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Comprehensive effects of traditional Chinese medicine treatment on heart failure and changes in B-type natriuretic peptide levels: A meta-analysis

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World Journal of Clinical Cases 2024年第4期12卷 766-776页

作者： Li-Li Xia Shu-Yun Yang Jun-Yao Xu Han-Qing Chen Zhu-Yuan Fang Hypertension Research Institute Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210004Jiangsu ProvinceChina Department of General practice Southeast University Affiliated Zhongda HospitalNanjing 210009Jiangsu ProvinceChina

BACKGROUND Heart failure(HF),a common cardiovascular condition,is characterized by significant morbidity and *** traditional Chinese medicine(TCM)is often used as a complementary approach in HF management,systematic evalua-tions of its impact on clinical outcomes,TCM syndrome scores,and B-type natriuretic peptide(BNP)levels are *** study fills this gap through a comprehensive analysis of randomized controlled trials(RCTs)focusing on TCM for HF *** encompasses an assessment of methodological quality,a meta-analysis,and an evaluation of evidence quality based on established *** results offer crucial insights into the potential advantages and constraints of TCM in HF *** on TCM for HF treatment published since the establishment of the database were searched in four Chinese and English databases,including China National Knowledge Infrastructure,Wanfang,VIP Information Chinese Science and Technology Journal,and *** quality was assessed for the included studies with the cochrane risk-of-bias assessment tool,and the meta-analysis and publication bias assessment was performed with the RevMan5.3 ***,the quality of evidence was rated according to the GRADE *** A total of 1098 RCTs were initially *** screening,16 RCTs were finally included in our study,which were published between 2020 and *** RCTs involved 1660 HF patients,including 832 in the TCM group[TCM combined with conventional Western medicine(CMW)treatment]and 828 in the CWM group(CWM treatment).The course of treatments varied from 1 wk to 3 *** syndrome differentiation was analyzed in 11 of the included *** all included RCTs,outcome indicators included comprehensive clinical outcomes,TCM syndrome scores,and BNP *** meta-analysis results showed significant differences between the TCM and CWM groups in terms of comprehensive clinical outcomes[risk ratio=-0.54;95%confidence interval(CI)=-0

关键词： Traditional Chinese medicine Heart failure Comprehensive clinical outcomes Traditional Chinese medicine syndrome score B-type natriuretic peptide level Meta-analysis©The Author(s)2024.Published by Baishideng Publishing group Inc.

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Safety and predictors of adherence of a new rehabilitation program for older women with congestive heart failure

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Journal of Geriatric Cardiology 2012年第3期9卷 243-246页

作者： Nahid A. Azad Kathy Bouchard Alain Mayhew Maureen Carter Frank J. Molnar Geriatric Assessment Unit Ottawa Hospital Civic Campus 1053 Carling Avenue Ottawa Ontario K1Y4E9 Canada cochrane effective practice and organisation of care group Ottawa Hospital Civic Campus 1053 Carling Avenue Ottawa Ontario K1Y4E9 Canada JET Programme Ottawa Hospital Civic Campus 1053 Carling Avenue Ottawa Ontario K1Y4E9 Canada The IElisabeth-Bruybre Research Institute 43 Bruybre St. Ottawa Ontario KIN 5C8 Canada

Objectives To assess the safety of a cardiac rehabilitation program for older women with Congestive Heart Failure （CHF） and determine if certain factors influence adherence. Methods Women over the age of 65 with CHF attended an exercise program supervised by a physiotherapist. Quality of life was measured by the Minnesota Living with Heart Failure Questionnaire （MLHFQ） and severity of disease by the New York Heart Association （NYHA） Class. Subjects were classified into those who attended 90% or more of the sessions and those who attended less than 90% of the sessions. Results Fifty-one subjects were studied. Eight subjects did not attend any sessions. Of the 43 attendees, the average percentage of sessions attended was 87%. There were no significant differences between the two groups in age, MLHFQ or NYHA Class. There was only one adverse event out of 280 participant attendances. Conclusions The program had a high level of adherence in this population. Age, MLHFQ or NYHA Class did not impact on session attendance. Our data suggests this program is safe for this population. Further research is needed to determine other predictors of attendance and the examination of safety issues and long-term adherence to exercise in this population.

关键词： Congestive heart failure Exercise Elderly women Adherence

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Status of adult inpatient burn rehabilitation in Europe: are we neglecting metabolic outcomes?

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Burns & Trauma 2021年第1期9卷 613-628页

作者： David R.Schieffelers Eric van Breda Nick Gebruers Jill Meirte Ulrike Van Daele Multidisciplinary Metabolic Research Unit(M2RUN) MOVANT Research GroupDepartment of Rehabilitation Sciences and PhysiotherapyFaculty of Medicine and Health SciencesUniversity of AntwerpUniversiteitsplein 12610WilrijkAntwerpBelgium Multidisciplinary Edema Clinic Antwerp University HospitalWilrijkstraat 102650EdegemAntwerpBelgium OScare Organisation for burnsscar after-care and researchVan Roiestraat 182170 MerksemAntwerpBelgium

Background:Hypermetabolism,muscle wasting and insulin resistance are challenging yet important rehabilitation targets in the management of *** the absence of concrete practice guidelines,however,it remains unclear how these metabolic targets are currently *** study aimed to describe the current practice of inpatient rehabilitation across ***:An electronic survey was distributed by the European Burn Association to burn centres throughout Europe,comprising generic and profession-specific questions directed at therapists,medical doctors and *** concerned exercise prescription,metabolic management and treatment priorities,motivation and knowledge of burn-induced metabolic *** ratios were computed to analyse associations between data derived from the responses of treatment priorities and knowledge of burn-induced metabolic ***:Fifty-nine clinicians with 12.3±9 years of professional experience in burns,representing 18 out of 91 burn centres(response rate,19.8%)across eight European countries *** and aerobic exercises were only provided by 42%and 38%of therapists to intubated patients,87%and 65%once out-of-bed mobility was possible and 97%and 83%once patients were able to leave their hospital room,*** assessment of resting energy expenditure by indirect calorimetry,muscle wasting and insulin resistance was carried out by only 40.7%,15.3%and 7.4%respondents,respectively,with large variability in employed frequency and *** all clinicians changed their care in cases of hypermetabolism(59.3%),muscle wasting(70.4%)or insulin resistance(44.4%),and large variations in management strategies were *** interdisciplinary variation was present in treatment goal importance ratings,motivation and knowledge of burn-induced metabolic *** prevention of metabolic sequelae was regarded as the least important treatment goal,while the restoration of functional status

关键词： Burn care Burn rehabilitation Exercise Early mobilization Hypermetabolism Adults

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Influence of hepatitis viruses on clinico-pathological profiles and long-term outcome in patients undergoing surgery for hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2014年第2期13卷 162-172页

作者： Anna-Maria Tanase Traian Dumitrascu Simona Dima Razvan Grigorie Agnes Marchio Pascal Pineau Irinel Popescu Center of General Surgery and Liver Transplant Fundeni Clinical Institute Unité "organisation nucléaire et oncogenèse" INSERM U993Institut

BACKGROUND: The global risk of hepatocellular carcinoma(HCC) is largely due to hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. In recent years, however, an increased prevalence of non-viral HCC has been noted. The clinical impact of the presence/absence of viral infections in HCC remains controversial. The present study aimed to assess the effect of hepatitis viruses on demographics, clinical and pathological features and long-term outcome in a large cohort of Romanian patients who underwent surgery for HCC. METHODS: The study included 404 patients with HCC who had undergone resection, transplantation or radiofrequency ablation at a single institution between 2001 and 2010. The patients were divided into four groups: 85 patients with hepatitis B virus infection (HBV group), 164 patients with hepatitis C virus infection (HCV group), 39 patients with hepatitis B and C virus co-infection (HBCV group), and 116 patients without viral infection (non-BC group). RESULTS: The patients of both HBV (56.0±11.3 years) and HBCV groups (56.0±9.9 years) were significantly younger than those of the HCV (61.0±8.5 years, P=0.001) and non-BC groups(61.0±13.0 years, P=0.002). Interestingly, the prevalence of liver cirrhosis was significantly lower in the non-BC group (47%)than in any other subsets (72%-90%, Pgroups (Pgroups (P=0.001). No significant differences in the disease-free or overall survival rates were observed among these groups. CONCLUSIONS: Patients with non-viral HCC are diagnosed at advanced ages and stages, a situation plausibly due to the poor effectiveness of cancer surveillance in community practice. The presence of viral infections does not appear to impair the longterm prognosis after surgical treatm

关键词： hepatitis B virus hepatitis Cvirus hepatocellular carcinoma recurrence prognosis

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Minimum sample size estimates for trials in inflammatory bowel disease:A systematic review of a support resource

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World Journal of Gastroenterology 2021年第43期27卷 7572-7581页

作者： Morris Gordon Svetlana Lakunina Vasiliki Sinopoulou Anthony Akobeng Biomedical Evidence Synthesis and Translation to practice Unit School of MedicinePreston PR17BHUnited Kingdom Division of Gastroenterology Sidra Med and Res CtrDoha 26999Qatar

BACKGROUND Of 25%of randomised controlled trials(RCTs)on interventions for inflammatory bowel disease(IBD)have no power *** To systematically review RCTs reporting interventions for the management of IBD and to produce data for minimum sample sizes that would achieve appropriate power using the actual clinical *** We included RCTs retrieved from cochrane IBD specialised Trial register and CENTRAL investigating any form of therapy for either induction or maintenance of remission against control,placebo,or no intervention of IBD in patients of any *** relevant data was extracted,and the studies were grouped according to the intervention *** recalculated sample size and the achieved difference,as well as minimum sample sizes needed in the *** A total of 105 trials were *** was a large discrepancy between the estimated figure for the minimal clinically important difference used for the calculations(15%group differences observed vs 30%used for calculation)explaining substantial actual sample size *** minimum sample sizes indicated for future trials based on the 25 years of trial data were calculated and grouped by the *** A third of intervention studies in IBD within the last 25 years are underpowered,with large variations in the calculation of sample *** authors present a sample size estimate resource constructed on the published evidence base for future researchers and key stakeholders within the IBD trial field.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Gastroenterology Statistics Sample size

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effectiveness of mesenchymal stem cellconditioned medium in bone regeneration in animal and human models:a systematic review and meta-analysis

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Cell Regeneration 2020年第1期9卷 27-48页

作者： Maria Paula Benavides-Castellanos Nathaly Garzón-Orjuela Itali Linero Research group of Oral and Maxillofacial Surgery Faculty of DentistryUniversidad Nacional de ColombiaBogotáColombia Research group on Equity in Health Faculty of MedicineUniversidad Nacional de ColombiaBogotáColombia Research group of Oral and Maxillofacial Surgery Faculty of DentistryResearch Group of Stem Cell BiologyFaculty of MedicineUniversidad Nacional de ColombiaBogotáColombia Faculty of Dentistry Universidad Nacional de ColombiaCiudad UniversitariaEdificio 210BogotáColombia

Background:Given the limitations of current therapies for the reconstruction of bone defects,regenerative medicine has arisen as a new therapeutic strategy along with mesenchymal stem cells(MSCs),which,because of their osteogenic potential and immunomodulatory properties,have emerged as a promising alternative for the treatment of bone *** vivo studies have demonstrated that MSCs have a positive effect on regeneration due to their secretion of cytokines and growth factors that,when collected in conditioned medium(MSC-CM)and applied to an injured tissue,can modulate and promote the formation of new ***:To evaluate the effectiveness of application of conditioned medium derived from mesenchymal stem cells in bone regeneration in animal and human ***:We conducted a systematic review with a comprehensive search through February of 2018 using several electronic databases(MEDLINE,EMBASE,SCOPUS,CENTRAL(Ovid),and LILACS),and we also used the“snowballing technique”.Articles that met the inclusion criteria were selected through abstract review and subsequent assessment of the full *** assessed the risk of bias with the SYRCLE and cochrane tools,and three metaanalyses were ***:We included 21 articles,19 of which used animal models and 2 of which used human *** animal models,the application of MSC-CM significantly increased the regeneration of bone defects in comparison with control *** studies reported early mineralization in regenerated bones,and no bone resorption,inflammation,nor local or systemic alterations were observed in any *** meta-analysis showed an overall favorable effect of the application of ***:The application of MSC-CM to bone defects has a positive and favorable effect on the repair and regeneration of bone tissue,particularly in animal *** is necessary to perform additional studies to support the application of MSC-CM in clinical practice.

关键词： Bone regeneration Conditioned medium Mesenchymal stem cell Secretome Regenerative medicine

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中医药临床随机对照试验报告规范(征求意见稿)

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中国循证医学杂志 2007年第8期7卷 601-605页

作者：吴泰相李幼平卞兆祥李廷谦李静 Simon Dagenais David Moher 无卫生部中国循证医学中心、中国cochrane中心、INCLEN华西资源与培训中心、中国临床试验注册中心成都610041 香港浸会大学中医学院 Chalmers Research group （CRG） University of Ottawa Evidence-Based Practice Center （UO-EPC） Department of PediatricsEpidemiology ＆ Community Medicine University of OttawaCanada 代表CONSORT for TCM工作组

1 制订中医药临床随机对照试验报告规范（CONSORT for TCM）的必要性中医对疾病及其治疗的认识有别于西医,尤其中医“辨证论治”和“临证察机”的治疗原则比西医分型分类更加复杂，其临床研究因而有不同于西医的特点。但无论多么复杂，... 详细信息

1 制订中医药临床随机对照试验报告规范（CONSORT for TCM）的必要性中医对疾病及其治疗的认识有别于西医,尤其中医“辨证论治”和“临证察机”的治疗原则比西医分型分类更加复杂，其临床研究因而有不同于西医的特点。但无论多么复杂，随机对照试验（RCT）仍是目前公认的中医药防治性研究偏倚可能性最小的设计方案。由于中医药临床试验采用RCT方案仅约30年，试验设计还需要深人探索，试验结果报告还不规范。2005年，中国循证医学中心对中医药临床“随机对照试验”的主要研究者进行电话采访，调查随机方法正确性。

关键词：临床试验报告规范临床试验中医药

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循证口腔医学25年:从理念迈向实践

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口腔医学研究 2018年第11期34卷 1149-1153页

作者：花放武汉大学口腔医院循证口腔医学中心湖北武汉430079 曼彻斯特大学牙学院cochrane口腔健康组曼彻斯特M139PL

自cochrane口腔健康组于1994年成立以来,循证口腔医学已历经25年的发展。相关理念及方法逐渐得到了国内外口腔医学领域专家学者及医护人员的广泛认同,并已成为口腔诊疗、教学、研究和政策制订中不可或缺的重要组成部分。本文将简要介绍... 详细信息

自cochrane口腔健康组于1994年成立以来,循证口腔医学已历经25年的发展。相关理念及方法逐渐得到了国内外口腔医学领域专家学者及医护人员的广泛认同,并已成为口腔诊疗、教学、研究和政策制订中不可或缺的重要组成部分。本文将简要介绍循证口腔医学过去25年的主要发展历程,并对其未来发展方向作一展望,以帮助国内同行更好地理解循证口腔医学的本质及价值,推动循证口腔医学研究与实践在我国的进一步发展。

关键词：循证口腔医学循证医疗实践口腔医学史

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effectiveness of resilience-promoting interventions in adolescents with diabetes mellitus:a systematic review and meta-analysis

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World Journal of Pediatrics 2023年第4期19卷 323-339页

作者： Yi Wu Yi-Yun Zhang Ya-Ting Zhang Hui-Jing Zhang Tian-Xue Long Qi Zhang Jing Huang Ming-Zi Li Peking University Health Science Center 38 Huayuan RoadHaidian DistrictBeijing100191China School of Nursing Peking UniversityBeijingChina Peking University Health Science Centre for Evidence-Based Nursing A Joanna Briggs Institute Affiliated GroupBeijingChina School of Nursing Jilin UniversityChangchunChina

Background This study aimed to analyze the efficacy of resilience-promoting interventions among adolescents and youth aged 10-24 years with any type of *** A systematic literature search was performed using the PubMed,Web of Science,Embase,cochrane Library,CINAHL,and PsycINFO databases from inception to May 25,*** cochrane risk of bias tool(version 2)was used to assess the quality of the included studies.A meta-analysis was performed to calculate the pooled effects of resilience-promoting *** Nineteen articles were included covering an overall sample of 2048 adolescents with *** analyzing the effectiveness of resilience-promoting interventions,hemoglobin A1c(HbA1c)at six months[mean difference=-0.47,95%confidence interval(CI)=-0.83 to-0.12,P=0.009]after the intervention was ***,long-term(≥12 months)improvement in HbA1c was not *** addition,comparing the control group,there were significant differences in the effect size for stress[standardized mean difference(SMD)=-0.87,95%CI=-1.25 to-0.48,Ppractice.

关键词： Adolescents Diabetes mellitus Intervention Meta-analysis Resilience

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实施临床试验报告规范,提高临床试验透明度

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中国循证医学杂志 2007年第8期7卷 551-554页

作者：吴泰相李幼平卞兆祥陈可冀张伯礼商洪才 David Moher 卫生部中国循证医学中心中国Cochrane中心INCLEN华西资源与培训中心中国临床试验注册中心成都610041 香港浸会大学中医学院中国中医科学院天津中医药大学 Chalmers Research group(CRG) University of Ottawa Evidence-Based Practice Center(UO-EPC)Department of PediatricsEpidemiology&Community MedicineUniversity of OttawaCanada

临床试验是指以人为对象的前瞻性研究,预先将受试者或受试人群分配至接受一种或多种医疗干预,以评价医疗干预对健康结局的影响。其中“医疗干预”包括但不仅限于药物，也包括细胞及其他生物制品、外科治疗、放射治疗、医疗器械、行为疗... 详细信息

临床试验是指以人为对象的前瞻性研究,预先将受试者或受试人群分配至接受一种或多种医疗干预,以评价医疗干预对健康结局的影响。其中“医疗干预”包括但不仅限于药物，也包括细胞及其他生物制品、外科治疗、放射治疗、医疗器械、行为疗法、治疗过程的改变和预防保健等。

关键词：临床试验报告规范临床试验

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