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Crosstalk between degradation and bioenergetics: how autophagy and endolysosomal processes regulate energy production

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Neural Regeneration Research 2025年第3期20卷 671-681页

作者： Angelid Pabon Jagannatham Naidu Bhupana Ching-On Wong Department of biological sciences Rutgers UniversityNewarkNJUSA

Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between degradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between degradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.

关键词： autophagy bioenergetics endolysosome energy production glycolysis metabolic reprogramming mitochondria

Post-fire recovery of Puya raimondii, vegetation and birds in the puna of Huascarán National Park, Perú

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Journal of Mountain Science 2024年第1期21卷 20-32页

作者： Mery L.SUNI Giovana P.VADILLO César ARANA Enoc JARA-PENA Letty SALINAS M.Estela PONCE Paul M.RAMSAY Plant Physiology Laboratory Faculty of Biological SciencesUniversidad Nacional Mayor de San MarcosLima 15081Peru Natural History Museum Universidad Nacional Mayor de San MarcosLima 15072Peru Applied Phytology Laboratory Faculty of Biological SciencesUniversidad Nacional Mayor de San MarcosLima 15081Peru Department of Statistics Faculty of Mathematical SciencesUniversidad Nacional Mayor de San MarcosLima 15081Peru Department of Chemical and biological sciences Universidad de las Américas PueblaSan Andrés Cholula CP Cholula CP 72810Mexico

A large fire of 233 ha in Huascarán National Park in Peru provided an opportunity to compare plant and bird responses in burned and nearby unburned zones of the puna. Heights and live diameters of flagship Puya raimondii rosettes(assigned to four broad developmental phases), plant communities(66 species in 24 families and nine growth forms) and bird communities(77 species in six trophic guilds) were monitored after the fire. Although no mortality was observed, Puya raimondii plants were affected by the fire, losing approximately 60% of their photosynthetic area across all developmental phases, but recovered quickly during the first two years after fire. The comparison of Puya rosette recovery after fire was complicated by the changes in live rosette diameter for unburned plants, which showed plasticity of photosynthetic area linked to seasonal and annual fluctuations in precipitation in this relatively dry environment(decreased by 26% for mature adult plants over the study period). Fire caused an immediate change in the density, biomass and composition of vegetation. Although the species present remained similar, their abundances changed significantly immediately after the fire, with notable reductions in dominant tussock grasses. This provided opportunities for other plants, resulting in higher postfire diversity of plant species, genera, families and growth forms. In turn, the changes in vegetation after fire affected the composition of birds according to their trophic guild. Granivores largely disappeared,generalists were mostly unaffected, and other guilds showed a more complex response. As the vegetation recovered, most displaced birds returned within approximately one year.

关键词： Burning Plant biomass Trophic guilds Andes Giant rosette plants

Toward predictable universal genetic circuit design

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Quantitative Biology 2024年第2期12卷 225-229页

作者： Yuanli Gao Baojun Wang college of Chemical and biological Engineering Zhejiang UniversityHangzhouChina ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhouChina School of biological sciences University of EdinburghEdinburghUK

In thepast 2decades,synthetic biologists have applied systematic engineering principles to genetic circuit design to devise biological systems with bespoke behaviors,such as Boolean logic gates,signal filters,oscillators,state machines,perceptrons,and genetic controllers[1,2].Following a bottom-up strategy,the genetic circuits are designed by assembling a set of well-characterized biological components,or genetic parts[3],and optimized through the iterative Design-Build-Test-Learn(DBTL)cycles.

关键词： circuit predictability genetic circuit design host independent part characterization portability

A phase separation-fortified bi-specific adaptor for conditional tumor killing

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Science China(Life sciences) 2024年第7期67卷 1385-1397页

作者： Yuyan Liu Yuting Zhu Weifan Xu Pilong Li State Key Laboratory of Membrane Biology Frontier Research Center for Biological StructureTsinghua University-Peking University Joint Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China

A common approach in therapeutic protein development involves employing synthetic ligands with multivalency,enabling sophisticated control of signal *** the emerging concept of liquid-liquid phase separation(LLPS)and its ability to organize cell surface receptors into functional compartments,we herein have designed modular ligands with phase-separation modalities to engineer programmable interreceptor communications and precise control of signal pathways,thus inducing the rapid,potent,and specific apoptosis of tumor *** their simplicity,these“triggers”,named phase-separated Tumor Killers(hereafter referred to as psTK),are sufficient to yield interreceptor clustering of death receptors(represented by DR5)and tumor-associated receptors,with notable features:LLPSmediated robust high-order organization,well-choreographed conditional activation,and broad-spectrum capacity to potently induce apoptosis in tumor *** development of novel therapeutic proteins with phase-separation modalities showcases the power of spatially reorganizing signal *** approach facilitates the diversification of cell fate and holds promising potential for targeted therapies against challenging tumors.

关键词： phase separation therapeutic proteins receptor-ligand interactions DR5 tumor apoptosis

Rosmarinic acid improves tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 100-105页

作者： Vahideh Abbasnia Mohsen Foadoddini Delaram Eslimi Esfahani Mohammad Reza Khazdair Shahrbanoo Oryan Department of Biology Payame Noor UniversityTehranIran Cardiovascular Diseases Research Center Birjand University of Medical SciencesBirjandIran Department of Animal sciences Faculty of Biological SciencesKharazmi UniversityTehranIran

Objective:To evaluate the effect of rosmarinic acid on tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized ***:Rats were randomly divided into six groups:the control group,the asthmatic group,and the asthmatic groups treated with dexamethasone(1 mg/kg;oral gavage)or three doses of rosmarinic acid(0.5,1,and 2 mg/kg;oral gavage).For induction of asthma,rats received intraperitoneal injections and inhalation of *** 21 days,bronchoalveolar lavage fluid and lung samples were collected for histopathological ***,total and differential white blood cell counts were ***:The rosmarinic acid-treated group had significantly lower tracheal smooth muscle responses to methacholine than the asthmatic *** addition,rosmarinic acid reduced white blood cell count and the percentages of eosinophils,monocytes,and neutrophils while increasing the percentage of ***-induced lung pathological changes were significantly improved by treatment with rosmarinic ***:Rosmarinic acid improves tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats.

关键词： Rosmarinic acid Asthma Ovalbumin Tracheal responsiveness Inflammation White blood cell

Spatial evolution and spatial production of traditional villages from "backward poverty villages" to "ecologically well-off villages": Experiences from the hinterland of national nature reserves in China

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Journal of Mountain Science 2024年第4期21卷 1100-1118页

作者： Zhang Yiyi LI Yangbing college of Geography and Environmental sciences Guizhou Normal UniversityGuiyang 550001China

With the rapid urbanization process,the space of traditional villages in China is undergoing significant *** the spatial evolution of traditional villages is significant in promoting rural spatial transformation and realizing rural revitalization and sustainable rural *** on the traceability analysis of spatial production theory,this paper constructed an analytical framework for the spatial production evolution of traditional villages,analyzed the spatial evolution process and characteristics of traditional villages by using buffer analysis,spatial syntax,and other research methods,and revealed the characteristics of the spatial production evolution of traditional villages and the driving *** results show that:(1)The village spatial formation and development follow the village life cycle theory and usually develop from embryonic villages to diversified and integrated villages;(2)The evolution of village spatial production is characterized by the diversity of material space,the sublimation of daily life space,and the integration of social system space and generalization of emotional space;(3)The evolution of village spatial production from backward and poor village to ecologically well-off village is influenced by a combination of factors;(4)The village has formed a spatial structure of"people-land-scape-culture-industry",realized comprehensive reconstruction and spatial *** study results reflect the spatial evolution characteristics of traditional villages in mountainous areas in a more comprehensive way,which helps to promote the protection and development of traditional villages in mountainous areas and,to a certain extent,provides a reference for the development of rural revitalization.

关键词： Traditional villages Spatial production Spatial evolution Spatial reconstruction

Symmetry quantification and segmentation in STEM imaging through Zernike moments

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Chinese Physics B 2024年第8期33卷 39-48页

作者： Jiadong Dan Cheng Zhang 赵晓续 N.Duane Loh Department of biological sciences National University of SingaporeSingapore Center for Bioimaging sciences(CBIS) National University of SingaporeSingapore Department of Physics National University of SingaporeSingapore School of Materials Science and Engineering Peking UniversityBeijing 100871China

We present a method using Zernike moments for quantifying rotational and reflectional symmetries in scanning transmission electron microscopy(STEM)images,aimed at improving structural analysis of materials at the atomic *** technique is effective against common imaging noises and is potentially suited for low-dose imaging and identifying quantum *** showcase its utility in the unsupervised segmentation of polytypes in a twisted bilayer TaS_(2),enabling accurate differentiation of structural phases and monitoring transitions caused by electron beam *** approach enhances the analysis of structural variations in crystalline materials,marking a notable advancement in the characterization of structures in materials science.

关键词： scanning transmission electron microscopy(STEM) symmetry segmentation

Recent Advances in C-F Bond Formation from Carbon-Centered Radicals

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Chinese Journal of Chemistry 2024年第9期42卷 1009-1031页

作者： Jihua Zhang Juanjuan Wang Qiang Cheng college of Chemistry and Molecular sciences Wuhan UniversityWuhanHubei 430072China

Construction of C-F bonds is a direct and efficient method for introducing fluorine into pharmaceuticals,agrochemicals,and *** such as nucleophilic,electrophilic,radical,and transition-metal catalyzed fluorination have been developed to meet the demand of diverse C-F bond *** them,radical fluorination has been witnessed with substantial advancement in a recent ***,we reviewed methods for formation of C-F bonds with carbon-centered radicals as key intermediates,especially in recent five *** introduce in the paper with different fluorinating reagents,strategies for radical generation,and application in late-stage functionalization and synthesis of PET *** also indicate the current limitations and propose the direction of the field for the future development.

关键词： Fluorine Fluorinating reagents Late-stage fluorination [^(18)F]jfluorination Radical reactions Synthetic methods

Identification of in situ Generated Iron-Vacancy Induced Oxygen Evolution Reaction Kinetics on Cobalt Iron Oxyhydroxide

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Chinese Journal of Chemistry 2024年第4期42卷 343-350页

作者： Na Yao Juan Zhu Hongnan Jia Hengjiang Cong Wei Luo college of Chemistry and Molecular sciences Wuhan UniversityWuhanHubei430072 China

Developing highly efficient and low-cost electrocatalysts towards oxygen evolution reaction(OER)is essential for practical application in water electrolyzers and rechargeable metal-air *** Fe-based oxyhydroxides are regarded as state-of-the-art non-noble OER electrocatalysts,the origin of performance enhancement derived from Fe doping remains a hot topic of considerable ***,we demonstrate that in situ generated Fe vacancies in the pristine CoFeOOH catalyst through a pre-conversion process during alkaline OER result from dynamic Fe dissolution,identifying the origin of Fe-vacancy-induced enhanced OER *** functional theory(DFT)calculations and experimental results including X-ray absorption fine-structure spectroscopy,in situ UV-Vis spectroscopy,and in situ Raman spectroscopy reveal that the Fe vacancies could significantly promote the d-band center and valence states of adjacent Co sites,alter the active site from Fe atom to Co atom,accelerate the formation of high-valent active Co^(4+)species,and reduce the energy barrier of the potential-determining step,thereby contribute to the significantly enhanced OER performance.

关键词： CoFe oxyhydroxide Oxygen evolution reaction Fe vacancy Electrocatalysis Kinetics Reaction mechanisms