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Semi-Automated Synthesis of [F-18]FBAM, a Thiol Reactive Prosthetic Group, Using Continuous Flow chemistry

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International Journal of Organic chemistry 2016年第3期6卷 177-185页

作者： Murthy R. Akula Srinivasa R. Marepally Lee T. Collier W. George Kabalka departments of chemistry and Radiology University of Tennessee Knoxville Tennessee USA Advion Biosystems Ithaca NY USA

[F-18]FBAM, a thiol reactive bifunctional agent, was successfully synthesized using continuous flow chemistry in a micro reactor that is part of Advion NanoTek Micro-fluidic Synthesizer. As the radiofluorination was carried out microfluidically, a very small amount of precursor was used and over all radiochemical yield was 38% ± 4% (n = 8, decay corrected) and the radiochemical purity was ≥98% with specific activity of 430 mC/μmol. The total reaction time including HPLC purification was 55 min that is 14 min more than manual synthesis and 6 min less than fully automated synthesis.

关键词： Bifunctional Agent Micro-Reactor 6-Bromohexnol Radiofluorination Appel Reaction

Self-assembled multifunctional DNA nanoflowers for the circumvention of multidrug resistance in targeted anticancer drug delivery

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Nano Research 2015年第11期8卷 3447-3460页

作者： Lei Mei Guizhi Zhu Liping Qiu Cuichen Wu Huapei Chen Hao Liang Sena Cansiz Yifan Lv Xiaobing Zhang Weihong Tan Molecular Sciences and Biomedicine Laboratory State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering College of Biology Collaborative Innovation Center for Chemistry and Molecular Medicine Hunan University Changsha 410082 China departments of chemistry Physiology and Functional Genomics Center for Research at the Bio/Nano Interface Shands Cancer Center UF Genetics Institute and McKnight Brain Institute University of Florida Gainesville FL 32611-7200 USA Laboratory of Molecular Imaging and Nanomedicine National Institute of Biomedical Imaging and Bioengineering National Institutes of Health Bethesda MD 20892 USA

癌症化疗被它的副作用和 multidrug 抵抗(MDR ) 限制了。因此，指向了能围绕 MDR 的药交货系统被需要。这里，我们向 chemosensitive 和在白血病和乳癌房间模型围绕了 MDR 的 MDR 癌症房间为指向的药交货汇报多功能的 DNA nanoflowers (... 详细信息

癌症化疗被它的副作用和 multidrug 抵抗(MDR ) 限制了。因此，指向了能围绕 MDR 的药交货系统被需要。这里，我们向 chemosensitive 和在白血病和乳癌房间模型围绕了 MDR 的 MDR 癌症房间为指向的药交货汇报多功能的 DNA nanoflowers (NF ) 。NF 经由卷圆复制， NF 为特定的癌症房间识别，为 bioimaging 的 fluorophores，和 doxorubicin (纪录影片) 用 aptamers 在期间被合并产生的 DNA 和镁焦磷酸盐的潜在的一起沉淀是自我装配的为药交货的有约束力的 DNA。NF 尺寸是悦耳的(在直径击倒 nm 到 200 ) ，并且浓密地包装的药绑定主题和多孔的 intrastructures 赋予 NF 以一个高装载药的能力(71.4% ， wt/wt ) 。尽管 Doxloaded NF (NF 纪录影片) 在生理的 pH 是稳定的，药版本在酸或基本的条件下面被便于。NF 交付纪录影片进目标 chemosensitive 和 MDR 癌症房间，阻止药流出并且提高在 MDR 房间的药保留。NF 纪录影片在两个目标 chemosensitive 房间和 MDR 房间，然而并非在 nontarget 房间导致有势力 cytotoxicity，并发地因此围绕 MDR 并且减少副作用。总的来说，这些 NF 为在指向的癌症治疗围绕 MDR 正在答应工具。

关键词：多药耐药 DNA 多功能自组装纳米抗癌药肿瘤细胞药物释放

Zinc-substituted hemoglobin with specific drug binding sites and fatty acid resistance ability for enhanced photodynamic therapy

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Nano Research 2019年第8期12卷 1880-1887页

作者： Yiting Xu Jiamei Xu Xiaoxiao Hu Xin Xia Qian Dong Zhangkun Liu Zhuo Chen Weihong Tan Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of Life SciencesAptamer Engineering Center of Hunan ProvinceHunan Provincial Key Laboratory of Biomacromolecular Chemical BiologyHunan UniversityChangsha 410082China Department of chemistry Departments of Physiology and Functional GenomicsCenter for Research at the Bio/Nano InterfaceUF Health Cancer CenterUF Genetics Institute and McKnight Brain InstituteUniversity of FloridaGainesvilleFlorida 32611USA

Precisely designed protein-based nanodrugs, as a kind of colloidal drug system, have attracted significant attention in tumor therapy because of their refined drug loading ratio, controlled delivery efficacy and natural biocompatibility. However, most drugs are conjugated to the protein carriers randomly without specific binding sites. Moreover, such sites could easily be replaced by lipophilic molecules in the physiological environment and result in low delivery efficiency. With strong and specific binding locations especially comparatively narrow spatial binding sites and nonflexible structure, hemin (FePPIX)-free hemoglobin or apohemoglobin (apoHb), as a natural metalloporphyrin protein carrier, represents great potential in bioapplication. Therefore, we herein introduce a folate acid (FA) modified, zinc-substituted hemoglobin (ZnPHb-FA) as a naturally occurring protein matrix-based photosensitizer for cancer photodynamic therapy (PDT). Noncovalent inserted ZnPPIX molecules in apoHb possess an extremely stable property and significant recovered photoproperties with superior biocompatibility and phototoxicity, both in vitro and in vivo. This stability was verified by molecular docking analysis and calculation of binding constant, representing a total of five drug binding sites of apoHb for ZnPPIX molecules, four of which are energetically favorable (△G value of -11.9 kcal/mol), and one which is energetically acceptable (△G value of -9 kcal/mol). Folate acid modification has been shown to efficiently enhance the internalization and retention time of ZnPHb nanodrug. ZnPHb-FA is also an efficient depressor of hemin oxygenase-1 (HO-1), which could, in turn, lower the antioxidant ability of cancer cells by decreasing the production of biiirublin. Results in vitro and in vivo both indicated that the firmly combination of apoHb and ZnPPIX described here represents a novel and efficient protein nanodrug systems for cancer therapy.

关键词： natural metalloporphyrin protein carrier specific drug binding sites fatty acid resistance ability photodynamic therapy hemin oxygenase-1 (HO-1)

Effect of Ni particle size on the production of renewable methane from CO_(2) over Ni/CeO_(2) catalyst

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Journal of Energy chemistry 2021年第10期30卷 602-611,I0015页

作者： Lili Lin Clifford A.Gerlak Chang Liu Jordi Llorca Siyu Yao Ning Rui Feng Zhang Zongyuan Liu Sen Zhang Kaixi Deng Christopher B.Murray José A.Rodriguez Sanjaya D.Senanayake chemistry Division Brookhaven National LaboratoryUptonNY 11973USA Institute of Industrial Catalysis State Key Laboratory of Green Chemistry Synthesis TechnologyCollege of Chemical EngineeringZhejiang University of TechnologyHangzhou 310014ZhejiangChina Department of chemistry University of VirginiaCharlottesvilleVA 22904USA Institute of Energy Technologies Department of Chemical Engineering and Barcelona Research Center in Multiscale Science and EngineeringUniversitat Politècnica de CatalunyaEEBEEduard Maristany 10-1408019 BarcelonaSpain Zhejiang University Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027ZhejiangChina chemistry Department State University of New YorkStony BrookNYUSA departments of chemistry and Materials Science&Engineering University of Pennsylvania231 South 34th Street394PhiladelphiaPA 19104USA

Production of’renewable Methane’has attracted renewed research interest as a fundamental probe reaction and process for CO_(2)utilization through potential use in Cl fuel production and even for future space exploration ***_(2)methanation is a structure sensitive reaction on Ni/CeO_(2)*** precisely elucidate the size effect of the Ni metal center on the CO_(2)methanation performance,we prepared2%Ni/CeO_(2)catalysts with pre-synthesized uniform Ni particles(2,4 and 8 nm)on a high surface area CeO_(2)*** electron microscopy(TEM)and ambient pressure X-ray photo spectroscopy(AP-XPS)characterization have confirmed that the catalyst structure and chemical state was uniform and stable under reaction *** 8 nm sized catalyst showed superior methanation selectivity over the 4 and 2 nm counterparts,and the methanation activity in term of TOF is 10 times and 70 times higher than for the 4 and 2 nm counterparts,*** DRIFTS studies revealed that the larger Ni(8 nm particles)over CeO_(2)efficiently facilitated the hydrogenation of the surface formate intermediates,which is proposed as the rate determining step accounting for the excellent CO_(2)methanation performance.

关键词： CO_(2)methanation Particle size effect Ni/CeO_(2) In situ DRIFTS Mechanism investigation

One-pot synthesis of salicylaldehyde containing biaryl frameworks via an aminocatalytic Diels-Alder-retro-Diels-Alder cascade reaction of ynals with 2-pyrones

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Green Synthesis and Catalysis 2020年第1期1卷 66-69页

作者： Xixi Song Yueteng Zhang Peng Ji Fanxun Zeng Fangchao Bi Wei Wang College of chemistry Zhengzhou UniversityNo.100 Science AvenueZhengzhou 450001China departments of Pharmacology and Toxicology and chemistry and Biochemistry And BIO5 InstituteUniversity of ArizonaArizona 85721United States School of Pharmacy East China University of Science and TechnologyShanghai 200237China

Salicylaldehyde containing biaryls are efficiently synthesized via an unprecedented amine promoted Diels-Alderretro-Diels-Alder cascade reaction of ynals with 2-pyrones in good *** reaction is instrumentally metalfree... 详细信息

关键词： Aminocatalysis Biaryls Cascade reactions Diels-Alder reaction Organocatalysis Ynals

Downregulation of transforming growth factor-<i>β</i>(TGF-<i>β</i>) and vascular endothelial growth factor (VEGF) in ehrlich ascites carcinoma-bearing mice using stearic acid-grafted carboxymethyl chitosan (SA-CMC)

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Natural Science 2012年第11期4卷 808-818页

作者： Salem A. Habib Yassin A. Aggour Hossam A. Taha Biochemistry Division Chemistry Department Damietta Faculty of Science Mansoura University Mansoura Egypt chemistry departments Damietta Faculty of Science Mansoura University Mansoura Egypt

The present study was conducted to investigate the use of stearic acid-grafted carboxymethyl chitosan(SA-CMC) as a downregulator for trans- forming growth factor-β (TGF- β) and vascular endothelial growth factor (VEGF) in Ehrlich ascites carcinoma (EAC)-bearing mice. The antitumor effect of stearic acid-grafted carboxymethyl chitosan was assessed by the estimation of TGF- β and VEGF in serum in addition to the estimation of tumor volume, median survival time (MST), percentage of increase in life span (ILS%) as well as the contents of total lipid, DNA and RNA in liver tissues. Hematological profiles (hemoglobin, red blood cells, and platelets) were also assessed. In addition, liver function tests and the redox status were estimated. TGF- β, VEGF, DNA, RNA, and malondialdehyde (MDA) levels, in addition to serum alanine transaminase (ALT) and gamma glutamyl transferase (GGT) activities as well as total white blood cells counts and tumor volume were all highly significantly increased (P < 0.001) in untreated EAC-bearing mice compared to controls. However, hematological profiles, total lipid in liver tissues and serum albumin were highly decreased in EAC-bearing mice compared to controls. All these parameters were restored to the normal levels in SA-CMC treated EAC-bearing mice com- pared to the untreated EAC-bearing mice. It is thus concluded that stearic acid-grafted carboxymethyl chitosan has a remarkable antitumor activity against EAC in Swiss albino mice through downregulation of TGF-β and VEGF.

关键词： Transforming Growth Factor-β Vascular Endothelial Growth Factor EAC Cells Stearic Acid-Grafted Carboxymethyl Chitosan

Improved degradation of azo dyes by lignin peroxidase following mutagenesis at two sites near the catalytic pocket and the application of peroxidase-coated yeast cell walls

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Frontiers of Environmental Science & Engineering 2021年第2期15卷 33-42页

作者： Karla IlićĐurđić Raluca Ostafe Olivera Prodanović AleksandraĐurđevićĐelmaš Nikolina Popović Rainer Fischer Stefan Schillberg Radivoje Prodanović University of Belgrade-Faculty of chemistry Studentski trg 12-1611000 BelgradeSerbia Molecular Evolution Protein Engineering and Production facility(MEPEP) Purdue UniversityWest LafayetteIN 47907USA Institute of Molecular Biotechnology RWTH Aachen University52074 AachenGermany Institute for Multidisciplinary Research Kneza Višeslava 111030 BelgradeSerbia departments of Biological Sciences and chemistry Purdue UniversityWest LafayetteIN 47907USA Fraunhofer Institute for Molecular Biology and Applied Ecology IME 52074 AachenGermany

The enzymatic degradation of azo dyes is a promising alternative to ineffective chemical and physical remediation *** peroxidase(LiP)from Phanerochaete chrysosporium is a hemecontaining lignin-degrading oxidoreductase that catalyzes the peroxide-dependent oxidation of diverse molecules,including industrial *** enzyme is therefore ideal as a starting point for protein ***,we subjected two positions(165 and 264)in the environment of the catalytic Trp171 residue to saturation mutagenesis,and the resulting library of 104 independent clones was expressed on the surface of yeast *** yeast display library was used for the selection of variants with the ability to break down structurally-distinct azo dyes more *** identified mutants with up to 10-fold greater affinity than wild-type LiP for three diverse azo dyes(Evans blue,amido black 10B and Guinea green)and up to 13-fold higher catalytic ***,cell wall fragments displaying mutant LiP enzymes were prepared by toluene-induced cell lysis,achieving significant increases in both enzyme activity and stability compared to a whole-cell *** cell wall fragments retained their initial dye degradation activity after 10 reaction cycles each lasting 8 *** best-performing mutants removed up to 2.5-fold more of each dye than the wild-type LiP in multiple reaction cycles.

关键词： Bioremediation Enzyme immobilization Protein engineering Yeast surface display

Origin of Symmetry Breaking and Confinement in Conducting Polymers with Ring Structures

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Communications in Theoretical Physics 2007年第2X期48卷 366-368页

作者： YUAN Yuan Thomas F. George SUN Xin Research Center for Quantum Manipulation Fudan University Shanghai 200433 China National Lab of Infrared Physics Shanghai 200083 China Office of the Chancellor and Center for Molecular Electronics Departments of Chemistry & Biochemistry and Physics & Astronomy Univ.ersity of Missouri-St. Louis St. Louis Missouri 63121 USA

A model to describe the main features of conjugated polymers with ring structures, such as polythiophene and polypyrrole, is constructed. It is shown that the origin of the symmetry breaking and confinement of a solit... 详细信息

关键词：对称破缺聚合物分支理论限制条件

Instrumentation Development of Multi-Scaled Scattering of Bio-Macromolecular Systems

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Instrumentation Development of Multi-Scaled Scattering of Bi...