检索结果-南通市图书馆

New insights into the fascinating world of glucocorticoids:the dexamethasone-miR-342-Rictor axis in regulatory T cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第3期18卷 520-522页

作者： Frank Buttgereit Timo Gaber Department of Rheumatology and Clinical Immunology Charity University MedicineBerlinGermany

In a recent issue of Immunity,Kim et *** previously unknown effects of glucocorticoids on murine regulatory T(Treg)cells,and this report added another very interesting perspective to the already very diverse body of knowledge about these important hormones and therapeutics compared to the body of knowledge about other clinically used drugs.1 Treg cells are important regulators of the immune response in autoimmune and allergic inflammation.

关键词： drugs allergic

Hepatic macrophages in liver homeostasis and diseasesdiversity,plasticity and therapeutic opportunities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第1期18卷 45-56页

作者： Yankai Wen Joeri Lambrecht Cynthia Ju Frank Tacke Department of Anesthesiology McGovern Medical SchoolUniversity of Texas Health Science Center at HoustonHoustonTXUSA Department of Hepatology and Gastroenterology Charity University Medicine BerlinBerlinGermany

Macrophages,which are key cellular components of the liver,have emerged as essential players in the maintenance of hepatic homeostasis and in injury and repair processes in acute and chronic liver *** liver injury,resident Kupffer cells(KCs)sense disturbances in homeostasis,interact with hepatic cell populations and release chemokines to recruit circulating leukocytes,including monocytes,which subsequently differentiate into monocyte-derived macrophages(MoMφs)in the *** KCs and MoMφs contribute to both the progression and resolution of tissue inflammation and injury in various liver *** diversity of hepatic macrophage subsets and their plasticity explain their different functional responses in distinct liver *** this review,we highlight novel findings regarding the origins and functions of hepatic macrophages and discuss the potential of targeting macrophages as a therapeutic strategy for liver disease.

关键词： Kupffer cells monocyte-derived macrophages liver inflammation liver fibrosis liver cancer

Induction of Heme Oxygenase-1 in Human Hepatocytes to Protect Them From Ethanol-induced Cytotoxicity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2004年第3期17卷 315-326页

作者： LIE-GANGLIU HONGYAN WENZHANG PINGYAO XI-PINGZHANG XIU-FASUN ANDREASK.NUSSLER DepartmentofNutritionandFoodHygiene TongjiMedicalCollegeHuazhongUniversityofScienceandTechnologyWuhan430030HubeiChina DepartmentofGeneral VisceralandTransplantationSurgeryHumboldtUniversityCharitYCampusVirchowAugustenburgerPlatz113353BerlinGermany DepartmentofNutritionandFoodHygiene TongjiM.edical_Coll_egeHuazhongUniversityofScienceandTechnology13HangkongRoadWuhan430030HubeiChina

Background/Aim We investigated the relationship between ethanol exposure and heme oxygenase (HO-1) in human hepatocytes in order to ascertain if induction of HO-1 can prevent ethanol induced cellular damage. Methods Dose-dependent (25-100 mmol/L) and time-dependent (0-24 h) ethanol exposure were used in the present study. HO-1 mRNA and protein expression were detected by PT-PCR and Western blot respectively. HO-1 activity was indicated by bilirubin and Fe2+ formation. Cytotoxicity was investigated by means of lactate dehydrogenate (LDH) and aspartate transaminase (AST) level in culture supernatants, as well as the intracellular formation of malondialdehyde (MDA), cellular glutathione (GSH) status and CYP 2E1 activity. Results We first demonstrated a dose-dependent response between ethanol exposure and HO-1 mRNA and protein expression in human hepatocytes. We further observed a time-dependent increase of HO-1 mRNA expression using 100 mmol/L ethanol starting 30 minutes after ethanol exposure, reaching its maximum between 3 h and 9 h. Being similar to what had been demonstrated with the mRNA level, increased protein expression started at 6 h after ethanol exposure, and kept continuous elevated over 18 h. In addition, we found that ethanol exposure to hepatocytes markedly increased HO-1 enzyme activity in a time-dependent manner measured as bilirubin and Fe2+ formation in human hepatocytes. Our results clearly showed that ethanol exposure caused a significant increase of LDH, AST, and MDA levels, while the antioxidant GSH was time-dependently reduced. Furthermore, we demonstrated that pre-administration of cobalt protoporphyrin (CoPP) induced HO-1 in human hepatocytes, and prevented an increase of MDA and a decrease of GSH. These effects could be partially reversed by zinc protoporphyrin (ZnPP), an antagonist of HO-1 induction. Conclusion HO-1 expression in cells or organs could lead to new strategies for better prevention and treatment of ethanol-induced oxidat

关键词： Heme oxygenase-1 Ethanol Cellular stress Human hepatocytes

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

酒精滥用与围手术期免疫功能障碍

麻醉与镇痛 2011年第2期7卷 86-90页

作者： Alexandra Lau, MD Vera von Dossow, MD Michael Sander, MD Martin MacGuill, MD Nadine Lanzke, DVW Claudia Spies, MD 王海涛(译) 李士通(校) Department Of Anesthesiology and Intensive Care Medicine Unit Campus Virchow-Klinikum and Campus Charite Mitte CharitY-University Hospital Berlin Berlin Germany 不详

长期酗酒患者的麻醉不良后果包括：手术后感染风险增加3～5倍，重症监护室停留时间和住院时间延长。手术后高感染率的原因归结为长期酗酒患者免疫反应的改变。手术前，长期酗酒患者T辅助淋巴细胞1/T辅助淋巴细胞2（Th1/Th2）降低，手术... 详细信息

长期酗酒患者的麻醉不良后果包括：手术后感染风险增加3～5倍，重症监护室停留时间和住院时间延长。手术后高感染率的原因归结为长期酗酒患者免疫反应的改变。手术前，长期酗酒患者T辅助淋巴细胞1/T辅助淋巴细胞2（Th1/Th2）降低，手术后仍然减低。围手术期低Th1／Th2是迟发感染的预兆。长期酗酒患者手术后的细胞毒性淋巴细胞（Tc1／Tc2）也减低，并且减低状态会持续5天。手术后，长期酗酒患者全血的白介素（IL）-6／IL-10比值以及脂多糖（LPS）激发的γ干扰素（INF-γ）／IL-10比值也是减低的。Th1／Ih2、Tc1/Tc2以及脂多糖激发INF-γ／IL-10比值的降低是手术后迟发感染的预兆。因此，围手术期干预的目的在于尽力减轻免疫系统的调控异常。

关键词：围手术期免疫功能障碍酒精滥用 T辅助淋巴细胞1 Th1/Th2 细胞毒性淋巴细胞 IL-10 Tc1/Tc2