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INPUT-OUTPUT MODELS OF SCIENCE AND TECHNOLOGY AND ITS APPLICATION IN EVALUATING PROGRESS OF ENTERPRISE SCIENCE AND TECHNOLOGY

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Transactions of Nonferrous Metals Society of China 1996年第1期6卷 153-158页

作者： Hu Zhenhua Luo Fayou He Xiaojie Department of Economics and Trade CSUTChangsha 410083 Department of Business Administration CSUTChangsha 410083

The method of compiling input-output models of science and technology was studied,and the application of input-output techniques in evaluating the progress of enterprise science and technology was *** the models for determining direct,indirect and full contributions of the progress of enterprise science and technology have been set up which can be used to analyse and evaluate the direct,indirect and full benefits of the progress of enterprise science and technology.

关键词： input-output techniques input-output models progress of science and technology full economic benefits

Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing Liu Hongli Li Lemei Zhu Lingfeng Zeng Zhen Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng Jialin Chen Jinghong Xu Bin Jiang Lei Li Yawei Li Yuliang Dai Bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury

Synthesis of amorphous Ti-Al alloys by mechanical alloying of elemental powders

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中国有色金属学会会刊：英文版 2002年第4期12卷 610-614页

作者：张俊红黄伯云贺跃辉周科朝刘咏 Central South University Changsha 410083 Central South University State Key Laboratory for Powder Metallurgy Changsha 410083

Blended elemental powders with the nominal compositions (mole fraction, %) of Ti 54 Al 46 , Ti 52 Al 48 and Ti 50 Al 50 were mechanically alloyed in a planetary ball milling system for up to *** structure evolution in these powders was characterized by scanning electron microscope, X ray diffraction and differential thermal analysis techniques. It was found that elemental powders were progressively transformed into nanocrystalline Ti(Al) supersaturated solid solution, then into amorphous phase. With increasing Al content, the formation of a fully Ti(Al) supersaturated solid solution and amorphous phase were accelerated, which are attributed to the fine grain size. And the grain size condition for formation of amorphous phase in this system is ≤16?nm.

关键词：非晶合金 TiAl合金机械合金化粉末冶金

Recombination Efficiency in Double-Layer Organic Light-Emitting Devices

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Chinese Physics Letters 2005年第3期22卷 719-722页

作者：许雪梅彭景翠翟述李宏建吴建好欧阳玉 DepartmentofAppliedPhysics HunanUniversityChangsha410082//SchoolofPhysicsScienceandTechnologyCentralSouthUniversityChangsha410083 DepartmentofAppliedPhysics HunanUniversityChangsha410082 SchoolofP-hysicsScience-andTechnology CentralSouthUniversityChangsha410083

We analyse the influence of properties of organic/organic interface (OOI) on the characteristics of recombination efficiency of organic double-layer light-emitting diodes. Based on the disordered hopping theory model, spatial and energetic disorder of hopping states are also discussed for the case of space charge limited currents in hole transmitting layers but injection-limited currents in electron transporting layers. The results show that the recombination efficiency increases firstly and then decreases for different OOI parameters, and there is a maximum value changed with different spatial disorder parameters and energetic disorder scale. Different spatial disorder parameters make carrier mobilities change greatly, and the energetic disorder scale causes various localized state densities. Our calculated results are qualitatively in agreement with the experimental data.

关键词： Recombination Efficiency Double-Layer Organic Light-Emitting Devices

A practical method for identifying key factors in the distribution and formation of heavy metal pollution at a smelting site

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Journal of Environmental Sciences 2023年第5期127卷 552-563页

作者： Jiaqing Zeng Wenshun Ke Min Deng Jingqiang Tan Chuxuan Li Yizhi Cheng Shengguo Xue School of Metallurgy and Environment Central South UniversityChangsha 410083China School of Geosciences and Info-physics Central South UniversityChangsha 410083China New World Environment Protection Group of Hunan Changsha 410083China

Smelting activities are the main pathway for the anthropogenic release of heavy metals(HMs)into the soil-groundwater *** is vital to identify the factors affecting HMs pollution to better prevent and manage soil *** present study conducted a comprehensive investigation of HMs in soil from a large abandoned Zn smelting *** integrated approach was proposed to classify and quantify the factors affecting HMs pollution in the ***,the quantitative relationship between hydrogeological characteristics,pollution transmission pathways,smelting activities and HMs pollutionwas *** showed that the soils were highly contaminated by HMs with a pollution index trend of As>Zn>Cd>Pb>*** identifying the pollution hotspots,we conclude that the pollution hotspots of Pb,As,Cd,and Hg present a concentrated distribution ***-detector method results showed that the dominant driving factors for HMs distribution and accumulation were the potential pollution source and soil ***,the main drivers are variable for different HMs,and the interaction among factors also enhanced soil HMs *** analysis illustrates how the confounding influences from complex environmental factors can be distilled to identify key factors in pollution formation to guide future remediation strategies.

关键词： Zinc smelting site Heavy metal pollution Spatial distribution Hotspot identification Geographical detector

New high-strength Ti–Al–V–Mo alloy: from high-throughput composition design to mechanical properties

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International Journal of Minerals,Metallurgy and Materials 2019年第9期26卷 1151-1165页

作者： Di Wu Wan-lin Wang Li-gang Zhang Zhen-yu Wang Ke-chao Zhou Li-bin Liu School of Metallurgy and Environment Central South UniversityChangsha 410083China School of Material Science and Engineering Central South UniversityChangsha 410083China Key Laboratory of Non-Ferrous Metallic Materials Science and Engineering Ministry of EducationChangsha 410083China State Key Laboratory of Powder Metallurgy Changsha 410083China

The high-throughput diffusion-multiple technique and thermodynamics databases were used to design new high-strength Ti alloys. The composition–microstructure–property relationships of the Ti64–xMo alloys were obtained. The phase fraction and composition of the α and β phases of the Ti64–xMo alloys were calculated using the Thermo-Calc software. After aging at 600℃, the Ti64–6 Mo alloy precipitated ultrafine α phases. This phenomenon was explained on the basis of the pseudo-spinodal mechanism by calculating the Gibbs energy curves of the α and β phases of the Ti64–xMo alloys at 600℃. Bulk forged Ti64–6 Mo alloy exhibited high strength and moderate plasticity after α/β-phase-field solution treatment plus aging. The tensile properties of the alloy were determined by the size and morphology of the primary and secondary α phases and by the β grain size.

关键词： high-strength titanium alloy Ti–6Al–4V–xMo diffusion multiple Thermo-Calc microstructure and mechanical properties

Microstructures of spinodal phases in Cu-15Ni-8Sn alloy

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Journal of University of Science and Technology Beijing 2005年第3期12卷 243-247页

作者： YanhuiWang MingpuWang BinHong SchoolofMaterialScienceandEngineering CentralSouthUniversityChangsha410083China

The microstructures of spinodal phases in Cu-15Ni-8Sn alloy were studied by TEM. It was found that when the alloy is completely in a as-quenched state, spinodal decomposition is quick. Ordering appears after spinodal decomposition. The ordered phase with DO22 structure has three variants obtained from coarsening spinodal structure. The reason of ordering appeared after spinodal decomposition is that the content of solute atoms needed by ordering is higher than the average, which can be reached by the composition fluctuation of spinodal decomposition. It was speculated that the morphology of the ordered phase is needle-like.

关键词： Cu-15Ni-8Sn alloy spinodal decomposition DO22 ordering variant

High-performance spherical LiVPO4F/C cathode enabled by facile spray pyrolysis

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Science China(Technological Sciences) 2020年第12期63卷 2729-2734页

作者： DING XiaoBo ZHOU YongMao YAN GuoChun LI JiaYi WANG JieXi School of Metallurgy and Environment Central South UniversityChangsha 410083China Middle School Attached to Central South University Changsha 410083China State Key Laboratory for Powder Metallurgy Central South UniversityChangsha 410083China

LiVPO4F suffers problems of difficulty in synthesis and poor conductivity. To solve these,herein sub-micro spherical LiVPO4F/C is synthesized from a highly-reactive hollow VPO4/C sphere that is derived from a facile and fast spray pyrolysis for the first time. Uniform carbon coating layer with a thickness of 5–8 nm is observed on the surface of the particles,helping to improve the electronic conductivity,suppress the particle growth and protect the particles from corrosion by the electrolyte. The particles are shaped as fine sub-micro spheres,which are beneficial for shortening the distance for Li+ transport. Rietveld refinement for the X-ray diffraction pattern of as-prepared sample shows high-purity triclinic LiVPO4F with an enlarged lattice volume,enabling faster Li+ transport in the prepared material. Accordingly,the resulted LiVPO4F/C demonstrates superior electrochemical properties,delivering 135.4,91.1 mA hg-1 at 1,40 C respectively,and remaining the capacity of 93.3 mA hg-1 after 500 cycles at 20 C with the retention of 95.0%. The method introduced here provides an efficient way to address the serious problems of preparing high-purity Li VPO4F with good conductivity.

关键词： lithium ion battery cathode material spray pyrolysis LiVPO4F carbon coating