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Sleep Posture Classification Using RGB and Thermal Cameras Based on Deep Learning Model

Computer Modeling in Engineering & Sciences 2024年第8期140卷 1729-1755页

作者： Awais Khan Chomyong Kim Jung-Yeon Kim Ahsan Aziz Yunyoung Nam Department of ICT Convergence Soonchunhyang UniversityAsan31538Korea ICT Convergence Research center Soonchunhyang UniversityAsan31538Korea Emotional and Intelligent child care Convergence Research center Soonchunhyang UniversityAsan31538Korea

Sleep posture surveillance is crucial for patient comfort,yet current systems face difficulties in providing compre-hensive studies due to the obstruction caused by *** posture assessment remains challenging because of the complex nature of the human body and variations in sleep ***,this study introduces an innovative method utilizing RGB and thermal cameras for comprehensive posture classification,thereby enhancing the analysis of body position and *** method begins by capturing a dataset of sleep postures in the form of videos using RGB and thermal cameras,which depict six commonly adopted postures:supine,left log,right log,prone head,prone left,and prone *** study involves 10 participants under two conditions:with and without ***,the database is normalized into a video *** subsequent step entails training a fine-tuned,pretrained Visual Geometry Group(VGG16)and ResNet50 *** the third phase,the extracted features are utilized for *** fourth step of the proposed approach employs a serial fusion technique based on the normal distribution to merge the vectors derived from both the RGB and thermal ***,the fused vectors are passed to machine learning classifiers for final *** dataset,which includes human sleep postures used in this study’s experiments,achieved a 96.7%accuracy rate using the Quadratic Support Vector Machine(QSVM)without the ***,the Linear SVM,when utilized with a blanket,attained an accuracy of 96%.When normal distribution serial fusion was applied to the blanket features,it resulted in a remarkable average accuracy of 99%.

关键词： Human sleep posture VGG16 deep learning ResNet50 fusion machine learning

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Changes in the Non-targeted Metabolomic Profile of Three-year-old Toddlers with Elevated Exposure to Polycyclic Aromatic Hydrocarbons

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Biomedical and Environmental Sciences 2024年第5期37卷 479-493页

作者： LI Yang LIN Dan ZHANG Xiu Qin JU Guang Xiu SU Ya ZHANG Qian DUAN Hai Ping YU Wei Sen WANG Bing Ling PANG Shu Tao Department of Epidemiology and Health Statistics School of Public HealthQingdao UniversityQingdao 266021ShandongChina Department of Environmental Health Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Physicochemical Laboratory Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Section of child Health care Huangdao Maternity and Child Health Care Hospital of QingdaoQingdao 266499ShandongChina Qingdao Blood center Qingdao 266071ShandongChina

Objective To investigate changes in the urinary metabolite profiles of children exposed to polycyclic aromatic hydrocarbons(PAHs)during critical brain development and explore their potential link with the intestinal *** Liquid chromatography-tandem mass spectrometry was used to determine ten hydroxyl metabolites of PAHs(OH-PAHs)in 36-month-old ***,37 children were categorized into low-and high-exposure groups based on the sum of the ten ***-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was used to identify non-targeted metabolites in the urine ***,fecal flora abundance was assessed by 16S rRNA gene sequencing using Illumina *** The concentrations of 21 metabolites were significantly higher in the high exposure group than in the low exposure group(variable importance for projection>1,Pchildren affected metabolic homeostasis,particularly that of certain gut microbiota-derived *** investigation is needed to explore the potential influence of PAHs on the gut microbiota and their possible association with neurodevelopmental outcomes.

关键词： child Gut microbiota Non-targeted metabolomics Polycyclic aromatic hydrocarbons Urinary metabolite profile

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Reproductive Characteristics and Trends of Major Pregnancy Outcomes of Women at Different Parities-Beijing Municipality,China,2013-2022

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China CDC weekly 2024年第31期6卷 786-792页

作者： Zhaoxia Jia Yongxian Zhao Lei Wang Qingqing Wu Moning Guo Jianpeng Zheng Lili Huang Junhua Wang Zhao Wang Di Zhang Minghui Wu Department of information and statistics Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing Maternal and Child Health Care HospitalBeijingChina Department of data resources and statistics Beijing Municipal Health Big Data and Policy Research CenterBeijingChina

Summary What is already known about this topic?With socioeconomic development,the increase of older pregnancies and multiparas has brought risks to mothers and *** is added by this report?As parities increased,the proportion of women of advanced maternal age(AMA)and non-local domicile increased,while the proportion of women with higher education levels *** with≥3 parities are more likely to have preterm birth(PTB)and *** are the implications for public health practice?A comprehensive analysis of pregnancy traits among women at different parities offers a robust foundation for tailored strategies against adverse pregnancy outcomes.

关键词： mother pregnancy likely

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A review of the interaction between diet composition and gut microbiota and its impact on associated disease

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未来食品学报(英文) 2024年第3期4卷 221-232页

作者： Zhaoxi Liu Meihua Liu Jing Meng Lushan Wang Min Chen State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266237China Qingdao center Medical Group Qingdao 266200China Jinan Maternity and child care Hospital Jinan 250000China

Dietary intake has an impact on the development of gut *** require carbohydrates,protein,fat,and other nutrients on a daily basis to provide energy for the growth,maintenance,and repair of body *** nutrition-induced changes in gut microbiota may be used to alter host physiology,including disease development and progression,such as obesity and *** research is needed to fully understand how diet influences microbiota and how microbiota influence host *** pathways of carbohydrate,protein,and fat metabolism,as well as their interactions and regulatory mechanisms,are described in this review,as well as how diet shapes the microbiota,how dietary-microbiome crosstalk may affect disease development and progression,and how this information could be used to maintain intestinal health.

关键词： Gut microbiota Carbohydrates Amino acids Short-chain fatty acids Prebiotics

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Identification of research gaps to improve care for healthy ageing:a scoping review

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Family Medicine and Community Health 2024年第4期12卷 9-16页

作者： Matteo Cesari Marco Canevelli Jotheeswaran Amuthavalli Thiyagarajan Soung-Eun Choi Polina Grushevska Saloni Kumar Muyan Chen Hyobum Jang Yuka Sumi Anshu Banerjee Ageing and Health Unit Department of MaternalNewbornChild and Adolescent Health and AgeingWorld Health OrganizationGenevaSwitzerland Department of Neurobiology Care Sciences and SocietyStockholm UniversityStockholmSweden National center for Disease Prevention and Health Promotion Italian National Institute of HealthRomeItaly Department of Human Neuroscience Sapienza UniversityRomeItaly Master in Health and International development London School of EconomicsLondonUK Department of Maternal NewbornChild and Adolescent Health and AgeingWorld Health OrganizationGenevaSwitzerland

Objective Several research gaps affect the improvement of care for healthy *** identification is crucial to developing a specific research prioritisation agenda supporting progress at the micro(clinical),meso(service delivery)and macro(system)*** achieve this,a scoping review was carried out to describe the most significant gaps impeding the improvement of care for healthy *** A scoping review of the literature was conducted according to the Joanna Briggs Institute *** selected articles were analysed to identify topics or areas essential for improving care for healthy ageing but requiring further support from *** criteria Every type of scientific article,except for randomised controlled trials,was considered of potential interest without restrictions on publication date,type of publication and *** sources A systematic search(last search:6 December 2023)was conducted using PubMed,MEDLINE and *** Overall,1558 articles were retrieved from the *** these,310 were finally retained for this work.A total of 1195 research gaps were identified(average:3.85 per article)and clustered into the 13 primary areas:ageing,care approach,caregivers,health economics,health,interventions,policies,research,settings,training,technology,specific populations and understanding the older *** particular,research for improving the person-centred approach(n=38),better considering cultural diversities(n=27),implementing integrated care(n=25)and ensuring access to care(n=25)were the most prevalent priorities reported in the *** A wide range of factors spanning multiple disciplines,from clinical to policy levels,require special consideration,exploration and *** findings of this scoping review represent an essential step in identifying gaps for developing a research prioritisation agenda to improve care for healthy ageing.

关键词： policy service supporting

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Role of mitochondrial dysfunction in kidney disease:Insights from the cGAS-STING signaling pathway

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Chinese Medical Journal 2024年第9期137卷 1044-1053页

作者： Lu Li Fei Liu Chunyue Feng Zhenjie Chen Nan Zhang Jianhua Mao Department of Nephrology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouZhejiang 310052China Department of Pediatric Intensive care Unit Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouZhejiang 310052China

Over the past decade,mitochondrial dysfunction has been investigated as a key contributor to acute and chronic kidney ***,the precise molecular mechanisms linking mitochondrial damage to kidney disease remain *** recent insights into the cyclic guanosine monophosphate-adenosine monophosphate(GMP-AMP)synthetase(cGAS)-stimulator of interferon gene(STING)signaling pathway have revealed its involvement in many renal *** of these findings is that mitochondrial DNA(mtDNA)induces inflammatory responses via the cGAS-STING ***,we provide an overview of the mechanisms underlying mtDNA release following mitochondrial damage,focusing specifically on the association between mtDNA release-activated cGAS-STING signaling and the development of kidney ***,we summarize the latest findings of cGAS-STING signaling pathway in cell,with a particular emphasis on its downstream signaling related to kidney *** review intends to enhance our understanding of the intricate relationship among the cGAS-STING pathway,kidney diseases,and mitochondrial dysfunction.

关键词： Mitochondrial dysfunction Mitochondrial DNA cGAS-STING pathway Kidney diseases Chronic kidney disease

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Clinical-based phenotypes in children with pediatric post-COVID-19 condition

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World Journal of Pediatrics 2024年第7期20卷 682-691页

作者： Lieke C.E.Noij Jelle M.Blankestijn Coen R.Lap Marlies A.van Houten Giske Biesbroek Anke-Hilse Maitland-van der Zee Mahmoud I.Abdel-Aziz Johannes B.van Goudoever Mattijs W.Alsem Caroline L.H.Brackel Kim J.Oostrom Simone Hashimoto Suzanne W.J.Terheggen-Lagro Department of Pediatric Pulmonology and Allergy Amsterdam UMCLocation AMCEmma Children’s HospitalAmsterdam University Medical CenterRoom G2-222Meibergdreef 91105AZAmsterdamThe Netherlands Department of Pulmonary Medicine Amsterdam UMCAmsterdamThe Netherlands Department of Pediatrics Spaarne GasthuisHoofddorpThe Netherlands Department of Pediatrics Emma Children’s HospitalAmsterdam University Medical CenterAmsterdamThe Netherlands Department of Rehabilitation Medicine Amsterdam Movement SciencesMeibergdreef 9AmsterdamThe Netherlands Department of Paediatric Pulmonology Department of PaediatricsTergooi MCHilversumThe Netherlands Department of child and Adolescent Psychiatry and Psychosocial care Amsterdam UMCAmsterdam Reproduction and DevelopmentAmsterdamThe Netherlands

Background Pediatric post coronavirus disease 2019(COVID-19)condition(PPCC)is a heterogeneous syndrome,which can significantly affect the daily lives of *** study aimed to identify clinically meaningful phenotypes in children with PPCC,to better characterize and treat this *** Participants were children with physician-diagnosed PPCC,referred to the academic hospital Amsterdam UMC in the Netherlands between November 2021 and March *** factors and information on post-COVID symptoms,comorbidities,and impact on daily life were *** clusters were identified using an unsupervised and unbiased approach for mixed data *** Analysis of 111 patients(aged 3–18 years)revealed three distinct clusters within *** 1(n=62,median age=15 years)predominantly consisted of girls(74.2%).These patients suffered relatively more from exercise intolerance,dyspnea,and smell *** 2(n=33,median age=13 years)contained patients with an even gender distribution(51.5%girls).They suffered from relatively more sleep problems,memory loss,gastrointestinal symptoms,and *** 3(n=16,median age=11 years)had a higher proportion of boys(75.0%),suffered relatively more from fever,had significantly fewer symptoms(median of 5 symptoms compared to 8 and 10 for clusters 1 and 2 respectively),and experienced a lower impact on daily *** This study identified three distinct clinical PPCC phenotypes,with variations in sex,age,symptom patterns,and impact on daily *** findings highlight the need for further research to understand the potentially diverse underlying mechanisms contributing to post-COVID symptoms in children.

关键词： Adolescents Clusters Long COVID Pediatric Phenotypes Post-COVID syndrome

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RNF187 governs the maintenance of mouse GC-2 cell development by facilitating histone H3 ubiquitination at K57/80

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Asian Journal of Andrology 2024年第3期26卷 272-281页

作者： Bing-Ya Xu Xiang-Ling Yu Wen-Xin Gao Ting-Ting Gao Hao-Yue Hu Tian-Tian Wu Cong Shen Xiao-Yan Huang Bo Zheng Yi-Bo Wu Human Reproductive and Genetic center Affiliated Hospital of Jiangnan UniversityWuxi 214122China State Key Laboratory of Reproductive Medicine Department of Histology and EmbryologySchool of Basic Medical SciencesNanjing Medical UniversityNanjing 211166China Changzhou Maternal and child Health care Hospital Changzhou Medical CenterNanjing Medical UniversityChangzhou 213000China State Key Laboratory of Reproductive Medicine Center for Reproduction and GeneticsSuzhou Municipal HospitalThe Affiliated Suzhou Hospital of Nanjing Medical UniversityGusu SchoolNanjing Medical UniversitySuzhou 215002China

RING finger 187(RNF187),a ubiquitin-ligating(E3)enzyme,plays a crucial role in the proliferation of cancer ***,it remains unclear whether RNF187 exhibits comparable functionality in the development of germline *** investigate thepotential involvement of RNF187 in germ cell development,we conducted interference and overexpression assays using GC-2 cells,a mouse spermatocyte-derived cell *** findings reveal that the interaction between RNF187 and histone H3 increases theviability,proliferation,and migratory capacity of GC-2 ***,we provide evidence demonstrating that RNF187 interactswith H3 and mediates the ubiquitination of H3 at lysine 57(K57)or lysine 80(K80),directly or indirectly resulting in increasedcellular *** is a study to report the role of RNF187 in maintaining the development of GC-2 cells by mediatinghistone H3 ubiquitination,thus highlighting the involvement of the K57 and K80 residues of H3 in the epistatic regulation of *** discoveries provide a new theoretical foundation for further comprehensive investigations into the functionof RNF187 in the reproductive system.

关键词： GC-2 cell histone H3 RNF187 ubiquitination

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Positive Effect of Transcranial Direct Current Stimulation on Visual Verbal Working Memory in Patients with Attention-Deficit/Hyperactivity Disorder

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Open Journal of Psychiatry 2024年第4期14卷 334-346页

作者： Tomoko Uchida Daisuke Matsuzawa Tadashi Shiohama Katsunori Fujii Akihiro Shiina Masamitsu Naka Katsuo Sugita Eiji Shimizu Naoki Shimojo Hiromichi Hamada Department of Pediatrics Graduate School of Medicine Chiba University Chiba Japan Research center for child Mental development Chiba University Chiba Japan Division of Medical care and Treatment Center for Forensic Mental Health Chiba University Chiba Japan Department of Cognitive Behavioral Physiology Graduate School of Medicine Chiba University Chiba Japan

Background: Working memory is an executive function that plays an important role in many aspects of daily life, and its impairment in patients with attention-deficit/hyperactivity disorder (ADHD) affects quality of life. The dorsolateral prefrontal cortex (DLPFC) has been a good target site for transcranial direct current stimulation (tDCS) due to its intense involvement in working memory. In our 2018 study, tDCS improved visual-verbal working memory in healthy subjects. Objective: This study examines the effects of tDCS on ADHD patients, particularly on verbal working memory. Methods: We conducted an experiment involving verbal working memory of two modalities, visual and auditory, and a sustained attention task that could affect working memory in 9 ADHD patients. Active or sham tDCS was applied to the left DLPFC in a single-blind crossover design. Results: tDCS significantly improved the accuracy of visual-verbal working memory. In contrast, tDCS did not affect auditory-verbal working memory and sustained attention. Conclusion: tDCS to the left DLPFC improved visual-verbal working memory in ADHD patients, with important implications for potential ADHD treatments.

关键词： Working Memory Attention-Deficit/Hyperactivity Disorder Dorsolateral Prefrontal Cortex Transcranial Direct Current Stimulation

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Bifidobacterium longum subsp. infantis CCFM1269 promotes intestinal barrier and release of IFN-β through TLR4-TRIF dependent way in growing mice

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Food Science and Human Wellness 2024年

作者： Mengfan Ding Bo Yang Bowen Li Haiqin Chen Renqiang Yu R.Paul Ross Catherine Stanton Shilong Jiang Jianxin Zhao Wei Chen State Key Laboratory of Food Science and Resources， Jiangnan University Teagasc Food Research Centre Nutrition and Metabolism Research Division， Innovation center， Heilongjiang Feihe Dairy Co.， Ltd. Department of Neonatology， Wuxi Maternity and child Health care Hospital， Affiliated Women's Hospital of Jiangnan University National Engineering Research center for Functional Food， Jiangnan University School of Food Science and Technology， Jiangnan University PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan development International Joint Research center for Probiotics & Gut Health， Jiangnan University APC Microbiome Ireland， University College Cork

Bifidobacterium longum subsp. infantis is a commensal bacterium that predominates in the infant gut， playing a critical role in both preventing foreign infections and facilitating immune development. This study aimed to explore the effects of B. longum subsp. infantis supplementation on interferon-beta (IFN-β) secretion and intestinal barrier improvement in growing mice. Female and male mice were orally administered either saline or B. longum subsp. infantis CCFM1269 or I5TI (1 × 109CFU/mice per day， n = 8) from 1-week-age until 3-， 4-， and 5-week-age. RNA sequencing analysis revealed that CCFM1269 exhibited potential antiviral capacity through increasing 2’-5’ oligoadenylate synthetase (OAS). Additionally， CCFM1269 supplementation significantly increased colonic IFN-β levels which combined with OAS in 3-week-old female and male mice by activating the TLR4-TRIF-dependent signaling pathway. However， this effect was not observed in 4- and 5-week-old mice. Furthermore， both CCFM1269 were found to modulate the gut microbiota composition and enhance the intestinal barrier function in 3-， 4-， and 5-week-old mice. In summary， the results of this study suggested that B. longum subsp. infantis CCFM1269 promoting intestinal barrier and releasing IFN-β in growing mice was in a strain-specific and time-dependent manner.

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