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DETECTION OF Ca^(2+)-DEPENDENT NEURONAL ACTIVITY SIMULTANEOUSLY WITH DYNAMIC CHANGES IN CEREBRAL BLOOD VOLUME AND TISSUE OXYGENATION FROM THE LIVE RAT BRAIN

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Journal of Innovative Optical Health Sciences 2009年第2期2卷 189-200页

作者： CONGWU DU ZHONGCHI LUO MEI YU HELENE BENVENISTE MELISSA TULLY RUBING PAN BRITTON CHANCE Medical department Brookhaven National Laboratory UptonNY 11973-5000USA department of Biomedical Engineering SUNY at Stony Brook Stony BrookNY 11794USA department of Anesthesiology SUNY at Stony Brook Stony BrookNY 11794USA department of Biology University of Illinois at Urbana-Champaign UrbanaIL 61801 department of Biophysics and Physical chemistry university of Pennsylvania PhiladelphiaPA19104

We present a catheter-based optical diffusion and fluorescence(ODF)probe to study the functional changes of the brain in *** ODF probe enables the simultaneous detection ofthe multi-wavelength absorbance and fluorescence emission from the living rat *** previous studies,including a transient stroke experiment of the rat brain as well as the brainresponse to cocaine,have established the feasibility of simultaneously determining changes incerebral blood volume(CBV),tissue oxygenation(StO2)and intracellular calcium([Ca^(2+)]i,using the fluorescence indicator Rhod2).Here,we present our preliminary results of somatosensory response to electrical forepaw stimulation obtained from the rat cortical brain by using theODF probe,which indicate that the probe could track brain activation by directly detecting[Ca^(2+)]i along with separately distinguishing CBV and StO2 in real *** changes of CBV,StO2 and[Ca^(2+)]i are comparable with the blood-oxygen-level-dependent(BOLD)response tothe stimulation obtained using functional magnetic resonance imaging(fMRI).However,thehigh temporal resolution of the optical methodology is advanced,thus providing a new modalityfor brain functional studies to understand the hemodynamic changes that underlie the neuronalactivity.

关键词： Optical spectroscopy calcium fluorescence Rhod2 labeling brain ischemia and cocaine addiction forepaw stimulation.

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Applications of 3D printed chimeric DNA biomaterials

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Engineered Regeneration 2022年第1期3卷 13-23页

作者： Stephanie Dobres Giridhar Mula Jonathan Sauer Donghui Zhu department of Biomedical Engineering Stony Brook University100 Nicolls RdStony BrookNY 11794USA

The influence of genetic engineering on daily life is prominent,from genetically modified food to transgenic,antibiotic resistant *** direct manipulation of an organism’s genotype has opened the door to a myriad of applications in an effort to treat chronic *** paper proposes the unification of chimeric DNA technology and three-dimensional bioprinting to spark the development of new *** studies of chimeric DNA,*** DNA,have been conducted since 1970,bioprinting is a budding method for tissue engineering and regenerative *** technologies are further described in the background section of this paper,and followed by a detailed analysis into current research,benefits,and limitations of 3D printed chimeric *** benefits include low-cost and effective treatments for cancer,bio-morphological nanostructures for targeted drug delivery,personalized medicine with the use of stem cells,and a significantly reduced rate of addi-tional surgeries and transplant rejection after ***,there are several shortcomings with current chimeric DNA applications,***-T cell therapies,and ethical dilemmas regarding the creation and regulation of human-animal *** review then presents future directions,in which inks made from chimeric DNA and live cells can be printed into bioactive engineered tissue,or biodegradable vehicles for targeted delivery of hiPSCs or CAR ***,this review concludes with a reaffirmation of its main points and the authors’thoughts on the potential of 3D printed chimeric biomaterials.

关键词： Chimeric DNA biomaterials Chimeric biomaterials Recombinant DNA 3D printing Bioprinting Tissue engineering Regenerative medicine CAR T-cell therapy

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Effect of Laser Injection Seeder on Rotationally Resolved Spectra of Benzonitrile

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Chinese Physics Letters 2010年第8期27卷 77-79页

作者：徐海峰 JOHNSON Philip M. SEARS Trevor J. Institute of Atomic and Molecular Physics 3ilin University~ Changchun 130012 chemistry department Stony Brook University Stony Brook NY 11974 USA department of chemistry Brookhaven National Laboratory Upton NY 11973 USA

High resolution lasers are necessary to derive the most information from molecular spectra. However, their use uncovers some photophysical processes that compromise the ability to resolve rotational structure. We study the influence of laser optical mode structure on the high resolution spectra of the S1 states of benzonitrile in a supersonic molecular beam using an Ar^＋ pumped cw ring dye laser which is amplified by a pulsed Nd： YA G laser. The latter could be operated either in one optical mode by injecting （seeding） its oscillator with a single mode diode laser, or with many optical modes by not using the seeder. Rotationally resolved lines are obtained when the oscillator of the YAG laser are operated in one single optical mode, but only a continuum is seen when the YAG laser has multiple modes. It is argued that the ac Stark effect is the most probable reason for broadening and blurring the rotational lines.

关键词： OPTICAL detectors INJECTION lasers NITRILES MOLECULAR spectra MOLECULAR beams ND-YAG lasers STARK effect

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Characteristics of lateral heterogeneities with thermal and chemical origins in the pyrolitic lower mantle

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Progress in Natural Science:Materials International 2009年第11期19卷 1603-1611页

作者： Baosheng Li~* Mineral Physics Institute,stony brook university,stony brook,NY 11794,USA [a]Mineral Physics Institute Stony Brook University Stony Brook NY 11794 USA

The relative changes between shear and compressional velocities(RSP=(?)ln VS/(?) ln VP),bulk sound and shear velocities (RCS=(?) ln VC/(?) ln VS),and density versus shear wave velocity(RρS=(?) lnρ/(?) ln VS) in response to thermal and chemical variations were investigated for the pyrolitic lower *** heterogeneities with thermal origins,RSPincreases from 1.7 to 2.0 together with RρSdecreasing from 0.4 to 0.2 and RCS=～0.27 from the top to the bottom of the lower *** comparison,chemical variations (bulk iron or silica contents) are characterized by RSP0.5 at lower mantle *** values of RρSand RCSare indicative of chemical anomalies in the lower mantle,but a combination of thermal and chemical heterogeneities may be required to produce velocity and density anomalies at the magnitudes observed in seismic *** refinement of these characteristics requires data on the higher order pressure and temperature derivatives of the elastic moduli of the constituent phases.

关键词： Lower mantle Lateral heterogeneity Elasticity Pyrolite

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Self Localization Method Using Parallel Projection Model for Mobile Sensor in Navigation Applications

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Journal of Computer Science & Technology 2009年第3期24卷 588-603页

作者： Shung Han Cho Yuntai Kyong Sangjin Hong We-Duke Cho department of Electrical and Computer Engineering Stony Brook University- SUNY Stony Brook NY U.S.A. department of Electronics Engineering College of Information Technology Ajou University Suwon Korea

This paper presents a novel self localization method using parallel projection model for mobile sensor in navigation applications. The algorithm estimates the coordinate and the orientation of mobile sensor using projected references on visual image. The proposed method considers the lens non-linearity of the camera and compensates the distortion by using a calibration table. The method determines the coordinates and orientations with iterative process, which is very accurate with low computational demand. We identify various sources of error on the coordinate and orientation estimations, and present both static sensitivity analysis of the algorithm and dynamic behavior of the mobile sensor. The algorithm can be utilized in mobile robot navigation as well as positioning application where accurate self localization is necessary.

关键词： mobile sensors localization parallel projection model visual processing

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Piezo1 channel activation in response to mechanobiological acoustic radiation force in osteoblastic cells

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Bone Research 2021年第2期9卷 223-232页

作者： Guangdao Zhang Xiaofei Li Lin Wu Yi-Xian Qin department of Biomedical Engineering Stony Brook UniversityStony BrookNY 11794USA department of Prosthodontics School of StomatologyChina Medical UniversityShenyangChina

Mechanobiological stimuli,such as low-intensity pulsed ultrasound(LIPUS),have been shown to promote bone regeneration and fresh fracture repair,but the fundamental biophysical mechanisms involved remain ***,we propose that a mechanosensitive ion channel of Piezo1 plays a pivotal role in the noninvasive ultrasound-induced mechanical transduction pathway to trigger downstream cellular signal *** study aims to investigate the expression and role of Piezo1 in MC3T3-E1 cells after LIPUS *** analysis shows that Piezo1 was present on MC3T3-E1 cells and could be ablated by shRNA ***3T3-E1 cell migration and proliferation were significantly increased by LIPUS stimulation,and knockdown of Piezo1 restricted the increase in cell migration and *** labeling with Fluo-8,MC3T3-E1 cells exhibited fluorescence intensity traces with several high peaks compared with the baseline during LIPUS *** obvious change in the fluorescence intensity tendency was observed after LIPUS stimulation in shRNA-Piezo1 cells,which was similar to the results in the GsMTx4-treated *** phosphorylation ratio of ERK1/2 in MC3T3-E1 cells was significantly increased(P<0.01)after LIPUS *** addition,Phalloidin-iFluor-labeled F-actin filaments immediately accumulated in the perinuclear region after LIPUS stimulation,continued for 5 min,and then returned to their initial levels at 30 *** results suggest that Piezo1 can transduce LIPUS-induced mechanical signals into intracellular *** influx of Ca2+serves as a second messenger to activate ERK1/2 phosphorylation and perinuclear F-actin filament polymerization,which regulate the proliferation of MC3T3-E1 cells.

关键词： stimulation Piezo1 activation

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Female reproductive success in a species with an age-inversed hierarchy

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Integrative Zoology 2016年第6期11卷 433-446页

作者： Dorien DE VRIES Andreas KOENIG Carola BORRIES Interdepartmental Doctoral Program in Anthropological Sciences Stony Brook UniversitySUNYNYUSA department of Anthropology Stony Brook UniversitySUNYNYUSA

In most group-living mammals,reproductive success declines with increasing age and increases with increasing *** effects have mainly been studied in matrilineal and in“age positive”hierarchies,which are stable and in which high ranking females often outperform low ranking *** relationships are less well-understood in age-inversed dominance hierarchies,in which a female’s rank changes over *** analyzed demographic data of 2 wild,unprovisioned groups of gray langurs(Semnopithecus schistaceus)near Ramnagar,Nepal covering periods of 5 years *** rank was unstable and *** measured reproductive success via birth rates(57 births),infant survival(proportion of infants surviving to 2 years)and number of offspring surviving to 2 years of age(successful births)for 3 age and 3 rank *** found that old females performed significantly worse than expected(birth rate P=0.04;successful births P=0.03).The same was true for low ranking females(P=0.04,and P<0.01,respectively).Infant survival was highest for young and middle-aged as well as for high and middle ranking ***,the results for these unstable hierarchies were rather similar to those for stable hierarchies of other mammals,particularly several nonhuman ***pared to a provisioned population of a closely related species,the wild and unprovisioned population examined(i)showed stronger age effects,while(ii)female reproductive success was equally affected by *** comparative studies are needed to examine whether captive or provisioned populations deviate predictably from wild populations.

关键词： birth rate gray langurs offspring survival provisioning Semnopithecus schistaceus

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3D Printing of Ceramic Biomaterials

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Engineered Regeneration 2022年第1期3卷 41-52页

作者： Michael Ly Sarah Spinelli Shayne Hays Donghui Zhu department of Biomedical Engineering Stony Brook University100 Nicolls RdStony BrookNY 11794United States

Bioceramics are a popular class of materials used in biomedical applications due to their mechanical stability and *** exist in a variety of fields including hip joints for orthopedics,tooth fillings for dentistry,and scaffolds for tissue engineering;however,the standard processes currently used to manufacture these ce-ramic products can be time-consuming and *** response,current literature alternatively proposes additive manufacturing(3D printing)strategies to fabricate bioceramic materials in a cost-effective and efficient ***,we briefly cover five common processes and materials used in additive manufacturing bioceramics:fused deposition modeling,material jetting,binder jetting,powder bed fusion,and vat ***-thermore,we discuss the potential of these 3D printed ceramic structures when applied to different biomedical technologies such as bone tissue scaffolds and structural implants.

关键词： Extrusion Binder jetting Material jetting Powder bed fusion Vat photopolymerization

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The radial organization of neuronal primary cilia is acutely disrupted by seizure and ischemic brain injury

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Frontiers in Biology 2017年第2期12卷 124-138页

作者： Gregory W. Kirschen Hanxiao Liu Tracy Lang Xuelin Liang Shaoyu Ge Qiaojie Xiong Medical Scientist Training Program (MSTP) Stony Brook University Stony Brook NY 11794 USA Molecular & Cellular Pharmacology Program Stony Brook University Stony Brook NY 11794 USA department of Neurobiology & Behavior Stony Brook University Stony Brook NY 11794 USA Simons Summer Research Program (SSRP)

BACKGROUND： Neuronal primary cilia are sensory organelles that are critically involved in the proper growth, development, and function of the central nervous system （CNS）. Recent work also suggests that they signal in the context of CNS injury, and that abnormal ciliary signaling may be implicated in neurological diseases. METHODS： We quantified the distribution of neuronal primary cilia alignment throughout the normal adult mouse brain by immunohistochemical staining for the primary cilia marker adenylyl cyclase Ⅲ （ACⅢ） and measuring the angles of primary cilia with respect to global and local coordinate planes. We then introduced two different models of acute brain insult--temporal lobe seizure and cerebral ischemia, and re-examined neuronal primary cilia distribution, as well as ciliary lengths and the proportion of neurons harboring cilia. RESULTS： Under basal conditions, cortical cilia align themselves radially with respect to the cortical surface, while cilia in the dentate gyms align themselves radially with respect to the granule cell layer. Cilia of neurons in the striatum and thalamus, by contrast, exhibit a wide distribution of ciliary arrangements. In both cases of acute brain insult, primary cilia alignment was significantly disrupted in a region-specific manner, with areas affected by the insult preferentially disrupted. Further, the two models promoted differential effects on ciliary lengths, while only the ischemia model decreased the proportion of ciliated cells. CONCLUSIONS： These findings provide evidence for the regional anatomical organization of neuronal primary cilia in the adult brain and suggest that various brain insults may disrupt this organization.

关键词： cerebral cortex dentate gyrus temporal lobe seizure cerebral ischemia

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Enhancing Dehydration Performance of Isopropanol by Introducing Intermediate Layer into Sodium Alginate Nanofibrous Composite Pervaporation Membrane

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Advanced Fiber Materials 2019年第2期1卷 137-151页

作者： Peiyun Li Cheng Cheng Ke Shen Tonghui Zhang Xuefen Wang Benjamin S.Hsiao State Key Lab for Modification of Chemical Fibers and Polymer Materials Donghua UniversityShanghai 201620People’s Republic of China department of chemistry Stony Brook UniversityStony BrookNY 11794USA

A novel three-tier composite membrane based on highly porous nanofibrous substrate was demonstrated for efficient iso-propanol dehydration by ***,polyethyleneimine(PEI)modified graphene oxide(GO)sheets were vacuum-assistant assembled onto porous electrospun polyacrylonitrile(PAN)nanofibrous substrate to achieve a smooth,hydrophilic and compact PEI-GO intermediate *** introduction of PEI chains endowed GO interlayer with sufficient interaction for bonding adjacent GO nanosheets to enhance stability in water/isopropanol mixture and also with the ascended inter-lamellar space to improve the water-sorption ability due to the abundant active amino *** from PEI-GO layer,a defect-free sodium alginate(SA)skin layer could be facilely manufactured with elaborately controlled thickness as thin as possible in order to reduce mass transfer resistant and enhance permeability ***,the interlayer would also contribute to enhance interfacial adhesion to promote the structure integrity of three-tier thin-film nanofibrous composite(TFNC)membrane in pervaporation dehydration *** fine-tuning of membrane preparation process,the SA/PEI(75)-GO-60/PAN TFNC membrane exhibited competitive pervaporation performance with the permeate flux of 2009 g/m2 h and the separation factor of 1276 operated at 70°C for dehydration of 90 wt%isopropanol *** unique three-tier composite membrane structure suggested an effective and facile approach to design novel membrane structure for further improvement of pervaporation performance.

关键词： Polyethyleneimine modified graphene oxide Intermediate layer Thin-film nanofibrous composite membrane Pervaporation membrane

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