Cortical activity in patients with high-functioning ischemic stroke during the Purdue Pegboard Test:insights into bimanual coordinated fine motor skills with functional near-infrared spectroscopy

作     者：Siyun Chen Mengchai Mao Guangyue Zhu Yufeng Chen Yuqi Qiu Bin Ye Dongsheng Xu Siyun Chen;Mengchai Mao;Guangyue Zhu;Yufeng Chen;Yuqi Qiu;Bin Ye;Dongsheng Xu

作者机构：The Second Rehabilitation Hospital of ShanghaiShanghaiChina College of Rehabilitation ScienceShanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent RehabilitationMinistry of EducationShanghaiChina School of StatisticsEast China Normal UniversityShanghaiChina The Third Rehabilitation Hospital of ShanghaiShanghaiChina Tongji UniversityShanghaiChina Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2024年第19卷第5期

页      面：1098-1104页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Key R&D Program of China No.2020YFC2004202(to DX) 

主　　题：bilateral arm training bimanual coordination cortical activity fine motor dexterity functional near-infrared spectroscopy(fNIRS) high-functioning Purdue Pegboard Test stroke 

摘      要：After stroke,even high-functioning individuals may experience compromised bimanual coordination and fine motor dexterity,leading to reduced functional *** arm training has been proposed as a promising intervention to address these ***,the neural basis of the impairment of functional fine motor skills and their relationship to bimanual coordination performance in stroke patients remains unclear,limiting the development of more targeted *** address this gap,our study employed functional near-infrared spectroscopy to investigate cortical responses in patients after stroke as they perform functional tasks that engage fine motor control and ***-four high-functioning patients with ischemic stroke(7 women,17 men;mean age 64.75±10.84 years)participated in this cross-sectional observational study and completed four subtasks from the Purdue Pegboard Test,which measures unimanual and bimanual finger and hand *** found significant bilateral activation of the sensorimotor cortices during all Purdue Pegboard Test subtasks,with bimanual tasks inducing higher cortical activation than the assembly ***,patients with better bimanual coordination exhibited lower cortical activation during the other three Purdue Pegboard Test ***,the observed neural response patterns varied depending on the specific *** the unaffected hand task,the differences were primarily observed in the ipsilesional *** contrast,the bilateral sensorimotor cortices and the contralesional hemisphere played a more prominent role in the bimanual task and assembly task,*** significant correlations were found between cortical activation and unimanual tasks,no significant correlations were observed with bimanual *** study provides insights into the neural basis of bimanual coordination and fine motor skills in high-functioning patients after stroke,highlighting task-dependent neural resp