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Unimolecular Self-Assembled Hemicyanine-Oleic Acid Conjugate Acts as a Novel Succinate Dehydrogenase Inhibitor to Amplify Photodynamic Therapy and Eliminate Cancer Stem Cells

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Research 2024年第2期6卷 449-461页

作者： Qiang Wang Tian Yang Shiyou Li Chen Xu Chong Wang Yuxuan Xiong Xing Wang Jiangling Wan Xiangliang Yang Zifu Li National Engineering Research Center for Nanomedicine College of Life Science and Technology.Huazhong University of Science and TechnologyWuhan 430074P.R.China Key Laboratory of Molecular Biophysics of Ministry of Education College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074P.R.China .3Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medical Huazhong University of Science and TechnologyWuhan 430074P.R.China Hubei Engineering Research Center for Biomaterials and Medical Protective Materials Huazhong University of Science and TechnologyWuhan 430074P.R.China Hubei Bioinformatics and Molecular Imaging Key Laboratory College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074P.R.China

Photodynamic therapy with reactive oxygen species production is a prospective treatment to combat cancer stem cells(CSCs).However,the innate drawbacks,including short lifetime and diffusion distance of reactive oxygen species and hypoxia within solid tumors,have become bottlenecks for clinical applications of photodynamic ***,we develop a mitochondria-targeting hemicyanine-oleic acid conjugate(CyOA),which can self-assemble into supramolecular nanoparticles(NPs)without any exogenous *** is also shown for targeting the mitochondrial complex II protein succinate dehydrogenase to inhibit oxidative phosphorylation and reverse tumor hypoxia,resulting in 50.4-fold higher phototoxicity against breast cancer stem cells(BCSCs)compared to SO_(3)-CyOA NPs that cannot target to *** 4T1 and BCSC tumor models,CyOA NPs achieve higher tumor inhibition and less lung metastasis nodules compared to the clinically used photosensitizer *** study develops a self-assembled small molecule that can serve as both oxidative phosphorylation inhibitor and photosensitizer for eradication of CSCs and treatment of solid tumors.

关键词： cyanine oxidative treatment

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A new centrality measure based on neighbor loop structure for network dismantling

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Digital Communications and Networks 2024年第2期10卷 472-480页

作者： Qingxia Liu Bang Wang Jiming Qi Xianjun Deng School of Electronic Information and Communications Huazhong University of Science and TechnologyWuhan430074China School of Cyber science and Engineering Huazhong University of Science and TechnologyWuhan430074China

Nearly all real-world networks are complex networks and usually are in danger of ***,it is crucial to exploit and understand the mechanisms of network attacks and provide better protection for network *** dismantling aims to find the smallest set of nodes such that after their removal the network is broken into connected components of sub-extensive *** overcome the limitations and drawbacks of existing network dismantling methods,this paper focuses on network dismantling problem and proposes a neighbor-loop structure based centrality metric,NL,which achieves a balance between computational efficiency and evaluation *** addition,we design a novel method combining NL-based nodes-removing,greedy tree-breaking and ***,we compare five baseline methods with our algorithm on ten widely used real-world networks and three types of model networks including Erd€os-Renyi random networks,Watts-Strogatz smallworld networks and Barabasi-Albert scale-free networks with different network generation *** results demonstrate that our proposed method outperforms most peer methods by obtaining a minimal set of targeted attack ***,the insights gained from this study may be of assistance to future practical research into real-world networks.

关键词： Complex networks Network dismantling Centrality measure

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Paving continuous heat dissipation pathways for quantum dots in polymer with orangeinspired radially aligned UHMWPE fibers

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Opto-Electronic Advances 2024年第7期7卷 27-38页

作者： Xuan Yang Xinfeng Zhang Tianxu Zhang Linyi Xiang Bin Xie Xiaobing Luo School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan 430074China School of Mechanical science and Engineering Huazhong University of Science and TechnologyWuhan 430074China

Thermal management of nanoscale quantum dots(QDs)in light-emitting devices is a long-lasting *** existing heat transfer reinforcement solutions for QDs-polymer composite mainly rely on thermal-conductive ***,this strategy failed to deliver the QDs’heat generation across a long distance,and the accumulated heat still causes considerable temperature rise of QDs-polymer composite,which eventually menaces the performance and reliability of lightemitting *** by the radially aligned fruit fibers in oranges,we proposed to eliminate this heat dissipation challenge by establishing long-range ordered heat transfer pathways within the QDs-polymer *** molecular weight polyethylene fibers(UPEF)were radially aligned throughout the polymer matrix,thus facilitating massive efficient heat dissipation of the *** a UPEF filling fraction of 24.46 vol%,the in-plane thermal conductivity of QDs-radially aligned UPEF composite(QDs-RAPE)could reach 10.45 W m^(−1) K^(−1),which is the highest value of QDs-polymer composite reported so *** a proof of concept,the QDs’working temperature can be reduced by 342.5℃ when illuminated by a highly concentrated laser diode(LD)under driving current of 1000 mA,thus improving their optical *** work may pave a new way for next generation high-power QDs lighting applications.

关键词： quantum dots UHMWPE fibers radial alignment heat dissipation light-emitting devices

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Impacts of multi-foulings on salinity gradient energy conversion process in negatively charged conical nanochannels

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science China(Technological sciences) 2024年第6期67卷 1714-1726页

作者： MAO RuiJie CHEN Xi ZHOU RuHong LONG Rui LIU ZhiChun LIU Wei School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan430074China China-EU Institute for Clean and Renewable Energy Huazhong University of Science and TechnologyWuhan430074China School of Mechanical science and Engineering Huazhong University of Science and TechnologyWuhan430074China

Membrane fouling inevitably occurs during nanofluidic reverse ***,the impact of multi-fouling on the energy conversion performance of negatively charged conical nanochannels under asymmetrical configurations is systematically *** results reveal that in Configuration I,where a high-concentration solution is applied at the tip side,at small concentration ratios,multiple foulings reduce the electric *** Configuration II,where a low-concentration solution is applied at the tip side,multiple foulings near the base side contribute to the electric *** fouling that formed near the lowconcentration entrance diminished the electric power and energy conversion ***-fouling lowered the electrical power consumption by 69.27%and 99.94%in Configurations I and II,*** Configuration I,the electric power first increased with increasing fouling surface charge density,reached its maximum value,and thereafter *** Configuration II,the electric power first decreased with increasing fouling surface charge density,reached its minimum value,and thereafter *** negative or positive charge densities of fouling contribute to the electric power and energy conversion efficiency.

关键词： conical nanochannel fouling nanofluidic reverse electrodialysis salinity gradient energy

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Research Progress on Bionic Water Strider Robots

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Journal of Bionic Engineering 2024年第2期21卷 635-652页

作者： Jianhao Liu Mingjun Shen Ziqiang Ma Xinping Zhou School of Mechanical science and Engineering Huazhong University of Science and TechnologyWuhan430074China State Key Laboratory of Intelligent Manufacturing Equipment and technology Huazhong University of Science and TechnologyWuhan430074China

Biological water striders have advantages such as flexible movement,low disturbance to the water surface,and low *** have developed a large number of biomimetic water strider robots based on their movement mechanism,which have broad application prospects in water quality testing,water surface reconnaissance,and *** article mainly reviews the research progress of biomimetic water strider ***,the biological and kinematic characteristics of water striders are outlined,and some mechanical parameters of biological water striders are *** basic equations of water strider movement are then ***,an overview is given of the past and current work on skating and jumping movements of biomimetic water strider robots based on surface tension and water pressure *** on the current research status of biomimetic water strider robots,the shortcomings of current research on biomimetic water striders are summarized,and the future development of biomimetic water strider robots is *** article provides new insights for the design of biomimetic water strider robots.

关键词： Bionics Water strider Robot Motion of robots on water surface

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Minimal Context-Switching Data Race Detection with Dataflow Tracking

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Journal of Computer science & technology 2024年第1期39卷 211-226页

作者：郑龙李洋辛杰刘海峰郑然廖小飞金海 National Engineering Research Center for Big Data technology and System School of Computer Science and Technology Huazhong University of Science and TechnologyWuhan 430074China Services Computing technology and System Laboratory School of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Cluster and Grid Computing Laboratory School of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China

Data race is one of the most important concurrent anomalies in multi-threaded *** con-straint-based techniques are leveraged into race detection,which is able to find all the races that can be found by any oth-er sound race ***,this constraint-based approach has serious limitations on helping programmers analyze and understand data ***,it may report a large number of false positives due to the unrecognized dataflow propa-gation of the ***,it recommends a wide range of thread context switches to schedule the reported race(in-cluding the false one)whenever this race is exposed during the constraint-solving *** ad hoc recommendation imposes too many context switches,which complicates the data race *** address these two limitations in the state-of-the-art constraint-based race detection,this paper proposes DFTracker,an improved constraint-based race detec-tor to recommend each data race with minimal thread context ***,we reduce the false positives by ana-lyzing and tracking the dataflow in the *** this means,DFTracker thus reduces the unnecessary analysis of false race *** further propose a novel algorithm to recommend an effective race schedule with minimal thread con-text switches for each data *** experimental results on the real applications demonstrate that 1)without removing any true data race,DFTracker effectively prunes false positives by 68%in comparison with the state-of-the-art constraint-based race detector;2)DFTracker recommends as low as 2.6-8.3(4.7 on average)thread context switches per data race in the real world,which is 81.6%fewer context switches per data race than the state-of-the-art constraint based race ***,DFTracker can be used as an effective tool to understand the data race for programmers.

关键词： data race satisfiability modulo theory multi-threaded program dynamic detection

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Journal of Computer science & technology 2024年第1期39卷 63-81页

作者：陈章玉华宇左鹏飞孙园园郭云程 wuhan National Laboratory for Optoelectronics School of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China

Image bitmaps,i.e.,data containing pixels and visual perception,have been widely used in emerging applica-tions for pixel operations while consuming lots of memory space and *** with legacy DRAM(dynamic ran-dom access memory),non-volatile memories(NVMs)are suitable for bitmap storage due to the salient features of high density and intrinsic ***,writing NVMs suffers from higher energy consumption and latency compared with read *** precise or approximate compression schemes in NVM controllers show limited performance for bitmaps due to the irregular data patterns and variance in *** observe the pixel-level similarity when writing bitmaps due to the analogous contents in adjacent *** exploiting the pixel-level similarity,we propose SimCom,an approximate similarity-aware compression scheme in the NVM module controller,to efficiently compress data for each write access *** idea behind SimCom is to compress continuous similar words into the pairs of base words with *** storage costs for small runs are further mitigated by reusing the least significant bits of base *** adaptively selects an appropriate compression mode for various bitmap formats,thus achieving an efficient trade-off be-tween quality and memory *** implement SimCom on GEM5/zsim with NVMain and evaluate the perfor-mance with real-world image/video *** results demonstrate the efficacy and efficiency of our SimCom with an efficient quality-performance trade-off.

关键词： approximate computing data compression memory architecture non-volatile memory

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Tripartite motif-containing protein 11(TRIM11):a novel weapon against Alzheimer’s disease

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Signal Transduction and Targeted Therapy 2024年第2期9卷 339-340页

作者： Yichu Fu Bi Zhang Jianfeng Liu college of life science and technology Key Laboratory of Molecular Biophysics of MOEHuazhong University of Science and TechnologyWuhanHubei 430074China

In a recent study published in science,Zhang et *** that tripartite motif-containing(TRIM)protein 11(TRIM11)exhibited strong inhibition on tau aggregation,which is a pathological characteristic of tauopathies including Alzheimer’s disease(AD).1 This makes TRIM11 a promising novel target for the treatment of AD and other tauopathies.

关键词： Alzheimer tau TRIM

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Flexible one-dimensional photonic crystal films composed of chalcogenide glass and water-soluble polymer for curvature sensing

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Chinese Optics Letters 2024年第2期22卷 135-140页

作者：陈新宇黎张成赵若兰何钰何月梁治陶光明侯冲 School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Vascular Aging Ministry of EducationTongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China State Key Laboratory of Material Processing and Die&Mould technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China Shenzhen huazhong university of science and technology Research Institute Shenzhen 518063China

Curvature sensing plays an important role in structural health monitoring,damage detection,real-time shape control,modification,*** curvature sensors with large measurement ranges,high sensitivity,and linearity remains a major *** this study,a curvature sensor based on flexible one-dimensional photonic crystal(1D-PC)films was *** flexible 1D-PC films composed of dense chalcogenide glass and water-soluble polymer materials were fabricated by solution *** flexible 1D-PC film curvature sensor has a wide measurement range of 33-133 m-1and a maximum sensitivity of0.26 nm/m^(-1).The shift of the transmission peak varies approximately linearly with the curvature in the entire measurement *** kind of 1D-PC film curvature sensor provides a new idea for curvature sensing and measurement.

关键词： curvature sensor one-dimensional photonic crystals solution processing chalcogenide glass flexible film

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Time-space multiplexed photonic-electronic digital multiplier

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Photonics Research 2024年第3期12卷 499-504页

作者： WENKAI ZHANG BO WU WENTAO GU JUNWEI CHENG HAILONG ZHOU LIAO CHEN WENCHAN DONG JIANJI DONG XINLIANG ZHANG wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China

Optical computing has shown immense application prospects in the post-Moore ***,as a crucial component of logic computing,the digital multiplier can only be realized on a small scale in optics,restrained by the limited functionalities and inevitable loss of optical *** this paper,we propose a time-space multiplexed architecture to realize large-scale photonic-electronic digital multiplication.

关键词： multiplier electronic restrained

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