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Sensitive skin syndrome: Research progress on mechanisms and applications

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Journal of dermatologic science and cosmetic technology

Journal of dermatologic science and co.metic technology 2024年第2期1卷 63-70页

作者： Chuanxia Jiang Chaowan Guo Jipeng Yan Jie Chen Shujing Peng Haishu Huang Weizhi Wu Yanfeng Nie Yunlin Pei Huaiqing Sun Guangdong Marubi biotechnology co. Ltd.Guangzhou510700China Guangzhou Marumed Research co. Ltd.Guangzhou510700China

Sensitive skin is a clinical syndrome characterized by a hyper-reactive state of the skin,primarily on the *** is acco.panied by subjective symptoms such as burning,stinging,itching,and tightness when exposed to physical,chemical,or psychological *** signs,such as erythema,scales,and dilated blood vessels,may or may not be *** disco.fort associated with sensitive skin can be triggered by various endogenous and exogenous factors,which usually have no significant effect on the individual and do not induce irritant *** skin often presents as a subjective state without clinical signs and exhibits diversity,posing challenges in sensitive skin research and *** review summarizes the prevalence,key factors,pathophysiological mechanisms,diagnosis,and progress in daily care for sensitive *** aim is to provide a clearer and more systematic understanding of sensitive skin and offer guidance for sensitive skin care.

关键词： Sensitive skin Endogenous and exogenous factors Epidemiology Pathophysiological mechanisms Sensitive skin care

Nanoparticle drug delivery system for the treatment of brain tumors:Breaching the blood–brain barrier

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2786-2789页

作者： Qiyu Tang Guo Zhao Hong Fang Yale Jiang Peiwen Ma Jiawei Zhoua Dongyan Liu Shujun Xing Gaoquan Li Nian Liu Huiyu Chen Shuhang Wang Ning Li Clinical Trial Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Chongqing Upgra biotechnology co. Ltd.Chongqing 401331China

To the Editor:Malignant brain tumors represent a substantial morbidity and mortality burden globally,with 308,102 new cases and 251,329 cancer-related deaths in *** tumors enco.pass primary tumors originating in the brain and brain metastases(BM)that have been spread from cancer lesions of other ***,BM are the most prevalent intracranial malignant tumor affecting approximately 20%-40%of cancer patients2.

关键词： Nanoparticle Drug delivery system Blood-brain barrier Tumor Glioma

Bioactive co.pounds in Hericium erinaceus and their biological properties:a review

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Food Science and Human Wellness 2024年第4期13卷 1825-1844页

作者： Yue Qiu Genglan Lin Weiming Liu Fuming Zhang Robert J.Linhardt Xingli Wang Anqiang Zhang co.lege of Food Science and Engineering Zhejiang University of TechnologyHangzhou 310014China Zhejiang Biosan Biotech co. Ltd.Hangzhou 310052China Department of Chemical and Biological Engineering Center for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNY 12180USA Departments of Chemistry and Chemical Biology and Biomedical Engineering Biological ScienceCenter for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNY 12180USA

Hericium erinaceus is a nutritious edible and medicinal fungi,rich in a variety of functional active ingredients,with various physiological functions such as antioxidation,anticancer,and enhancing *** is also effective in protecting the digestive system and preventing neurodegenerative *** this review paper,we summarize the sources,structures and efficacies of the main active co.ponents in *** fruiting body,mycelium,and culture media,and update the latest research progress on their biological activities and the related molecular *** on this information,we provide detailed challenges in current research,industrialization and information on the active ingredients of *** for future studies and new applications of *** are proposed.

关键词： Hericium erinaceus Bioactive co.pounds Biological activities Antioxidation Neuroprotection Immunoregulation

DeepCBA:A deep learning framework for gene expression prediction in maize based on DNA sequences and chromatin interactions

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Plant co.munications 2024年第9期5卷 38-53页

作者： Zhenye Wang Yong Peng Jie Li Jiying Li Hao Yuan Shangpo Yang Xinru Ding Ao Xie Jiangling Zhang Shouzhe Wang Keqin Li Jiaqi Shi Guangjie Xing Weihan Shi Jianbing Yan Jianxiao Liu National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China Hubei Key Laboratory of Agricultural Bioinformatics Huazhong Agricultural UniversityWuhan 430070China co.lege of Informatics Huazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China Microsoft co.poration RedmondWA 98052USA WIMI biotechnology co. Ltd.Changzhou 213000China

Chromatin interactions create spatial proximity between distal regulatory elements and target genes in the genome,which has an important impact on gene expression,transcriptional regulation,and phenotypic *** date,several methods have been developed for predicting gene ***,existing methods do not take into co.sideration the effect of chromatin interactions on target gene expression,thus potentially reducing the accuracy of gene expression prediction and mining of important regulatory el*** this study,we developed a highly accurate deep learning-based gene expression prediction model(DeepCBA)based on maize chromatin interaction *** with existing models,DeepCBA exhibits higher accuracy in expression classification and expression value *** average Pearson co.relation co.fficients(PCCs)for predicting gene expression using gene promoter proximal interactions,proximaldistal interactions,and both proximal and distal interactions were 0.818,0.625,and 0.929,respectively,representing an increase of 0.357,0.16,and 0.469 over the PCCs obtained with traditional methods that use only gene proximal *** important motifs were identified through DeepCBA;they were enriched in open chromatin regions and expression quantitative trait loci and showed clear tissue ***tantly,experimental results for the maize flowering-related gene ZmRap2.7 and the tillering-related gene ZmTb1 demonstrated the feasibility of DeepCBA for exploration of regulatory elements that affect gene ***,promoter editing and verification of two reported genes(ZmCLE7 and ZmVTE4)demonstrated the utility of DeepCBA for the precise design of gene expression and even for future intelligent *** is available at http://***/or http://124.***.197.196/.

关键词： maize gene expression prediction chromatin interactions deep learning promoter editing regulatory elements and motifs

Host-induced gene silencing of the Verticillium dahliae thiamine transporter protein gene(VdThit)co.fers resistance to Verticillium wilt in co.ton

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Journal of Integrative Agriculture 2024年第10期23卷 3358-3369页

作者： Qi Wang Guoqiang Pan Xingfen Wang Zhengwen Sun Huiming Guo Xiaofeng Su Hongmei Cheng National Key Laboratory of Agricultural Microbiology/biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing100081China Xinjiang Jinfengyuan Seeds co. Ltd.Aksu 843100China co.lege of Agronomy Hebei Agricultural UniversityBaoding 071001China Institute of Microbiology Applications Xinjiang Academy of Agricultural SciencesUrumqi 830091China

Verticillium wilt(VW),induced by the soil-borne fungus Verticillium dahliae(Vd),poses a substantial threat to a diverse array of plant *** molecular breeding technology for the development of co.ton varieties with heightened resistance to VW stands out as one of the most efficacious protective *** this study,we successfully generated two stable transgenic lines of co.ton(Gossypium hirsutum L.),VdThitRNAi-1 and VdThit-RNAi-2,using host-induced gene silencing(HIGS)technology to introduce double-stranded RNA(dsRNA)targeting the thiamine transporter protein gene(VdThit).Southern blot analysis co.firmed the presence of a single-co.y insertion in each *** examination showed marked reductions in the co.onization and spread of Vd-mCherry in the roots of VdThit-RNAi co.ton co.pared to wild type(WT).The co.responding disease index and fungal biomass of VdThit-RNAi-1/2 also exhibited significant ***-time quantitative PCR(qRT-PCR)analysis demonstrated a substantial inhibition of VdThit expression following prolonged inoculation of VdThit-RNAi *** RNA sequencing(sRNA-Seq)analysis revealed the generation of a substantial number of VdThit-specific siRNAs in the VdThit-RNAi transgenic ***,the silencing of VdThit by the siVdThit produced by VdThit-RNAi-1/2 resulted in the elevated expression of multiple genes involved in the thiamine biosynthesis pathway in *** field co.ditions,VdThit-RNAi transgenic co.ton exhibited significantly enhanced disease resistance and yield co.pared with *** summary,our findings undersco.e the efficacy of HIGS targeting VdThit in restraining the infection and spread of Vd in co.ton,thereby potentially enabling the development of co.ton breeding as a promising strategy for managing VW.

关键词： Verticillium dahliae thiamine transporter host-induced gene silencing(HIGS) RNAi

Efficient degradation of aqueous dichloromethane by an enhanced microbial electrolysis cell:Degradation kinetics,microbial co.munity and metabolic mechanisms

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Journal of Environmental Sciences 2024年第5期139卷 150-159页

作者： Meng Wu Di Zhao Bing Gu ZiruWang Jun Hu Zhiliang Yu Jianming Yu co.lege of Environment College of Biotechnology and BioengineeringCollaborative Innovation Center of Yangtze River Delta Region Green PharmaceuticalsZhejiang University of TechnologyHangzhou 310014China Shentuo Environment(Hangzhou)co.Ltd. Hangzhou 311121China Zhejiang Tianyi Environmental co.Ltd. Hangzhou 310000China

Dichloromethane(DCM)has been listed as a toxic and harmful water pollutant,and its re moval needs *** electrolysis cells(MECs)are viewed as a promising alterna tive for pollutant removal,which can be strengthened from two aspects:microbial inocula tion and *** this study,the MEC for DCM degradation was inoculated with the ac tive sludge enhanced by Methylobacterium rhodesianum H13(strain H13)and then acclimated in the form of a microbial fuel cell(MFC).Both the introduction of strain H13 and the initi ation in MFC form significantly promoted DCM *** degradation kinetics were fitted by the Haldane model,with V_(max),K_(h),K_(i)and v_(max)values of 103.2 mg/L/hr,97.8 mg/L268.3 mg/L and 44.7 mg/L/hr/cm^(2),*** cyclic voltammogram implies that DCM redox reactions became easier with the setup of MEC,and the electrochemical impedance spectrogram shows that the acclimated and enriched microbes reduced the charge transfe resistance from the electrode to the *** the biofilm,the dominant genera shifted from Geobacter to Hyphomicrobium in acclimation ***,Methylobacterium played an increasingly important *** metabolism mainly occurred through the hydrolytic glutathione S-transferase pathway,given that the gene dcmA was identified rather than the dhlA and P450/*** exogenous electrons facilitated the reduction of GSSG,directly o indirectly accelerating the GSH-catalyzed *** study provides support fo the co.struction of an efficient and stable MEC for DCM removal in water environment.

关键词： Dichloromethane Microbial electrolysis cells Metabolic pathways Electron transfer Degradation kinetics

Highly sensitive nanozyme strip:An effective tool for forensic material evidence identification

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Nano Research 2024年第3期17卷 1785-1791页

作者： Juanji Hong Zhanjun Guo Dihan Duan Yi Zhang Xin Chen Yongjiu Li Zheng Tu Lei Feng Lei Chen Xiyun Yan Lizeng Gao Minmin Liang Demin Duan Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China co.lege of Bioscience and biotechnology Shenyang Agricultural UniversityShenyang 110866China Chongqing kangjuquanhong biology science and technology co. ltdChongqing 400026China Key Laboratory of Forensic Genetics Institute of Forensic ScienceMinistry of Public SecurityBeijing 100038China CAS Engineering Laboratory for Nanozyme Key Laboratory of BiomacromoleculesInstitute of BiophysicsChinese Academic of ScienceBeijing 100101China

During criminal case investigations,blood evidence tracing is critical for criminal ***,the blood stains are often cleaned or co.ered up after the crime,resulting in trace residue and difficult ***,a highly sensitive and specific method for the rapid detection of human blood stains remains *** solve this problem,we established a nanozyme-based strip for rapid detection of blood evidence with high sensitivity and *** co.struct reliable nanozyme strips,we synthesized co.e_(2)O_(4) nanozymes with high peroxidase-like activity by scaling up to gram level,which can be supplied for six million tests,and co.jugated antibody as a detection probe in nanozyme *** developed co.e_(2)O_(4) nanozyme strip can detect human hemoglobin(HGB)at a co.centration as low as 1 ng/mL,which is 100 times lower than the co.mercially available co.loidal gold strips(100 ng/mL).Moreover,this co.e_(2)O_(4) nanozyme strip showed high generality on 12 substrates and high specificity to human HGB among 13 animal blood ***,we applied the developed co.e_(2)O_(4) nanozyme strip to successfully detect blood stains in three real cases,where the current co.mercial co.loidal gold strip failed to *** results suggest that the co.e_(2)O_(4) nanozyme strip can be used as an effective on-scene detection method for human blood stains,and can further be used as a long-term preserved material evidence for traceability inquiry.

关键词： co.e_(2)O_(4)nanozyme nanozyme strip peroxidase-like activity human hemoglobin blood evidence

Ionic Liquid-Enhanced Assembly of Nanomaterials for Highly Stable Flexible Transparent Electrodes

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Nano-Micro Letters 2024年第7期16卷 441-455页

作者： Jianmin Yang Li Chang Xiqi Zhang Ziquan Cao Lei Jiang Key Laboratory of Bio-Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China co.lege of Chemistry and Chemical Engineering Chongqing University of TechnologyChongqing 400054People’s Republic of China Binzhou Institute of Technology Binzhou 256600People’s Republic of China Nanomics biotechnology co. Ltd.HangzhouPeople’s Republic of China

The co.trolled assembly of nanomaterials has demon-strated significant potential in advancing technological ***,achieving highly efficient and low-loss assembly technique for nanomate-rials,enabling the creation of hierarchical structures with distinctive func-tionalities,remains a formidable ***,we present a method for nanomaterial assembly enhanced by ionic liquids,which enables the fabrication of highly stable,flexible,and transparent electrodes featuring an organized layered *** utilization of hydrophobic and non-volatile ionic liquids facilitates the production of stable interfaces with water,effectively preventing the sedimentation of 1D/2D nanomaterials assembled at the ***,the interfacially assembled nanomaterial monolayer exhibits an alternate self-climbing behavior,enabling layer-by-layer transfer and the formation of a well-ordered MXene-wrapped silver nanowire network *** resulting co.posite film not only demonstrates exceptional photoelectric performance with a sheet resistance of 9.4Ωsq^(-1) and 93%transmittance,but also showcases remarkable environmental stability and mechanical *** noteworthy is its application in transparent electromagnetic interference shielding materials and triboelectric nanogenerator *** research introduces an innovative approach to manufacture and tailor functional devices based on ordered nanomaterials.

关键词： Ionic liquids Assembly Silver nanowires MXene nanosheets Flexible transparent electrodes

PAHs removal by soil washing with thiacalix[4]arene tetrasulfonate

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Environmental Science and Eco.echnology 2024年第5期21卷 256-267页

作者： Le-Yao Xing Guan-Han Meng Ji-Xian Yang Ming-Han Xu Yi-Ming Xu Hai-Xiao Xie Ai-Jie Wang Yi-Lu Sun State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin150090China Key Laboratory of Environmental biotechnology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China Hangzhou Yanqu Information Technology co. Ltd.Y2Hangzhou310003China

Remediating soil co.taminated with polycyclic aromatic hydrocarbons(PAHs)presents a significant environmental challenge due to their toxic and carcinogenic *** PAHs remediation methodsdchemical,thermal,and bioremediationdalong with co.ventional soil-washing agents like surfactants and cyclodextrins face challenges of co.t,eco.ogical harm,and *** we show an effective and environmentally friendly calixarene derivative for PAHs removal through soil ***[4]arene tetrasulfonate(TCAS)has a unique molecular structure of a sulfonate group and a sulfur atom,which enhances its solubility and facilitates selective binding with *** forms host-guest co.plexes with PAHs through p-p stacking,OH-p interactions,hydrogen bonding,van der Waals forces,and electrostatic *** interactions enable partial encapsulation of PAH molecules,aiding their desorption from the soil *** results show that a 0.7%solution of TCAS can extract approximately 50%of PAHs from co.taminated soil while preserving soil nutrients and minimizing adverse environmental *** research unveils the pioneering application of TCAS in removing PAHs from co.taminated soil,marking a transformative advancement in resource-efficient and sustainable soil remediation strategies.

关键词： Calixarenes Soil-washing Host-guest interaction PAHs