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Neuroendocrine control of natural killer cell function through the checkpoint molecule PD-1

Cellular & Molecular Immunology 2019年第2期16卷 109-111页

作者： Justine devulder Anne Tsicopoulos Catherine Duez Pulmonary Immunity Institut National de la SantéEt de la Recherche MédicaleU1019F-59019 LilleFrance Institut Pasteur de lille Center for Infection and Immunity of LilleF-59019 LilleFrance CNrS UMr 8204 F-59000 LilleFrance Univ lille Nord de France F-59000 LilleFrance clinique des maladies respiratoires et centre hospitalier régional et universitaire de lille 59037 LilleFrance

Host defense strategies encompass resistance to reduce pathogen burden,and disease tolerance to preserve host fitness.1 Immunedriven resistance mechanisms have inevitably a negative impact on host fitness and can lead to *** tolerance limit immunopathology and therefore disease severity by preventing tissue damage or ameliorating tissue function without interfering with pathogen *** pathways cooperate to protect the *** pathways include metabolic and oxidative stress responses,2 and the interaction between neuroendocrine system and the immune system3 to favor resolution of inflammation and to prevent tissue damage.

关键词： damage killer inflammation

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Human genetic and immunological determinants of critical COVID-19 pneumonia

引用

四川生理科学杂志 2021年第11期43卷 1947-1947页

作者： Qian Zhang St Giles Laboratory of Human Genetics of Infectious Diseases Rockefeller Branch The Rockefeller University New York NY USA Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France University of Paris Imagine Institute Paris France Howard Hughes Medical Institute Paris France The rockefeller University & Howard Hughes Medical Institute New York NY USA Necker Hospital for Sick Children & INSErM Paris France department of Pediatrics Necker Hospital for Sick Children Paris France Cemil Taşcıoglu City Hospital Istanbul Turkey Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France Imagine Institute University of Paris Paris France Al Jalila Children’s Hospital Dubai United Arab Emirates San raffaele Telethon Institute for Gene Therapy IRCCS Ospedale San Raffaele and Vita Salute San Raffaele University Milan Italy Hospices Civils de Lyon Lyon France Helix San Mateo CA USA department of Intensive Care Medicine Critical Care Center CHU Lille Lille France Univ. lille CNRS Inserm CHU Lille Institut Pasteur de Lille U1019-UMR9017-CIIL-Centre d’Infection et d’Immunité deLille Lille France Shupyk National Medical Academy for Postgraduate Education Kiev Ukraine department of Medical Microbiology University Medical Center Utrecht Utrecht The Netherlands Sidra Medicine Doha Qatar Primary Immunodeficiencies Group Department of Microbiology and Parasitology School of Medicine University of Antioquia Medellín Colombia School of Microbiology University of Antioquia Medellín Colombia IIBB-CSIC IDIBAPS Barcelona Spain department of Immunology Second Faculty of Medicine Charles University University Hospital in Motol Prague Czech Republic department of Immunology Dmitry Rogachev National Medical Research Center of Pediatric Hematology Oncology and Immunology Moscow Russia Pulmonology department Cliniques Universitaire

SArS-CoV-2 infection is benign in most individuals but,in-10%of cases,it triggers hypoxemic COVID-19 pneumonia,which becomes critical in-3%of *** ensuing risk of death(-1%)doubles every five years from childhood onward and is-1.5 times greater in men than in *** are the molecular and cellular determinants of critical COVID-19 pneumonia?Inborn errors of type I IFNs,including autosomal TLr3 and X-linked TLr7 deficiencies,are found in-1-5%of patients with critical pneumonia under 60 years old.

关键词： pneumonia critical cases

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