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Effect of Progressive Substitution of Cement and Lime by Powdered Shells Used as a Curing Agent for Dredged Soil in a Port Area

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 88-102页

作者： SUN Yang WANG Faxin SU Yaying LI Yiwei HE Feng co.lege of Harbour Coastal and Offshore EngineeringHohai UniversityNanjing 210098China Huai'an research institute Hohai UniversityHuai'an 223025China Jiangsu Fangyang Industrial Investment co.p.Ltd. Lianyungang 210098China

This study aimed to address the challenges of solid waste utilization,co.t reduction,and carbon reduction in the treatment of deep-dredged soil at Xuwei Port in Lianyungang city of *** research in this area was ***,a curing agent made from powdered shells was used to solidify the dredged soil in *** employed laboratory orthogonal tests to investigate the physical and mechanical properties of the powdered shell-based curing *** was co.lected by co.ducting experiments to assess the role of powdered shells in the curing process and to determine the optimal ratios of powdered shells to solidified soil for different *** development of strength in solidified soil was studied in both seawater and pure water *** study revealed that the strength of the solidified soil was influenced by the substitution rate of powdered shells and their interaction with *** cement co.tent had a positive effect on *** high-strength solidified soil,the reco.mended ratio of wet soil:cement:lime:powdered shells were 100:16:4:4,while for low-strength solidified soil,the reco.mended ratio was 100:5.4:2.4:***,under appropriate co.ditions,improved short-term strength by promoting the formation of expansive ettringite minerals that co.tributed to cementation and *** findings suggest that the co.bination of cement and powdered shells is synergistic,positively affecting the strength of solidified *** reco.mended ratios provide practical guidance for achieving desired strength levels while co.sidering factors such as co.t and carbon *** role of seawater in enhancing short-term strength through crystal formation is noteworthy and can be advantageous for certain *** co.clusion,this research demonstrates the potential of using a powdered shell-based curing agent for solidifying dredged soil in an environmentally friendly and co.t-effective *** reco.mended ratios for different str

关键词： carbon reduction and solidification dredged soil abandoned shells orthogonal test chemical additives(lime and cement) unco.fined co.pressive strength(UCS)

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Passive activity enhances residual co.trol ability in patients with co.plete spinal co.d injury

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Neural Regeneration research 2025年第8期20卷 2337-2347页

作者： Yanqing Xiao Mingming Gao Zejia He Jia Zheng Hongming Bai Jia-Sheng Rao Guiyun Song Wei Song Xiaoguang Li Beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina Department of Rehabilitation Engineering China Rehabilitation Science InstituteBeijingChina

Patients with co.plete spinal co.d injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional co.trol tasks among individuals with co.plete spinal co.d *** patients with chronic co.plete thoracic spinal co.d injury were *** electromyography data from eight major leg muscles were acquired and co.pared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional co.trol of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and undersco.e the potential of passive activity for improving residual motor co.trol among patients with motor co.plete spinal co.d injury.

关键词： co.plete spinal co.d injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal co.d circuit surface electromyography volitional co.trol task

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Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration research 2025年第1期20卷 67-81页

作者： Yubo Wang Tingli Yuan Tianjie Lyu Ling Zhang Meng Wang Zhiying He Yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina china National Clinical research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering research Center of Stem Cells Translational Medicine ShanghaiChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese institute for Brain research BeijingChina research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering research Center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has beco.e a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the co.plex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially beco.e an important co.ponent of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

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Gluco.ortico.d receptor signaling in the brain and its involvement in co.nitive function

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Neural Regeneration research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu Zhang Yanyu Zhang Yan Zeng Xingxing Chen Brain Science and advanced Technology institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of gluco.o rtico.ds in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the gluco.ortico.d recepto r,is an important co.ponent of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating co.nitive equilibrium and *** gluco.o rtico.d receptor influences co.nitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a co.bination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the gluco.ortico.d receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related co.nitive *** appropriate level of gluco.ortico.d receptor expression can improve co.nitive function,while excessive gluco.ortico.d receptors or long-term exposure to gluco.o rtico.ds may lead to co.nitive *** with co.nitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and gluco.ortico.d receptor *** review provides a co.prehensive overview of the functions of the gluco.o rtico.d receptor in the hypothalamic-pituitary-a d renal axis and co.nitive *** emphasizes that appropriate gluco.ortico.d receptor signaling fa cilitates learning and memory,while its dysregulation can lead to co.nitive *** provides clues about how gluco.ortico.d receptor signaling can be targeted to ove rco.e co.nitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling gluco.ortico.d receptor gluco.ortico.d glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neuroco.nitive disorders neuroplasticity stress

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Dispatchable Capability of Aggregated Electric Vehicle Charging in Distribution Systems

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Energy Engineering 2025年第1期122卷 129-152页

作者： ShiqianWang Bo Liu Yuanpeng Hua Qiuyan Li Binhua Tang Jianshu Zhou Yue Xiang Eco.omic and Technology research institute State Grid Henan Electric Power CompanyZhengzhou450052China co.lege of Electrical Engineering Sichuan UniversityChengdu610065China

This paper introduces a method for modeling the entire aggregated electric vehicle(EV)charging process and analyzing its dispatchable *** methodology involves developing a model for aggregated EV charging at the charging station level,estimating its physical dispatchable capability,determining its eco.omic dispatchable capability under eco.omic incentives,modeling its participation in the grid,and investigating the effects of different scenarios and EV penetration on the aggregated load dispatch and dispatchable *** results indicate that using eco.omic dispatchable capability reduces charging prices by 9.7%co.pared to physical dispatchable capability and 9.3%co.pared to disorderly ***,the peak-to-valley difference is reduced by 64.6%when applying eco.omic dispatchable capability with 20%EV penetration and residential base load,co.pared to disorderly charging.

关键词： Aggregated charging dispatchable capability peak shaving and valley filling the eco.omics of charging demand response

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Flexible Strain Sensors with Ultra‑High Sensitivity and Wide Range Enabled by Crack‑Modulated Electrical Pathways

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Nano-Micro Letters 2025年第3期17卷 246-264页

作者： Yunzhao Bai Yunlei Zhou Xuanyu Wu Mengfei Yin Liting Yin Shiyuan Qu Fan Zhang Kan Li YongAn Huang State Key Laboratory of Intelligent Manufacturing equipment and Technology Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Flexible Electronics research Center Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Hangzhou institute of Technology Xidian UniversityHangzhou 311200People’s Republic of China School of Mechano‑Electronic Engineering Xidian UniversityXi’an 710071People’s Republic of China Department of Aerospace and Mechanical Engineering University of Southern CaliforniaLos AngelesCA 90089USA

This study presents a breakthrough in flexible strain sensor technology with the development of an ultrahigh sensitivity and wide-range sensor,addressing the critical challenge of reco.ciling sensitivity with measurement *** by the structure of bamboo slips,we introduce a novel approach that utilises liquid metal to modulate the electrical pathways within a cracked platinum fabric *** resulting sensor demonstrates a gauge factor greater than 108 and a strain measurement capability exceeding 100%.The integration of patterned liquid metal enables customisable tuning of the sensor’s response,while the porous fabric structure ensures superior co.fort and air permeability for the *** design not only optimises the sensor’s performance but also enhances the electrical stability that is essential for practical *** systematic investigation,we reveal the intrinsic mechanisms governing the sensor’s response,offering valuable insights for the design of wearable strain *** sensor’s exceptional performance across a spectrum of applications,from micro-strain to large-strain detection,highlights its potential for a wide range of real-world uses,demonstrating a significant advancement in the field of flexible electronics.

关键词： Flexible strain sensor Fabric Crack Response regulation Epidermal device

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Unraveling brain aging through the lens of oral microbiota

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Neural Regeneration research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu Si Wang Weiqi Zhang Jing Qu Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina advanced Innovation Center for Human Brain Protection and National Clinical research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker co.sortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a co.plex physiological co.munity enco.passing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes co.tribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

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Direct Photolithography of WO_(x)Nanoparticles for High‑Resolution Non‑Emissive Displays

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Nano-Micro Letters 2025年第3期17卷 297-309页

作者： Chang Gu Guojian Yang Wenxuan Wang Aiyan Shi Wenjuan Fang Lei Qian Xiaofei Hu Ting Zhang Chaoyu Xiang Yu‑Mo Zhang Laboratory of Optoelectronic Information Technology and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201People’s Republic of China Hangzhou Bay Laboratory of advanced Nano‑Optoelectronic Materials and Devices Qianwan Institute of CNITECHNingbo 315336People’s Republic of China Smart Materials for Architecture research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100People’s Republic of China University of Science and Technology of china Hefei 230026People’s Republic of China State Key Lab of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012People’s Republic of China

High-resolution non-emissive displays based on electrochromic tungsten oxides(WOx)are crucial for future near-eye virtual/augmented reality interactions,given their impressive attributes such as high environmental stability,ideal outdoor readability,and low energy ***,the limited intrinsic structure of inorganic materials has presented a significant challenge in achieving precise patterning/pixelation at the micron ***,we successfully developed the direct photolithography for WOx nanoparticles based on in situ photo-induced ligand *** strategy enabled us to achieve ultra-high resolution efficiently(line widthco.oration efficiency(119.5 cm^(2) C^(−1)),good optical modulation(55.9%),and durability(>3600 cycles),as well as promising applications in electronic logos,pixelated displays,flexible electronics,*** success and advancements presented here are expected to inspire and accelerate research and development(R&D)in high-resolution non-emissive displays and other ultra-fine micro-electronics.

关键词： Electrochromic Direct photolithography WOx nanoparticles In situ photo-induced ligand exchange High-resolution displays

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Decreased levels of phosphorylated synuclein in plasma are co.related with poststroke co.nitive impairment

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Neural Regeneration research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning Li Yakun Gu Wei Ma Yuying Guan Mengyuan Guo Qianqian Shao Xunming Ji Jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke co.nitive impairment is a major seco.dary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke co.nitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke co.nitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively co.related with co.nition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly co.related with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant co.nitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased co.nitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke co.nitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke co.nitive impairment

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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei Mei Yan Zeng Brain Science and advanced Technology institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the co.tico.imbic system,including the ventral tegmental area,nucleus accumbens,prefrontal co.tex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the co.tico.imbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress co.tico.imbic system depression hippocampus medial prefrontal co.tex nucleus accumbens social stress models ventral tegmental area

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