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Therapeutic potential of urine-derived stem cells in renal regeneration following acute kidney injury:A comparative analysis with mesenchymal stem cells

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World Journal of Stem Cells 2024年第5期16卷 525-537页

作者： Fang Li Bin Zhao Lei Zhang Guo-Qing Chen Li Zhu Xiao-Ling Feng Meng-Jia Gong Cheng-Chen Hu Yuan-Yuan Zhang Ming Li Yong-Qiang Liu Department of general Surgery Chongqing General HospitalChongqing 401147China Department of Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqing 401147China

BACKGROUND Acute kidney injury(AKI)is a common clinical syndrome with high morbidity and mortality *** use of pluripotent stem cells holds great promise for the treatment of ***-derived stem cells(USCs)are a novel and versatile cell source in cell-based therapy and regenerative medicine that provide advantages of a noninvasive,simple,and low-cost approach and are induced with high multidifferentiation *** these cells could serve as a potential stem cell source for the treatment of AKI has not been *** Stem cell markers with multidifferentiation potential were isolated from human amniotic *** severe combined immune deficiency(SCID)mice models were induced by means of an intramuscular injection with *** isolated from human-voided urine were administered via tail *** functional changes in the kidney were assessed by the levels of blood urea nitrogen and serum *** histologic changes were evaluated by hematoxylin and eosin staining and transferase dUTP nick-end labeling ***,we compared the regenerative potential of USCs with bone marrow-derived mesenchymal stem cells(MSCs).RESULTS Treatment with USCs significantly alleviated histological destruction and functional *** renal function was rapidly restored after intravenous injection of 5×105 human USCs into SCID mice with glycerol-induced AKI compared with injection of *** from secretion assays conducted in vitro demonstrated that both stem cell varieties released a wide array of cytokines and growth *** suggests that a mixture of various mediators closely interacts with their biochemical *** types of stem cells showed enhanced tubular cell prolif-eration and decreased tubular cell apoptosis,although USC treatment was not more effective than MSC *** found that USC therapy significantly improved renal function and histological damage,inhibited inflammation and apoptosis processes in the kid

关键词： Urine-derived stem cells Regenerative medicine Acute kidney injury Renal function recovery Cell therapy

Appendiceal bleeding caused by vascular malformation: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2457-2462页

作者： Qin Ma Jin-Jie Du Department of general Surgery Fuling Hospital Affiliated to Chongqing UniversityChongqing 408000China Department of Geriatrics Fuling Hospital Affiliated to Chongqing UniversityChongqing 408000China

BACKGROUND Acute lower gastrointestinal bleeding(LGIB)is a common occurrence in clinical ***,appendiceal bleeding is an extremely rare condition that can easily be overlooked and *** preoperative detection of appen-diceal bleeding often poses challenges due to the lack of related guidelines and consensus,resulting in controversial treatment *** SUMMARY We presented a case of a 33-year-old female who complained of hematochezia that had lasted for 1 *** revealed continuous bleeding in the appen-diceal orifice.A laparoscopic appendectomy was performed immediately,and a pulsating blood vessel was observed in the mesangium of the appendix,accor-dingly,active bleeding into the appendicular lumen was *** examination revealed numerous hyperplastic vessels in the appendiceal mucosa and dilated capillary *** The preoperative detection of appendiceal bleeding is often challenging,colo-noscopy is extremely important,bowel preparation is not routinely recommend-ed for patients with acute LGIB or only low-dose bowel preparation is *** appendectomy is the most appropriate treatment for appendiceal bleeding.

关键词： Lower gastrointestinal bleeding Appendiceal bleeding Colonoscopy Vas-cular malformation Laparoscopic appendectomy Case report

Juvenile cardiomyopathy with dystrophin deficiency

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Genes & Diseases 2024年第3期11卷 30-33页

作者： Yuhui Luo Qinglan Shu Yi Wang Min Gu Hao Zhang Siqi Hong Rui Wang Lixue Yin Department of Cardiology Chongqing General HospitalChongqing 401147China Department of Cardiovascular Ultrasound and Noninvasive Cardiology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of China(UESTC)ChengduSichuan 610072China Department of RadiologyChongqing General HospitalChongqing 401147China Department of Neurology Children's Hospital of Chongqing Medical UniversityChongqing 400014China School of Medicine Zunyi Medical UniversityZunyiGuizhou 563000China

Pseudohypertrophic muscular dystrophy is a lethal X-linked recessive neuromuscular disorder caused by mutations in the dystrophin *** gene encodes a cytoskeletal protein that is extensively expressed in muscle cells and that enables the strength,stability,and functionality of *** dystrophy can be grouped into two different categories based on the mutational rate and clinical severity,Duchenne muscular dystrophy(DMD)and Becker muscular dystrophy(BMD).DMD is the most common and the more severe type of *** patients usually become wheelchair-bound by the age of 12 years and die in their late teens to early twenties.^(1)In contrast,BMD is relatively less severe and the patients can potentially have alonger lifeexpectancy.

关键词： dystrophin dystrophy Becker

Multifaceted functions of Drp1 in hypoxia/ischemia- induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy

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Military Medical Research 2024年第4期11卷 589-615页

作者： Shuai Hao He Huang Rui-Yan Ma Xue Zeng Chen-Yang Duan Department of Anesthesiology the Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Research Institute of general Surgery Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China Department of Cardiovascular Surgery Xinqiao HospitalArmy Medical UniversityChongqing 400037China Institute for Brain Science and Disease Chongqing Medical UniversityChongqing 400010China

Hypoxic-ischemic injury is a common pathological dysfunction in clinical *** are sensitive organelles that are readily damaged following ischemia and ***-related protein 1(Drp1)regulates mitochondrial quality and cellular functions via its oligomeric changes and multiple modifications,which plays a role in mediating the induction of multiple organ damage during hypoxic-ischemic ***,there is active controversy and gaps in knowledge regarding the modification,protein interaction,and functions of Drp1,which both hinder and promote development of Drp1 as a novel therapeutic ***,we summarize recent findings on the oligomeric changes,modification types,and protein interactions of Drp1 in various hypoxic-ischemic diseases,as well as the Drp1-mediated regulation of mitochondrial quality and cell functions following ischemia and ***,potential clinical translation prospects for targeting Drp1 are *** review provides new ideas and targets for proactive interventions on multiple organ damage induced by various hypoxic-ischemic diseases.

关键词： Dynamin-related protein 1(Drp1) Hypoxic-ischemic injury Mitochondrial quality imbalance Cell dysfunction Organ damage

Predictors of complications after prophylactic ileostomy reversal for rectal cancer:A retrospective study

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1354-1362页

作者： Quan Lv Xin-Peng Shu Dong Peng Si-Qi Li Zheng Xiang Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China chongqing Key Laboratory of Department of general Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Previous studies have analyzed the risk factors for complications after ileostomy reversal for rectal cancer(RC),but there were significant differences in the reported risk factors for complications after stoma *** studies have analyzed the risk factors for stoma-related complications and overall postoperative com-plications *** To analyze the risk factors for overall complications and stoma-related complications after ileostomy reversal for patients with *** This was a retrospective study of 439 patients who underwent ileostomy reversal at a clinical center and were followed up between September 2012 and September *** variables are expressed as the mean±SD and were analyzed with independent-sample t tests,while frequency variables are expressed as n(%),and theχ2 test or Fisher’s exact test was *** and multivariate logistic regression analyses were used to identify predictors of overall complications and stoma-related *** The overall complication rate after ileostomy reversal was 11.4%.Patients with lower preoperative albumin concentration(P<0.01),greater blood loss(P=0.017),and longer operative times(P<0.01)were more likely to experience postoperative *** incidence of stoma-related complications was 6.4%.Analysis of the study showed that a higher body mass index(BMI)(P<0.01),preoperative comorbid hypertension(P=0.049),time from primary surgery to ileostomy reversal(P<0.01)and longer operation time(P=0.010)were more likely to result in stomarelated complications *** logistic regression analysis revealed that a lower preoperative albumin level(P<0.01,OR=0.888,95%CI:0.828-0.958)was an independent risk factor for overall ***,multivariate analysis revealed that BMI(P<0.01,OR=1.176,95%CI:1.041-1.330)and time from primary surgery to ileostomy reversal(P<0.01,OR=1.140,95%CI:1.038-1.252)were independent risk factors for stoma-related compl

关键词： Ileostomy Reversal Risk factors Complications Rectal cancer

Oncological features and prognosis of colorectal cancer in human immunodeficiency virus-positive patients: A retrospective study

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 29-39页

作者： Fu-Yu Yang Fan He De-Fei Chen Cheng-Lin Tang Saed Woraikat Yao Li Kun Qian Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of general Surgery Chongqing Public Health Medical CenterChongqing 400036China

BACKGROUND Due to the prolonged life expectancy and increased risk of colorectal cancer(CRC)among patients with human immunodeficiency virus(HIV)infection,the prognosis and pathological features of CRC in HIV-positive patients require *** To compare the differences in oncological features,surgical safety,and prognosis between patients with and without HIV infection who have CRC at the same tumor stage and *** In this retrospective study,we collected data from HIV-positive and-negative patients who underwent radical resection for *** random stratified sampling,24 HIV-positive and 363 HIV-negative patients with colorectal adenocarcinoma after radical resection were *** propensity score matching,we selected 72 patients,matched 1:2(HIV-positive:negative=24:48).Differences in basic characteristics,HIV acquisition,perioperative serological indicators,surgical safety,oncological features,and long-term prognosis were compared between the two *** Fewer patients with HIV infection underwent chemotherapy compared to patients ***-positive patients had fewer preoperative and postoperative leukocytes,fewer preoperative lymphocytes,lower carcinoembryonic antigen levels,more intraoperative blood loss,more metastatic lymph nodes,higher node stage,higher tumor node metastasis stage,shorter overall survival,and shorter progression-free survival compared to patients who were *** Compared with CRC patients who are HIV-negative,patients with HIV infection have more metastatic lymph nodes and worse long-term survival after *** treatment options for HIV-positive patients with CRC should be explored.

关键词： Colorectal cancer Human immunodeficiency virus Propensity score matching Oncological features Surgical safety Prognosis

Perioperative outcomes of transvaginal specimen extraction laparoscopic total gastrectomy and conventional laparoscopicassisted total gastrectomy

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1527-1536页

作者： Zhi-Cao Zhang Wen-Sheng Wang Jiang-Hong Chen Yuan-Hang Ma Qi-Fa Luo Yun-Bo Li Yang Yang Dan Ma Department of general Surgery Xinqiao Hospital of Army Medical UniversityChongqing 400037China

BACKGROUND Natural orifice specimen extraction surgery(NOSES)has emerged as a promising alternative compared to conventional laparoscopic-assisted total gastrectomy(LATG)for treating gastric cancer(GC).However,evidence regarding the efficacy and safety of NOSES for GC surgery is *** study aimed to compare the safety and feasibility,in addition to postoperative complications of NOSES and *** Dual circular staplers were used in Roux-en-Y digestive tract reconstruction for transvaginal specimen extraction LATG,and its outcomes were compared with LATG in a cohort of 51 GC patients with tumor size≤5 *** study was conducted from May 2018 to September 2020,and patients were categorized into the NOSES group(n=22)and LATG group(n=29).Perioperative parameters were compared and analyzed,including patient and tumor characteristics,postoperative outcomes,and anastomosis-related complications,postoperative hospital stay,the length of abdominal incision,difference in tumor type,postoperative complications,and postoperative *** Postoperative exhaust time,operation duration,mean postoperative hospital stay,length of abdominal incision,number of specific staplers used,and Brief Illness Perception Questionnaire score were significant in both groups(Phospital stay,and length of abdominal incision were significantly shorter than those in the LATG *** in the NOSES group had faster postoperative recovery,and achieved abdominal minimally invasive incision that met aesthetic *** were no significant differences in gender,age,tumor type,postoperative complications,and postoperative survival between the two *** The application of dual circular staplers in Roux-en-Y digestive tract reconstruction combined with NOSES gastrectomy is safe and *** approach offers better short-term outcomes compared to LATG,while long-term survival

关键词： Gastric cancer Circular stapler Natural orifice specimen extraction surgery Laparoscopic-assisted total gastrectomy

Endoscopic-ultrasound-guided biliary drainage with placement of electrocautery-enhanced lumen-apposing metal stent for palliation of malignant biliary obstruction:Updated meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 907-920页

作者： Zu-Xiang Peng Fang-Fang Chen Wen Tang Xu Zeng Hong-Juan Du Ru-Xian Pi Hong-Ming Liu Xiao-Xiao Lu Department of Hepatobiliary Surgery Daping HospitalArmy Medical UniversityChongqing 400042China Department of Oncology Chongqing General HospitalChongqing UniversityChongqing 401147China Department of Gastroenterology and Hepatobiliary Surgery People’s Hospital of Fenggang CountyGuizhou 564200Guizhou ProvinceChina Hepatobiliary and Pancreatic Tumor Center Chongqing University Cancer HospitalChongqing 400030China

BACKGROUND Endoscopic ultrasound-guided biliary drainage using electrocautery-enhanced(ECE)delivery of lumen-apposing metal stent(LAMS)is gradually being re-cognized as a viable palliative technique for malignant biliary obstruction after endoscopic retrograde cholangiopancreatography(ERCP)***,most of the studies that have assessed its efficacy and safety were small and *** meta-analyses of six or fewer studies that were published 2 years ago were therefore underpowered to yield convincing *** To update the efficacy and safety of ECE-LAMS for treatment of biliary ob-struction after ERCP *** We searched PubMed,EMBASE,and Scopus databases from the inception of the ECE technique to May 13,*** outcome measure was pooled technical success rate,and secondary outcomes were pooled rates of clinical success,re-intervention,and adverse ***-analysis was performed using a random-effects model following Freeman-Tukey double-arcsine transformation in R soft-ware(version 4.1.3).RESULTS Fourteen eligible studies involving 620 participants were ultimately *** pooled rate of technical success was 96.7%,and clinical success was 91.0%.Adverse events were reported in 17.5%of *** reinter-vention rate was 7.3%.Subgroup analyses showed results were generally *** ECE-LAMS has favorable success with acceptable adverse events in relieving biliary obstruction when ERCP is *** consistency of results across most subgroups suggested that this is a generalizable approach.

关键词： Biliary obstruction Biliary drainage Electrocautery-enhanced lumen-apposing metal stents Endoscopic ultrasound Endoscopic retrograde cholangiopancreatography failure

Microglia in brain aging:An overview of recent basic science and clinical research developments

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Journal of Biomedical Research 2024年第2期38卷 122-136页

作者： Haixia Fan Minheng Zhang Jie Wen Shengyuan Wang Minghao Yuan Houchao Sun Liu Shu Xu Yang Yinshuang Pu Zhiyou Cai chongqing Medical University Chongqing 400042China Department of Neurology Chongqing General HospitalChongqing 400013China chongqing Key Laboratory of Neurodegenerative Diseases Chongqing 400013China Department of Neurology the First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Gerontology the First People's Hospital of JinzhongJinzhongShanxi 030009China

Aging is characterized by progressive degeneration of tissues and organs,and it is positively associated with an increased mortality *** brain,as one of the most significantly affected organs,experiences age-related changes,including abnormal neuronal activity,dysfunctional calcium homeostasis,dysregulated mitochondrial function,and increased levels of reactive oxygen *** changes collectively contribute to cognitive *** is also a key risk factor for neurodegenerative diseases,such as Alzheimer's disease and Parkinson's *** many years,neurodegenerative disease investigations have primarily focused on neurons,with less attention given to microglial ***,recently,microglial homeostasis has emerged as an important mediator in neurological disease ***,we provide an overview of brain aging from the perspective of the *** doing so,we present the current knowledge on the correlation between brain aging and the microglia,summarize recent progress of investigations about the microglia in normal aging,Alzheimer's disease,Parkinson's disease,Huntington's disease,and amyotrophic lateral sclerosis,and then discuss the correlation between the senescent microglia and the brain,which will culminate with a presentation of the molecular complexity involved in the microglia in brain aging with suggestions for healthy aging.

关键词： microglia brain aging Alzheimer's disease Parkinson's disease Huntington's disease