the influence of sft-4 on PWN pathogenicity may be mainly through regulating reproductive function of PWN and its lifespan.

关键词： Black pine Pinaceae Bursaphelenchus xylophilus Sft-4 In situ hybridization RNAi Pathogenicity

Strigolactones modulate cotton fiber elongation and secondary cell wall thickening

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Journal of Integrative Agriculture 2024年第6期23卷 1850-1863页

作者： Yunze Wen Peng He Xiaohan Bai Huizhi Zhang Yunfeng Zhang Jianing Yu college of life sciences Shaanxi Normal UniversityXi’an 710119China

Cotton is one of the most important economic crops in the world,and it is a major source of fiber in the textile ***(SLs)are a class of carotenoid-derived plant hormones involved in many processes of plant growth and development,although the functions of SL in fiber development remain largely ***,we found that the endogenous SLs were significantly higher in fibers at 20 days post-anthesis(DPA).Exogenous SLs significantly increased fiber length and cell wall ***,we cloned three key SL biosynthetic genes,namely GhD27,GhMAX3,and GhMAX4,which were highly expressed in fibers,and subcellular localization analyses revealed that GhD27,GhMAX3,and GhMAX4 were localized in the *** exogenous expression of GhD27,GhMAX3,and GhMAX4 complemented the physiological phenotypes of d27,max3,and max4 mutations in Arabidopsis,*** of GhD27,GhMAX3,and GhMAX4 in cotton resulted in increased numbers of axillary buds and leaves,reduced fiber length,and significantly reduced fiber *** findings revealed that SLs participate in plant growth,fiber elongation,and secondary cell wall formation in *** results provide new and effective genetic resources for improving cotton fiber yield and plant architecture.

关键词： strigolactones fiber elongation secondary cell wall thickening cotton

Endochondral ossification of hindlimbs in embryonic development of Japanese Quail(Coturnix japonica)

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Avian Research 2024年第1期15卷 123-132页

作者： Xuan Li Yuxin Zhang Hongfeng Zhao college of life sciences Shaanxi Normal UniversityXi’an710119China

The endochondral ossification of hindlimb is essential to a bird’s ability to stand,walk and *** hindlimb is ossified in the embryos before hatching in precocial ***,the molecular mechanisms of hindlimb ossification in birds is still ***,we tried to examine the process of hindlimb ossification and its molecular regulation by using an animal model—Japanese Quail(Coturnix japonica).We selected four critical stages(Embryo Day:E6,E8,E12 and E16) of skeletal development of embryonic quails for hindlimb skeleton staining to show the process of endochondral ossification and to examine the molecular regulation of endochondral osteogenesis by RNA-Seq *** results showed that ossification became increased with embryonic development and most hindlimb was ossified before ***-Seq analysis revealed that various signaling pathways were involved with endochondral ossification with thyroid hormone signaling and WNT signaling pathway particularly ***,the expression levels of 42 genes were continuously upregulated and 14 genes were continuously downregulated from E6 to *** present study might provide new insights into complex molecular mechanisms in regulation of endochondral ossification.

关键词： Embryos Hindlimb Ossification Precocial Transcriptomics