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Indocyanine Green-Conjugated Magnetic Prussian Blue nanoparticles for Synchronous Photothermal/Photodynamic Tumor Therapy

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nano-micro Letters 2018年第4期10卷 324-338页

作者： Peng Xue Ruihao Yang Lihong Sun Qian Li Lei Zhang Zhigang Xu Yuejun Kang Faculty of materials and Energy Institute for Clean Energy and Advanced Materials Southwest University chongqing engineering research center for micro-nano biomedical materials and devices State Key Laboratory of Silkworm Genome Biology Southwest University

Indocyanine green(ICG) is capable of inducing a photothermal effect and the production of cytotoxic reactive oxygen species for cancer therapy. However, the major challenge in applying ICG molecules for antitumor therapy is associated with their instability in aqueous conditions and rapid clearance from blood circulation,which causes insufficient bioavailability at the tumor ***, we conjugated ICG molecules with Prussian blue nanoparticles enclosing a Fe_3O_4 nanocore, which was facilitated by cationic polyethyleneimine via electrostatic adsorption. The nanocarrier-loaded ICG formed stable aggregates that enhanced cellular uptake and prevented fluorescence quenching. Moreover, the strong superparamagnetism of the Fe_3O_4 core in the obtained nanocomposites further improved cellular internalization of the drugs guided by a localized magnetic field. The therapeutic efficacy of this nanoplatform was evaluated using tumor models established in nude mice, which demonstrated remarkable tumor ablation in vivo due to strong photothermal/photodynamic effects. This study provides promising evidence that this multifunctional nanoagent might function as an efficient mediator for combining photothermal and photodynamic cancer therapy.

关键词： Combination therapy Prussian blue nanoparticles Photothermal therapy Photodynamic therapy Indocyanine green

The Systematic Evaluation of Physicochemical and Biological Properties In Vitro and In Vivo for Natural Silk Fibroin nanoparticles

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Advanced Fiber materials 2022年第5期4卷 1141-1152页

作者： Xinyi Li Mengjie Ye Yong‑E.Gao Shengxin Hou Peng Jia Peng Xue Yuejun Kang Zhigang Xu State Key Laboratory of Silkworm Genome Biology School of Materials and Energy and Chongqing Engineering Research Center for Micro‑Nano Biomedical Materials and DevicesSouthwest UniversityChongqing 400715People’s Republic of China chongqing Key Laboratory of Soft‑Matter Material Chemistry and Function Manufacturing Southwest UniversityChongqing 400715People’s Republic of China

nanoparticle-based theranostics has served as a preferential technology for diagnosis and treatment of ***,there are still massive challenges in constructing the ideal platform,which hopefully integrate various characteristics such as easy preparation,multiple utilization,and high therapeutic effect and safety into a single ***,we reported a drug delivery system-based on natural silk fibroin(denoted as SF NPs),and systematically evaluated the physicochemi-cal properties,biological properties and the biosafety assessment of SF *** in vitro and in vivo experimental results confirmed that SF NPs showed high stability,low blood hemolysis and the universal delivery ability of ***,the SF NPs could rapidly enter into cells due to its nanoscale size,and had a weak cytotoxicity against MCF-7,4T1 and L929 ***,the SF NPs showed enhanced tumor permeability in a simulative model of multicellular spheroids,combined with excellent in vivo biosafety and the negligible organ injury,demonstrate that SF-based nanomedicine presents the utilization potentiality for drug delivery and may provide a new view for cancer treatment.

关键词： Silk fibroin Drug delivery Biocompatibility Cytotoxicity nanotheranostics

Effect of doping Gd^(3+) on crystal structure and luminescent properties of Sr_2SiO_4:Eu^(2+) phosphor

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Journal of Rare Earths 2015年第7期33卷 693-699页

作者：赵聪朱达川高唯韩涛彭玲玲涂铭旌 College of materials Science and engineering Sichuan University Department of Chemical & materials engineering The University of Auckland research center for Material Interdisciplinary Science Chongqing University of Arts and ScienceChongqing Engineering Research Center for Optoelectronic Materials and Devices

Sr1.995-1.5xGdxSiO4：0.005Eu^2＋ phosphor series with x=0-0.08 mol for near-ultraviolet white light-emitting diodes （NUV w-LEDs） were synthesized via solid-state reaction method. XRD profile pattern and refinement results demonstrated that doping Gd^3＋ ions resulted in the phase transformation （β-Sr2SiO4→α＇-Sr2SiO4）. The photoluminescenee spectrum of the sample with x=0 tool displayed two emission peaks centered at 470 and 525 nm. The two-peak spectra became one-peak spectra with the Gd^3＋ concentration increasing. Actually, the fitting results demonstrated that the one-peak spectra were still composed of two single emission spectra. The photoluminescence intensity was improved and the CIE chromaticity coordinates were adjusted via doping Gd^3＋.

关键词： doping solid-state reaction photoluminescence Sr2SiO4 phosphors rare earths

Muscle-inspired soft robots based on bilateral dielectric elastomer actuators

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microsystems & nanoengineering 2023年第5期9卷 245-254页

作者： Yale Yang Dengfeng Li Yanhua Sun Mengge Wu Jingyou Su Ying Li Xinge Yu Lu Li Junsheng Yu State Key Laboratory of Electronic Thin Films and Integrated devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of China(UESTC)ChengduPR China chongqing Key Laboratory of materials Surface&Interface Science Chongqing Co-Innovation Center for Micro/Nano Optoelectronic Materials and DevicesMicro/Nano Optoelectronic Materials and Devices International Science and Technology Cooperation Base of ChinaSchool of Materials Science and EngineeringChongqing University of Arts and SciencesChongqingPR China Hong Kong Centre for Cerebro-Cardiovascular Health engineering(COCHE) Hong KongSARChina Department of biomedical engineering City University of Hong KongHong KongSARChina

Muscle groups perform their functions in the human body via bilateral muscle actuation,which brings bionic inspiration to artificial robot *** soft robotic systems with artificial muscles and multiple control dimensions could be an effective means to develop highly controllable soft ***,we report a bilateral actuator with a bilateral deformation function similar to that of a muscle group that can be used for soft *** construct this bilateral actuator,a low-cost VHB 4910 dielectric elastomer was selected as the artificial muscle,and polymer films manufactured with specific shapes served as the actuator *** end-to-end connecting these bilateral actuators,a gear-shaped 3D soft robot with diverse motion capabilities could be developed,benefiting from adjustable actuation *** on the ground with all feet on the ground,a crawling soft robot with dexterous movement along multiple directions was ***,the directional steering was instantaneous and *** two feet standing on the ground,it also acted as a rolling soft robot that can achieve bidirectional rolling motion and climbing motion on a 2°***,inspired by the orbicularis oris muscle in the mouth,a mouthlike soft robot that could bite and grab objects 5.3 times of its body weight was *** bidirectional function of a single actuator and the various combination modes among multiple actuators together allow the soft robots to exhibit diverse functionalities and flexibility,which provides a very valuable reference for the design of highly controllable soft robots.

关键词： robot artificial dielectric

nanoparticles for the treatment of spinal cord injury

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Neural Regeneration research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di Lu Jiuping Wu Fuming Liang Huayi Wang Junjie Yang Ganggang Zhang Chen Wang Yanlian Yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

Origami-inspired folding assembly of dielectric elastomers for programmable soft robots

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microsystems & nanoengineering 2022年第2期8卷 73-83页

作者： Yanhua Sun Dengfeng Li Mengge Wu Yale Yang Jingyou Su Tszhung Wong Kangming Xu Ying Li Lu Li Xinge Yu Junsheng Yu State Key Laboratory of Electronic Thin Films and Integrated devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of China(UESTC)Chengdu 610054People's Republic of China chongqing Key Laboratory of materials Surface&Interface Science Chongqing Co-Innovation Center for Micro/Nano Optoelectronic Materials and DevicesMicro/Nano Optoelectronic Materials and Devices International Science and Technology Cooperation Base of ChinaSchool of Materials Science and EngineeringChongqing University of Arts and SciencesChongqing 402160People's Republic of China Department of biomedical engineering City University of Hong KongHong Kong SAR 999077People's Republic of China

Origami has become an optimal methodological choice for creating complex three-dimensional(3D)structures and soft *** simple and low-cost origami-inspired folding assembly provides a new method for developing 3D soft robots,which is ideal for future intelligent robotic ***,we present a series of materials,structural designs,and fabrication methods for developing independent,electrically controlled origami 3D soft robots for walking and soft *** 3D soft robots are based on soft actuators,which are multilayer structures with a dielectric elastomer(DE)film as the deformation layer and a laser-cut PET film as the supporting flexible *** triangular and rectangular design of the soft actuators allows them to be easily assembled into crawling soft robots and pyramidal-and square-shaped 3D *** crawling robot exhibits very stable crawling behaviors and can carry loads while *** by origami folding,the pyramidal and square-shaped 3D soft robots exhibit programmable out-of-plane deformations and easy switching between two-dimensional(2D)and 3D *** electrically controllable origami deformation allows the 3D soft robots to be used as soft manipulators for grasping and precisely locking 3D *** work proves that origami-inspired fold-based assembly of DE actuators is a good reference for the development of soft actuators and future intelligent multifunctional soft robots.

关键词： robot folding dielectric

The design and synthesis of dextran-doxorubicin prodrug-based pH-sensitive drug delivery system for improving chemotherapy efficacy

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Asian Journal of Pharmaceutical Sciences 2020年第5期15卷 605-616页

作者： Xiaoli Zhang Tian Zhang Xianbin Ma Yajun Wang Yi Lu Die Jia Xiaohua Huang Jiucun Chen Zhigang Xu Feiqiu Wena Department of Hematology and Oncology Shenzhen Children’s HospitalShenzhen 518038China School of materials and Energy Southwest UniversityChongqing 400715China chongqing engineering research center for micro-nano biomedical materials and devices Chongqing 400715China Guangan Changming research Institute for Advanced Industrial Technology Guangan 638500China

Tumor cells show acidic conditions compared with normal cells,which further inspires scientist to build nanocarrier responsive to tumor microenvironment(TME)for enhancing tumor therapeutic ***,we report a pH-sensitive and biocompatible polyprodrug based on dextran-doxorubicin(DOX)prodrug(DOXDT)for enhanced *** DOX component was covalently decorated on the nanocarrier and the drug molecules could be effectively released in the acidic tumor tissue/cells,improving chemotherapy ***,a dextran-based copolymer was preliminarily prepared by one-step atom transfer radical polymerization(ATRP);then DOX was conjugated on the copolymer component via pH-responsive hydrazone *** structure of DOXDT can be *** resulting DOXDT was able to further self-assemble into nanoscale micelles with a hydration diameter of about 32.4 nm,which presented excellent micellar *** to lipid-based drug delivery system,the DOXDT prodrug showed higher drug load capacity up to 23.6%.In addition,excellent stability and smaller size of the nanocarrier contributed to better tissue permeability and tumor suppressive effects in ***,this amphipathic DOXDT prodrug is promising in the development of translational DOX formulations,which would be widely applied in cancer therapy.

关键词： Dextran Chemotherapy Prodrug Tumor acidic microenvironment Controlled release

microenvironment-responsive chemotherapeutic nanogels for enhancing tumor therapy via DNA damage and glutathione consumption

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Chinese Chemical Letters 2022年第9期33卷 4197-4202页

作者： Mengjie Ye Yuan Gao Mengyun Liang Wei Qiu Xian bin Ma Jiming Xu Junfeng Hu Peng Xue Yuejun Kang Zhigang Xu Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationSchool of Materials and Energy and Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and DevicesSouthwest UniversityChongqing 400715China Key Laboratory of Laser Technology and Optoelectronic Functional materials of Hainan Province College of Chemistry and Chemical EngineeringHainan Normal UniversityHaikou 571158China

Although targeted therapy and immunotherapy are now shining in the treatment of some cancers,chemotherapy is still the cornerstone of drug treatment for many cancer *** emergence of chemotherapy prodrugs can improve the drug activity and reduce the side effects of *** used,the tumor microenvironment has characteristics different from normal tissues,and the existence of the microenvironment provided a more convenient way to design responsive ***,we designed a glutathione(GSH)-responsive prodrug nanogels for enhancing tumor *** the nanogels of HHNP,10-hydroxycamptothecin(HCPT)played an essential role in killing cancer *** was jointed with a cross-linker agent with disulfide bond and was further coated with polyethylene glycol,which not only prolonged the half-life of the drug,but also made HCPT accurate transport to the tumor fractions and achieved precise and controllable *** proposal of HHNP effectively retained the biological activity of the drug,and introduced functions such as targeting,selective release and biodegradation,which greatly improved the medical efficiency of the drug and effectively reduced the toxic and side *** chemotherapeutic prodrug nanogel offers a new window for constructing efficient drug delivery platform.

关键词： nanogel Prodrug GSH-responsive DNA damage Chemotherapy

microenvironment responsive pod-structured astaxanthin nanocarrier for ameliorating inflammatory bowel disease

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Chinese Chemical Letters 2024年第7期35卷 360-366页

作者： Jingting Wang Yuanyuan Chen Linlin Han Shasha Xia Xingyao Zhang Peng Xue Yuejun Kang Jian Ming Zhigang Xu Key Laboratory of Luminescence Analysis and Molecular Sensing Ministry of EducationSchool of Materials and Energy&Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and DevicesSouthwest UniversityChongqing 400715China College of Food Science Southwest UniversityChongqing 400715China State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan UniversityChangsha 410082China

Anti-inflammatory drugs targeting inflammatory bowel disease(IBD)have attracted considerable attention but still face low therapeutic outcomes and frequent side ***(ATX),a natural ketone,possesses potent antioxidant and anti-inflammatory ***,it faces problems such as poor water solubility,photothermal instability,and low ***,we employed a supramolecular encapsulation strategy to create a nanoscale oral delivery system for ATX(referred to as FC-ATX NPs)by coupling fucoidan(FUC)with chitosan oligosaccharides(COS).The obtained FC-ATX NPs exhibited a particular“bean pod”structure with uniform size,good encapsulation efficiency,excellent physical and chemical stability,pH-triggered intestinal targeted slow-release properties,and potent antioxidant *** vitro cell culture experiments showed that FC-ATX NPs promoted cellular uptake and scavenged excessive intracellular reactive oxygen species(ROS).In mouse models of colitis,FC-ATX NPs enhanced the drug absorption of intestinal epithelial cells and effectively accumulated at the site of *** work provides an efficient approach to enhance the bioavailability of ATX and has excellent application potential as an oral targeted delivery system for colitis therapy.

关键词： Oral administration Astaxanthin nanocarrier Anti-oxidant activity Colon targeting