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Cortical activity in patients with high-functioning ischemic stroke during the Purdue Pegboard Test:insights into bimanual coordinated fine motor skills with functional near-infrared spectroscopy

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Neural Regeneration Research 2024年第5期19卷 1098-1104页

作者： Siyun Chen Mengchai Mao Guangyue Zhu Yufeng Chen Yuqi Qiu Bin Ye Dongsheng Xu The Second rehabilitation Hospital of Shanghai ShanghaiChina College of rehabilitation science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent rehabilitation Ministry of EducationShanghaiChina School of Statistics East China Normal UniversityShanghaiChina The Third rehabilitation Hospital of Shanghai ShanghaiChina Tongji University ShanghaiChina Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine ShanghaiChina

After stroke,even high-functioning individuals may experience compromised bimanual coordination and fine motor dexterity,leading to reduced functional independence.Bilateral arm training has been proposed as a promising intervention to address these deficits.However,the neural basis of the impairment of functional fine motor skills and their relationship to bimanual coordination performance in stroke patients remains unclear,limiting the development of more targeted interventions.To address this gap,our study employed functional near-infrared spectroscopy to investigate cortical responses in patients after stroke as they perform functional tasks that engage fine motor control and coordination.Twenty-four high-functioning patients with ischemic stroke(7 women,17 men;mean age 64.75±10.84 years)participated in this cross-sectional observational study and completed four subtasks from the Purdue Pegboard Test,which measures unimanual and bimanual finger and hand dexterity.We found significant bilateral activation of the sensorimotor cortices during all Purdue Pegboard Test subtasks,with bimanual tasks inducing higher cortical activation than the assembly subtask.Importantly,patients with better bimanual coordination exhibited lower cortical activation during the other three Purdue Pegboard Test subtasks.Notably,the observed neural response patterns varied depending on the specific subtask.In the unaffected hand task,the differences were primarily observed in the ipsilesional hemisphere.In contrast,the bilateral sensorimotor cortices and the contralesional hemisphere played a more prominent role in the bimanual task and assembly task,respectively.While significant correlations were found between cortical activation and unimanual tasks,no significant correlations were observed with bimanual tasks.This study provides insights into the neural basis of bimanual coordination and fine motor skills in high-functioning patients after stroke,highlighting task-dependent neural responses.The findings also suggest that patients wh

关键词： bilateral arm training bimanual coordination cortical activity fine motor dexterity functional near-infrared spectroscopy(fNIRS) high-functioning Purdue Pegboard Test stroke

Neuronal conversion from glia to replenish the lost neurons

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Neural Regeneration Research 2024年第7期19卷 1446-1453页

作者： Shiyu Liang Jing Zhou Xiaolin Yu Shuai Lu Ruitian Liu National Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijingChina School of Chemical Engineering University of Chinese Academy of SciencesBeijingChina Department of Geriatric rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Neuronal injury,aging,and cerebrovascular and neurodegenerative diseases such as cerebral infarction,Alzheimer’s disease,Parkinson’s disease,frontotemporal dementia,amyotrophic lateral sclerosis,and Huntington’s disease are characte rized by significant neuronal loss.Unfo rtunately,the neurons of most mammals including humans do not possess the ability to self-regenerate.Replenishment of lost neurons becomes an appealing therapeutic strategy to reve rse the disease phenotype.Transplantation of pluripotent neural stem cells can supplement the missing neurons in the brain,but it carries the risk of causing gene mutation,tumorigenesis,severe inflammation,and obstructive hydrocephalus induced by brain edema.Conversion of neural or non-neural lineage cells into functional neurons is a promising strategy for the diseases involving neuron loss,which may overcome the above-mentioned disadvantages of neural stem cell therapy.Thus far,many strategies to transfo rm astrocytes,fibroblasts,microglia,Muller glia,NG2 cells,and other glial cells to mature and functional neurons,or for the conversion between neuronal subtypes have been developed thro ugh the regulation of transcription factors,polypyrimidine tra ct binding protein 1(PTBP1),and small chemical molecules or are based on a combination of several factors and the location in the central nervous system.However,some recent papers did not obtain expected results,and discrepancies exist.Therefore,in this review,we discuss the history of neuronal transdifferentiation,summarize the strategies for neuronal replenishment and conversion from glia,especially astrocytes,and point out that biosafety,new strategies,and the accurate origin of the truly co nverted neurons in vivo should be focused upon in future studies.It also arises the attention of replenishing the lost neurons from glia by gene therapies such as up-regulation of some transc ription factors or downregulation of PTBP1 or drug interfe rence therapies.

关键词： astrocytes neural stem cells neurodegenerative diseases neuron polypyrimidine tract binding protein 1 repair reprogramming small molecule transcription factor transdifferentiation

Efficacy of Daoyin combined with lower limb robot as a comprehensive rehabilitation intervention for stroke patients: a randomized controlled trial

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Journal of Traditional Chinese Medicine 2024年第3期44卷 530-536页

作者： TIAN Haolin YANG Yuanbin ZHANG Hu ZHAO Wenjing ZHOU Jing TIAN Jingfeng HE Long LI Xuechao SHEN Qinxuan SHUAI Mei Department of First rehabilitation Wangjing Hospital of China Academy of Chinese Medical Sciences Department of rehabilitation Shunyi HospitalBeijing Traditional Chinese Medicine Hospital School of Biological science and Medical Engineering Beihang University

OBJECTIVE: To assess the effectiveness of a comprehensive rehabilitation approach combining Traditional Chinese Medicine Daoyin with lower limb robotics during the recovery phase of stroke patients.METHODS: Stroke patients meeting the specified criteria were randomly assigned to one of four groups using a random number table: Control group, Daoyin group, lower limb robot group(LLR group), and Daoyin and lower limb robot group(DLLR group). Each group received distinct treatments based on conventional rehabilitation training.The treatment duration spanned two weeks with two days of rest per week. Pre-and post-intervention assessments included various scales: Fugl-Meyer Assessment(FMA),Berg balance scale(BBS), Barthel index(BI), Fatigue Scale-14(FS-14), Pittsburgh sleep quality index(PSQI),Hamilton Anxiety Scale(HAMA), and Hamilton Depression Scale(HAMD).RESULTS: Statistically significant differences were observed in the lower limb function measured by FAM between the Control group(15 ± 5) and the DLLR group(18 ± 5)(P = 0.049). In the Barthel index, a statistically significant difference was noted between the Control group(54 ± 18) and the DLLR group(64 ± 11)(P = 0.041).Additionally, significant differences were found in the Berg balance scale between the Control group(21 ± 10)and the DLLR group(27 ± 8)(P = 0.024), as well as between the Control group(21 ± 10) and the LLR group(26 ± 10)(P = 0.048).CONCLUSION: The findings of this study suggest that the combined use of Daoyin and robotics not only enhances motor function in stroke patients but also has a positive impact on fatigue, sleep quality, and mood. This approach may offer a more effective rehabilitation strategy for stroke patients.

关键词： Daoyin lower limb robot randomized controlled trial rehabilitation stroke

A Comparison of Four Neural Networks Algorithms on Locomotion Intention Recognition of Lower Limb Exoskeleton Based on Multi-source Information

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Journal of Bionic Engineering 2024年第1期21卷 224-235页

作者： Duojin Wang Xiaoping Gu Hongliu Yu institute of rehabilitation Engineering and Technology University of Shanghai for Science and Technology516 Jungong RoadShanghai 200093China Shanghai Engineering Research Center of Assistive Devices 516 Jungong RoadShanghai 200093China

Lower Limb Exoskeletons(LLEs)are receiving increasing attention for supporting activities of daily living.In such active systems,an intelligent controller may be indispensable.In this paper,we proposed a locomotion intention recognition system based on time series data sets derived from human motion signals.Composed of input data and Deep Learning(DL)algorithms,this framework enables the detection and prediction of users’movement patterns.This makes it possible to predict the detection of locomotion modes,allowing the LLEs to provide smooth and seamless assistance.The pre-processed eight subjects were used as input to classify four scenes:Standing/Walking on Level Ground(S/WOLG),Up the Stairs(US),Down the Stairs(DS),and Walking on Grass(WOG).The result showed that the ResNet performed optimally compared to four algorithms(CNN,CNN-LSTM,ResNet,and ResNet-Att)with an approximate evaluation indicator of 100%.It is expected that the proposed locomotion intention system will significantly improve the safety and the effectiveness of LLE due to its high accuracy and predictive performance.

关键词： Lower limb exoskeletons(LLEs) Locomotion intention ResNet Multi-source

Neuronomodulation of Excitable Neurons

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Neuroscience Bulletin 2024年第1期40卷 103-112页

作者： Yizhang Chen Lin Xiao Jian Qiu institute of Neuroscience Second Military Medical UniversityShanghai 200433China institute for Brain Research and rehabilitation Key Laboratory of BrainCognition and Education Sciences of Ministry of EducationSouth China Normal UniversityGuangzhou 510631China Department of Chemical Physiology and Biochemistry Oregon Health and Science UniversityPortlandOR 97239USA

Neuronomodulation refers to the modulation of neural conduction and synaptic transmission(i.e.,the conduction process involved in synaptic transmission)of excitable neurons via changes in the membrane potential in response to chemical substances,from spillover neuro-transmitters to paracrine or endocrine hormones circulating in the blood.Neuronomodulation can be direct or indirect,depending on the transduction pathways from the ligand binding site to the ion pore,either on the same molecule,i.***.the ion channel,or through an intermediate step on different molecules.The major players in direct neurono-modulation are ligand-gated or voltage-gated ion channels.The key process of direct neuronomodulation is the binding and chemoactivation of ligand-gated or voltage-gated ion channels,either orthosterically or allosterically,by various ligands.Indirect neuronomodulation involves metabotropic receptor-mediated slow potentials,where steroid hormones,cytokines,and chemokines can implement these actions.Elucidating neuronomodulation is of great significance for understanding the physiological mechanisms of brain function,and the occurrence and treatment of diseases.

关键词： Neuron Membrane potential Excitability Chemoactivation Neuronomodulation

Functional near-infrared spectroscopy in non-invasive neuromodulation

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Neural Regeneration Research 2024年第7期19卷 1517-1522页

作者： Congcong Huo Gongcheng Xu Hui Xie Tiandi Chen Guangjian Shao Jue Wang Wenhao Li Daifa Wang Zengyong Li Beijing Advanced Innovation Center for Biomedical Engineering Key Laboratory for Biomechanics and Mechanobiology of Ministry of EducationSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Beijing Key Laboratory of rehabilitation Technical Aids for Old-Age Disability National Research Center for Rehabilitation Technical AidsBeijingChina School of Mechatronic Engineering and Automation Foshan UniversityFoshanGuangdong ProvinceChina School of rehabilitation Engineering Beijing College of Social AdministrationBeijingChina Key Laboratory of Neuro-functional Information and rehabilitation Engineering of the Ministry of Civil Affairs BeijingChina

Non-invasive cerebral neuromodulation technologies are essential for the reorganization of cerebral neural networks,which have been widely applied in the field of central neurological diseases,such as stroke,Parkinson’s disease,and mental disorders.Although significant advances have been made in neuromodulation technologies,the identification of optimal neurostimulation paramete rs including the co rtical target,duration,and inhibition or excitation pattern is still limited due to the lack of guidance for neural circuits.Moreove r,the neural mechanism unde rlying neuromodulation for improved behavioral performance remains poorly understood.Recently,advancements in neuroimaging have provided insight into neuromodulation techniques.Functional near-infrared spectroscopy,as a novel non-invasive optical brain imaging method,can detect brain activity by measuring cerebral hemodynamics with the advantages of portability,high motion tole rance,and anti-electromagnetic interference.Coupling functional near-infra red spectroscopy with neuromodulation technologies offe rs an opportunity to monitor the cortical response,provide realtime feedbac k,and establish a closed-loop strategy integrating evaluation,feedbac k,and intervention for neurostimulation,which provides a theoretical basis for development of individualized precise neuro rehabilitation.We aimed to summarize the advantages of functional near-infra red spectroscopy and provide an ove rview of the current research on functional near-infrared spectroscopy in transcranial magnetic stimulation,transcranial electrical stimulation,neurofeedback,and braincomputer interfaces.Furthermore,the future perspectives and directions for the application of functional near-infrared spectroscopy in neuromodulation are summarized.In conclusion,functional near-infrared spectroscopy combined with neuromodulation may promote the optimization of central pellral reorganization to achieve better functional recovery form central nervous system diseases.

关键词： brain-computer interface cerebral neural networks functional near-infrared spectroscopy neural circuit neurofeedback neurological diseases neuromodulation non-invasive brain stimulation transcranial electrical stimulation transcranial electrical stimulation

Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy

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Chinese Chemical Letters 2024年第6期35卷 445-450页

作者： Leichen Wang Anqing Mei Na Li Xiaohong Ruan Xu Sun Yu Cai Jinjun Shao Xiaochen Dong Key Laboratory of Flexible Electronics(KLOFE)&institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)Nanjing 211800China School of Chemistry&Materials science Jiangsu Normal UniversityXuzhou 221116China Center for rehabilitation Medicine Rehabilitation&Sports Medicine Research Institute of Zhejiang ProvinceDepartment of Rehabilitation MedicineZhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)Hangzhou 310014China

Introducing heavy halogen atoms into organic small molecules is a practical strategy for efficient singlet oxygen(^(1)O_(2))generation.Generally,bromine or iodine atoms are introduced on the aza-borondipyrromethene(aza-BODIPY)core,rather than on the periphery aryl rings for efficient~1O_(2) generation.Herein,an aza-BODIPY dye NBDPBr with unexpected bromination on the periphery aryl rings was synthesized for photoacoustic(PA)imaging-guided synergistic photothermal therapy(PTT)and photodynamic therapy(PDT)in tumor cells.Owing to unexcepted bromination at the periphery aryl rings,NBDPBr demonstrated an outstanding singlet oxygen quantum yield(Φ_(Δ))of 66% which was superior to similar brominated photosensitizers previously reported.After encapsulation with amphiphilic polymer F-127,hydrophilic NBDPBr nanoparticles(NPs)were fabricated and exhibited an excellent photothermal conversion efficiency(η)of 43.0% under 660 nm photoirradiation.In vivo PA imaging results demonstrated that NBDPBr NPs could specifically accumulate at tumor sites and realized the maximum tumor retention at 7 h post-injection.All the in vitro and in vivo results indicated the significant potence of NBDPBr with unexpected bis-bromination for PA imaging-guided synergetic PDT/PTT.

关键词： Unexpected bromination Aza-BODIPY Photodynamic therapy Photothermal therapy Synergetic therapy

A multilayer network diffusion-based model for reviewer recommendation

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Chinese Physics B 2024年第3期33卷 700-717页

作者：黄羿炜徐舒琪蔡世民吕琳媛 institute of Fundamental and Frontier sciences University of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region institute (Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China institute of Dataspace Hefei Comprehensive National Science CenterHefei 230088China Big Data Research Center University of Electronic Science and Technology of ChinaChengdu 611731China School of Computer science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China School of Cyber science and Technology University of Science and Technology of ChinaHefei 230026China

With the rapid growth of manuscript submissions,finding eligible reviewers for every submission has become a heavy task.Recommender systems are powerful tools developed in computer science and information science to deal with this problem.However,most existing approaches resort to text mining techniques to match manuscripts with potential reviewers,which require high-quality textual information to perform well.In this paper,we propose a reviewer recommendation algorithm based on a network diffusion process on a scholar-paper multilayer network,with no requirement for textual information.The network incorporates the relationship of scholar-paper pairs,the collaboration among scholars,and the bibliographic coupling among papers.Experimental results show that our proposed algorithm outperforms other state-of-the-art recommendation methods that use graph random walk and matrix factorization and methods that use machine learning and natural language processing,with improvements of over 7.62%in recall,5.66%in hit rate,and 47.53%in ranking score.Our work sheds light on the effectiveness of multilayer network diffusion-based methods in the reviewer recommendation problem,which will help to facilitate the peer-review process and promote information retrieval research in other practical scenes.

关键词： reviewer recommendation multilayer network network diffusion model recommender systems complex networks

Investigation on Strengthening Mechanism of china Low-Activation Ferrite Steel upon Thermo-Mechanical Treatment

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 373-387页

作者： Dongtian Yang Liangyin Xiong Hongbin Liao Guoping Yang Xiaoyu Wang Shi Liu institute of Metal Research Chinese Academy of SciencesShenyang110016China School of Materials science and Engineering University of Science and Technology of ChinaShenyang110016China Center for Fusion science Southwestern Institute of PhysicsChengdu610041China

The objective of this study was to investigate the influence of strengthening mechanisms on the high-temperature mechanical properties of china low-activation ferrite(CLF-1)steel,which underwent thermodynamic design and thermo-mechanical treatment(TMT).The microstructure characterization in the normalized and tempered condition and the TMT condition was carried out using optical microscopy,X-ray diffractometer,and scanning electron microscopy with electron backscatter diffraction.High-resolution transmission electron microscopy was employed to determine the crystallographic structures of precipitated phases.The results indicated that the addition of Ti led to an increase in the allocation of C in MC phase and an enhancement in the content of MC phase.Compared to CLF-P steel in the normalized and tempered condition,a 1.5-fold increase in dislocation density and an order of magnitude improvement in MX phase density were achieved after TMT.The formation of high-density nano-scale MC phases during TMT played a significant role in precipitation strengthening due to their favorable coherent relationship with the matrix and low interfacial free energy.The excellent high-temperature mechanical properties observed in CLF-P steel after TMT can be attributed to the combined effects of precipitation strengthening,dislocation strengthening,and lath strengthening.

关键词： china low-activation ferrite(CLF-1)steel Thermo-mechanical treatment MC phase Crystallographic structure Strengthening mechanism