检索结果-南通市图书馆

Efficacy of acupuncture in refractory irritable bowel syndrome patients: a randomized controlled trial

FRONTIERS OF medICINE 2024年第4期18卷 678-689页

作者： Zhao, Jun Zheng, Hui Wang, Xin Wang, Xuefei Shi, Yunzhou Xie, Chaorong Tao, Qingfeng Li, Da Sun, Jingwen Tian, Junjian Gao, Junxia Liu, Huimin Shi, Suhua Ni, Jinxia Xue, Rongdan Hu, Hui Chen, Min Yu, Shuguang Li, Zhigang Beijing univ chinese med Sch Acupuncture Moxibust & Tuina Beijing 100029 Peoples R China Sichuan univ West China Hosp Dept Integrated Tradit & Western Med Chengdu Peoples R China chengdu univ tradit chinese med Hosp 3 Acupuncture & Tuina Sch Chengdu 610000 Peoples R China Capital med univ Beijing Hosp Tradit Chinese Med Beijing 100010 Peoples R China Beijing univ chinese med Dept Acupuncture & Moxibust Dongzhimen Hosp Beijing 100700 Peoples R China Beijing univ chinese med Affiliated Hosp 3 Dept Rehabil Beijing 100029 Peoples R China Beijing univ chinese med Dongfang Hosp Dept Acupuncture & Moxibust Beijing 100078 Peoples R China Hosp chengdu univ tradit chinese med Anorectal Dis Dept Chengdu 610075 Peoples R China

Previous studies have confirmed that acupuncture for irritable bowel syndrome (IBS) provided an additional benefit over usual care alone. Therefore, we performed a multicenter, randomized, sham-controlled trial to assess the efficacy and safety of acupuncture versus sham acupuncture for refractory IBS in patients in the context of conventional treatments. Patients in the acupuncture and sham acupuncture groups received real or sham acupuncture treatment in 3 sessions per week for a total of 12 sessions. The primary outcome was a change in the IBS-Symptom Severity Scale (IBS-SSS) score from baseline to week 4. A total of 521 participants were screened, and 170 patients (85 patients per group) were enrolled and included in the intention-to-treat analysis. Baseline characteristics were comparable across the two groups. From baseline to 4 weeks, the IBS-SSS total score decreased by 140.0 (95% CI: 126.0 to 153.9) in the acupuncture group and 64.4 (95% CI: 50.4 to 78.3) in the sham acupuncture group. The between-group difference was 75.6 (95% CI: 55.8 to 95.4). Acupuncture efficacy was maintained during the 4-week follow-up period. There were no serious adverse events. In conclusion, acupuncture provided benefits when combined with treatment as usual, providing more options for the treatment of refractory IBS.

关键词： acupuncture functional gastrointestinal disorders irritable bowel syndrome clinical trial

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Allosteric regulation of Keap1 by 8b-hydroxy-a-cyclocostunolide for the treatment of acute lung injury

引用

ACTA PHARMACEUTICA SINICA B 2024年第9期14卷 4174-4178页

作者： Zhang, Juan Zhang, Min Zhu, Qi-Meng Xu, Xin-Rong Feng, Yan-Li Lin, Sheng Qiu, Feng Sun, Cheng-Peng Tianjin univ tradit chinese med Sch Chinese Mat Med Tianjin Key Lab Therapeut Subst Tradit Chinese Med Tianjin 301617 Peoples R China Beijing univ chinese med Dongzhimen Hosp Key Lab Chinese Internal Med Minist Educ & Beijing Beijing 100700 Peoples R China

To the Editor: Acute lung injury (ALI) is a debilitating lung disease characterized by pulmonary edema, diffuse alveolar damage, and uncontrolled neutrophil infiltration1. Severe cases of ALI can potentially lead to the development of acute respiratory distress syndrome (ARDS), which can lead to impaired respiratory function, multimay be caused by various factors, including aspiration, severe pneumonia, sepsis, trauma, fatty embolism, pancreatitis, and

关键词： Macrophage overactivation Keap1 8b-Hydroxy-a-cyclocostunolide b-Hydroxy- a-cyclocostunolide Nrf2 Acute lung injury

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Federation of Acupuncture-Moxibustion Societies (WFAS) Technical Benchmark of Acupuncture and Moxibustion: Filiform Needle

引用

WORLD JOURNAL OF ACUPUNCTURE-MOXIBUSTION 2024年第3期34卷 231-236页

作者： Zhou, Liang Zhang, Si-qi Fang, Meng Dong, Gui-rong Dong, Hong-sheng Shanghai univ tradit chinese med Yueyang Hosp Integrated Tradit Chinese & Western M Shanghai 200437 Peoples R China Shanghai Res Inst Acupuncture & Meridian Shanghai 200030 Peoples R China

On December 31, 2023, World Federation of Acupuncture-Moxibustion Societies (WFAS) officially issued Technical Benchmark of Acupuncture and Moxibustion: Filiform Needle. This technical benchmark clarifies terms and definitions, operating procedures and requirements, safety requirements, etc. The promulgation and implementation of this technical benchmark would provide a standard for acupuncture practitioners to apply filiform needle in clinical practice, and may play a positive role in the safe use and promotion of filiform needle. (c) 2024 World Journal of Acupuncture - Moxibustion House. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license ( http://***/licenses/by-nc-nd/4.0/ )

关键词： Acupuncture Filiform needle Academic organization International standards Technical operation Specification

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transparency and reporting characteristics of randomized controlled trials with chinese herbal medicine formulas interventions

引用

FRONTIERS OF medICINE 2024年第4期18卷 757-761页

作者： Wang, Juan Shi, Dongni Wang, Yaochen Zhang, Xuanqi Li, Han Wang, Xihong Luo, Shufeng Hu, Lihan Deng, Jiashuai Zhang, Lin Lau, Chung Tai Cheng, Chung Wah Han, Fei Li, Ji Wang, Ping Lyu, Aiping Bian, Zhaoxiang Zhang, Xuan Hong Kong Baptist univ Inst Res & Continuing Educ Shenzhen 518057 Peoples R China Hong Kong Baptist univ Chinese EQUATOR Ctr Hksar 999077 Peoples R China Hong Kong Baptist univ Sch Chinese Med Hksar 999077 Peoples R China Hong Kong Baptist univ Ctr Chinese Herbal Med Drug Dev Hksar 999077 Peoples R China Tianjin univ tradit chinese med Sch Tradit Chinese Med Tianjin 301617 Peoples R China Beijing univ chinese med Sch Chinese Med Beijing 100105 Peoples R China China Acad chinese med Sci Guanganmen Hosp Dept Pediat Beijing 100053 Peoples R China China Acad chinese med Sci Xiyuan Hosp Beijing 100091 Peoples R China

Transparency and reporting characteristics of randomized controlled trials with chinese herbal medicine formulas interventions

关键词： Transparency reporting characteristics trials herbal medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Federation of Acupuncture-Moxibustion Societies (WFAS) Technical Benchmark of Acupuncture and Moxibustion: Electroacupuncture

引用

WORLD JOURNAL OF ACUPUNCTURE-MOXIBUSTION 2024年第3期34卷 227-230页

作者： Li, Pei-qi Dang, Si-jie Li, Fan-lian Cai, Fei-hong Zhang, Yu-chen Wu, Yi-fan Shi, Jia-ni Li, Jia-wei Fu, Xin Guo, Meng-hu Xiao, Bin Yang, Hua-yuan Shanghai univ tradit chinese med Sch Acupuncture Moxibust & Tuina Shanghai 201203 Peoples R China univ Sydney Fac Med & Hlth Sydney 2006 Australia Shanghai univ tradit chinese med Sch Publ Hlth Shanghai 201203 Peoples R China univ Sydney Sch Psychol Sydney 2006 Australia New Zealand Coll chinese med Auckland 1051 New Zealand

World Federation of Acupuncture-Moxibustion Societies (WFAS) Technical Benchmark of Acupuncture and Moxibustion: Electroacupuncture, developed under the leadership of Shanghai university of traditional chinese medicine, was approved by WFAS. This technical benchmark was issued on October 9, 2023, and implemented on December 31, 2023. The main contents include the scope, normative references, terms and definitions, acupuncture and moxibustion procedures and rules, and safety. This article focuses on the above contents. An outlook on the application, popularization, and update plan of this technical benchmark is proposed. (c) 2024 World Journal of Acupuncture - Moxibustion House. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/)

关键词： Technical benchmark Acupuncture and moxibustion Electroacupuncture World Federation of Acupuncture-Moxibustion Societies (WFAS) Standard

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Federation of Acupuncture-Moxibustion Societies (WFAS) Clinical Practice Guideline on Acupuncture and Moxibustion: Allergic Rhinitis recommendation summaries

引用

WORLD JOURNAL OF ACUPUNCTURE-MOXIBUSTION 2024年第3期34卷 179-188页

作者： Du, Shi-hao Liu, Jing Chen, Sheng Wang, Shan-ze Wang, Guan-qun Du, Shuo Xie, Xiao-long Peng, Bi-hui Guo, Wei Yang, Chao Zhao, Ji-ping Beijing univ chinese med Dongzhimen Hosp Dept Acupuncture & Moxibust Beijing 100700 Peoples R China China Acad chinese med Sci Inst Acupuncture & Moxibust Beijing 100700 Peoples R China Guangdong Prov Hosp tradit chinese med Dept Acupuncture & Moxibust Guangzhou 510120 Peoples R China Shanghai Jiao Tong univ Sch Med Shanghai Peoples Hosp 9 Dept Tradit Chinese Med Shanghai 200011 Peoples R China

Clinical Practice Guideline on Acupuncture and Moxibustion: Allergic Rhinitis was revised and released by the Standards Working Committee of World Federation of Acupuncture-Moxibustion Societies (WFAS) on October 9, 2023. This is the first clinical practice guideline (CPG) on acupuncture and moxibustion for allergic rhinitis approved by an international academic organization, which provides evidence-based recommendations and the practical therapeutic protocols for acupuncture practitioners globally. This CPG was developed by following Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) methodology, and the principles of the World Health Organization Handbook for Guideline Development . The members in the guideline development group (GDG) were from different countries, with different professions, and they played a critical role in the development of clinical questions, recommendations, and therapeutic protocols. Recommendations are the core of a CPG and the direct answers to clinical questions, due to which this article focuses on the recommendations of this CPG. The recommendations were developed by using the modified Delphi method and the GRADE grid rules, based on the updated systematic reviews of clinical evidence. A total of 15 recommendations for 15 clinical questions were developed in this CPG, including one strong recommendation for intervention based on high-quality evidence, three conditional recommendations for either the intervention or the comparison based on very low quality of evidence, and 11 conditional recommendations for the intervention based on very low quality of evidence. (c) 2024 World Journal of Acupuncture - Moxibustion House. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license ( http://***/licenses/by-nc-nd/4.0/ )

关键词： Allergic rhinitis Acupuncture Moxibustion Clinical practice guideline (CPG) Clinical questions COST-EFFECTIVENESS CONTROLLED-TRIAL MANAGEMENT CONSENSUS SYMPTOMS medICINE STRENGTH QUALITY

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Triple three-dimensional MS/MS spectrum facilitates quantitative ginsenosides-targeted sub-metabolome characterization in notoginseng

引用

ACTA PHARMACEUTICA SINICA B 2024年第9期14卷 4045-4058页

作者： Zhang, Ke Jia, Jinru Li, Ting Liu, Wenjing Tu, Pengfei Wan, Jian-Bo Li, Jun Song, Yuelin Beijing univ chinese med Beijing Res Inst Chinese Med Modern Res Ctr Tradit Chinese Med Beijing 100029 Peoples R China SCIEX China Beijing 100015 Peoples R China Henan univ chinese med Sch Pharm Zhengzhou 450046 Peoples R China univ Macau Inst Chinese Med Sci State Key Lab Qual Res Chinese Med Taipa 999078 Macao Peoples R China

Although serving as the workhorse, MS/MS cannot fully satisfy the analytical requirements of quantitative sub-metabolome characterization. Because more information intrinsically correlates to more structural and concentration clues, here, efforts were devoted to comprehensively tracing and deciphering MS/MS behaviors through constructing triple three-dimensional (3x3D)-MS/MS spectrum. Ginsenosides-targeted metabolomics of notoginseng, one of the most famous edible medicinal plants, was employed as a proof-of-concept. Serial authentic ginsenosides were deployed to build the correlations between 3x3D-MS/MS spectra and structure/concentration features. Through assaying ginsenosides with progressive concentrations using QTOF-MS to configure 1(st) 3D spectrum, the generations of MS1 spectral signals, particularly multi-charged multimer anions, e.g., [2M-2H](2-) and [2M+2HCOO](2-) ions, relied on both concentration and the amount of sugar chains. By programming progressive collision energies to the front collision cell of Qtrap-MS device to gain 2(nd) 3D spectrum, optimal collision energy (OCE) corresponding to the glycosidic bond fission was primarily correlated with the masses of precursor and fragment ions and partially governed by the glycosidation site. The quantitative relationships between OCEs and masses of precursor and fragment ions were utilized to build large-scale quantitative program for ginsenosides. After applying progressive exciting energies to the back collision chamber to build 3(rd) 3D spectrum, the fragment ion and the decomposition product anion exhibited identical dissociation trajectories when they shared the same molecular geometry. After ginsenosides-focused quantitative metabolomics, significant differences occurred for sub-metabolome amongst different parts of notoginseng. The differential ginsenosides were confirmatively identified by applying the correlations between 3x3D-MS/MS spectra and structures. Together, 3x3D-MS/MS spectrum covers all

关键词： Quantitative sub- metabolome characterization Ginsenosides Structural identification Notoginseng Full exciting energy ramp- MS3 spectrum MASS-SPECTROMETRY PANAX-NOTOGINSENG NATURAL COMPOUNDS IDENTIFICATION CHROMATOGRAPHY STRATEGY GINSENG TECHNOLOGY DISCOVERY SAPONINS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insights into therapeutic peptides in the cancer-immunity cycle: Update and challenges

引用

ACTA PHARMACEUTICA SINICA B 2024年第9期14卷 3818-3833页

作者： Zhang, Xiaokun Wu, Ye Lin, Jiayi Lu, Shengxin Lu, Xinchen Cheng, Aoyu Chen, Hongzhuan Zhang, Weidong Luan, Xin Shanghai univ tradit chinese med Inst Interdisciplinary Integrat Med Res Shanghai Frontiers Sci Ctr Chinese Med Chem Biol Shanghai 201203 Peoples R China Shanghai univ tradit chinese med Shuguang Hosp Shanghai 201203 Peoples R China Fudan univ Sch Pharm Dept Pharmacol Shanghai 201203 Peoples R China chinese Acad med Sci & Peking Union med Coll Inst Med Plant Dev Beijing 100193 Peoples R China Second Mil med univ Sch Pharm Shanghai 200433 Peoples R China

Immuno therapies hold immense potential for achieving durable potency and long-term survival opportunities in cancer therapy. As vital biological mediators, peptides with high tissue penetration and superior selectivity offer significant promise for enhancing cancer immunotherapies (CITs). However, physicochemical peptide features such as conformation and stability pose challenges to their on-target efficacy. This review provides a comprehensive overview of recent advancements in therapeutic peptides targeting key steps of the cancer-immunity cycle (CIC), including tumor antigen presentation, immune cell regulation, and immune checkpoint signaling. Particular attention is given to the opportunities and challenges associated with these peptides in boosting CIC within the context of clinical progress. Furthermore, possible future developments in this field are also discussed to provide insights into emerging CITs with robust efficacy and safety profiles.

关键词： Cancer-immunity cycle Oncolytic peptide Peptide neoantigen vaccine Peptide mimotope Immune checkpoint blockade Cancer immunotherapy Synthetic long peptide vaccine Peptide-major histocompatibility complex CHECKPOINT BLOCKADE TUMOR-ANTIGENS T-CELLS IMMUNOTHERAPY TIGIT ANTAGONIST RESPONSES STRATEGY BLOCKING TARGETS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CRISPR-Cas9 gene editing strengthens cuproptosis/chemodynamic/ferroptosis synergistic cancer therapy

引用

ACTA PHARMACEUTICA SINICA B 2024年第9期14卷 4059-4072页

作者： Wu, Xiaoyu Bai, Zijun Wang, Hui Wang, Hanqing Hou, Dahai Xu, Yunzhu Wo, Guanqun Cheng, Haibo Sun, Dongdong Tao, Weiwei Nanjing univ chinese med Affiliated Hosp Dept Surg Oncol Nanjing 210029 Peoples R China Nanjing univ chinese med Sch Integrated Med Nanjing 210023 Peoples R China Nanjing univ chinese med Jiangsu Collaborat Innovat Ctr Tradit Chinese Med Nanjing 210023 Peoples R China Nanjing univ chinese med Sch Pharmacol Nanjing 210023 Peoples R China Ningxia med univ Sch Pharmacol Yinchuan 750004 Peoples R China

Copper-based nanomaterials demonstrate promising potential in cancer therapy. Cu+ efficiently triggers a Fenton-like reaction and further consumes the high level of glutathione, initiating chemical dynamic therapy (CDT) and ferroptosis. Cuproptosis, a newly identified cell death modality that represents a great prospect in cancer therapy, is activated. However, active homeostatic systems rigorously keep copper levels within cells exceptionally low, which hinders the application of cooper nanomaterials-based therapy. Herein, a novel strategy of CRISPR-Cas9 RNP nanocarrier to deliver cuprous ions and suppress the expression of copper transporter protein ATP7A for maintaining a high level of copper in cytoplasmic fluid is developed. The Cu2O and organosilica shell would degrade under the high level of glutathione and weak acidic environment, further releasing RNP and Cu+. The liberated Cu+ triggered a Fenton-like reaction for CDT and partially transformed to Cu2+, consuming intracellular GSH and initiating cuproptosis and ferroptosis efficiently. Meanwhile, the release of RNP effectively reduced the expression of copper transporter ATP7A, subsequently increasing the accumulation of cooper and enhancing the efficacy of CDT, cuproptosis, and ferroptosis. Such tumor microenvironment responsive multimodal nanoplatform opens an ingenious avenue for colorectal cancer therapy based on gene editing enhanced synergistic cuproptosis/CDT/ferroptosis. (c) 2024 The Authors. Published by Elsevier B.V. on behalf of chinese Pharmaceutical Association and Institute of Materia medica, chinese Academy of medical Sciences. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

关键词： GSH- and pH-responsive Effective copper delivery CRISPR-Cas9 ATP7A Cuproptosis Chemodynamic Ferroptosis Synergistic therapy FERROPTOSIS COMBINATION

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

In Vitro Propagation and Artificial Seed Production of Fritillaria cirrhosa D. Don, an Endangered medicinal Plant

引用

Phyton-International Journal of Experimental Botany 2024年第6期93卷 1297-1310页

作者： Qian Tao Guiqi Han Bujin Ma Hongmei Jia Can Zhao Wenshang Li Zhuyun Yan chengdu university of traditional chinese medicine State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest ChinaChengdu610000China

Fritillaria cirrhosa ***(Liliaceae)is an endangered perennial bulbous plant and its dry bulb is a valuable med-icinal material with antitussive and expectorant ***,lack of resources and expensive prices make it difﬁcult to meet clinical *** study presents a regeneration system aimed at overcoming the challenge of inadequate supply in ***,focusing on:(1)callus induction,(2)bulblets and adventitious bud induction,and(3)artiﬁcial seed *** development was achieved in 84.93%on Murashige and Skoog(MS)medium fortiﬁed with 1.0 mg·L^(-1) *** optimal medium for callus differentiation into regenerated bulb-lets was MS medium supplemented with 1.0 mg·L^(-1)6-benzyladenine(6-BA)and 0.2 mg·L^(-1)α-naphthaleneacetic acid(NAA).Subsequently,bulblets and adventitious buds were induced from regenerated bulblet sections cul-tured on MS medium fortiﬁed with 0.3 mg·L^(-1)6-BA+1.0 mg·L^(-1)2,4-dichlorophenoxyacetic acid(2,4-D),2.0 mg·L^(-1)6-BA+0.5 mg·L^(-1),and the induction rates were 88.17%and 84.24%,*** regenerated bulblets were transplanted into a substrate of humus soil,river sand,and pearlite(1:1:1)after low-temperature *** germination rate was 42.80%after culture for 30 *** bulblets were used for encap-sulations in liquid MS medium containing 3%sucrose(w/v)+0.5 mg·L^(-1) NAA+2.0 mg·L^(-1)6-BA+3%sodium alginate(w/v)with a 10 min exposure to 2%CaCl_(2).Under non-aseptic conditions,the germination rate reached 81.67%,while the rooting rate was 20.56%after 45 *** capsule added 1.0 g·L^(-1) carbendazim and 1.0 g·L^(-1) activated carbon was the best component of artiﬁcial *** study successfully established an efﬁcient regen-eration system for the rapid propagation of ***,involving in vitro bulblet regeneration and artiﬁcial seed *** method introduces a novel approach for efﬁcient breeding and germplasm preservation,making it suitable for large-scale industrial resou

关键词： Artiﬁcial seed callus induction Fritillaria cirrhosa organogenesis plant propagation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：