Indocyanine Green-Conjugated Magnetic Prussian Blue Nanoparticles for Synchronous Photothermal/Photodynamic Tumor Therapy

作     者：Peng Xue Ruihao Yang Lihong Sun Qian Li Lei Zhang Zhigang Xu Yuejun Kang 

作者机构：Faculty of Materials and Energy Institute for Clean Energy and Advanced Materials Southwest University Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices State Key Laboratory of Silkworm Genome BiologySouthwest University 

出 版 物：《Nano-Micro Letters》 (纳微快报（英文版）)

年 卷 期：2018年第10卷第4期

页      面：324-338页

核心收录：

学科分类：0808[工学-电气工程] 1002[医学-临床医学] 0809[工学-电子科学与技术（可授工学、理学学位）] 07[理学] 0817[工学-化学工程与技术] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0702[理学-物理学] 10[医学] 

基　　金：financial support from Fundamental Research Funds for Central Universities (XDJK2016A010 and XDJK2017C001) National Natural Science Foundation of China (51703186 and 31671037) Southwest University (SWU116032 and SWU115059) 

主　　题：Combination therapy Prussian blue nanoparticles Photothermal therapy Photodynamic therapy Indocyanine green 

摘      要：Indocyanine green(ICG) is capable of inducing a photothermal effect and the production of cytotoxic reactive oxygen species for cancer therapy. However, the major challenge in applying ICG molecules for antitumor therapy is associated with their instability in aqueous conditions and rapid clearance from blood circulation,which causes insufficient bioavailability at the tumor ***, we conjugated ICG molecules with Prussian blue nanoparticles enclosing a Fe_3O_4 nanocore, which was facilitated by cationic polyethyleneimine via electrostatic adsorption. The nanocarrier-loaded ICG formed stable aggregates that enhanced cellular uptake and prevented fluorescence quenching. Moreover, the strong superparamagnetism of the Fe_3O_4 core in the obtained nanocomposites further improved cellular internalization of the drugs guided by a localized magnetic field. The therapeutic efficacy of this nanoplatform was evaluated using tumor models established in nude mice, which demonstrated remarkable tumor ablation in vivo due to strong photothermal/photodynamic effects. This study provides promising evidence that this multifunctional nanoagent might function as an efficient mediator for combining photothermal and photodynamic cancer therapy.